جست‌وجوی استاد و پژوهشگر

Sean McKennaمشاهده پروفایل

استاد

• RNA Biochemistry
• Cancer Biology
• Virology
• +۳ مورد دیگر

Sean McKenna is a Professor and Associate Dean (Programs) in the Department of Chemistry at the University of Manitoba, Faculty of Science. His research focuses on RNA-protein interactions in biological systems, combining biochemistry, structural biology, and molecular biology. He leads the McKenna Lab, investigating non-coding RNA roles in cancer and immune responses to viral infections. Key projects include studying BC200 long non-coding RNA in tumors and the regulation of 2'-5'-oligoadenylate synthetases in viral defense. His work is supported by grants from NSERC and CIHR. McKenna has supervised over 50 students and postdocs, many now in academic and industry roles. He co-launched White Otter Biotech, advancing environmental DNA/RNA monitoring. His lab recently renovated, now housing collaborations with the Ripstein group. Education: PhD (Biochemistry, University of Alberta), Postdoc (Stanford University), BSc (Queen's University). Awards include NSERC Discovery Grants, CIHR funding, and early-career accolades. Research spans RNA dynamics, cancer biology, and viral immunology. Research Highlights: Non-coding RNA BC200’s role in tumor proliferation 2'-5'-OAS enzymes in antiviral immunity SRP9/SRP14 regulation of Alu RNA Recent Publications: Over 70 articles, including work on Alu RNA mechanisms (RNA Biology, 2024) and BC200 processing (RNA Journal, 2024). Awards: NSERC (2024), CIHR (2020), Jamieson Scholarship (2021). Lab & Collaborations: McKenna-Ripstein lab merger (2024), White Otter Biotech (DNA/RNA biodiversity tech).

• Genomics
• Non-coding RNA research
• Phenotype-genotype relationships
• +۷ مورد دیگر

Professor Marcel Dinger is a prominent academic and researcher currently serving as Professor and Head of School for Biotechnology and Biomolecular Sciences at UNSW Sydney. With over 20 years of experience in genomics, he has established himself as a leading figure in both academic and entrepreneurial spheres within the field. He has published 153 papers with over 24,000 citations and maintains an h-index of 61 on Google Scholar. His leadership extends beyond academia as he serves as President of the Australasian Genomics Technologies Association (AGTA) and holds director positions at Pryzm Health and the National Centre for Indigenous Genomics (NCIG). Professor Dinger's research laboratory focuses on establishing new links between phenotype and genotype, particularly examining rare and complex diseases in relation to underexplored regions of the genome including pseudogenes, repetitive elements, non-canonical DNA structures, and noncoding RNAs. His work harnesses population-scale genomic datasets and sophisticated data science methods to bring an objective perspective to understanding how the genome stores information and how it is transacted in biology. His research interests span genomics, non-coding RNA biology, clinical applications of genomic medicine, and the development of computational approaches for analyzing complex genomic data. Analysis of Professor Dinger's recent publications reveals a strong emphasis on non-coding RNA research, particularly long noncoding RNAs and their roles in disease mechanisms. His work spans cancer genomics, neurological disorders, and fundamental genomic mechanisms including DNA secondary structures like i-motifs and G-quadruplexes. His research combines experimental approaches with advanced bioinformatics to address fundamental questions in genomic medicine and has significant translational implications for disease diagnosis and treatment. Highly Cited Researcher in Cross-Field category (2019, 2020, 2021) Fellow of the Faculty of Science (Research), Royal Society of Pathologists of Australasia (2016) NHMRC Career Development Award (2010) Queensland Government Smart Futures Fellowship (2009) Foundation of Research, Science and Technology New Zealand Postdoctoral Fellowship (2005) Professor Dinger has been instrumental in establishing and leading several significant research initiatives including Genome.One, one of the first companies globally to provide clinical whole genome sequencing services, and the Kinghorn Centre for Clinical Genomics at the Garvan Institute of Medical Research. His entrepreneurial experience includes founding four biotechnology and IT startups. He serves on multiple governance boards including the National Centre for Indigenous Genomics, focusing on using genomics to improve health outcomes for Australia's First Peoples. His laboratory at UNSW continues to advance our understanding of genomic regulation and its implications for human health and disease.

Gabriel Bosséمشاهده پروفایل

استادیار

• Neuroscience
• Opioid Addiction
• Neurosteroids
• +۷ مورد دیگر

Gabriel Bossé is an Assistant Professor at the Department of Psychiatry and Neuroscience , Faculty of Medicine, Laval University. His research focuses on leveraging zebrafish models to investigate the neurobiology of opioid addiction , neurosteroid effects on behavior , and long-term consequences of neonatal opioid exposure . He employs genetic tools (CRISPR-Cas9, transgenic lines), pharmacology, and imaging to uncover novel biological pathways and therapeutic targets for addiction. Key Techniques: Behavioral assays, molecular imaging, CRISPR-Cas9, miRNA analysis Laboratory: Boosé Lab , focusing on integrative neuroscience and experimental therapies His work bridges addiction biology and drug discovery , emphasizing neurosteroid pathways and genetic/pharmacological interventions . Publications highlight opioid self-administration mechanisms, neurosteroid modulation, and miRNA turnover in neuronal systems. For contact: gabriel.bosse@cervo.ulaval.ca . Lab website and academic profiles are accessible via Twitter , ORCID , and Google Scholar .

Sabah Hussainمشاهده پروفایل

استاد

• Skeletal muscle atrophy and wasting
• Autophagy and mitophagy
• Proteasomal degradation pathways
• +۷ مورد دیگر

Sabah Hussain, MD, PhD, is Distinguished James McGill Professor in the Department of Medicine, Faculty of Medicine and Health Sciences at McGill University and Senior Scientist in the Translational Research in Respiratory Diseases Program of the Research Institute of the McGill University Health Centre (RI-MUHC, Glen site). She leads an integrated bench-to-bedside program focused on skeletal-muscle wasting, autophagy, and angiogenesis. Education & Training: MD – University of Baghdad, 1978 PhD (Physiology) – McGill University, 1989 Research Focus: Dr Hussain’s laboratory investigates the molecular machinery governing skeletal-muscle mass in health and disease. Using transgenic models of angiopoietin signaling, sepsis, COPD and mechanical ventilation, her team has dissected how autophagy, mitophagy and proteasomal pathways drive diaphragmatic and locomotor muscle atrophy. A second axis of work explores gene-therapy delivery of angiopoietins to accelerate muscle regeneration after injury or in Duchenne Muscular Dystrophy models. More recently, her group is mapping epigenetic regulators—microRNAs and long non-coding RNAs—that fine-tune these degradative pathways. Scientific Awards & Funding: Distinguished James McGill Professorship CIHR Project Grant – Fall 2024 competition NSERC Discovery Grant – 2024 competition Advising & Mentorship: Dr Hussain mentors graduate students, post-doctoral fellows and clinical research trainees. Sami Sedraoui, a PDF in her group, received the April 2025 Relève-Étoile Jacques-Genest Award from CIHR. Laboratory & Affiliations: Her laboratory is located in the Meakins-Christie Laboratories, RI-MUHC Block E, Glen site (1001 Decarie Blvd, Montréal). The group is embedded within the Centre for Translational Biology and benefits from the RI-MUHC Technology Platforms including Proteomics, Small-Animal Imaging and Molecular Imaging Services.

• Reproductive biology
• Uterine biology
• Transcriptomics
• +۱۱ مورد دیگر

Professor Niamh Forde serves as Professor of Molecular Reproductive Biosciences within the School of Medicine at the University of Leeds. She co-founded and co-directs LeedsOmics, a virtual research institute advancing interdisciplinary omics applications. Her work bridges human and animal reproductive sciences through comparative molecular physiology across mammalian species. Education: BA (Mod) Biochemistry from Trinity College Dublin PhD from University College Dublin Research Focus: Professor Forde pioneers investigations into embryo-endometrial molecular crosstalk during early pregnancy using multi-omics approaches. Her lab integrates in vivo studies with cutting-edge in vitro platforms including microfluidics, organoids, and extracellular scaffolds to dissect non-coding RNA mechanisms and protein signaling. Key emphases include species-comparative analysis (human, bovine, porcine, murine), maternal metabolic impacts, embryo sex effects, and extracellular vesicle-mediated communication—all with implications for fertility, food security, and developmental origins of health and disease. Publication Trends: Recent work (2022-2025) demonstrates consistent innovation in modeling conceptus-maternal interactions through engineered systems like endometrium-on-a-chip. Publications reveal growing emphasis on conserved molecular pathways (e.g., PDI/CAPG proteins), microRNA networks in implantation, and translational applications for livestock fertility and human reproductive health. Her team increasingly leverages cross-species genomic analyses to identify evolutionary innovations underpinning placental mammal pregnancy. Leadership and Collaboration: As Associate Editor for Reproduction and member of SSR/SRF/Biochemical Society, she shapes reproductive science discourse. Her affiliations with Leeds Institute of Cardiovascular and Metabolic Medicine and Multidisciplinary Cardiovascular Research Centre foster translational synergies. Current PhD projects focus on 3D uterine modeling and non-coding RNA function, training next-generation scientists in advanced reproductive technologies.

Fereydoun Hormozdiariمشاهده پروفایل

دانشیار

• Computational Genomics
• Structural Variation Discovery
• Genome Assembly
• +۳ مورد دیگر

Dr. Fereydoun Hormozdiari is an Associate Professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis School of Medicine. His research focuses on developing computational methods for analyzing genomic data, particularly in structural variation discovery, genome assembly, and disease prediction using omics data. He leads a lab that integrates machine learning and combinatorial algorithms to address challenges in understanding complex disorders like autism and cancer. Key research areas include: Structural variation discovery and genotyping using next-generation sequencing technologies. Development of novel algorithms for de novo genome assembly. Identification of genetic modules and pathways linked to neurological disorders. Prediction of complex disorders through integrated analysis of genomic and transcriptomic data. Recent work includes advancements in early-stage cancer detection using cell-free RNA biomarkers and AI, as well as tools for tumor phylogeny reconstruction and structural variant genotyping. His contributions span over 80 publications in high-impact journals like Nature, Cell, and Genome Research. Lab and team collaborations involve interdisciplinary approaches, combining computational biology with clinical applications. Ongoing projects emphasize translating genomic insights into predictive models for personalized medicine and disease intervention.

Yao Wei Luمشاهده پروفایل

استادیار

• Cardiovascular Biology
• Cardiovascular Disease
• Molecular Medicine
• +۳ مورد دیگر

Yao Wei Lu is an Assistant Professor of Medicine at the University of Southern California, affiliated with the Hastings Center for Pulmonary Research and leading the Lu Lab. Their research focuses on cardiovascular development, regeneration, and diseases, particularly investigating mechanisms underlying cardiac fibrosis, diabetic complications, and the role of non-coding RNAs in cardiovascular pathologies. Key areas include endothelial dysfunction, metabolic disorders, and molecular signaling pathways in heart disease. Research interests emphasize translational studies targeting therapies for cardiac hypertrophy, atherosclerosis, and heart failure. Dr. Lu's work integrates molecular biology, cell biology, and systems biology approaches to understand disease mechanisms and develop novel treatments. Notable achievements include the receipt of the American Heart Association (AHA) Second Century Early Faculty Independence Award in 2023. The lab's studies often involve collaborative projects on nanotherapies, epigenetic regulation, and cellular senescence. Current projects explore therapeutic inhibition of non-coding RNAs and mitochondrial dysfunction's role in cardiomyocyte regeneration.

Zhengdong Zhangمشاهده پروفایل

استاد

• Genetics of complex human diseases
• Systems biology
• Aging
• +۵ مورد دیگر

Zhengdong Zhang is a Professor in the Department of Genetics at Albert Einstein College of Medicine. His research focuses on the genetics of aging, Alzheimer's disease, and complex human diseases, combining computational methods with clinical data to uncover genetic mechanisms. His lab develops novel algorithms for genetic analysis, including post-GWAS gene prioritization, Bayesian statistical methods for genomic data, and systems biology approaches. Education details are not explicitly listed, but his professional background includes significant contributions to computational genetics and aging research. Key research areas include method development for genetic analysis, aging-related genetic networks, and disease genetics of Alzheimer's and schizophrenia. His lab has pioneered studies on long-lived species' genomic features, such as naked mole rats and beavers, to understand longevity and disease resistance. Research highlights include identifying rare coding variants linked to schizophrenia risk in 22q11.2 deletion syndrome patients, developing frameworks for Alzheimer's immune pathway analysis, and exploring DNA repair mechanisms in long-lived species. His work emphasizes interdisciplinary approaches integrating data science with clinical insights. Zhengdong Zhang's lab is located in the Michael F. Price Center at Einstein College of Medicine, focusing on translational research to bridge genetic discoveries with clinical applications.

Dagmar Wirthمشاهده پروفایل

استاد پژوهشی

• Virology
• Immunology
• Gene Regulation
• +۴ مورد دیگر

Prof. Dagmar Wirth is a Research Professor and Head of the 'Model Systems for Infection and Immunity' research group at the Helmholtz Centre for Infection Research (HZI). Her work focuses on gene regulation, viral infections, and immune evasion mechanisms, with a particular emphasis on developing genetically modified mouse models for studying infectious diseases and immune responses. She leads the Service Unit 'Transgenic Mice' (TGSM), providing expertise in transgenic model systems to the HZI community. Affiliations: HZI (since 2004), previously at the Medical University of Hannover. Education: Chemistry studies in Braunschweig, PhD at GBF (now HZI), postdoctoral research on viral recombination and gene therapy. Her research interests include viral pathogenesis (e.g., Kaposi's sarcoma-associated herpesvirus), engineered cell-based therapies, and controlled drug delivery systems using macrophages and nanoparticles. She has pioneered models for hepatitis C virus infection in mice and developed biosensors to detect bacterial infections. Publications: Over 150 peer-reviewed articles, focusing on virology, immunology, and genetic engineering. Recent work includes studies on antibacterial coatings for implants, ultrasound-activated drug release, and the role of senescence in herpesvirus infection. Labs/Teams: Leads the MSYS group and collaborates with teams in virology, immunology, and biomedical engineering. Active in developing 3D in vitro models for studying infection and immune responses.

Kwaku Dayieمشاهده پروفایل

استاد

• RNA structural biology
• Nuclear Magnetic Resonance (NMR) spectroscopy
• Biophysical methods
• +۷ مورد دیگر

Kwaku Dayie is a Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research focuses on RNA structural biology, NMR spectroscopy, and biophysical methods to study RNA dynamics and function. He leads a lab developing advanced NMR techniques for large RNA molecules and has contributed to understanding RNA's role in catalysis, gene regulation, and viral processes. Education: B.A., Physics with Honors, 1990, Hamilton College Ph.D., Biophysics, 1996, Harvard University Postdoctoral, MIT (1998), Scripps Research Institute (2000) Research Interests: The structural basis of RNA signaling in pathogenic bacteria, RNA viruses (HIV, HBV), and long noncoding RNAs. His lab develops isotopic labeling methods and NMR tools to study RNA dynamics and function, aiming to guide RNA-based drug design. Awards: Henry C. Welcome Fellowship (2008) National Technical Association Nsoroma Technology Award (2007) Jane Coffin Childs Memorial Fund Postdoctoral Fellowship (1998) Grants & Service: NIH review panelist (2012-2018), NSF reviewer (2005-2006), and judge for Intel ISEF (2003). Serves on editorial boards for Molecules and NPG Scientific Reports (2018). Labs & Teams: Directs an interdisciplinary lab focused on RNA structural biology, collaborating on NMR method development and RNA-drug interaction studies.

Raffaella Santoroمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Dynamics
• Cancer Biology
• +۵ مورد دیگر

Prof. Raffaella Santoro is a Professor and Principal Investigator at the Department of Molecular Mechanisms of Disease (University of Zurich). She holds a PhD in Biochemistry from the University of Rome La Sapienza and has held research positions at the Hans Knöll Institute (Germany) and ETH Zurich before joining the University of Zurich in 2009. Her laboratory focuses on epigenetic and chromatin regulatory mechanisms in cancer, stem cell pluripotency, and early development, with a particular emphasis on nucleolar function and genome architecture. Key research themes include the role of the nucleolus in repressive chromatin domains, epigenetic alterations in prostate cancer, and the interplay between chromatin and gene expression during development. Her work combines molecular and cell biology with high-throughput genomic approaches, as highlighted in over 100 publications in journals like Molecular Cell, Nature Communications, and EMBO Reports. She leads a dynamic research group comprising PhD students, postdocs, and master’s researchers, and actively recruits talent through the Life Science Zurich Graduate School. Her group collaborates with initiatives such as the NCCR and EMBO, contributing to advancements in epigenetic medicine and cancer biology. Educational Background: PhD in Biochemistry, University of Rome La Sapienza (Italy); Postdoctoral Research at the German Cancer Research Center (Heidelberg, Germany). Research Interests: Chromatin dynamics, nucleolar architecture, epigenetic regulation in cancer and development, prostate cancer heterogeneity, stem cell pluripotency, and spatial genomics. Collaborative efforts include the development of novel methods for 3D chromosome mapping and nucleolar interaction analysis. Scientific Contributions: Pioneering studies on nucleolar heterochromatin formation, the role of BAZ2A in cancer stem cells, and the epigenetic control of melanoma invasiveness. Her lab also explores oxidative stress impacts on early embryonic epigenetic reprogramming and the therapeutic potential of targeting epigenetic modifiers in cancer. Labs & Teams: The Santoro Lab at the University of Zurich integrates interdisciplinary approaches, with ongoing projects funded by ERC, EMBO, and the Swiss National Science Foundation. Current initiatives include modeling prostate cancer heterogeneity and identifying epigenetic biomarkers for disease prognosis.

• Molecular Systems Biology
• RNA Processing
• mRNA Metabolism
• +۱۲ مورد دیگر

Bin Tian, Ph.D., is a Professor in the Department of Biochemistry and Biophysics at The Wistar Institute and serves as Program Co-Leader of the Genome Regulation and Cell Signaling Program at the Ellen and Ronald Caplan Cancer Center. He is also the Director of the Center for Systems & Computational Biology. His research integrates molecular biology, computational genomics, and functional studies to understand RNA processing, particularly alternative polyadenylation (APA), and its roles in cancer and immunity. His educational background includes a B.S. in Biochemistry from East China University of Science and Technology and a Ph.D. in Molecular Biology from Rutgers Biomedical and Health Sciences (formerly UMDNJ). He completed postdoctoral training in bioinformatics and genomics at Johnson & Johnson before establishing his independent lab at Rutgers New Jersey Medical School in 2003, where he became a tenured professor in 2014. He joined The Wistar Institute in 2020. His research focuses on molecular systems biology of RNA, including functional genomics of cleavage and polyadenylation, regulation of gene expression through early transcriptional termination, spatial and temporal control of mRNA metabolism via alternative 3’UTRs, and cleavage and polyadenylation inhibition (CPAi) as a cancer therapeutic strategy. His lab has developed key bioinformatics resources like PolyA_DB, APAlyzer, and MAAPER. His recent publications show a strong trend in dissecting APA mechanisms across physiological and pathological contexts, including cancer, neuronal function, and immune cell differentiation. The work combines high-throughput sequencing, single-cell analysis, and computational modeling to uncover how APA regulates mRNA stability, localization, and function. He mentors a team of postdoctoral fellows, predocotoral trainees, and research assistants, contributing to training the next generation of scientists. His lab is actively pursuing novel therapeutics targeting mRNA 3’ end processing in cancer and immune disorders.

Kristen W. Lynchمشاهده پروفایل

استاد

• RNA Biology
• Alternative Splicing
• Alternative Polyadenylation
• +۷ مورد دیگر

Kristen W. Lynch, PhD, is the Benjamin Rush Professor of Biochemistry and Chair of the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. She leads research at the Lynch Lab and co-directs the Institute for RNA Innovation , focusing on RNA processing mechanisms in human immune responses. Education: Harvard University (B.A. 1990, Ph.D. 1996) Postdoctoral Training: University of California, San Francisco (1997-2001) Her work bridges RNA splicing , alternative polyadenylation , and gene regulation in immune cells and cancer. She discovered kinase pathways controlling RNA-binding protein (RBP) activity and demonstrated how antigen stimulation and viral infections reprogram splicing networks to modulate immunity. Collaborative studies with oncologists revealed splicing defects phenocopying genetic mutations in leukemias and identified therapeutic vulnerabilities in RNA processing . Her recent publications highlight TREX-2 complex in mRNA export, hnRNP L repressing cryptic exons, and DDX39B structural analysis . Collaborations span RNA-Seq , splicing codes , and epithelial cell post-transcriptional programs . She explores spliceosomal assembly mechanisms and signal-responsive RBPs in T cells and influenza pathogenesis.

• Genomics
• Functional Genomics
• Structural Genomics
• +۳ مورد دیگر

Massimo Delledonne is a Full Professor in the Department of Biotechnology at the University of Verona. His research focuses on clinical genomics, functional genomics, structural genomics, and metagenomics. He teaches modules such as Genetics and Human Genomics across undergraduate and graduate programs, including Molecular and Medical Biotechnology and Medical Bioinformatics. Affiliations: Department of Biotechnology, University of Verona Committees: Faculty Board of PhD in Biotechnology, Biotechnology Teaching Committee Spin-offs: EDIVITE s.r.l., Microbion S.r.l., Enerzyme s.r.l. (among others) His research interests include genome assembly, single nucleotide variant analysis, and applications of next-generation sequencing technologies. Projects span plant and human genomics, with a focus on crop improvement, disease diagnostics, and microbial interactions. Recent work includes studies on lupin diversity, common bean evolution, and grapevine genetics. Key projects include IBEARAD (Bioinformatics for Agricultural Resilience) and SYMPHONY (Phaseolus vulgaris genome analysis). He leads interdisciplinary efforts in genomic medicine, plant genomics, and environmental genomics.

Stefan Hüttelmaierمشاهده پروفایل

استاد

• Molecular Biology
• Cancer Biology
• RNA Biology
• +۳ مورد دیگر

Stefan Hüttelmaier is a Full Professor of Molecular Cell Biology at Martin-Luther University Halle-Wittenberg, Germany. He leads the Core Facility Imaging at the Charles Tanford Protein Center and directs research into RNA-binding proteins' roles in cancer. His career includes postdoctoral work at Albert Einstein College of Medicine and leadership roles in the RTG 1591 research group. His work focuses on RAVER1 protein dynamics, perinucleolar compartments, and RNA metabolism in cancer progression. Education: PhD in Biotechnology (2000, University of Braunschweig), postdoctoral training at Albert Einstein College of Medicine (2001–2004). Academic milestones include Associate Professor (2009) and Full Professor (2014) positions. Research spans RNA-protein interactions, cancer biology, and translational mechanisms in tumors. Key research interests include RNA-binding proteins' roles in cancer (RAVER1, IGF2BP1), alternative splicing, and miRNA regulation. His lab investigates how these molecules influence cancer cell behavior, metastasis, and therapeutic resistance. Recent work highlights druggable targets like IGF2BP1 and mechanisms linking RNA modifications to oncogenesis. Leadership roles include RTG 1591 speaker and Core Facility director. Publications emphasize RNA biology in cancer, with contributions to understanding post-transcriptional control and therapeutic strategies targeting RNA pathways. His interdisciplinary approach combines molecular biology, biochemistry, and computational modeling to address clinical challenges in oncology.