Professor Elaine Cole is a leading academic in Trauma Sciences at the Blizard Institute, Queen Mary University of London. She serves as Director of Research and Innovation for the London Major Trauma System, focusing on improving care for older trauma patients. Cole co-leads the international online MSc in Trauma Sciences and directs the undergraduate Trauma Sciences and Care of the Injured Patient Programme (TSCIPP), which integrates clinical placements at Barts Health NHS Trust and Centre for Trauma Sciences. Research Focus : Drivers of poor outcomes after severe injury, MODS phenotypes, trauma system innovation, and geriatric trauma care. Recent Studies : National MODS investigation (ORDIT), pan-London MODET study, and development of clinical prediction models like STUMBL Score. Education Leadership : Pioneered distance learning trauma programs and run-through undergraduate placements. Collaborative Roles : Evaluates trauma team activation tools, co-led ELOTS study on London Trauma System, and develops national guidance for elderly trauma care. Contact : e.cole@qmul.ac.uk
Dr. Harsha K. Chandnani is an Associate Professor in the Department of Pediatrics, specializing in Pediatric Intensive Care at Loma Linda University School of Medicine. With extensive clinical and research experience in pediatric critical care, Dr. Chandnani serves as Principal Investigator on multiple NIH-funded research projects focused on improving outcomes for critically ill children. Dr. Chandnani's educational background includes an MD, MBA, and MPH, reflecting a strong foundation in clinical medicine, healthcare administration, and public health. This multidisciplinary training supports their work at the intersection of clinical care, research, and healthcare systems improvement in pediatric critical care settings. Dr. Chandnani's research primarily focuses on pediatric critical care medicine with specific expertise in multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2, bronchiolitis and respiratory support, cardiac critical care, and transfusion medicine. Their work often examines immunological responses in critically ill children and develops clinical pathways to improve outcomes. Recent research has investigated the immune dysregulation in MIS-C, bacterial co-detection in respiratory infections, and innovative approaches to managing critically ill pediatric patients. Dr. Chandnani's publications demonstrate a consistent trend toward understanding the immunological basis of critical illness in children, particularly regarding post-infectious inflammatory conditions like MIS-C, while also developing practical clinical interventions to improve care delivery and patient outcomes in the pediatric intensive care unit. Notable research contributions include: Principal Investigator for 'Federal Transfusion Associated Pathophysiology in Multiple Organ Dysfunction Syndrome (TRAP-MODS)' funded by NICHD/NIH (2025-2026) Principal Investigator for 'An Observational Cohort Study to Determine Late Outcomes and Immunological Responses after SARS-CoV-2 Infection in Children' funded by NCI/NIH (2024-2025) Development of 'Better Etiquette for Effective Paging (B.E.E.P.)' to improve communication systems in the PICU Creation of standardized clinical pathways for status asthmaticus that reduced ICU and hospital lengths of stay Dr. Chandnani's work bridges clinical practice, research, and healthcare systems improvement, with a particular emphasis on understanding the immunological mechanisms of critical illness in children while developing practical interventions to enhance patient care and outcomes in pediatric intensive care settings.
Jacques LACROIX is a Professor at the Faculty of Medicine , University of Montreal , specialized in Pediatric Intensive Care and Transfusion Medicine . With over 200 peer-reviewed publications and 74 research grants totaling CAD $39,930,284, he leads studies on Multiple Organ Dysfunction Syndrome , Anemia , and Blood Transfusion Safety in critically ill children. Founded the PALISI Network (70+ pediatric ICUs) Developed the PELOD clinical scoring system for MODS severity Research Trends : 15-year focus on blood transfusion optimization in pediatrics, with recent projects examining PICU discharge safety , transfusion thresholds , and HBV/HIV screening in blood donors. His 2015 New England Journal of Medicine study on blood storage duration remains highly cited. Scientific Awards : PALISI Leadership Award (2014) Prix Alan Ross (2013) Fondation des étoiles Career Prize (2009) University of Montreal Teaching Excellence (2002-2007) Advises 20+ graduate students across disciplines, with particular focus on hematology , critical care , and clinical trial design . Current projects include post-PICU home discharge safety (2023-2027), transfusion conservation strategies (2023-2025), and blood donor eligibility expansion (2020-2025).
Harsha Chandnani, MD, MBA, MPH is an Associate Professor in the Department of Pediatrics at Loma Linda University School of Medicine, specializing in Pediatric Intensive Care. He is actively engaged in clinical research, quality improvement, and medical education, with a strong focus on critical care outcomes, immunology in pediatric infections, and systems-based practice improvement. Loma Linda University, School of Medicine, Department of Pediatrics Principal Investigator and Site PI on multiple NIH and institutional grants Active in multicenter research networks including PALISI and Red Colaborativa Pediátrica de Latinoamérica His research interests include pediatric critical care, multisystem inflammatory syndrome in children (MIS-C), bronchiolitis, ECMO, mechanical ventilation, and quality improvement in pediatric intensive care units. He has led studies on immunological responses in MIS-C, clinical care pathways for status asthmaticus, and end-of-life care practices in children. His work combines clinical investigation with data analytics and systems engineering to improve patient outcomes. His 15 most recent publications reflect a strong trend in pediatric critical care, with emphasis on immunology of post-infectious syndromes (especially MIS-C), quality improvement initiatives, mechanical ventilation, and end-of-life care. The research spans clinical trials, retrospective cohort studies, and multicenter collaborations, published in journals such as Pediatric Critical Care Medicine , Critical Care Medicine , and Journal of Clinical Investigation . Principal Investigator, Exosomes and the Immune Response in Allograft Outcomes in Pediatric Transplant Recipients (Stanford University) Principal Investigator, Federal Transfusion Associated Pathophysiology in MODS (NIH) Site PI, TRAP-MODS, BACON Study, and ASCEND Study Multiple internal grants at Loma Linda University on MIS-C, bronchiolitis, and cardiac critical care Dr. Chandnani advises a multidisciplinary research team and collaborates with intensivists, immunologists, and pharmacists. He is involved in several grants focusing on immunological responses, transfusion medicine, and critical care pathways. His leadership in quality improvement is evident through projects like B.E.E.P. (Better Etiquette for Effective Paging) and standardized care pathways for asthma and post-operative care. He is a member of key institutional committees including the PCCM Fellowship Clinical Competence Committee, Pediatric Critical Care Morbidity and Mortality Committee, and ECMO Morbidity and Mortality Committee, reflecting his integral role in clinical governance and education.
James Beal is an Assistant Professor in the Department of Pediatrics, specializing in pediatric hematology, immunology, and critical care medicine. His research addresses life-threatening conditions such as Hemophagocytic Lymphohistiocytosis (HLH) and Multiple Organ Dysfunction Syndrome (MODS), with a focus on innovative therapeutic strategies. His recent publication (2023) demonstrates expertise in alternative HLH/MODS treatments using emapalumab, reflecting a research emphasis on immunotherapy and cytokine-targeted interventions in pediatric critical care.
Daniel J. McKeone, MD, serves as an Assistant Professor in the Department of Pediatrics and is affiliated with the Pediatric Cardiovascular Research Center. His clinical-research focus centers on immune dysregulation mechanisms in critically ill pediatric patients, with emphasis on cytokine profiling and critical care interventions. His primary research domains include Immunology, Critical Care Medicine, and Pediatric Subspecialties. Key investigations involve immune profiling of hyper-/hypo-inflammatory subphenotypes, pediatric acute respiratory distress syndrome (PARDS), multiple organ dysfunction syndrome (MODS), and inflammatory biomarker dynamics. This work directly contributes to UN Sustainable Development Goal 3 (Good Health and Well-Being) through precision critical care approaches. Analysis of his 2023-2025 publications reveals concentrated exploration of immune biomarker trajectories in pediatric critical illness. Dominant themes include cytokine-based subphenotyping, tissue injury markers in PARDS, and predictive modeling of organ failure in sepsis, demonstrating integration of immunology with clinical critical care to advance personalized therapeutic strategies. Dr. McKeone conducts his research within the Pediatric Cardiovascular Research Center, where his team applies rapid immune profiling techniques to identify critical illness endotypes and develop targeted interventions for high-risk pediatric populations.
Lazaro N Sanchez-Pinto serves as Associate Professor in Pediatrics (Critical Care) and Preventive Medicine (Biostatistics and Informatics) at Northwestern University Feinberg School of Medicine, with clinical practice at Ann & Robert H. Lurie Children's Hospital of Chicago. His dual expertise bridges pediatric critical care medicine and biomedical informatics to advance data-driven precision medicine for critically ill children. His educational trajectory includes: MD from Autonomous University of Barcelona (2006) Pediatrics Residency at Cincinnati Children's Hospital Medical Center (2011) Pediatric Critical Care Fellowship at Children's Hospital Los Angeles (2014) Advanced Informatics Fellowship and Master of Biomedical Informatics (MBI) from Oregon Health & Science University (2015) Sanchez-Pinto's NIH-funded research pioneers data-driven phenotyping of pediatric sepsis, ARDS, and MODS through integration of clinical, physiologic, and multi-omics data. He develops predictive enrichment strategies to enable personalized critical care interventions, with emphasis on operationalizing clinical decision support tools at the bedside. His work spans biomedical informatics infrastructure development and translational analytics for precision medicine. His 2025 publications reveal accelerating focus on multi-omics integration (metabolomics/cytokines) for sepsis subphenotyping and hemodynamic parameter optimization. Key trends include development of prognostic enrichment frameworks for acute kidney injury in sepsis, refinement of international sepsis definitions, and validation of dynamic arterial elastance metrics for fluid responsiveness prediction in pediatric critical care. Major recognitions include: Fellow of American College of Critical Care Medicine (2025) Northwestern Excellence in Scholarship Award (2024) Three-time STAR Research Award from Society of Critical Care Medicine (2019-2020) Endowed research scholar awards from Stanley Manne Children’s Research Institute (2019, 2021) FAMIA Fellowship and multiple teaching awards As KL2 Career Development Award recipient, he leads the PRIMER-PICU study advancing precision medicine in pediatric ICUs. His mentorship earned the Lurie Children's Outstanding Fellowship Mentorship Award (2020), while his editorial service includes Pediatric Critical Care Medicine's editorial board. He actively shapes national guidelines through the Pediatric Sepsis Definition Task Force and PICU Data Collaborative leadership. Sanchez-Pinto drives innovation as core member of Northwestern's Institute for Augmented Intelligence in Medicine and IPHAM's Center for Dissemination and Implementation Science. His Virtual PICU initiative establishes collaborative data infrastructure across 150+ pediatric ICUs, accelerating implementation of data-driven critical care protocols while leading the Pediatric Analytics and Data Science (PEDAL) subgroup for PALISI Network.
