- Neuroscience
- Neurophysiology
- Alcohol Research
- +۷ مورد دیگر
Igor Spigelman is a Professor in the Dentistry Department at the University of California Los Angeles (UCLA), with a robust research program spanning neuroscience, alcohol effects on the brain, pain mechanisms, and cannabinoid pharmacology. His work bridges dental and medical neuroscience, focusing on the neural mechanisms underlying pain, addiction, and stress responses. Spigelman's research interests primarily center on neurophysiological mechanisms of pain and addiction. His laboratory investigates GABAergic neurotransmission, trigeminal system function, and the molecular basis of alcohol dependence. He has made significant contributions to understanding how chronic alcohol exposure alters neuronal function in brain regions involved in stress response and reward processing. His work on peripheral cannabinoid receptors has implications for developing novel pain therapeutics without central side effects. Recent research has expanded into AI applications for neurodegenerative disease biomarker discovery, particularly for ALS. Analysis of his publication record reveals consistent research themes across three decades: the neurobiology of alcohol dependence, trigeminal pain pathways, and GABA receptor plasticity. His most cited work focuses on ethanol-induced changes in GABA receptor function and the role of peripheral cannabinoid receptors in pain management. The research demonstrates strong translational potential, with several publications exploring therapeutic approaches for alcohol use disorders and chronic pain conditions. Spigelman's laboratory has maintained active collaborations across multiple institutions, with frequent co-authorship with researchers from UCLA's neuroscience, psychology, and medical departments. His work shows consistent funding support as evidenced by the sustained publication record and involvement in NIH T32 training grants mentioned in the departmental information.









