جست‌وجوی استاد و پژوهشگر

Alexis Battleمشاهده پروفایل

دانشیار

• Genomics
• Machine Learning
• Computational Biology
• +۳ مورد دیگر

Alexis Battle is an Associate Professor at Johns Hopkins University with appointments in Biomedical Engineering , Computer Science , and Genetic Medicine (secondary). She directs the Malone Center for Engineering in Healthcare and serves as Deputy Director of the Data Science and AI Institute . Educated at Stanford University (PhD in Computer Science, 2013), Battle transitioned to academia after leadership roles at Google. Research Focus: Battle’s work bridges genomics and machine learning , emphasizing the impact of genetic variation on human health. Her lab develops tools like Watershed to predict functional effects of rare variants, aiming to enhance rare disease diagnosis. Key themes include non-coding DNA analysis , personalized genomics , and systems biology , with applications in cardiovascular disease and neurodegenerative disorders . Publications & Awards: Over 60 peer-reviewed articles in journals like Nature , Science , and Genome Biology , with recent emphasis on single-cell transcriptomics , multiomics integration , and telomere biology . Recipient of the President’s Frontier Award (2022), Microsoft Investigator Fellowship (2019), and Searle Scholar (2016). Scientific Awards: 2022 President’s Frontier Award 2019 Microsoft Investigator Fellowship 2019 Johns Hopkins Discovery Award 2017 Johns Hopkins Catalyst Award 2016 Searle Scholar Advising & Funding: Mentors 11 PhD students, 3 undergraduates, and postdoctoral fellows. Her research is funded by NIH, Searle Scholars, and institutional grants. The Battle Lab collaborates on projects like the GTEx Consortium , focusing on gene regulation and clinical genomics .

Vakil Takhaveevمشاهده پروفایل

مدرس

• DNA Damage and Repair
• Aging Mechanisms
• Cancer Biology
• +۶ مورد دیگر

Dr. Vakil Takhaveev is a Lecturer at ETH Zurich's Department of Health Sciences and Technology, within the Institute of Food, Nutrition and Health. His research focuses on DNA damage mechanisms, aging, cancer, and neurodegeneration, with particular emphasis on developing novel DNA-damage-sequencing methods like click-code-seq and TRABI-Seq . He investigates anticancer drug action (e.g., trabectedin), aging clocks using DNA oxidation profiling, and stress-induced carcinogenesis. His work integrates multi-omics approaches and advanced sequencing techniques. Research Directions: Novel DNA-Damage-Sequencing Methods: Developed click-code-seq and TRABI-Seq for genomic mapping of DNA lesions and repair dynamics. Anticancer Drug Action: Explored mechanisms of trabectedin and other chemotherapeutics, linking DNA repair vulnerabilities to therapy resistance. Aging Clocks: Created DNA oxidation-based biomarkers for biological aging using genome-wide profiling in human and mouse models. Stress-Induced Pathologies: Studies metabolic and DNA damage links to early tumorigenesis and neurodegeneration. Awards & Recognition: 2025 Public Award Winner in PIs of Tomorrow competition 2024 ETH Zurich Career Seed Award Best presentation awards (Swiss Chemical Society, American Chemical Society) Grants & Collaborations: Impetus grants for aging clock development Swiss Chemical Society and American Chemical Society fellowships Labs & Teams: Leads research on DNA damage and aging mechanisms at ETH Zurich, collaborating with international groups in oncology and toxicology.

Rotem Karniمشاهده پروفایل

دانشیار

• Alternative RNA Splicing
• RNA Biology
• Cancer Therapy
• +۴ مورد دیگر

Rotem Karni, PhD, is an Associate Professor of Genetics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He leads a research lab focused on understanding how alternative RNA splicing contributes to cancer and genetic diseases, with a strong emphasis on translating these findings into RNA-based therapies. Karni's lab develops decoy oligonucleotides, small molecules, and splice-switching technologies to modulate splicing factors and enhance immunotherapy. Education BSc in Biological Chemistry from The Hebrew University of Jerusalem (1997) PhD in Biological Chemistry from The Hebrew University of Jerusalem, Israel (2002) Postdoctoral Fellowship at Cold Spring Harbor Laboratory, NY (2002-2007) Karni's research explores the deregulation of alternative splicing in oncogenesis, particularly how splicing factors like RBFOX2 and S6K1 influence metastasis, DNA repair, and immune checkpoint modulation. His team investigates m6A RNA modifications for stabilizing mutant genes, with applications in Duchenne Muscular Dystrophy and pancreatic cancer. The lab's work is commercialized through biotech companies: SKIP Therapeutics, Andlit Therapeutics, and RNAble. Selected Research Trends RNA mis-splicing and neoantigen generation (2025) Splicing factor inhibition for tumor suppression (2023) Metastatic splicing signatures in pancreatic cancer (2023) Immune checkpoint splicing in cancer immunotherapy (2021) m6A modulation for mRNA stabilization (2023) Advising & Collaborations Karni has mentored numerous PhD and postdoctoral researchers, many of whom now hold leadership roles in academia, biotech, and medical institutions globally. His lab collaborates extensively on projects involving RNA innovation, including partnerships with the Institute for RNA Innovation. Contact Department of Genetics & Institute for RNA Innovation, One uCity Square, Room 4018, Philadelphia, PA 19104 Phone: 215-898-5072 Email: Rotem.Karni@Upenn.edu

Ardalan Amiri Saniمشاهده پروفایل

دانشیار

• Mobile Systems
• Operating Systems
• Security
• +۵ مورد دیگر

Ardalan Amiri Sani is an Associate Professor in the Computer Science Department at the University of California, Irvine (UCI), affiliated with the Donald Bren School of Information & Computer Sciences. He leads the Trustworthy Systems Lab (TrussLab), focusing on secure and reliable mobile systems, operating systems, and virtualization. His research bridges mobile computing, security, and OS design, addressing challenges in I/O devices, kernel hardening, and verifiable provenance. Education: Ph.D. and M.Sc. from Rice University (ECE), B.Sc. from Sharif University of Technology. Awards include the NSF CAREER Award, Google ASPIRE Award, and UCI Dean's Mid-Career Research Award. He has advised numerous graduate and undergraduate students, many of whom now work in academia and industry. Research highlights include Tabellion (secure legal contracts on mobile devices), ProvCam (verifiable video provenance), and work on minimizing smartphone TCBs via hardware isolation. His grants include NSF funding for OS kernel security and NSA support for provenance systems. Education: Ph.D., Electrical and Computer Engineering, Rice University, 2014 B.Sc., Electrical Engineering, Sharif University of Technology Grants: $500K NSF Award (with UCR) for OS kernel security (2020) NSF SaTC Award for GPU security in browsers Google ASPIRE Award for Android system call filtering Labs/Teams: Trustworthy Systems Lab (TrussLab), collaborating with industry partners like Intel and Broadcom.

Kenneth Hoehnمشاهده پروفایل

استادیار

• Computational Immunology
• Evolutionary Biology
• B Cell Biology
• +۵ مورد دیگر

Kenneth Hoehn is an Assistant Professor in the Department of Biomedical Data Science at the Geisel School of Medicine, Dartmouth College. As a computational immunologist with expertise in evolutionary biology, he develops computational evolutionary approaches to trace cellular lineages, particularly B cells, in contexts such as infection, vaccination, cancer, and autoimmune diseases. His research focuses on understanding adaptive immunity in conditions like COVID-19 Food allergies Myasthenia gravis through collaborations with experimental teams. Key projects include: Phylogenetic modeling of B cell responses Evolutionary signatures in immune repertoires Tracking B cell dissemination in autoimmune diseases Epigenetic regulation of memory B cells Recent publications highlight trends in single-cell immunology , phylogenetic inference , and computational tools for analyzing B cell dynamics. His lab at Dartmouth integrates evolutionary genetics with high-resolution immune profiling.

• Statistical Methods in Biomedical Research
• Biomarker Analysis
• Clinical Trial Design
• +۷ مورد دیگر

Todd A. Alonzo is a Professor of Research in the Department of Preventive Medicine at the University of Southern California . As Group Statistician for the Children's Oncology Group , he focuses on statistical methods for biomarker analysis, medical diagnostic testing, and clinical trial design in pediatric acute myeloid leukemia (AML). Education: B.S. in Statistics, California State Polytechnic University (1994) MS and PhD in Biostatistics, University of Washington (1997, 2000) Research Interests include: Development of statistical frameworks for diagnostic accuracy Genomic and proteomic profiling in AML Pharmacogenomic score systems for chemotherapy response Non-inferiority trial design in low-event-rate settings Health disparities in pediatric oncology Scientific Awards : Fellow, American Statistical Association (2018) Outstanding Teacher Award, International Society for Magnetic Resonance in Medicine (2017) NIH Predoctoral Cardiovascular Biostatistics Training Grant (1995) ENAR Biometrics Society Distinguished Student Paper Award (1999) WNAR Biometrics Society Best Student Oral Presentation (1999) Leadership & Service includes editorial board memberships (Biometrics, Pediatric Blood & Cancer, Biometrical Journal), reviewer for 30+ scientific journals, and roles on multiple Data Safety and Monitoring Boards. He served as President of the International Biometric Society Western Northern America Region (WNAR) in 2009.

Gabriela V. Cohen Freueمشاهده پروفایل

دانشیار

• Statistical Methodology
• High-Dimensional Data Analysis
• Robust Statistics
• +۶ مورد دیگر

Gabriela V. Cohen Freue is an Associate Professor in the Department of Statistics at the University of British Columbia (UBC), Vancouver Campus, and holds a Canada Research Chair (CRC Tier 2). She leads an interdisciplinary research program focusing on developing robust statistical methodologies for analyzing high-dimensional data in genomics and proteomics, with applications in medical sciences. Her work addresses challenges such as outliers, collinearity, and measurement errors, with applications in biomarker discovery for diseases like multiple sclerosis, cardiovascular disorders, and asthma. Her academic journey includes collaborations across disciplines, including with the BC Cancer Agency, PROOF Centre of Excellence, and iCAPTURE. She has pioneered methods like the Penalized Elastic Net S-Estimator (PENSE) and contributed to proteomic data analysis tools such as the Protein Group Code Algorithm (PGCA). She also co-developed the MDQC quality control method for microarrays. Research interests include robust regression, biomarker development, and statistical methods for big data. Her team includes postdocs, PhD, and MSc students, with a focus on training in both statistical rigor and interdisciplinary collaboration. Notable grants include a CANSSI Collaborative Research Team Project (CRT) award for robust causal inference and prediction modeling. Teaching responsibilities span statistical consulting, high-dimensional biological data analysis, and generalized linear models. She emphasizes active learning and real-world problem-solving in her courses. Her lab’s work is supported by grants from the Data Science Institute (DSI) and collaborations with institutions like the PROOF Centre. Alumni of her group hold positions in academia (e.g., George Mason University) and industry (e.g., Merck, BC Cancer Research Centre).

Brock C Christensenمشاهده پروفایل

استاد

• Epigenetics
• Cancer Biology
• Genomics
• +۷ مورد دیگر

Brock C Christensen is a Professor at the Geisel School of Medicine , Dartmouth, affiliated with the Departments of Epidemiology , Community and Family Medicine , and Molecular and Systems Biology . His research integrates molecular biology, genomics, and bioinformatics with epidemiology to investigate epigenetic mechanisms in human health and disease. Harvard University, PhD (2008) University of Wisconsin - Madison, BS (2002) Dr. Christensen's work focuses on epigenetic susceptibility traits , environmental interactions, and translational applications in cancer diagnostics and treatment. His recent publications explore DNA methylation patterns in triple-negative breast cancer , head and neck cancer , and pediatric CNS tumors . He serves as course director for PEMM103: Introductory Applied Biostatistics with R and leads the Christensen Lab , which specializes in epigenomic profiling and computational biology.

• Cancer Genetics
• Prostate Cancer
• Genomic Evolution
• +۵ مورد دیگر

Colin Cooper is a Professor of Cancer Genetics at the Norwich Medical School, University of East Anglia. He is also a member of the Metabolic Health and Cancer Studies research groups. His work focuses on genomic evolution, tumor microbiome dynamics, and biomarker development for prostate cancer and musculoskeletal health. Cooper’s recent research explores the interplay between cancer genetics and microbial communities, emphasizing their role in prognosis and treatment outcomes. He investigates clonal evolution in tumors, mutational signatures, and non-invasive diagnostic tools like urinary extracellular vesicles. His collaborations span genomics, microbiology, and clinical applications. 2025: Causes of evolutionary divergence in prostate cancer (Genomics, Precision Medicine) 2024: Applications of urinary extracellular vesicles... (Biomarker Development, Liquid Biopsy) 2023: Caution regarding pan-cancer microbial structure (Methodological Considerations, Microbiome Analysis) In 2022, Cooper received the European Urology Oncology SoMe Award for his contributions. His work is frequently cited and has been featured in media outlets globally, highlighting his impact on cancer and aging research.

Franz Lennard Ricklefsمشاهده پروفایل

استاد

• Neurosurgery
• Neuro-oncology
• Molecular Neurobiology
• +۵ مورد دیگر

Prof. Dr. med. Franz Lennard Ricklefs is a Senior Physician and Head of the Working Group at the Department of Neurosurgery, University of Hamburg Faculty of Medicine. He is a Medical Specialist in Neurosurgery with cross-disciplinary expertise in neuro-oncology, molecular pathology, and extracellular vesicle research. Affiliations: University Medical Center Hamburg-Eppendorf (UKE), European Liquid Biopsy Society (ELBS), International Consortium on Meningiomas (ICOM) Research Interests: His work focuses on neurosurgical oncology, particularly glioblastoma and meningioma pathobiology. He investigates DNA methylation patterns, extracellular vesicle biomarkers, and liquid biopsy implementation in clinical neuro-oncology. Additional interests include surgical outcomes for epilepsy and aneurysm management. Article Trends: Over the last decade, Dr. Ricklefs has published extensively on: Extracellular vesicle applications as liquid biopsy markers DNA methylation subclasses for glioblastoma and meningioma Multicenter surgical outcome benchmarking Immune evasion mechanisms in neuro-oncology Technological innovations in neurosurgical visualization Molecular characterization of rare CNS tumors Professional Contributions: He co-authored the MISEV2023 guidelines for extracellular vesicle studies and participates in international consensus reviews for meningioma classification. His collaborations span institutions across Europe and North America.

Sai Zhangمشاهده پروفایل

استادیار

• Machine Learning
• Genomics
• Precision Medicine
• +۵ مورد دیگر

Sai Zhang is an Assistant Professor in the Department of Epidemiology at the University of Florida (UF), holding affiliations with the College of Public Health & Health Professions and College of Medicine. He is also an Affiliate Faculty in the J. Crayton Pruitt Family Department of Biomedical Engineering at the Herbert Wertheim College of Engineering. Previously, he was an Instructor at Stanford University School of Medicine and a Research Associate at the VA Palo Alto Epidemiology Research and Information Center (ERIC). Dr. Zhang completed his Ph.D. in Computer Science and Technology at Tsinghua University, followed by postdoctoral training in Dr. Michael Snyder’s lab at Stanford Genetics. His research integrates machine learning, genomics, and precision medicine to uncover genomic bases of complex diseases. Key focuses include developing algorithms for multiomic data analysis, modeling genotype-phenotype relationships, and leveraging deep learning for biological sequence analysis. His work emphasizes cell-type-specific mechanisms in diseases like ALS, coronary artery disease, and neurodegenerative disorders. Notable contributions include frameworks for polygenic risk scoring (e.g., PRS-Net), biomarker discovery for ALS, and tools for time-to-event prediction in neurological diseases. He leads the Zhang Laboratory, advancing computational systems for precision health applications.

Jude M. Phillipمشاهده پروفایل

استادیار

• Aging
• Mechanobiology
• Cancer Biology
• +۵ مورد دیگر

Jude M. Phillip, PhD, is an Assistant Professor in the Departments of Biomedical Engineering and Chemical and Biomolecular Engineering at Johns Hopkins University. His research integrates engineering principles with aging and cancer biology to develop cell-based biomarkers and mechanistic insights into age-related diseases. He leads the Phillip tiME Lab, which focuses on aging dynamics, tumor microenvironment interactions, and translational technologies. Education : PhD, Chemical and Biomolecular Engineering, Johns Hopkins University, 2015 Postdoctoral Research, Melnick/Cerchietti Labs, Weill Cornell Medicine, 2016-2020 B.Eng, Chemical Engineering, City College of New York, 2010 Research Interests : Dr. Phillip’s work spans aging mechanisms, cancer biology, and mechanobiology. Key areas include: Cell-based biomarkers for aging and disease Scale-dependent aging pathways Lymphoma tumor-immune microenvironment (tiME) Single-cell profiling of senescence subtypes ECM mechanoregulation of stem cell fate His lab employs longitudinal cell profiling, data science, and clinical measures to bridge biological aging research with translational medicine. Recent Highlights : 2025: NIH R35 MIRA Award for lymphoma microenvironment research 2024: Johns Hopkins Catalyst Award for aging biomarker studies 2023: AFAR-Glenn Foundation Award for senescence subtype classification Lab & Collaborations : The Phillip Lab collaborates with the Institute for NanoBioTechnology and maintains a living patient-derived tumor biorepository for lymphoma studies. Current projects include ovarian aging organoid models and immune-mechanical interactions in cancer progression.

Martin Peiferمشاهده پروفایل

استاد

• Computational Cancer Genomics
• Tumor Evolution
• Genome Instability
• +۵ مورد دیگر

Professor Martin Peifer is a computational cancer genomics researcher at the University of Cologne, where he leads the Department of Translational Genomics. He serves as Principal Investigator of the Peifer Lab, which focuses on developing computational methods to analyze cancer genome sequencing data. His work is deeply integrated with the Center for Data and Simulation Science and he is an active member of the International Cancer Genome Consortium and the Pan-Cancer Analysis of Whole Genomes project. Peifer's research interests center on computational approaches to understanding cancer biology, with particular emphasis on tumor evolution and genome instability mechanisms. His lab develops methods to analyze somatic genome alterations including point mutations, copy number changes, and rearrangements. They also create computational tools for integrative genome analyses, tumor evolution reconstruction, and single-cell sequencing data analysis (both RNA and DNA). His interdisciplinary team applies high-performance computing and machine learning to interpret complex cancer sequencing data, aiming to better understand tumorigenesis, clonal evolution, and therapy resistance. Analysis of Peifer's extensive publication record reveals a strong focus on neuroblastoma and lung cancer genomics, with particular attention to tumor evolution patterns and genomic instability mechanisms. His work spans multiple cancer types but maintains consistent themes of computational methodology development and application to understand cancer progression and treatment resistance. The publications demonstrate increasing sophistication in analyzing intra-tumor heterogeneity and clonal dynamics over time. Peifer leads an active research group including postdoctoral fellows (Joel Kaufmann, Dr. Stephanie Pabel, Agnieszka Rumińska) and PhD students (Magdalena Seiffert, Justinas Valiulis). His lab is involved in the Collaborative Research Center 1399 focused on Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer, indicating significant grant funding and collaborative research efforts. The Peifer Lab operates at the intersection of computational biology and cancer research, maintaining an interdisciplinary approach that combines bioinformatics, machine learning, and high-performance computing to address complex questions in cancer genomics. Their work has significant implications for understanding cancer evolution and developing more effective treatment strategies.

• Neuro-oncology
• Neuropathology
• Glioblastoma
• +۳ مورد دیگر

Professor Patrick Harter is a faculty member at the Institute of Neuropathology, Ludwig Maximilian University of Munich (LMU), where he leads research in neuro-oncology and molecular diagnostics of CNS tumors. His work focuses on glioblastoma, meningioma, and brain metastasis, with emphasis on epigenetic mechanisms like DNA methylation and metabolic adaptations in the tumor microenvironment. Research interests span: Molecular classification of brain tumors using DNA methylation profiling Therapeutic targeting of BRAF/MEK and PI3K/Akt/mTOR pathways Role of hypoxia and metabolic plasticity in treatment resistance Liquid biopsy development for non-invasive tumor monitoring His recent publications demonstrate a strong trend toward integrating epigenetic, metabolic, and immunotherapeutic approaches. Articles frequently explore: Novel biomarkers for tumor grading and prognosis Mechanisms of therapy resistance in gliomas Impact of tumor microenvironment on metastasis

Olga Kovalchukمشاهده پروفایل

استاد

• Epigenetics
• Cancer Biology
• Radiation Biology
• +۵ مورد دیگر

Olga Kovalchuk is a Professor in the Department of Biological Sciences at the University of Lethbridge. She leads the Epigenetics of Health and Disease research laboratory, which is affiliated with the Southern Alberta Cancer Research Institute (SACRI) and Alberta Health Services/Alberta Cancer Foundation (AHS/ACF). Her research program has received significant funding including a $3.2 million Canada Foundation for Innovation (CFI) start-up grant and NSERC Discovery Grants. Dr. Kovalchuk's research focuses on the role of epigenetic mechanisms in health and disease, particularly in the context of radiation exposure and cancer. Her primary areas of investigation include epigenetic dysregulation in carcinogenesis, radiation epigenetics, DNA damage and repair mechanisms, and transgenerational effects of radiation exposure. She has made significant contributions to understanding how radiation-induced epigenetic changes affect genome stability, cancer development, and treatment responses. Analysis of her recent publications reveals a strong focus on microRNA regulation in cancer, sex-specific radiation responses, and the epigenetic basis of radiation-induced bystander effects. Her work demonstrates how epigenetic changes, particularly DNA methylation and microRNA expression patterns, mediate radiation responses in various tissues and can be transmitted across generations. Much of her research utilizes mouse models to investigate these mechanisms in vivo. Board of Governors Research Chair at University of Lethbridge CIHR Institute of Gender and Health Research Chair in New Perspectives in Gender, Sex and Health Canada Foundation for Innovation Start-up Funding ($3.2 Million) NSERC Discovery Grant recipient Editor's Choice Paper Award for research on radiation-induced bystander effects Cover Page feature for transgenerational radiation effects research Dr. Kovalchuk actively mentors numerous graduate students and postdoctoral fellows, with a research team comprising PhD students, MSc students, research assistants, and postdoctoral associates. Her laboratory collaborates extensively with researchers at MIT, Harvard University, and other institutions. She has secured significant grant funding including NSERC Discovery Grants and CFI start-up funds to support her research program investigating epigenetic mechanisms in radiation biology and cancer. Her laboratory, the Epigenetics of Health and Disease research group, maintains strong collaborations with the Southern Alberta Cancer Research Institute and has established partnerships with researchers across North America. Dr. Kovalchuk's work has important implications for understanding radiation risks, improving cancer therapies, and developing strategies to mitigate radiation damage.