Tatiana Segura is a Professor of Biomedical Engineering, Neurology, and Dermatology at Duke University's Pratt School of Engineering, where she also serves as Co-director of the Center for Biotechnology and Tissue Engineering and MPI of the T32 Biotechnology Training grant. Her research focuses on designing biomaterials to promote endogenous repair through geometry design and delivery of genes, proteins, and drugs. She has made significant contributions to the development of microporous annealed particle (MAP) hydrogels and other biomaterial systems for tissue regeneration. B.S. in Bioengineering from University of California, Berkeley (1999) Ph.D. in Chemical Engineering from Northwestern University (2004) Professor Segura's research centers on biomaterials engineering for tissue repair and regeneration. Her lab designs innovative biomaterial interventions that promote brain plasticity after stroke, enable scarless healing in skin wounds, induce tolerance of transplanted skin, and promote constructive immune responses after biomaterial implantation. She pioneered the development of microporous annealed particle (MAP) hydrogels that have become widely adopted in regenerative medicine research. Her work uniquely bridges immunology, materials science, and clinical applications to create therapeutic biomaterials that harness the body's own healing capabilities. Her recent publications demonstrate a strong focus on spatial control of biomaterial properties, with emphasis on void space analysis, immune cell recruitment, and vascularization. The research shows a progression from fundamental biomaterial characterization to increasingly sophisticated therapeutic applications, particularly in stroke recovery and wound healing. Her work integrates proteomics, lipidomics, and advanced imaging to understand the molecular mechanisms underlying biomaterial-mediated tissue regeneration. Senior Member of the National Academy of Inventors (2023) Acta Biomaterialia Silver Medal (2021) Clemson Award for Contributions to Literature (2024) 15 d/e Plenary Award from AICHE Food, Pharmaceutical, and Bioengineering Division (2018) Fellow of the American Institute for Medical and Biological Engineers (2016) Professor Segura actively mentors the next generation of scientists, currently supervising 12 graduate students, 4 postdoctoral scholars, 2 master's students, 16 undergraduates, and other trainees. Her laboratory has been continuously funded since 2008 with multiple NIH grants, including her current role as MPI of the T32 Biotechnology Training grant. She has received substantial support from the NSF (including a CAREER award), American Heart Association, and American Society of Gene and Cell Therapy. Her Segura Lab operates as a multidisciplinary team comprising engineers, biologists, and clinicians working together to translate biomaterial discoveries into clinical applications. The lab's 'MAP' technology platform has enabled numerous collaborations across Duke and other institutions, focusing on brain repair after stroke, scarless skin healing, and immune-modulating biomaterials. The lab maintains strong industry partnerships to accelerate the translation of their biomaterial technologies into clinical use.
