جست‌وجوی استاد و پژوهشگر

Seena Ajitمشاهده پروفایل

استاد

• Molecular mechanisms of pain
• Epigenetic regulation
• MicroRNA expression and regulation
• +۳ مورد دیگر

Seena Ajit, PhD, is a Professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine. She leads the Ajit Lab, which focuses on epigenetic mechanisms of pain, particularly involving microRNAs and extracellular vesicles. Her research investigates biomarkers for chronic pain conditions like complex regional pain syndrome (CRPS) and the role of exosomes in intercellular communication. Education: PhD from Rutgers University. Research Interests: Molecular mechanisms of neuropathic and inflammatory pain, epigenetic regulation, miRNA expression, and biomarker discovery. The lab explores exosome-mediated signaling and the role of noncoding RNAs such as XIST in pain pathogenesis, with a focus on sex-based differences. Awards: Mary DeWitt Pettit Fellowship (2017), Faculty Mentoring Award (2016), Rita Allen Foundation Grant (2010–2013). Advising & Grants: Supervises PhD and MS students in pharmacology, physiology, and related disciplines. Collaborates on grants including a CURE Formula Grant with Dr. Mortensen on sex differences in neuropathic pain. Mentored numerous students, many of whom hold academic or industry roles. Labs & Teams: Director of the Ajit Lab, part of the Pharmacology & Physiology Department. Active in the Drexel University College of Medicine’s research community, contributing to drug discovery and translational pain research initiatives.

Sean Limesandمشاهده پروفایل

استاد

• Fetal Development
• Endocrinology
• Animal Physiology
• +۳ مورد دیگر

Sean Limesand, PhD is a Professor at the University of Arizona's School of Animal Sciences & Comparative Biomedical Sciences. His research focuses on fetal development, endocrine adaptations, and metabolic programming in animal models, particularly sheep and goats. Key areas include fetal growth restriction (FGR), placental insufficiency, and the long-term impacts of in utero stressors like hypoxia, heat, and maternal infections. His work integrates molecular biology (e.g., transcriptomics), cellular physiology (e.g., β-cell function), and whole-animal studies. Notable contributions include identifying dysregulated pathways in growth-restricted fetal tissues, characterizing mitochondrial adaptations in FGR, and exploring therapeutic interventions (e.g., oxygen/glucose therapy in ovine models). Research also addresses environmental challenges like maternal heat stress and its effects on lactation/placental function, as well as SARS-CoV-2's impact on maternal-neonatal outcomes. His studies often involve interdisciplinary approaches, combining omics technologies with physiological measurements to understand developmental origins of health and disease. Current studies investigate single-cell transcriptomics of SS-cells in FGR, epigenetic modifications in thermotolerant ewes, and molecular mechanisms linking fetal programming to adult metabolic disorders. These efforts aim to translate findings into clinical strategies for managing growth-restricted infants and improving livestock resilience.

• Graphical Models
• Bayesian Nonparametrics
• Bayesian Variable Selection
• +۳ مورد دیگر

Yabo Niu is an Assistant Professor and Presidential Frontier Faculty in the Department of Mathematics at the University of Houston, with a joint appointment in the Department of Health Systems & Population Health Sciences within the Tilman J. Fertitta Family College of Medicine. They hold a Ph.D. in Statistics from Texas A&M University (2019) and a B.S. in Statistics from Nankai University, China (2013). Their research focuses on Bayesian statistical methods, including graphical models, nonparametric approaches, variable selection, and tree-based regression/classification techniques. Recent contributions include the 2024 JASA Reproducibility Award-winning paper on covariate-assisted Bayesian graph learning for heterogeneous data. Dr. Niu has developed novel methodologies in network modeling and hybrid estimation techniques (e.g., EPSOM-Hyb). Their work bridges statistical theory with applications in health systems, neuroscience, and genomics. In 2024, they introduced a new Bayesian Statistics course (MATH 6397) at the University of Houston. Education: Ph.D. in Statistics, Texas A&M University (2014–2019) B.S. in Statistics, Nankai University (2009–2013) Research Highlights: Developed robust high-dimensional network modeling frameworks Advanced Bayesian approaches for heterogeneous data integration Investigated astrocyte structural plasticity using machine learning Teaching: Bayesian Statistics course (Spring 2024) Current research emphasizes integrating omics data and advancing reproducible statistical practices. Dr. Niu’s group includes postdoctoral researchers like Ji Shi (jointly supervised with Demetrio Labate and Peng Zhao).

Tae Hoon Kimمشاهده پروفایل

دانشیار

• Functional Genomics
• Epigenetics
• Transcriptional Regulation
• +۶ مورد دیگر

Tae Hoon Kim is an Associate Professor in the Department of Biological Sciences at The University of Texas at Dallas (UTD), where he also served as Department Head from 2019 to 2023. His research focuses on functional genomics, epigenetics, and transcriptional regulation, with applications to cancer biology, innate immunity, and chronic pain. He holds a Ph.D. in Biochemistry from Harvard University, an M.A. in Molecular and Cellular Biology from Harvard, and a B.A. in Biology from Reed College. His work integrates genomic and computational approaches to study nuclear processes, chromosomal organization, and disease mechanisms. Kim’s research group has pioneered studies on enhancer function, CTCF-mediated chromatin interactions, and the role of long noncoding RNAs in cancer. Notable contributions include uncovering links between metabolic pathways and oncogenesis, as well as mechanisms underlying lymphatic vascular development. His lab, the Functional Genomics Laboratory, innovates techniques like ChIP-seq and 3C-based analyses to study gene regulation at the genome scale. Kim has received prestigious awards such as the Pew-Stewart Scholar Award (2011), Sidney Kimmel Scholar Award (2008), and Rita Allen Scholar Award (2007). His work has been published in high-impact journals, including Brain , Nature , and Genome Research . Collaborations with institutions like MD Anderson Cancer Center and Baylor College of Medicine highlight his interdisciplinary approach to translational research. His current projects address chronic pain mechanisms, leveraging transcriptomic data from human dorsal root ganglia, and targeting metabolic vulnerabilities in squamous cell carcinomas. Kim’s training includes postdoctoral work at the Ludwig Institute for Cancer Research (2002–2006) and a prior faculty position at Yale University (2006–2013).

• Genetics
• Genomics
• Bioinformatics
• +۷ مورد دیگر

Yingleong (Rigel) Chan, PhD , is an Assistant Professor at the UMass Chan Medical School with appointments in the Department of Neurology . His research bridges Genetics/Genomics and Computational Biology to study Neurodegenerative Diseases like Alzheimer's and Multiple Sclerosis, utilizing Stem Cell Models and CRISPR-Cas9 technologies. Education: National University of Singapore: BS in Computing National University of Singapore: MS in Bioinformatics Harvard University: PhD in Genetics & Genomics His lab focuses on high-throughput in-vitro modeling to link genetic variants with cell-type-specific phenotypes. Recent work includes HSV-1 infection studies in cerebral organoids and mitochondrial heteroplasmy analysis in Alzheimer's disease. Collaborative projects span autism genomics and immune evasion in gene therapy . Key article trends include: 2025 : Microglia subtypes and IgG4 in Alzheimer's 2024 : HSV-1-induced AD-like transcripts and clinical cost analysis 2023 : Pooled iPSC generation and mitochondrial polymorphism modeling 2018 : CRISPR repressor development and yeast variant libraries

• RNA Therapeutics
• Gene Editing Technologies
• Molecular Biology
• +۷ مورد دیگر

Jonathan Watts is a Professor at the UMass Chan Medical School's RNA Therapeutics Institute and holds multiple academic positions across the T.H. Chan School of Medicine and Morningside Graduate School of Biomedical Sciences. His primary focus is on RNA-based therapies, gene editing technologies, and nucleic acid delivery systems. Watts earned his BS in Chemistry from Dalhousie University and his PhD in Bio-organic Chemistry from McGill University. His research integrates molecular biology, drug design, and clinical application to develop treatments for genetic disorders. Key areas include antisense oligonucleotides for neurodegenerative diseases (e.g., ALS), CRISPR-Cas9 and prime editing systems, and viral vector engineering for in vivo gene therapy. Notable contributions include work on APOBEC3 inhibitors, dNTP optimization for prime editing, and mitigating oligonucleotide toxicity in the CNS. Watts has authored over 150 publications in top journals like *Nature Biotechnology*, *Lancet*, and *Molecular Therapy*. His collaborations span academia and industry, including NIH-funded programs for somatic cell genome editing. He actively contributes to translational research, aiming to bridge nucleic acid chemistry with clinical outcomes for conditions like fragile X syndrome, glioblastoma, and SARS-CoV-2 infection.

Alexander Marsonمشاهده پروفایل

استاد

• Genetic circuits
• Autoimmune diseases
• CRISPR genome engineering
• +۳ مورد دیگر

Alexander Marson, MD, PhD, is a Professor of Medicine at the University of California, San Francisco (UCSF), School of Medicine, Department of Medicine. His research focuses on understanding genetic circuits controlling human immune cell function in health and disease, developing CRISPR-based tools for genome engineering in primary immune cells, and advancing cell-based therapies for cancer, autoimmunity, and infectious diseases. His lab has pioneered methods for efficient editing of T cells and identified genetic variants underlying autoimmune diseases. Education: AB in Biology, Harvard College, 2001 M.Phil in Biological Sciences, University of Cambridge, 2003 PhD in Biology, Massachusetts Institute of Technology, 2008 MD, Harvard Medical School, 2010 Research Interests: Dr. Marson's work integrates genetics, genomics, and immunology to dissect immune cell circuits. Key areas include CRISPR technologies, regulatory T cell biology, HIV latency mechanisms, and the translation of engineered immune cells into clinical therapies. His lab employs cutting-edge tools like Perturb-seq and single-cell analysis to map gene regulatory networks. Selected Achievements: Developed CRISPR tools for editing primary human T cells (Schumann et al., PNAS 2015; Roth et al., Nature 2018) Discovered genetic variants linked to autoimmune diseases (Farh et al., Nature 2015) Advanced engineered T cell therapies via SEED-Selection and CRISPRoff approaches Awards: 2022: Elected Member of Association of American Physicians 2019: CRI Lloyd J. Old STAR Career Award 2019: Elected Member of American Society of Clinical Investigators Grants & Funding: NIH grants (P01AI138962, R01DK119979) and support from the Chan Zuckerberg Biohub and Parker Institute for Cancer Immunotherapy highlight his leadership in translational immunology.

Jeffrey M. Friedmanمشاهده پروفایل

استاد

• Genetics
• Genomics
• Metabolism
• +۵ مورد دیگر

Jeffrey M. Friedman is the Marilyn M. Simpson Professor at The Rockefeller University and an Investigator at the Howard Hughes Medical Institute. He leads the Laboratory of Molecular Genetics, focusing on molecular and neural mechanisms regulating food intake and body weight. His groundbreaking discovery of leptin, a hormone critical for energy homeostasis, revolutionized obesity research. Friedman holds academic roles in the David Rockefeller Graduate Program and Tri-Institutional M.D.-Ph.D. Program. His research spans leptin signaling, neural circuits controlling feeding, and genetic studies of metabolic disorders. Education: B.S., Rensselaer Polytechnic Institute (1973) M.D., Albany Medical College (1977) Ph.D., The Rockefeller University (1986) Research Interests: Dr. Friedman explores how leptin regulates energy balance, identifies neural circuits driving feeding behavior, and investigates leptin resistance mechanisms. His work extends to genetic studies of obesity in humans and the role of leptin in conditions like lipodystrophy and diabetes. Key areas include hypothalamic signaling, adipose tissue innervation, and long noncoding RNAs affecting leptin expression. Recent Findings: Recent studies revealed leptin's role in adipose tissue nerve growth via BDNF signaling and identified ADCYAP1+ neurons influencing sickness behavior. His lab also uncovered LncOb's role in obesity and explored mesolimbic pathways hijacked by addictive drugs. Awards: Albert Lasker Basic Medical Research Award (2010) Breakthrough Prize in Life Sciences (2020) Wolf Prize in Medicine (2019) Advising & Labs: He mentors students in genetics and metabolism. His lab collaborates on human obesity studies in Turkey and Kosrae Island populations. Research extends to clinical applications of leptin and GLP-1-based therapies. Lab & Teams: The Laboratory of Molecular Genetics integrates genetics, neuroscience, and metabolism to dissect obesity's molecular basis. Collaborations include the Kavli Neural Systems Institute and Howard Hughes Medical Institute.

• Traumatic Brain Injury (TBI)
• Prion Diseases
• Neurodegenerative Disorders
• +۴ مورد دیگر

Kimbra Kenney, MD, is a Clinical Professor in the Department of Neurology at the Uniformed Services University of the Health Sciences (USUHS) School of Medicine. Her research focuses on traumatic brain injury (TBI), prion diseases, and biomarkers of neurological disorders, with a particular emphasis on military and veteran populations. She has held roles including Clinical Associate at the NIH, Medical Officer, and clinical researcher in programs such as the Comprehensive Neuroscience Program (CNP) and the National Intrepid Center of Excellence (NICoE). Dr. Kenney's work spans neuroimaging, cerebrovascular function, and neurodegenerative mechanisms in TBI, with a focus on translational research and clinical outcomes. Education B.A., The Johns Hopkins University (1980) M.D., University of Virginia School of Medicine (1984) Internship: Internal Medicine, Harbor-UCLA (1985) Residency: Neurology, Oregon Health Sciences University (1988) Fellowship: Neuropathology, University of Washington (1989) Research Interests Dr. Kenney's work addresses biomarkers of TBI, prion disease pathogenesis, and cerebrovascular dysfunction. She investigates links between TBI and chronic conditions such as dementia, headaches, and neurological inflammation. Her studies employ neuroimaging (e.g., MRI, fNIRS), blood-based biomarkers (e.g., neurofilament light, GFAP), and exosomal microRNA analysis to assess injury mechanisms and treatment efficacy. Grants & Collaboration Her research has been supported through collaborations with the NIH, Chronic Effects of Neurotrauma Consortium (CENC), and the ENIGMA Military Brain Injury Working Group. Key projects include the LIMBIC-CENC study on TBI epidemiology and the NICoE’s clinical trials for cerebrovascular therapies. Labs & Teams Dr. Kenney contributes to interdisciplinary teams at USUHS, NICoE, and the Department of Neurology, focusing on military-relevant neurological disorders and translational research initiatives.

• Nucleic Acid Structures
• DNA Repair
• RNA-Protein Interactions
• +۳ مورد دیگر

Prof. Katrin Paeschke is a Professor at the Institute of Clinical Chemistry and Clinical Pharmacology within the Medical Faculty of the University of Bonn. Her research focuses on nucleic acid structures and their roles in cellular processes, including DNA repair, genome stability, and immune regulation. She leads the Paeschke Lab, which investigates G-quadruplex structures in DNA and RNA, their interactions with proteins, and implications for diseases such as cancer and autoimmune conditions. Notable contributions include studies on UV-induced DNA damage repair mechanisms involving ZRF1 and the role of G4 structures in viral biology and antiviral strategies. Her work bridges molecular mechanisms with translational applications in therapy development. Selected research interests include: Mechanisms of G-quadruplex formation and resolution Impact of nucleic acid secondary structures on genome integrity Interplay between DNA damage and immune responses Therapeutic targeting of G-quadruplex structures in cancer Publications highlight interdisciplinary approaches, combining biochemistry, cell biology, and genetics to address fundamental questions in nucleic acid biology. Collaborations span virology, immunology, and oncology, reflecting her transdisciplinary research in TRA-Matter at the University of Bonn.

• Transposable Elements
• LINE-1 Retrotransposition
• Genome Structure and Function
• +۵ مورد دیگر

John V. Moran is the Gilbert S. Omenn Collegiate Professor of Human Genetics and a Professor of Internal Medicine at the University of Michigan Medical School. His research focuses on the molecular mechanisms and genomic impacts of LINE-1 and SINE retrotransposition. Education: B.S. in Chemistry (Rochester Institute of Technology), M.S. in Molecular Genetics (The Ohio State University), Ph.D. in Biochemistry (University of Texas Southwestern Medical School) Postdoctoral Training: Damon Runyon Fellow at Johns Hopkins University and University of Pennsylvania Dr. Moran’s laboratory investigates how transposable elements shape genome evolution and disease. His work spans molecular biology, genomics, and computational approaches to analyze retroelement dynamics in somatic and germline cells. His recent research highlights include LINE-1 retrotransposition in neural tissues , interactions with DNA repair pathways , and roles in somatic mosaicism in schizophrenia . Collaborative efforts include the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Scientific Awards: 2013 Curt Stern Award AAAS Fellow Howard Hughes Medical Institute Alumnus Dr. Moran actively mentors students and postdoctoral fellows. He also contributes to genomic resource development and serves on advisory boards for biotech companies.

Wei Zhangمشاهده پروفایل

استادیار

• Vascular Biology
• Smooth Muscle Cell Biology
• Noncoding RNA
• +۳ مورد دیگر

Wei Zhang, PhD is an Assistant Professor in the Department of Cardiovascular Sciences at the Lewis Katz School of Medicine, Temple University. His research focuses on vascular wall disorders, smooth muscle cell (VSMC) phenotypic changes, and therapeutic target discovery. BSc in Pharmacy - Sun Yat-Sen University PhD in Biomedical Engineering - Sun Yat-Sen University Dr. Zhang’s work explores how VSMC heterogeneity contributes to pathologies like restenosis, aneurysm dissection, and atherosclerosis. He investigates mechanisms of VSMC proliferation, migration, and transdifferentiation using genetic, surgical, and dietary rodent models, including conditional knockout mice and lineage-tracing systems. His publications highlight advancements in single-cell transcriptomics, lncRNA (INKILN) targeting, and prime editing for tissue-specific gene function. Articles span Redox Biology , Circulation , Genome Biology , and Aging (Albany NY) , with trends in multiomics, gene editing, and aging-related vascular pathways. Scientific Awards: 2023 AHA Transformational Project Award 2023 AHA Second Century Early Faculty Independence Award 2023 Augusta University Intramural Grant 2023 ATVB Travel Grant for Early Career Investigators 2018 AHA Career Development Award Dr. Zhang’s lab utilizes humanized transgenic mice, lineage-tracing models, and cell cycle/senescence reporters to study vascular disease initiation and progression at high resolution.

Kristian Bakerمشاهده پروفایل

دانشیار

• RNA Biology
• mRNA Translation
• mRNA Degradation
• +۵ مورد دیگر

Kristian Baker, PhD is an Associate Professor in the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine. She is also a Member of the Center for RNA Science and Therapeutics at the university. Dr. Baker serves the greater RNA scientific community as CEO of the international RNA Society. Dr. Baker received her PhD in Genetics from the University of British Columbia (UBC) in Vancouver, Canada in 2002. She completed post-doctoral training at the Howard Hughes Medical Institute at the University of Arizona under the mentorship of Dr. Roy Parker, a pioneer in the study of RNA regulation and metabolism. Dr. Baker's research focuses on the molecular mechanisms that regulate the interplay between mRNA translation and degradation, and how RNA quality control is maintained in the cell. She is particularly interested in understanding the mechanisms underlying nonsense-mediated mRNA decay (NMD) and how the cell recognizes and rapidly destroys aberrant transcripts. Her lab also investigates the identification and function of long noncoding RNAs. More recently, her work has expanded into transgender health research, exploring topics such as hormone therapy, mental health, and healthcare access for sexual and gender minority populations. Dr. Baker's publication record demonstrates a significant evolution from fundamental RNA biology to applied research in transgender health. Her early work established her expertise in RNA quality control mechanisms, particularly nonsense-mediated mRNA decay, while her more recent publications reflect a growing focus on health equity, transgender medicine, and inclusive research practices. This interdisciplinary trajectory highlights her ability to bridge basic science with pressing clinical and societal issues. CEO of the international RNA Society Outside of the lab, Dr. Baker is an engaged mentor and enthusiastic educator. She has made significant contributions to both basic RNA biology and transgender health research, demonstrating a commitment to advancing scientific knowledge while addressing important health disparities. Her leadership in the RNA Society indicates her active role in shaping the direction of RNA research globally. Dr. Baker leads a research laboratory that investigates fundamental mechanisms of RNA regulation while also contributing to the growing field of transgender health research. Her dual focus demonstrates an interdisciplinary approach that bridges basic molecular biology with clinical and public health applications.

Hanne Hoffmannمشاهده پروفایل

استادیار

• Circadian Rhythms
• Molecular Neuobiology
• Neuroendocrinology
• +۳ مورد دیگر

Hanne Hoffmann is an Assistant Professor in the Neuroscience Program at Michigan State University's College of Natural Science , with affiliations in the Genetics & Genome Sciences Program and Cell & Molecular Biology Program. She investigates molecular pathways linking circadian rhythms to reproductive physiology and health disorders. Focus on hypothalamic SCN as the body's pacemaker Impacts of light pollution and shiftwork on hormone release Develops novel mouse models for circadian-endocrine interactions Her research connects circadian dysregulation to endocrine disorders (diabetes, obesity, cardiovascular disease), mental health , and infertility , emphasizing translational relevance for 20% of the U.S. population affected by disrupted rhythms. Publications span 2011-2025, covering topics like: SCN transcription factor networks (Six3, Vax1, Otx2) Circadian control of GnRH neurons Placental chronobiology in preterm birth Light exposure effects on feline stress Chronopharmacology of oxytocin and GnRH

Lloyd M. Smithمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Bioinformatics
• +۳ مورد دیگر

Lloyd M. Smith is the W. L. Hubbell Professor and Hall-Fischer Professor of Chemistry at the University of Wisconsin–Madison. His research focuses on developing cutting-edge proteomics technologies that bridge biology, chemistry, and computational analysis. Key research areas include comprehensive proteoform identification Development of tools like ProteaseGuru, MetaMorpheus, and FlashLFQ Applications in neurodegenerative diseases (Alzheimer's), viral biology (HIV), and diabetes Research trends show strong emphasis on: Mass spectrometry innovations RNA-protein interaction networks Proteoform family concept development Machine learning integration in proteomics