Professor Daniel Segrè is a faculty member at Boston University, holding the title of Professor of Biology, Bioinformatics, and Biomedical Engineering. His research focuses on systems biology, microbial ecology, and metabolic engineering, with an emphasis on understanding complex biological networks and their applications in bioenergy and biomedicine. Segrè leads the Segre Lab ( segrelab.bu.edu ), where theoretical and computational approaches are applied to study metabolism, microbial interactions, and synthetic biology. Segrè earned his PhD from the Weizmann Institute of Science, Israel. His work bridges fundamental science and applied engineering, addressing topics such as microbial community dynamics, metabolic pathway design, and environmental microbiome applications. Research Interests: Systems biology of metabolism, evolution of biochemical networks, microbial interactions, bioinformatics, and environmental microbiome engineering. His lab develops computational models (e.g., COMETS) to simulate microbial ecosystems and design synthetic microbial communities for climate change mitigation and bioenergy production. Teaching: Courses include BE 777 (Computational Genomics), BF 821 (Bioinformatics Seminar), and BF 571 (Dynamics and Evolution of Biological Networks). These courses reflect his expertise in integrating computational methods with biological systems analysis.
Dr. Monica E. McCallum is an Assistant Professor of Chemistry in the Department of Chemistry at the University of Pennsylvania’s School of Arts & Sciences. Her research focuses on understanding the biochemical origins of natural products and their roles in microbial communication. She leads the McCallum Lab, which employs interdisciplinary approaches combining organic synthesis, biochemistry, microbiology, and microscopy to study microbial natural products in their native contexts. Education: 2016 – Postdoctoral Fellow at Harvard University under Prof. Emily P. Balskus 2016 – PhD in Organic Chemistry from Baylor University 2013 – PhD Candidate at Colorado State University 2011 – B.S. in Chemistry from University of California, Irvine Research Interests: Dr. McCallum’s work bridges organic synthesis and microbiology to decode microbial metabolite functions. Key themes include: Synthesizing complex natural products and their biosynthetic precursors Discovering novel enzyme-catalyzed reactions Unraveling microbial communication mechanisms via natural products Investigating environmental microbial community dynamics Lab & Collaborations: The McCallum Lab emphasizes interdisciplinary collaboration, integrating techniques from organic chemistry, molecular biology, and microscopy to study natural products in situ. Current projects focus on diazeniumdiolate biosynthesis pathways and enzymatic detoxification of marine toxins.
University of California, Los AngelesUnited States
Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.
University of California, Los AngelesUnited States
David S. Eisenberg is a Professor of Chemistry and Biochemistry and Biological Chemistry at the University of California, Los Angeles, where he also serves as Director of the UCLA-DOE Institute for Genomics and Proteomics and as an HHMI Investigator. His research focuses on protein interactions, particularly the structural basis for conversion of normal proteins to the amyloid state and conversion of prions to the infectious state. Dr. Eisenberg earned his undergraduate degree in biochemical sciences from Harvard College and his D.Phil. degree in theoretical chemistry from Oxford University on a Rhodes Scholarship. His postdoctoral research was on ice and water with Walter Kauzmann at Princeton and in protein crystallography with Richard Dickerson. He joined the UCLA faculty after his postdoctoral studies. Dr. Eisenberg and his research group focus on protein interactions in amyloid and prion diseases. These diseases involve protein aggregation where normal functional proteins convert to abnormal aggregated forms. Systemic amyloid diseases like dialysis-related amyloidosis result from fiber accumulation until organ failure, while neurodegenerative diseases like Alzheimer's, Parkinson's, ALS, and prion conditions appear to be caused by smaller oligomers. In 2005, his team determined the atomic-level structure for the amyloid fiber spine, revealing a 'steric zipper' of two parallel beta sheets packed across a dry interface. Since then, they've determined approximately 90 amyloid spines from 15 disease-related proteins. In 2010, they identified the structure of a toxic amyloid-related oligomer consisting of six anti-parallel beta strands forming a cylindrical barrel. His recent publications demonstrate continued innovation in amyloid research, with focus areas including structural prediction of amyloid formation, mechanisms of tau fibril disassembly in Alzheimer's disease, cryo-EM analysis of amyloid polymorphism, and structure-based design of inhibitors for amyloid toxicity. His work integrates computational, structural, and biochemical approaches to understand protein aggregation across multiple disease contexts. Dr. Eisenberg has received numerous prestigious awards and honors: National Academy of Sciences Member American Philosophical Society Member Institute of Medicine Member Howard Hughes Medical Institute Investigator Biophysical Society Emily M. Gray Award Harvard Westheimer Medal UCLA Seaborg Medal Technion - Israel Institute of Technology Harvey Prize in Human Health As Director of the UCLA-DOE Institute for Genomics and Proteomics and an HHMI Investigator, Dr. Eisenberg leads significant research initiatives in protein structure and aggregation. His laboratory combines X-ray crystallography, bioinformatics, and biochemical techniques to investigate protein interactions, with particular emphasis on amyloid-forming proteins and their role in disease. The Eisenberg Lab, located in Boyer Hall at UCLA, maintains an active research program investigating the structural basis of protein aggregation. The lab continues to build on its landmark discoveries of amyloid structures while exploring new frontiers in understanding protein misfolding diseases and developing potential therapeutic interventions.
Chang-Jun Liu is a Senior Scientist in the Plant Science Group of the Biology Department at Brookhaven National Laboratory, where he has conducted research on plant phenylpropanoid biosynthesis and lignin metabolism since joining in 2005. He also holds an Adjunct Professor position in the Biochemistry & Cell Biology Department at Stony Brook University and serves as Associate Editor for Plant Cell & Environment (2024-present) and Frontiers in Plant Sciences (2015-present). Dr. Liu's educational background includes: Ph.D. in Plant Biochemistry and Molecular Biology from the Shanghai Institute of Plant Physiology, Chinese Academy of Science (1999) Dr. Liu's research integrates approaches from biochemistry, molecular genetics, biophysics, protein engineering, metabolic engineering, and synthetic biology to investigate phenylpropanoid and lignin biosynthesis in plants. His laboratory addresses fundamental questions about how lignin and related compounds are synthesized and incorporated into cell walls, how regulatory networks govern metabolic activity, and how lignification influences cell wall structure and function. A central aim of his research is optimizing plant feedstocks for efficient lignocellulosic biomass utilization. Analysis of Dr. Liu's publication record reveals a consistent trajectory from fundamental biochemical mechanisms to applied bioenergy solutions. His recent work focuses on cytochrome b5 diversity, electron transfer mechanisms in phenolic biosynthesis, and metabolic engineering approaches to modify lignin composition. This research spans from evolutionary studies of lignin biosynthesis across plant lineages to practical applications in bioenergy crop improvement. Dr. Liu has received recognition for his contributions to science, including: Brookhaven National Laboratory Science and Technology Award (2018) Dr. Liu serves as Editorial Board Member for the Journal of Biological Chemistry (2020-present), PNAS Nexus (2024-present), and Plant Physiology Journal (2025-). He is Scientific Lead at the Joint BioEnergy Institute, Feedstocks Division, Lawrence Berkeley National Laboratory, and Project Lead at the Center for Bioenergy Innovation, Oak Ridge National Laboratory. His research is funded by the U.S. Department of Energy through multiple Bioenergy Research Centers. Dr. Liu leads a research group at Brookhaven National Laboratory focused on elucidating the posttranslational regulation and macromolecular organization of lignin biosynthesis, with applications toward developing designer lignins and reducing biomass recalcitrance for sustainable biofuel production. His work addresses the critical challenge of lignin's dual nature: while it impedes enzymatic access to polysaccharides in biofuel production, it also represents the most abundant renewable source of aromatic carbon for high-value bioproducts.
Dewey G. McCafferty is Professor of Chemistry at Duke University with appointments in Biochemistry and the Duke Cancer Institute. His research focuses on chemical biology of chromatin-modifying enzymes and ubiquitin signaling pathways relevant to neurodegeneration and infection. Notable work includes discovering the lasso peptide antibiotic Arcumycin, characterizing the Nedd4 ubiquitin ligase in Parkinson's disease models, and developing chemoproteomic approaches for target identification. Key contributions include elucidation of the futalosine pathway in Chlamydia infections, mechanisms of CPAF protease in bacterial pathogenesis, and engineering of histone demethylase enzymes. McCafferty received the Eli Lilly Award in Biological Chemistry (2005) and directs NIH-funded projects on ubiquitin ligases in neurodegeneration.
Steven L'Hernault is Professor and Chairman of Biology at Emory University, where he leads research on cellular and developmental processes using Caenorhabditis elegans models. His laboratory investigates molecular mechanisms underlying spermatogenesis, focusing on genetic controls of sperm development and function. The L'Hernault Lab studies highly conserved genome protection mechanisms in germ lines using genetic, molecular, and biochemical approaches. Key research areas include secretory vesicle function, membrane protein interactions, and ubiquitin ligase activity during sperm differentiation. Recent publications examine paternal epigenetic inheritance pathways and palmitoyltransferase functions in spermiogenesis. The lab maintains an extensive collection of C. elegans mutants with defective spermatogenesis to study fundamental cellular processes.
Michael Lampson is Professor of Biology at the University of Pennsylvania's School of Arts and Sciences, with secondary appointments in the Department of Cell and Developmental Biology. He serves as faculty in the Cell and Molecular Biology (CAMB) and Biochemistry and Molecular Biophysics (BMB) Graduate Groups, and is affiliated with the American Society for Cell Biology (ASCB). Ph.D., Cornell University, Weill Medical College, 2002 AB, Harvard College, 1994 Dr. Lampson's research program focuses on fundamental mechanisms of chromosome biology, with particular emphasis on cell division, centromere inheritance, and meiotic drive. His lab investigates how selfish genetic elements can violate Mendel's First Law through meiotic drive, the stability of centromere chromatin through the germline, and the role of repetitive satellite DNA in chromosome segregation. Using innovative approaches including mouse model systems, optogenetic tools, and biochemical techniques, his work bridges cell biology, genetics, and evolutionary biology to address questions with implications for reproductive biology, cancer, and genetic inheritance. Analysis of Dr. Lampson's recent publications reveals a strong focus on the intersection of centromere biology, meiotic drive, and chromosome segregation mechanisms. His work increasingly incorporates computational approaches alongside experimental systems to study evolutionary aspects of centromere function. The research demonstrates consistent innovation in methodology, particularly in developing optogenetic tools for precise manipulation of cellular processes. Key themes include the role of satellite DNA variation, mechanisms of non-Mendelian inheritance, and the stability of chromatin structures through cell division and development. Searle Scholar Award American Association for the Advancement of Science (AAAS) fellow Dr. Lampson's research is supported by multiple NIH grants including from NIGMS, NHGRI, NICHD, and NCI, as well as University of Pennsylvania funding sources including the University Research Foundation, Abramson Cancer Center, and several specialized research centers. He collaborates extensively with researchers across disciplines, including Ben Black (Biochemistry), Dennis Discher (Chemical Engineering), Dave Chenoweth (Chemistry), and Roger Greenberg (Cancer Biology), reflecting the interdisciplinary nature of his work. His lab has trained numerous graduate students and postdocs who have gone on to successful careers in academia and industry. The Lampson Lab maintains state-of-the-art facilities for cell biological, genetic, and biochemical research, with specialized equipment for live-cell imaging, optogenetic manipulation, and mouse genetics. The lab fosters a collaborative environment that bridges molecular, cellular, and evolutionary perspectives on chromosome biology.
Jonathan Conway is an Assistant Professor in the Department of Chemical and Biological Engineering at Princeton University and an associated faculty member of the High Meadows Environmental Institute (HMEI). He leads the Conway Lab, which focuses on engineering plant-microbe interactions for applications in bioagriculture, bioenergy, and biochemical industries. Education: B.S. Chemical Engineering, University of Notre Dame (2011) M.S. Chemical Engineering, North Carolina State University (2013) Ph.D. Chemical Engineering, North Carolina State University (2017) Postdoctoral Fellow, University of North Carolina Chapel Hill & Howard Hughes Medical Institute (2017-2021) Research Interests: The Conway Lab develops genetic engineering approaches for non-model bacteria at plant-microbe interfaces. Key research areas include: chemical signaling between plants and microbes, microbiome impacts on plant immunity, environmental stress responses in agricultural systems, and enzymatic degradation of lignocellulosic biomass using thermophilic bacteria. The lab employs bacterial genetics, systems biology, and biomolecular engineering to create technologies for sustainable bioindustries. Publication Trends: Recent work demonstrates strong emphasis on molecular mechanisms of plant-microbe communication (2020-2024), enzyme characterization in biomass degradation (2024-2025), and development of synthetic microbial communities for climate resilience (2024). Earlier research focused on extremophile enzymology and metabolic engineering (2012-2019). Student Advising: Currently mentors 4 graduate students and 8 undergraduates. Alumni include 9 former advisees who graduated between 2022-2024. The lab actively recruits students through Princeton's Chemical Engineering graduate program and undergraduate research initiatives. Laboratory: The Conway Lab develops microfluidic systems for root microbiome studies and genetic tools for engineering plant-associated bacteria. Current projects include designing thermophilic microbial consortia for consolidated bioprocessing and characterizing bacterial immune evasion strategies.
Yousif Shamoo is the Ralph and Dorothy Looney Professor of BioSciences at Rice University, where he has been a faculty member since 1998. He previously served as Vice Provost for Research (2014-2022) and Director of the Institute of Biosciences and Bioengineering (2008-2014). He holds a Ph.D. in Molecular Biophysics and Biochemistry from Yale University (1988). His research focuses on combating multi-drug resistant bacteria through experimental evolution and biophysical approaches. Key interests include: Evolutionary trajectories of antibiotic resistance in pathogens like Enterococcus and Acinetobacter Biochemical basis of adaptation using microfluidics, genomics, and structural biology Discovery of novel antimicrobial strategies targeting cell membrane stress pathways Microbial interactions in spatially structured environments Publications emphasize antimicrobial resistance mechanisms, evolutionary biophysics, and microfluidic technology development. Recent work explores daptomycin resistance pathways ( LiaFSR ), membrane lipid signaling, and high-throughput evolution platforms. Awards & Honors: AAAS Fellow (2024) Ralph and Dorothy Looney Professorship (2020) George R. Brown Award for Excellence in Teaching (2015) George R. Brown Superior Teaching Award (4×, 2009 onward) ASM Distinguished Lecturer (2011-2013) He leads an active research group funded by NIH and DoD, advising 15+ graduate students. Current projects integrate synthetic biology with Streptomyces-derived drug discovery and microfluidic biosurveillance platforms.
Ping He is a Professor in the Department of Molecular, Cellular, and Developmental Biology (MCDB) at the University of Michigan in Ann Arbor. His research focuses on plant immunity mechanisms, particularly using Arabidopsis as a model system to study pathogen defense activation, signaling pathways, and the interplay between immunity and environmental stress responses. He also leads the Molecular, Plant-Microbe Interaction Laboratory, applying interdisciplinary approaches (genetics, biochemistry, cellular biology) to enhance crop resilience through foundational plant science discoveries. His work bridges plant biology and computational biology, with recent contributions to AI-driven medical imaging applications such as bladder cancer treatment response assessment, lung cancer early detection, and breast tomosynthesis denoising. These efforts emphasize integrating machine learning into clinical workflows and establishing best practices for AI in healthcare. Research Highlights: Plant immunity signaling and environmental stress crosstalk Radiomics and deep learning for cancer diagnosis/prognosis AI model validation and multi-institutional clinical trials Medical imaging artifact correction (e.g., motion blur, noise) Publications emphasize AI applications in oncology imaging, radiologist decision support systems, and multimodal data fusion. He has contributed to AAPM task group guidelines for AI in computer-aided diagnosis and advocates for rigorous quality assurance frameworks in medical AI deployment.
Donald Rio holds the Richard and Rhoda Goldman Distinguished Chair in the Biological Sciences and is a Professor of Biochemistry, Biophysics, and Structural Biology. He is affiliated with the Division of Biochemistry and Molecular Biology and the Center for Integrative Genetics. His lab focuses on nucleic acid transactions, including transposable element mobilization (P elements) and RNA binding protein mechanisms controlling alternative splicing. Research highlights include studies on THAP9 proteins in humans/zebrafish, cryo-EM structural analysis of transposase-DNA complexes, and splicing regulation in neurodegenerative diseases like ALS and Parkinson’s. His work combines biochemical, genetic, and computational approaches, including the development of the Junction Usage Model (JUM) for splicing analysis. Research interests span transposition mechanisms linked to HIV integration, immune system recombination, and evolutionary genome dynamics. His team investigates how RNA binding proteins like hnRNPA1 influence splicing in disease contexts, with projects involving CRISPR-based models and patient RNA-seq data analysis. Collaborations include studies on splicing accuracy across tissues and age, and the impact of splicing defects in neurodegenerative disorders. Key awards include the Goldman Chair. His lab’s contributions bridge fundamental molecular mechanisms with translational applications in genetic disease modeling and drug discovery. Recent work focuses on isogenic stem cell models (iSCORE-PD) for Parkinson’s research and structural biology insights into transposase function. Grants and projects involve NIH funding for ALS splicing studies and collaborations with institutions like the Buck Institute. His lab actively publishes in top journals such as Genome Research , PNAS , and Nature , with a strong emphasis on cryo-EM and bioinformatic methods.
Hector Aguilar-Carreno is a Professor of Virology in the Department of Microbiology and Immunology at Cornell University's College of Veterinary Medicine, where he also serves as Associate Vice Provost in the Office of the Vice President for Research and Innovation. His research focuses on high-mortality paramyxoviruses including Nipah virus (NiV) and Hendra virus (HeV), as well as coronaviruses and other enveloped viruses. Dr. Aguilar-Carreno received his BS in Biochemical Engineering from Instituto Tecnologico de Tepic, Mexico, followed by an MS in Biology from California State University, Los Angeles, and a PhD in Biochemistry and Molecular Biology from the University of Southern California. He completed postdoctoral training in Virology at UCLA under Dr. Benhur Lee before becoming an Assistant Professor at Washington State University's Paul G. Allen School for Global Animal Health. His research spans four main areas: (1) Viral entry mechanisms, where his lab has identified novel domains in viral glycoproteins important for membrane fusion; (2) Viral egress, using multi-omics approaches to study viral assembly and budding; (3) Vaccine development using viral-like particles to generate neutralizing antibodies; and (4) Antiviral discovery targeting enveloped viruses. His lab employs innovative techniques including Flow Virometry and Raman Spectroscopy to study viral entry processes. Analysis of his recent publications reveals a strong focus on paramyxoviruses (particularly Nipah and Hendra viruses), coronavirus research, and the development of broad-spectrum antivirals. His work spans fundamental virology to translational applications, with numerous publications in high-impact journals including Nature, Science, and Cell Reports. President Elect of the American Society of Virology Chair of the American Society of Virology Diversity, Equity, and Inclusion committee Chair of the Cornell CVM Diversity Committee Director of the Cornell Program for Achieving Career Excellence Chair of 16 PhD student thesis committees Dr. Aguilar-Carreno has served on numerous scientific committees including the American Society for Virology Education Committee, the American Society of Microbiology Committee for Minority Education, and as a Standing Member of the VIR-A NIH study section. His leadership extends to chairing the Cornell CVM Diversity Committee and serving on the Cornell presidential postdoctoral fellowship committee, demonstrating significant commitment to diversity and mentorship in science.
Ralph Jimenez is an Adjunct Professor of Chemistry and Institute Fellow at JILA, University of Colorado Boulder. He holds a Ph.D. from the University of Chicago (1996) and completed postdoctoral work at the University of California, San Diego (1997-1998), followed by research at The Scripps Research Institute (1998-2003). His research focuses on quantum spectroscopy and photophysics of fluorescent proteins, leveraging quantum optics to enhance spectroscopic sensitivity and developing genetically encoded biomarkers with improved photophysical properties. Key achievements include fluorescence-lifetime-based methods to engineer brighter fluorescent proteins and machine-learning approaches to improve photostability. His awards include the Arthur S. Flemming Award (2017) and U.S. Department of Commerce Gold Medal (2017). His group's work integrates quantum engineering with biophysical studies, targeting real-world applications in molecular imaging and materials science. The Jimenez Group operates labs at JILA (B117, B119, B121) and collaborates on projects involving entangled photons, two-photon absorption, and ultrafast spectroscopy. Research themes include quantum-enhanced spectroscopy for complex systems and overcoming limitations in fluorescent protein imaging through physical chemistry strategies. His lab develops novel instrumentation, including microfluidic sorting systems and tabletop X-ray spectroscopy platforms, to advance biomarker engineering and environmental monitoring.
Ben Cosgrove is an Associate Professor in the Meinig School of Biomedical Engineering at Cornell University, serving as Director of Graduate Studies. His research focuses on systems bioengineering approaches to understand muscle stem cell dysfunction in aging and disease. He leads the Cosgrove Lab, a multidisciplinary group integrating biomedical engineering, stem cell biology, and systems biology to study microenvironmental signaling in muscle regeneration. His work includes developing biomimetic microenvironments for stem cell manufacturing and improving regenerative medicine therapies. Dr. Cosgrove holds a B.Eng. from the University of Minnesota (2003) and a Ph.D. in Bioengineering from MIT (2009). Postdoctoral training at Stanford University (with Dr. Helen Blau) followed. His research is supported by NIH grants (including R01, R21), the Glenn Medical Research Foundation, and others. He has been recognized with awards such as the BMES Graduate Research Award (2008), Rising Star Award (2015), and Swanson Teaching Excellence Award (2019). Research interests span bioengineering, biomechanics, computational science, and systems biology. His lab's innovations include spatial transcriptomic mapping and high-yield stem cell expansion platforms. Current projects aim to decode stem cell-niche interactions to treat muscle degeneration and aging. Grants: NIH K99/R00, R01, R21; Glenn Medical Research Foundation Labs/Teams: Cosgrove Lab (Cornell University) Future Work: Expanding applications of spatial transcriptomics and engineering regenerative therapies for muscle diseases
