جستجوی استاد راهنمای دانشگاهی

• Data Science
• Machine Learning
• Computational Harmonic Analysis
• +۶ مورد دیگر

Pierre Vandergheynst is a Full Professor at the Swiss Federal Institute of Technology Lausanne (EPFL) in the Department of Electrical Engineering, with a courtesy appointment in Computer and Communication Sciences. He serves as EPFL’s Vice-Provost for Education since 2015 and leads the Signal Processing Laboratory 2 (LTS2). His research spans harmonic analysis, sparse approximations, mathematical data processing, and applications in signal/image processing, computer vision, machine learning, and graph-based data analysis. PhD in Mathematical Physics (1998), Université catholique de Louvain Postdoctoral Researcher at EPFL (1998-2001) Assistant Professor at EPFL (2002-2007) His research explores geometry/symmetry in high-dimensional data, redundant dictionaries for dimensionality reduction, and computational harmonic analysis on manifolds. Recent work focuses on protein structure modeling, geometric deep learning, and graph-based signal processing. Key article trends include graph neural networks for protein analysis, geometric deep learning in neuroscience, and structured knowledge priors in neural models. His 2023-2025 publications emphasize interpretable AI, long-range dependencies in graphs, and molecular representation learning. Scientific Awards: IEEE Signal Processing Magazine Best Paper Award (2023) Signal Processing Society Best Paper Award (2022) Apple ARTS Award (2007) De Boelpaepe Prize, Royal Academy of Sciences of Belgium (2009-2010) He has supervised over 30 PhD theses and contributed to foundational work in graph signal processing, compressive sensing, and geometric deep learning. His lab develops tools for data science on non-Euclidean structures, with applications in medicine, astronomy, and wireless systems.

Bradley D. Olsenمشاهده پروفایل

استاد

• Polymer Science
• Materials Engineering
• Soft Condensed Matter Physics
• +۴ مورد دیگر

Bradley D. Olsen is a full professor in the Department of Chemical Engineering at the Massachusetts Institute of Technology (MIT), where he leads research at the intersection of polymer science, soft matter physics, and bioengineering. His work focuses on designing materials for critical applications in biotechnology, hemostasis, and sustainable polymer development while advancing fundamental understanding of polymer network mechanics and self-assembly. Education: Ph.D. in Chemical Engineering, University of California Berkeley (2007) S.B. in Chemical Engineering, Massachusetts Institute of Technology (2003) Olsen's research spans protein-based materials, block copolymer phase behavior, and mechanochemical hydrogels. He has pioneered methods for quantifying polymer network topology, developing hemostatic nanoparticles, and creating bio-inspired materials for selective biomolecular transport and medical applications. His recent publications emphasize data-driven approaches to polymer characterization and educational outreach in materials science. Scientific Awards: American Physical Society (APS) Fellow (2023) Fulbright Amazonia Scholar (2023) Alexander and I. Michael Kasser Chair in Chemical Engineering (2021) ACS Macro Letters Young Investigator Award (2021) MIT Committed to Caring Honor (2019) AIChE Owens Corning Early Career Award (2019) APS Dillon Medal (2018) Kavli Emerging Leader in Chemistry (2017) ACS Polymer Division Fellow (2016) Camille Dreyfus-Teacher Scholar (2015) Alfred P. Sloan Research Fellow (2014) NSF Career Grant (2013) NIH Postdoctoral Fellowship (2008-2009) Hertz Fellow (2003-2007) Barry M. Goldwater Scholarship (2002) Olsen has received significant grant support including NSF Career (2013) and AFOSR (2012) awards. His teaching activities include innovative international outreach like the 2025 soccer-themed science camp in Brazil. The Olsen Group at MIT explores advanced materials with applications ranging from trauma care to sustainable polymers.

John M. Woodleyمشاهده پروفایل

استاد

• Biocatalysis
• Bioprocess Engineering
• Enzyme Technology
• +۶ مورد دیگر

John M. Woodley is a distinguished Professor in the Department of Chemical and Biochemical Engineering at the Technical University of Denmark (DTU), where he leads research at the PROSYS - Process and Systems Engineering Centre and contributes to the DTU Microbes Initiative. With over 30 years of experience, he has established himself as a leading expert in biocatalysis and bioprocess engineering, with research spanning both theoretical and experimental work across multiple scales. His primary research interests focus on the interface of bioprocess engineering, process chemistry, and reaction engineering. Dr. Woodley's work encompasses multi-step biocatalysis (including systems biocatalysis and flow chemistry), downstream processing from biocatalytic reactors and fermentations (including ISPR), modeling tools for bioprocess assessment (thermodynamics, kinetics, process simulation, economic evaluation), and bio-oxidations (including oxygen supply methods). His enzymatic investigations particularly target alcohol oxidases, carbohydrate oxidases, cytochrome P450s, Baeyer-Villiger monooxygenases, and transaminases. His research portfolio demonstrates consistent innovation in sustainable chemical production, with particular emphasis on enzymatic synthesis of pharmaceuticals and chemicals from renewable resources. Analysis of his recent publications reveals a strong focus on overcoming industrial implementation challenges, particularly regarding enzyme stability in various reactor environments, optimization of multi-enzyme systems, and scale-up methodologies for biocatalytic processes. Dr. Woodley actively supervises multiple PhD students and leads several significant research projects, including 'P450-based biocatalytic processes for the pharmaceutical industry' (2025-2028), 'Integrated model for up- and downstream bioprocess intensification' (2024-2027), and 'ENFACE: A tool for prediction of enzyme stability at gas-liquid interfaces' (2024-2027). His work has resulted in an impressive publication record of 781 research outputs across various formats, including journal articles, book chapters, and conference proceedings. His research group operates within the Department of Chemical and Biochemical Engineering at DTU, utilizing advanced facilities for biocatalysis research, including specialized reactor systems for studying gas-liquid interfaces, computational modeling resources, and laboratories for enzyme characterization and bioprocess development. Through his leadership in the PROSYS center, he contributes to DTU's strategic focus on sustainable process technologies and systems engineering.

Ulf Hanefeldمشاهده پروفایل

استاد

• Biocatalysis
• Enzyme Engineering
• Green Chemistry
• +۷ مورد دیگر

Ulf Hanefeld is a Full Professor and Section Leader in the Department of Biotechnology at the Faculty of Applied Sciences , Delft University of Technology (TU Delft) , where he leads the Biocatalysis research section. His work integrates chemistry and biology to develop sustainable synthetic methodologies using enzymes. PhD from Georg-August-Universität zu Göttingen (1993) Postdoctoral experience at Imperial College London, University of Cambridge, and TU Delft Recipient of a Royal Netherlands Academy of Arts and Sciences (KNAW) fellowship His research interests center on biocatalysis , particularly enzymes that enable difficult chemical transformations such as C–C bond formation , enantioselective hydration , and ozonolysis . He focuses on enzyme discovery, engineering, immobilization, and application in flow chemistry to achieve sustainable and efficient synthesis. His work spans from fundamental enzyme mechanism studies to industrial applications in green chemistry . The publication trends reveal a consistent focus on enzyme immobilization , flow reactor systems , and chemo-enzymatic cascades . His recent work emphasizes the use of hydroxynitrile lyases , aldolases , and methyltransferases for the synthesis of chiral intermediates under environmentally benign conditions. The integration of biocatalysis with continuous manufacturing highlights a strong commitment to industrial applicability and process sustainability. Scientific contributions and recognition : Active contributor to high-impact journals in chemistry and biotechnology Coordinated research in the CassaFLOW project (international academic-industrial collaboration) Author of influential reviews, e.g., in Chemical Society Reviews (2022) Teaching and supervision : He teaches Catalysis (Bachelor) and Advanced Biocatalysis (Master), and supervises numerous Master’s theses (MEP) and Bachelor’s projects (BEP) . Students in his group are actively involved in research and often become co-authors on scientific papers. Projects center on green chemistry, enzyme engineering, and spectroscopic analysis of biochemical systems. Laboratory and research environment : The Ulf Hanefeld Group operates within the Biocatalysis section, a multidisciplinary environment fostering collaboration on enzyme discovery, immobilization, and cascade reactions. The group emphasizes practical innovation, with strong links to industry and international research networks.

LI Zhiمشاهده پروفایل

دانشیار

• Biocatalysis
• Green Chemistry
• Sustainable Manufacturing
• +۴ مورد دیگر

Associate Professor LI Zhi leads the Chemical & Biomolecular Engineering Department at the National University of Singapore (NUS). His research focuses on advanced biocatalysis for sustainable manufacturing, bio-based fuels, and functional materials. He holds a PhD in Organic Chemistry from the University of Vienna (1991), an MEng from Chinese Academy of Forestry (1985), and a BSc from Nanjing University (1982). Institutional Affiliations: NUS Faculty of Engineering, NUS ChBE Department. His lab actively collaborates with global institutions like A*STAR and the Singapore Catalysis Society. Research highlights include enzyme engineering for cascade reactions, CO₂ utilization, and biomaterial synthesis. Research Interests: Discovery of novel biocatalysts, engineering of biocatalytic systems, renewable feedstock utilization, and smart material development. Recent work emphasizes cascade biotransformations for chiral chemicals and sustainable processes. Lab Activities: Hosted international conferences (e.g., Southeast Asia Catalysis Conference 2019), collaborations with industry leaders (GSK, Pfizer), and visits from distinguished researchers like Prof. Zhao Huimin. Student milestones include PhD completions (e.g., Wang Wen, Joel Choo Ping Syong) and postdoc contributions across institutions. Grants & Labs: Active in grants related to biocatalysis and green chemistry. Lab members include researchers like Dr. Nicholas Goh and PhD students Li Li. Infrastructure includes advanced facilities for biotransformations and material synthesis.

Markus Heinonenمشاهده پروفایل

پژوهشگر ارشد

• Machine Learning
• Probabilistic Modeling
• Bayesian Inference
• +۵ مورد دیگر

Markus Heinonen is an Academy Research Fellow at Aalto University's Department of Computer Science within the School of Science. His academic position is tied to Harri Lähdesmäki's Professorship, focusing on probabilistic machine learning. He holds a Doctoral degree in Engineering and Technology from the University of Helsinki (2013). His research integrates probabilistic modeling , deep learning , and differential equations , with applications in computational biology, drug discovery, and biophysics. Key themes include Gaussian processes, Bayesian inference, generative models, and their use in understanding complex biological systems like immune cell behavior (e.g., T cell receptor analysis in aplastic anemia) and molecular design. He leads major projects such as the Deep Learning with Differential Equations initiative (2020–2025), exploring continuous-time models and physics-informed neural networks. His work bridges theory and application, evidenced by collaborations in diffusion models , optimal transport , and single-cell analysis . Publications span over 65 peer-reviewed outputs, with recent emphases on robust neural network training, multi-target molecular prediction, and interpretable drug design frameworks. His research contributes to UN Sustainable Development Goal 3 (Good Health) through advancements in disease modeling and therapeutic development. He has undertaken visiting research roles at the University of California, San Francisco (2017) and Telecom ParisTech (2013–2014). Media highlights include recognition for work on TCR-epitope prediction and AI-driven enzyme engineering.

Joel Weadgeمشاهده پروفایل

دانشیار

• Bacterial Biofilms
• Bacterial Carbohydrates
• Protein Structure and Function
• +۷ مورد دیگر

Joel Weadge is an Associate Professor in the Biology Department at Wilfrid Laurier University , Waterloo, Ontario. His research focuses on bacterial biofilms, glycobiology, and protein structure-function relationships. Contact: jweadge@wlu.ca , Office: BA425 (Bricker Academic). Education: PhD in Microbiology (University of Guelph, 2006) BSc (Hons) in Microbiology (University of Guelph, 2000) Research Interests center on bacterial biofilms as virulence factors in pathogens like E. coli and Salmonella . Key areas include: Structural and functional characterization of biofilm proteins (cellulose, curli fimbriae) Enzymology of carbohydrate modifications (acetylation, phosphoethanolamine transfer) Developing therapeutics targeting biofilm synthesis Biopolymer applications for medical/industrial use Publications highlight studies on Pseudomonas and Salmonella biofilm mechanisms, glycosyltransferases, and carbohydrate-active enzymes, with methodologies spanning X-ray crystallography to high-throughput biofilm profiling. Labs and Teams: The Weadge Lab investigates biofilm roles in food/water security and oral health, utilizing enzymology, mass spectrometry, and structural biology. Current members include graduate students, technicians, and research assistants.

Klavs F. Jensenمشاهده پروفایل

استاد

• Materials Science
• Chemical Engineering
• Machine Learning
• +۴ مورد دیگر

Professor Klavs F. Jensen is the Warren K. Lewis Professor of Chemical Engineering and Professor of Materials Science and Engineering at MIT. His research focuses on integrating automation, machine learning, and robotics to accelerate materials discovery and pharmaceutical synthesis. He leads the Jensen Research Group, pioneering automated reaction systems with online analytics and optimization algorithms. Education: MS in Chemical Engineering (Technical University of Denmark, 1976); PhD in Chemical Engineering (University of Wisconsin, 1980). Research Interests: Thermochemistry, electrochemistry, photochemistry, Bayesian optimization, high-throughput experimentation, and AI-driven synthesis planning. He collaborates with MIT’s Machine Learning for Pharmaceutical Discovery Consortium to develop algorithms for drug development and process chemistry. Awards: Member of National Academy of Sciences (2017), Member of National Academy of Engineering (2002), Fellow of the American Association for the Advancement of Science (2007), and Fellow of the National Academy of Inventors (2022). Grants & Labs: Editor-in-Chief of Reaction Chemistry and Engineering ; holds 63 US patents and over 490 journal articles. His lab’s innovations include ASKCOS (open-source synthesis planning software) and automated platforms for closed-loop molecular discovery.

Raphael Franziniمشاهده پروفایل

دانشیار

• Drug Discovery
• Medicinal Chemistry
• Bioorthogonal Chemistry
• +۳ مورد دیگر

Raphael Franzini serves as Associate Professor of Medicinal Chemistry at the University of Utah, actively contributing to the Biological Chemistry PhD Program. His research pioneers innovative chemical approaches for therapeutic development, with dual focus on DNA-encoded library technologies and bioorthogonal drug delivery systems. His educational foundation includes an M.S. from the Swiss Federal Institute of Technology (Lausanne) and a Ph.D. from Stanford University. This training underpins his group's multidisciplinary methodology combining organic synthesis, bioconjugation, computational modeling, and advanced imaging techniques. Dr. Franzini's research program centers on two transformative areas: First, advancing DNA-encoded library screening through computational integration to identify leads for challenging targets like Tankyrase and Sirtuin 6, with recent work addressing false negatives in machine learning prediction. Second, developing novel bioorthogonal release chemistry using isonitrile-tetrazine reactions for spatiotemporally controlled drug activation, validated in zebrafish models. His group emphasizes both technological innovation and therapeutic translation, with chemistry designed to minimize off-target effects in solid tumors. Analysis of his 15 most recent publications reveals escalating integration of computational methods with experimental library screening, alongside refinement of bioorthogonal release kinetics. The work spans chemical biology, medicinal chemistry, and pharmaceutical sciences, with growing emphasis on machine learning for library data interpretation and in vivo validation of drug-release systems. Dr. Franzini maintains an active research laboratory that provides comprehensive training in cutting-edge drug discovery methodologies. His group culture prioritizes both scientific innovation and researcher development, with projects spanning from fundamental reaction kinetics to therapeutic applications. The lab's infrastructure supports organic synthesis, molecular imaging, and computational analysis for advancing precision therapeutics.

Appala Raju Badireddyمشاهده پروفایل

دانشیار

• Water Quality Engineering
• Membrane Separation Processes
• Environmental Nanotechnology
• +۵ مورد دیگر

Dr. Appala Raju Badireddy is an Associate Professor in the Department of Civil and Environmental Engineering at the University of Vermont (UVM), and Director of the Water Treatment & Environmental Nanotechnology (WTEN) Laboratory. He is also co-founder and CTO of Secure Surgical Solutions LLC, and a founding member of Vermont Initiative for Biological and Environmental Surveillance (VIBES). His research focuses on sustainable membrane processes, environmental nanotechnology, nanometrology, and water security. Education: Ph.D., Environmental Engineering, University of Houston (2003-2009) M.Tech., Chemical Engineering, Indian Institute of Technology Madras (2001-2003) B.Tech., Chemical Engineering, Jawaharlal Nehru Technological University Hyderabad (1997-2001) Postdoctoral Research, Duke University (2009-2014) under Prof. Mark Wiesner Research Interests: Sustainable Membrane Processes: Water/wastewater treatment, desalination, anti-fouling strategies, and resource recovery. Environmental Nanotechnology: Nano-enabled sensors, remediation, and implications of nanomaterials in ecosystems. Environmental Chemodynamics: PFAS fate/transport, nutrient cycling, and contaminant toxicity. Water Security: Real-time monitoring systems and soil health assessments. His work integrates lab-scale innovations with field applications, emphasizing interdisciplinary collaboration. Recent Research Trends: Recent publications highlight advancements in PFAS remediation, electric-field enhanced filtration, and living lab approaches to precision agriculture. He explores nanomaterials for water treatment while addressing their environmental implications through novel detection methods like ED-HSI microscopy. Labs & Initiatives: WTEN Lab: Focuses on nanotechnology-driven water solutions. VIBES: Develops environmental surveillance tools for public health. Secure Surgical Solutions: Applies nanotechnology to medical devices.

• Biomaterials
• Peripheral Nerve Injury
• Neuromuscular Modeling and Repair
• +۲ مورد دیگر

Suradip Das is a Research Assistant Professor in the Department of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania, where he serves as a Senior Research Investigator. His work bridges neural engineering and regenerative medicine to address critical challenges in nerve and muscle repair. His academic training includes: B.Tech in Biotechnology from Heritage Institute of Technology (2010) PhD in Biosciences and Bioengineering from Indian Institute of Technology Guwahati (2016) Dr. Das specializes in biomaterials development , peripheral nerve injury models , neuromuscular interface engineering , and stem cell-based regeneration . His research pioneers innervated tissue-engineered muscle constructs, demonstrating how motor neurons and endothelial cells synergistically enhance skeletal myocyte maturation. He innovates custom mechanobioreactors that apply tensile forces to guide nanofiber alignment for optimal myofiber formation, significantly advancing volumetric muscle loss treatments. Analysis of his 15 most recent publications reveals a dominant focus on neuromuscular regeneration (75% of articles), with emerging exploration of psychedelic compounds in neural repair. His work consistently integrates human iPSC-derived models , multi-cellular co-cultures , and large-animal validation to address translational gaps. Key trends include optogenetic control of motor units (2023), porcine nerve injury models (2020), and the critical role of pre-innervation in creating pro-regenerative microenvironments (2020-2022). As a core member of the Cullen Lab, Dr. Das collaborates on developing biofabricated neural microtissues for delayed nerve fusion and rapid functional recovery. His research directly informs clinical strategies for peripheral nerve repair and muscle regeneration through rigorous mechanistic studies and innovative engineering solutions.

• Glycoengineering
• Biomaterials
• Biotechnology
• +۳ مورد دیگر

Prof. Dr. rer. nat. Lothar Elling is a University Professor and director at the Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Germany. His research focuses on biomaterials, glycoengineering, and enzymatic synthesis of carbohydrates and glycoconjugates. Institution: RWTH Aachen University Research Unit: Helmholtz Institute for Biomedical Engineering Academic Rank: Full Professor Prof. Elling's research interests include: Glycoengineering of biomaterials Enzymatic synthesis of glycans Glycosyltransferase immobilization Glycan-protein interactions Biocatalytic cascade reactions Biomedical applications of glycomaterials His recent publications demonstrate strong expertise in: - Automated enzymatic glycan synthesis - Multi-enzyme cascade systems for nucleotide sugar production - Glycosyltransferase engineering - Galectin-targeted glycomaterials - Microgel-based biosensors

Sharon Rozovskyمشاهده پروفایل

استاد

• Oxidative Stress
• Protein Quality Control
• ERAD Pathway
• +۵ مورد دیگر

Sharon Rozovsky is a Professor in the Department of Chemistry and Biochemistry at the University of Delaware's College of Arts & Sciences, where she leads research on oxidative stress response mechanisms and protein quality control pathways. Her work bridges biochemistry, chemical biology, and structural biology with direct implications for understanding neurodegenerative diseases and viral pathogenesis. Her academic foundation includes a B.S. from Tel Aviv University (1994) and a Ph.D. from Columbia University (2000), establishing her expertise in protein dynamics and redox biochemistry. These credentials underpin her innovative approaches to studying cellular stress responses. Rozovsky's research program centers on selenoproteins—proteins containing the rare amino acid selenocysteine—and their critical roles in endoplasmic reticulum (ER) stress resolution. She investigates how membrane-bound selenoproteins like Selenoprotein S and K regulate the ER-associated degradation (ERAD) pathway, with recent work revealing their surprising autoproteolytic activity and involvement in SARS-CoV-2 replication. Her lab pioneers chemical tools including expressed protein ligation and advanced 77Se NMR spectroscopy to characterize these systems at molecular resolution. Analysis of her 2021-2025 publications shows dominant themes in selenoprotein structure-function relationships, ER stress mechanisms, and viral interactions, alongside methodological innovations in cryo-EM grid technology and NMR. This body of work demonstrates consistent focus on redox biochemistry with expanding applications in virology and structural biology. No major scientific awards or fellowships were explicitly documented in the available materials, though her research impact is evident through high-impact publications and methodological contributions. She directs the active Rozovsky Research Group, mentoring graduate students and postdoctoral researchers in biochemical and biophysical techniques. Her laboratory operations are supported by competitive funding including an NSF CAREER award (2011) focused on selenoprotein reactivity, reflecting sustained recognition of her innovative research program.

Giulia Giordanoمشاهده پروفایل

استاد

• Automatic control
• Complex networks
• Control systems
• +۱۲ مورد دیگر

Giulia Giordano is a Full Professor in the Department of Industrial Engineering at the University of Trento, Italy, where she leads the Dynamical Networks and Systems Biology research group. She also holds a dual appointment as Visiting Professor and Delft Technology Fellow at the Delft Center for Systems and Control, Delft University of Technology, The Netherlands. Her career includes previous positions as Assistant Professor at Delft University of Technology (2017-2019), Postdoctoral Research Fellow at Lund University, Sweden (2016-2017), and Research Fellow at the University of Udine, Italy (2016). Giulia earned her Ph.D. in Industrial and Information Engineering: Automation (Excellent) from the University of Udine with a thesis titled "Structural Analysis and Control of Dynamical Networks." She completed her M.Sc. and B.Sc. in Electrical Engineering (both Summa cum laude) at the same institution. She also undertook research visits at Caltech (2012) as a SURF Fellow and at the University of Stuttgart (2015) as a DAAD Research Scholar. Her primary research focuses on the analysis and control of dynamical networks with applications in systems biology, mathematical ecology, and mathematical epidemiology. She develops mathematical frameworks that bridge control theory, network theory, and dynamical systems to address complex problems in biological systems. Her recent work spans epidemic modeling, opinion dynamics, biochemical networks, and neurological disorders, with a particular emphasis on structural analysis of networked systems. She employs both theoretical and computational approaches to understand system behavior under uncertainty. Giulia's publications reveal a strong interdisciplinary focus, spanning from theoretical control systems to practical applications in epidemiology and biology. Her recent work shows increasing emphasis on epidemic modeling (particularly related to mpox and SARS-CoV-2), network synchronization, and the application of control theory to biological phenomena like fibromyalgia pathogenesis and opinion formation. Many of her papers appear in top-tier control journals including Automatica and IEEE Transactions on Automatic Control. 2024: Outstanding Service as Associate Editor of IEEE Control Systems Letters 2021: SIAM Activity Group on Control and Systems Theory Prize 2020: Outstanding Reviewer, Annals of Internal Medicine 2017: NAHS Best Paper Prize and EECI PhD Award 2016: Outstanding TAC Reviewer, IEEE Transactions on Automatic Control Giulia actively mentors students and postdoctoral researchers, currently supervising five postdoctoral researchers and two Ph.D. students at the University of Trento. She has advised numerous M.Sc. and B.Sc. students on topics ranging from bio-inspired modeling to optimal control of epidemic systems. Her research is supported by competitive grants including the ERC Starting Grant INSPIRE (Integrated Structural and Probabilistic Approaches for Biological and Epidemiological Systems). She serves as Associate Editor for IEEE Control Systems Letters and Automatica, and is a Senior Member of IEEE and the Control Systems Society. Giulia leads the Dynamical Networks and Systems Biology research group at the University of Trento, which maintains strong international collaborations across Europe and North America. The group's work combines theoretical advances in control theory with practical applications to pressing problems in public health and biological systems, demonstrating the power of mathematical approaches to understanding complex phenomena in the life sciences.

Nicolas Thomäمشاهده پروفایل

استاد

• Chromatin Biology
• Transcription Regulation
• Ubiquitin-Proteasome System
• +۷ مورد دیگر

Nicolas Thomä is a Full Professor and head of the Thomä Lab at the École Polytechnique Fédérale de Lausanne (EPFL), where he holds the Paternot Chair in Cancer Research. He is affiliated with the School of Life Sciences (SV) and the Institute of Chemical and Biological Technology (ISREC), leading the UPTHOMAE research unit. His work bridges structural biology, chemical biology, and cancer research, with a focus on transcriptional regulation and targeted protein degradation. His research interests center on chromatin biology and the molecular mechanisms by which transcription factors access gene promoters within chromatin. He investigates how multi-protein complexes regulate gene expression, particularly focusing on the role of E3 ubiquitin ligases and molecular glues in targeted protein degradation. His lab combines structural techniques (including cryo-EM), biochemical assays, and functional genomics to unravel how small molecules can rewire protein interactions and induce degradation of disease-relevant proteins, especially transcription factors involved in cancer. The recent publications of his lab demonstrate a strong trajectory in understanding the structural basis of transcription factor binding to nucleosomes (e.g., OCT4-SOX2, MYC-MAX, CLOCK-BMAL1) and the mechanism of action of molecular glues like thalidomide. These studies highlight a shift toward therapeutic innovation through chemical biology, aiming to develop novel strategies for targeting 'undruggable' proteins in human diseases. Scientific Awards No specific awards listed in the provided text. Advising and Grants Thomä actively supervises a team of PhD students and postdoctoral researchers, including David Domjan, Laurin Tim Kanis, Alessandro Minafra, and Pierre Alexander Miranda Herrera. His lab is supported by institutional funding from EPFL and likely external grants related to cancer research, structural biology, and chemical biology, though specific grants are not mentioned. The lab’s interdisciplinary approach suggests collaboration with pharmaceutical and biotech partners. Labs and Teams The Thomä Lab, based at EPFL’s SV building, includes a multidisciplinary team of scientists, technical specialists, and administrative support. Key members include Fiona Bello (Technical Specialist), Regina Baur, Alexandra Bendel, Manuel Carminati, and others. The lab is structured around two main research pillars: Transcription Factors in Chromatin Biology and Ubiquitin Biology and Molecular Glues, reflecting its dual focus on fundamental mechanisms and therapeutic applications.