جست‌وجوی استاد و پژوهشگر

Jose F. Moruno Manchonمشاهده پروفایل

استادیار

• Neurodegeneration
• Cerebrovascular aging
• Autophagy
• +۳ مورد دیگر

Dr. Jose F. Moruno Manchon is an Assistant Professor in the Department of Neurology at UTHealth McGovern Medical School, where he was appointed in 2021. He leads the Moruno Lab within the BRAINS Research Laboratory, a multidisciplinary neuroscience research center with multiple specialized cores including Behavioral, Cell Culture, Histology, and Surgical Cores. Dr. Moruno received his PhD in Biotechnology from the Polytechnic University of Valencia in Spain, followed by post-doctoral training in the Department of Neurobiology and Anatomy at UTHealth McGovern Medical School. His academic journey spans over 10 years of experience in autophagy research and more than 7 years of specific expertise in neurodegeneration. Dr. Moruno's research focuses on two critical aspects of aged brain biology: The downregulation of autophagy (the brain's capacity to remove damaged organelles and toxic compounds from cells) The senescence (irreversible proliferative-arrest state) of cerebral vasculature endothelial cells His work demonstrates that both reduced autophagy and the accumulation of senescent cells in the aged brain are strongly associated with brain dysfunction and dementia. By identifying key molecular targets involved in these mechanisms, Dr. Moruno aims to develop novel therapeutic approaches to prevent or mitigate age-related cognitive decline. Dr. Moruno has published significant research in high-impact journals including eLife, Frontiers in Aging, and Cells. His publication record shows an evolving research trajectory from basic autophagy mechanisms to their specific roles in neurodegenerative conditions and cerebrovascular aging. His scientific contributions include: Discovering connections between G-quadruplex structures and cellular aging in cerebral endothelial cells Identifying sex-specific differences in autophagic responses to stroke Revealing novel pathways of autophagy regulation in neurons Exploring therapeutic targets for Huntington's disease As a relatively new faculty member (appointed in 2021), Dr. Moruno is establishing his independent research program with a clear focus on translational neuroscience. His work bridges fundamental molecular biology with clinically relevant questions about brain aging and dementia, positioning him at the forefront of age-related neurodegenerative disease research.

Andrey Tsvetkovمشاهده پروفایل

دانشیار

• Brain aging
• Huntington's disease
• Autophagy
• +۷ مورد دیگر

Andrey Tsvetkov is an Associate Professor in the Department of Neurology at McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth). Born in Kazakhstan, he received his Master's Degree in molecular biology from Moscow State University and his PhD in physiology and biophysics from the University of Illinois at Chicago. He completed postdoctoral training with Steven Finkbeiner at the University of California, San Francisco, Gladstone Institute of Neurological Disease. His research focuses on brain aging mechanisms, particularly investigating G-quadruplex DNA/RNA structures, autophagy processes, and sphingosine kinase signaling pathways. His laboratory provides a vibrant research environment for interdisciplinary interactions with colleagues across multiple institutions, including the University of Texas Health Science Center, MD Anderson Cancer Center, and other University of Texas institutions. Dr. Tsvetkov's publication record demonstrates significant contributions to understanding the molecular mechanisms of neurodegeneration. His recent work examines the relationship between G-quadruplex structures and cellular senescence, sphingosine kinase regulation of protein networks in neurons, and sex differences in lipid metabolism related to cognitive impairment. Funded by the National Institutes of Health (NINDS and NIA) Active contributor to consensus guidelines for autophagy research Interdisciplinary collaborations across multiple UT institutions His research has important implications for understanding and potentially treating neurodegenerative diseases including Huntington's disease and Alzheimer's disease, with particular attention to how nucleic acid structures and lipid metabolism contribute to brain aging processes.