Xiaofeng Zhu, PhD is a Professor in the Department of Population and Quantitative Health Sciences at Case Western Reserve University School of Medicine. He also serves as faculty at the Cleveland Institute for Computational Biology. His research focuses on developing statistical methods and computational tools for analyzing genetic and genomic data, particularly in the context of association analysis, admixture mapping, and rare variant identification. He leads the Continental Origins and Genetic Epidemiology Network (COGENT) consortium and has identified multiple genetic loci associated with blood pressure, sleep disorders, and Alzheimer's disease. Education: Ph.D. in Biostatistics, Epidemiology and Biostatistics, Case Western Reserve University (1998) M.S. in Statistics, University of Cincinnati (1994) M.S. and B.Sc. in Mathematics, Peking University (1989, 1986) Research Interests: Dr. Zhu's work emphasizes statistical genetics, including the development of methods to control population stratification, admixture mapping in admixed populations, and cross-phenotype association analyses. His lab integrates deep learning and bioinformatics to study complex traits such as cardiovascular disease, obesity, and sleep disorders. Recent efforts include analyzing whole-genome sequencing data to uncover rare variants influencing phenotypic variation. Publications Trends: His recent work spans Mendelian randomization methods (e.g., MRBEE), gene-sleep interaction studies, and multi-ancestry genomic analyses. Key themes include causal inference, pleiotropy analysis, and leveraging diverse genetic datasets to improve polygenic risk scores. Awards & Memberships: Fellow of the Royal Statistical Society Member, American Society of Human Genetics Member, International Genetic Epidemiology Society Advising & Grants: He has mentored 3 Master’s students, 9/10 PhD graduates, and 11/12 postdoctoral researchers. Notable mentees hold positions at Harvard, Mayo Clinic, and NIH. Active grants include studies on sleep health metrics, lipid loci discovery, and cardiovascular disease genetics. Labs & Teams: Leads COGENT consortium and collaborates with the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. His lab develops software tools for ancestry inference, rare variant analysis, and epigenetic association studies.











