جستجوی استاد راهنمای دانشگاهی

Dr. Patrick O'Donoghue is an Associate Professor and Canada Research Chair in Chemical Biology at Western University's Department of Biochemistry, Faculty of Science. His research focuses on proteome diversity mechanisms through protein modifications and mistranslation, with implications for cancer and neurodegenerative diseases. Education: Ph.D. from University of Illinois, Postdoctoral training at Yale University Research highlights include pioneering genetic code expansion techniques for programmed protein modifications in human cells and developing fluorescent reporters to visualize translation errors. His work connects protein synthesis fidelity to disease pathways through tRNA mutant studies. Scientific Contributions: 2024 Mechanisms and Delivery of tRNA Therapeutics review in Chemical Reviews 2023 HARS Disease Therapeutics in Genes (Basel) 2022 Expanding Codon Size in eLife 2021 Fluorescent Mistranslation Reporters in Cells Contact: Office in Medical Sciences Building Room 388, Phone: 519.850.2373, Email: patrick.odonoghue@uwo.ca

• Proteome Diversity
• Post-Translational Modifications
• Genetic Code Expansion
• +۵ مورد دیگر

Nediljko Budisa is a Professor and Tier 1 Canada Research Chair in Chemical Synthetic Biology and Xenobiology at the University of Manitoba's Faculty of Science, Department of Chemistry. His research program focuses on expanding the fundamental biochemical capabilities of living systems through genetic code engineering and synthetic biology approaches. Dr. Budisa's research spans multiple cutting-edge areas in synthetic biology, with particular emphasis on genetic code expansion , non-canonical amino acid incorporation , and protein engineering . His laboratory employs both classical biochemical techniques and advanced computational methods to develop orthogonal translation systems, engineer novel enzymes, and create synthetic cells with expanded biochemical repertoires. His work bridges chemistry, biology, and engineering to address fundamental questions about life processes while developing practical applications in biotechnology and medicine. Analysis of Dr. Budisa's publication record reveals a consistent trajectory of innovation in genetic code engineering, with recent work increasingly integrating machine learning approaches for protein design. His research spans from fundamental studies of protein structure-function relationships to applied research in metabolic engineering and antiviral strategies, demonstrating the versatility of synthetic biology approaches. Tier 1 Canada Research Chair in Chemical Synthetic Biology and Xenobiology Dr. Budisa leads an active research program supported by his Canada Research Chair position, with extensive collaborations across Canada and internationally. His work has resulted in numerous patents and commercial applications in biotechnology. He actively participates in the synthetic biology community through initiatives like Prairie iGEM BioExM and has delivered public lectures on methodological challenges in expanded genetic code research. His research is conducted through the Chemical Synthetic Biology and Xenobiology laboratory at the University of Manitoba, where his team explores the social, cultural, educational, ethical and philosophical aspects of synthetic biology alongside technical innovations, reflecting a comprehensive approach to advancing this transformative field.

• Synthetic Biology
• Xenobiology
• Genetic Code Engineering
• +۷ مورد دیگر

Haissi Cui is an Assistant Professor in the Department of Chemistry at the University of Toronto. Her research focuses on understanding RNA maturation and decoding processes in disease contexts, combining chemical tools, protein engineering, and cell biology. She leads the Cui Lab, which explores how RNA and protein localization impact inflammation, neurological diseases, and developmental disorders. Education: PhD (Dr. rer. nat.) in Experimental Medicine from Technical University of Munich, with postdoctoral training at Scripps Research Institute and Technical University of Munich. Affiliations: Principal Investigator at University of Toronto, Department of Chemistry. Research interests include aminoacyl-tRNA synthetases, tRNA regulation, and nuclear organization. Her lab has developed chemical tools to study mRNA splicing and metabolic pathways linked to disease. Recent work highlights the role of arginyl-tRNA synthetase in inflammatory processes and RNA splicing. Key achievements include a Nature Cell Biology paper on arg-tRNA synthetase’s role in inflammation, and a cover article on metabolic regulation of mRNA splicing. Awards include Human Frontiers Science Program and Deutsche Forschungsgemeinschaft fellowships. Scientific Awards: CIHR Postdoc Fellowship, Paul Schimmel Scholarship, Ontario Graduate Scholarship, NSERC USRA. Lab Members: Includes PhD students (Noha, Santiago, Samuel, Qingyu, Colette), postdocs (Jamie), and undergraduates across multiple projects. Grants & Funding: Supported by fellowships and institutional grants for interdisciplinary research initiatives. Collaborative efforts include work on non-viral mRNA delivery and structural biology. The lab emphasizes diversity and outreach through initiatives like ChemClub and Women in Science programs.

• RNA Maturation
• Protein Synthesis
• Inflammation Biology
• +۵ مورد دیگر

Patrick O’Donoghue is an Associate Professor of Chemistry and Biochemistry at the University of Western Ontario, holding the Canada Research Chair (Tier 2) in Chemical Biology. He leads research on proteome diversity and its role in cancer and neurodegeneration. His lab develops methods for programmed protein modification and investigates mistranslation in live cells. Key research areas include genetic code expansion, protein modification signaling, and neurodegenerative disease pathways linked to tRNA mutations. Education: PhD from University of Illinois at Urbana-Champaign; Postdoctoral Fellow at Yale University. Awards include NSF Biological Informatics Fellowship and PhRMA Foundation Informatics Fellowship. Teaching includes courses like Biochemistry/Chemistry 4415B and 9703. Recent publications focus on tRNA variants in disease, Akt1 phosphorylation mechanisms, and ubiquitin signaling in Parkinson’s disease. His lab’s innovations include fluorescent reporters for mistranslation detection and engineered tRNAs to study protein synthesis errors. Research highlights include uncovering links between tRNA mutations and neurodegenerative diseases, and developing tools for live-cell protein modification analysis.

• Genetic Code Expansion
• Programmed Protein Modification
• Protein Modifications in Disease
• +۳ مورد دیگر

Dr. John Pezacki is a Professor in the Department of Chemistry and Biomolecular Sciences at the University of Ottawa, cross-appointed to the Faculty of Medicine. His research focuses on developing chemical and biophysical tools to study host-pathogen interactions, with a particular emphasis on human viruses like hepatitis viruses, Dengue, and SARS-CoV-2. BSc, University of Toronto PhD, McMaster University His work integrates activity-based profiling , bioorthogonal chemistry , non-coding RNA screening , and expanded genetic code technologies to explore new therapeutic targets and vaccine strategies. He operates state-of-the-art labs for chemistry, microbiology, and cell biology, collaborating with the university’s core facilities. Recent publications highlight his contributions to understanding microRNA regulation in viral infections, machine learning applications in chemical reactions, and bioorthogonal methodologies for molecular labeling. His research has been recognized with awards such as the Armand-Frappier Outstanding Student Award and the Canadian Society of Microbiologists’ Armand-Frappier Gold Medal . john.Pezacki@uOttawa.ca The Pezacki Lab fosters a multidisciplinary environment for students and postdoctoral fellows, emphasizing innovation in chemical biology and virology.

• Host-Pathogen Interactions
• Biochemistry
• Microbiology
• +۱۰ مورد دیگر