جست‌وجوی استاد و پژوهشگر

Julien Licchesiمشاهده پروفایل

مدرس ارشد

• Ubiquitin Biology
• Protein Degradation
• Targeted Protein Degradation
• +۷ مورد دیگر

Dr. Julien Licchesi is a Senior Lecturer in the Department of Life Sciences at the University of Bath. His research focuses on ubiquitin biology and protein degradation mechanisms, with applications in neurodegenerative diseases and cancer therapeutics. Dr. Licchesi's research interests center on how ubiquitin regulates protein fate and function. His lab uses biochemical, structural, and cell biology techniques to study E3 ubiquitin ligases (particularly HECTD1) and deubiquitylases (particularly TRABID). His work has identified unique ubiquitin chain types (K29/K48 branched chains) and the TRABID-HECTD1 regulatory pair. His research has significant implications for Targeted Protein Degradation (TPD) therapeutics, which aim to address the 'undruggable proteome' comprising 85% of proteins not targetable by conventional drugs. Analysis of Dr. Licchesi's recent publications reveals a strong focus on HECTD1's role in cell proliferation, mitosis, and cancer (particularly glioblastoma), as well as its regulation by caspases during apoptosis. His work bridges fundamental ubiquitin biology with therapeutic applications, especially in neurodegenerative diseases and cancer. Dr. Licchesi has supervised 5 PhD students, with alumni working as Patent Attorneys, Manufacturing Scientists at BioRad Laboratories, or Lecturers at Kuwait University. He currently serves as Principal Investigator for multiple research projects including 'Proteostatic regulation of Glioblastoma stemness' (MRC-funded, 2023-2027) and 'New approach to destroy disease-causing proteins in Alzheimer's disease' (Alzheimer's Research UK-funded). His laboratory actively collaborates with institutions including Victoria University (Canada), EMBL Hamburg, University of Bristol, and Cardiff University. Current projects in his lab include structure-function studies of E3 ubiquitin ligases, developing new TPD modalities, exploring HECTD1 in cell signaling, and identifying new ubiquitin enzymes in pathogenic bacteria.

Narasimman Gurusamyمشاهده پروفایل

استادیار

• Epigenetics
• Cardiac diseases
• non-coding RNA
• +۳ مورد دیگر

Dr. Narasimman Gurusamy is an Assistant Professor at the Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, specializing in Pharmaceutical Sciences. He holds a Ph.D. in Pharmaceutical Sciences from Niigata University of Pharmacy and Applied Life Sciences (Japan) and completed postdoctoral training at UConn Health Center, Harvard Medical School, and University of Tennessee Health Science Center. Education: M.Pharm (Tamil Nadu Dr. MGR Medical University, India), Ph.D. (Niigata University, Japan) Research Focus: Epigenetic mechanisms in cardiac diseases, non-coding RNA regulation, exosome therapy, stem cell biology, and gene-environment interactions His work explores how long non-coding RNAs and epigenetic modifiers influence cardiac repair, particularly through induced mesenchymal stem cells and their exosomal signaling . Current projects investigate dietary and environmental impacts on epigenetic changes in the heart. Recent publications highlight advancements in RNA-based therapies and metabolic interventions for cardioprotection. Scientific Awards: American Heart Association Career Development Award, Young Research Scientist Award, Travel Awards Dr. Gurusamy serves as Grant Reviewer for the American Heart Association, Associate Editor for Frontiers in Cardiovascular Medicine , and Vice-Chair for the Communication Committee of the Society for South Asian Heart Research (SAHR). His lab employs in-vitro, in-vivo, and clinical trial approaches, utilizing PCR, ELISA, flow cytometry, and genomic repository analyses.

Alfredo Bensoمشاهده پروفایل

استاد

• Bioinformatics
• Systems Biology
• Artificial Intelligence
• +۱۶ مورد دیگر

Alfredo Benso is a Full Professor in the Department of Control and Computer Science (DAUIN) at the Polytechnic University of Turin, where he is also a member of the Interdepartmental Center PolitoBIOMed Lab - Biomedical Engineering Lab. He has been continuously involved in the Doctoral College for Computer and Systems Engineering since 2008, guiding PhD education across numerous cycles. His academic roles span teaching and research leadership in bioinformatics, systems biology, and computer engineering. Research interests: Bioinformatics and computational biology Systems biology and gene regulatory networks Artificial intelligence and machine learning in biomedicine Molecular modeling and multiscale simulation Biological database systems and data integration Health informatics and public health modeling His recent publications reflect a strong trend in applying AI and machine learning to biological and medical challenges, including protein function prediction, Alzheimer’s and Multiple Sclerosis modeling, food fraud detection, and viral genome analysis. These works span journals and conferences in bioinformatics, computational biology, and biomedical engineering, demonstrating interdisciplinary innovation. Scientific Awards: BIOINFORMATICS 2014 BEST PAPER AWARD (INSTICC, United Kingdom) Advising and Grants: He supervises PhD students, including Sofia Ostellino, and leads major research initiatives such as the BIGMECH (2023–2025) and FISHUB (2016–2018) projects. He has served as Scientific Director for collaborative agreements with public administrations and as Principal Investigator on EU, national (PRIN), and regional research grants focused on bioinformatics, space systems, and reliable digital technologies. Labs and Teams: He is a key member of the SBG - System Biology Group (DAUIN) and contributes to PolitoBIOMed Lab, fostering collaborative research in biomedical engineering and computational biology.

Min Chenمشاهده پروفایل

استاد

• Nanopore Technology
• Single-Molecule Sensing
• Membrane Protein Biophysics
• +۱۲ مورد دیگر

Min Chen is a Professor in the Department of Chemistry at the University of Massachusetts Amherst, with affiliations in the Molecular & Cellular Biology Program and the Institute for Applied Life Sciences (Center for Bioactive Delivery and Models to Medicine). Her research focuses on developing cutting-edge nanopore technologies for single-molecule analysis of proteins and nucleic acids. Education: Postdoctoral Fellow, University of Oxford, UK (2005–2008) Ph.D., University of Frankfurt, Germany (2004) MSc(Eng), Tianjin University, China (1999) BSc(Eng), Tianjin University, China (1996) Her research interests lie at the intersection of biophysics, molecular biology, and nanotechnology. The Chen lab develops nanopore tweezers to monitor protein structural dynamics in real time, engineers OmpG nanopores for sensitive biosensing, advances protein and peptide sequencing methods, and improves nanopore-based DNA/RNA sequencing . These technologies aim to enable point-of-care diagnostics, drug screening for cancer and infectious diseases, and fundamental understanding of membrane protein function. Her recent publications reveal a strong trend in developing label-free, single-molecule tools for studying enzyme dynamics, protein-ligand interactions, and nucleic acid-based data storage. The work leverages biological nanopores like ClyA, OmpG, and MspA, integrating biophysical measurements with molecular engineering. Applications span from kinase conformational analysis to antibody detection and protein translocation. Scientific Awards and Recognition: NIH R01 Grant (2023) as co-PI for developing asymmetric MspA nanopores for protein sequencing NIH Chemistry-Biology Interface (CBI) Fellowship awarded to her student David DeCoeur Min Chen actively mentors graduate students and has supervised several Ph.D. and Master’s theses. Her lab has received consistent grant support, including the NIH R01, indicating strong external funding. She leads a dynamic research team working on multiple fronts of nanopore technology development. The Chen Research Group operates within the Lederle Graduate Research Tower and is part of a vibrant interdisciplinary research ecosystem at UMass Amherst, collaborating with experts in computational modeling, genomics, and drug delivery.

• Chronic Rhinosinusitis
• Olfactory Dysfunction
• Vitamin D Metabolism
• +۵ مورد دیگر

Jennifer K. Mulligan is an Associate Professor in the Department of Otolaryngology – Head & Neck Surgery at the University of Florida. She holds multiple leadership roles including Vice Chair for Research, Co-Director of the UF Health Smell Disorders Program, and Director of Resident Research Education. Her academic work focuses on the immunopathogenesis of chronic rhinosinusitis (CRS) and olfactory dysfunction, with a particular interest in vitamin D metabolism, complement system regulation, and epithelial cell biology. Her research employs experimental models and clinical studies to investigate mechanisms underlying sinonasal inflammation and olfactory impairment. Notable contributions include elucidating roles of vitamin D3 in modulating immune responses and epithelial function, and developing biomarker-based endotyping strategies for CRS subtypes. She has pioneered nasal mucus proteomics and olfactory cleft analysis to identify novel therapeutic targets. Dr. Mulligan's grant portfolio includes NIH-funded projects on vitamin D modulation of CRS inflammation, immune responses to SARS-CoV-2 in upper airways, and biologic therapies for nasal polyposis. She leads clinical trials evaluating treatments like dupilumab for smell recovery. Over 100 peer-reviewed publications span immunology, otolaryngology, and translational research methodologies. Her teaching activities include instructing the GMS6847 course on translational research principles. She mentors residents and fellows in surgical research through structured educational programs. Active collaborations involve immunologists, bioengineers, and clinical researchers across multiple institutions.

• Osteoarthritis
• Degenerative Joint Diseases
• Chronic Pain Mechanisms
• +۷ مورد دیگر

Kyle Allen is a Professor at the University of Florida's Herbert Wertheim College of Engineering, specializing in Biomedical Engineering. His research focuses on understanding how degenerative musculoskeletal diseases like osteoarthritis (OA) and intervertebral disc degeneration lead to chronic pain and disability. He employs rodent disease models and clinical studies in both veterinary and human patients to explore behavioral, molecular, and structural aspects of these conditions. Education: B.S. in Mechanical Engineering & Economics, Rose-Hulman Institute of Technology (2002) Ph.D. in Bioengineering, Rice University (2006) Post-doctoral Fellowship in Orthopedic Surgery, Duke University (2011) Research Interests: Dr. Allen’s lab develops novel behavioral assays, magnetic nanoparticle-based diagnostic tools, and tissue engineering strategies to improve osteoarthritis treatment and preclinical-to-clinical translation. His work intersects biomechanics, molecular biology, and neurophysiology to address unmet clinical needs in joint disease management. Publications: His recent work includes AI-driven gait analysis in equine and rodent models, nanoparticle-based therapies, and proteomic studies of disease mechanisms. Key trends include leveraging machine learning for phenotypic analysis and exploring nanotechnology for targeted drug delivery. Awards: UF Doctoral Mentoring Award (2022-2023) NIH K99/R00 Pathways to Independence Award (2014) J. Crayton Pruitt Family Term Fellow (2017-2020) Advising & Grants: While specific student names are not listed, Dr. Allen’s lab focuses on training interdisciplinary researchers. His grants support studies on neuroimmune interactions in pain and translational biomaterials development. He chairs the Young Investigator Subcommittee for the Osteoarthritis Research Society International. Labs/Teams: The Orthopaedic Biomedical Engineering Laboratory collaborates with veterinary and clinical partners to bridge basic science and clinical applications in musculoskeletal health.

Alexander S. Bradleyمشاهده پروفایل

دانشیار

• Organic Geochemistry
• Isotope Geochemistry
• Geobiology
• +۳ مورد دیگر

Alexander S. Bradley is an Associate Professor of Earth, Environmental, and Planetary Sciences at Washington University in St. Louis, serving as Director of Graduate Studies. He holds a PhD from MIT in a related field. His research focuses on the coevolution of life and Earth, integrating organic and isotope geochemistry with microbiology to decode Earth’s biogeochemical history. Key areas include molecular fossils preservation, microbial physiology, and extraterrestrial life detection strategies. Bradley’s work spans field investigations (e.g., sediment sampling, cave exploration) and laboratory experiments (e.g., sulfur isotope fractionation studies). He teaches foundational courses like Geology in the Field (EEPS 104) , emphasizing practical skills in challenging environments. His lab, part of the McDonnell Center for the Space Sciences, explores biogeochemical cycles through modern and ancient samples, with applications to astrobiology and planetary science. His recent research highlights include sulfur isotope dynamics in microbial systems, organic carbon burial mechanisms during anoxic events, and lipid biomarker responses to environmental changes. The Bradley lab’s projects often involve advanced analytical techniques like SIMS imaging and proteomic analysis.

Chris Smithمشاهده پروفایل

استاد

• Alternative pre-mRNA splicing
• Vascular smooth muscle cells
• RNA-binding proteins
• +۳ مورد دیگر

Chris Smith is a Professor in the Department of Biochemistry at the University of Cambridge, leading research on the mechanisms of regulated alternative pre-mRNA splicing. His work combines molecular, biochemical, and computational approaches to study splicing regulators in vascular smooth muscle cells and lymphoid systems. Key research focuses include the master regulator RBPMS, phosphorylation-driven splicing activity, and PTBP1's role in B cell selection. Research Interests: Mechanisms of alternative splicing regulation RBPMS's role in smooth muscle cell differentiation PTBP proteins in immune cell function Global splicing networks and regulatory interactions Collaborations include Sanjay Sinha (Cambridge Stem Cell Institute), Helle Jørgensen (Department of Medicine), and Martin Turner (Babraham Institute). The group investigates splicing's role in cell-specific phenotypes and disease relevance. Lab activities include transcriptomic, proteomic, and structural studies. Contact: cwjs1@cam.ac.uk

Jocelyn Côtéمشاهده پروفایل

استاد

• RNA Biology
• Neurodevelopmental Disorders
• Neuromuscular Diseases
• +۳ مورد دیگر

Jocelyn Côté is a Full Professor in the Department of Cellular and Molecular Medicine at the University of Ottawa, holding a concurrent role as Assistant Dean, Research and Special Projects in the Faculty of Medicine. His research focuses on the role of arginine methylation in RNA-binding proteins and its implications in neurodevelopmental disorders, neuromuscular diseases, and cancer. He leads studies on the molecular pathways underlying spinal muscular atrophy, myotonic dystrophy, and cancer progression, with particular emphasis on Tudor domain-containing proteins and PRMT enzymes. Education: B.Sc. Biochemistry (Université de Sherbrooke, 1992), Ph.D. Molecular Biology (Université de Sherbrooke, 1998), Postdoctoral Fellowships at Washington University and McGill. Research interests include: (1) arginine methylation regulation in RNA processing, (2) Tudor domain protein functions in disease, and (3) cancer-related epigenetic pathways. His work integrates cell biology, molecular genetics, and proteomics to identify novel therapeutic targets. Publications emphasize RNA biology and disease mechanisms, with recent work highlighting Staufen1's role in myotonic dystrophy and PRMT7's contribution to breast cancer metastasis. While no awards are explicitly listed, his research has implications for neuromuscular and oncological therapies. He collaborates with the Centre for Neuromuscular Diseases and the uOttawa Brain & Mind Research Institute, advancing translational research in neurodegenerative and neuromuscular disorders.

Chibuike Udenigweمشاهده پروفایل

استاد

• Food Biochemistry
• Food Proteins and Peptides
• Food Nanotechnology
• +۶ مورد دیگر

Chibuike Udenigwe is a Full Professor and University Research Chair in Food Properties and Nutrient Bioavailability at the University of Ottawa's Faculty of Health Sciences. He is also cross-appointed in the Department of Chemistry and Biomolecular Sciences and affiliated with the Institute for Science, Society and Policy. His research focuses on food biochemistry, sustainable food processing, and biomaterial applications of food proteins and peptides. He holds Fellowships from the Royal Society of Chemistry and the American Chemical Society. Education: PhD (Food and Nutritional Sciences, University of Manitoba, 2010), MSc (Chemistry, University of Manitoba, 2007), BSc (Honours Biochemistry, University of Nigeria, 2003). Research Interests: Food proteins and peptides, food nanotechnology, bioactive peptides, nutrient bioavailability, sustainable protein sources, food allergens, and functional biomaterials. Notable Articles (2024): Explores nutraceutical regulation of redox enzymes, DPP-IV inhibition via fermented lentils, and structural dynamics of food-derived antidiabetic peptides. Recent work emphasizes peptide-polyphenol interactions, protein nanostructuring, and food additive manufacturing. Awards: FRSC, FAGFD-ACS, FAAS. Grants and Labs: Leads research on food-health nexus innovations, including edible bioplastics, nano-delivery systems, and sustainable protein valorization.

• Autophagy
• Mitophagy
• Retinal Degeneration
• +۷ مورد دیگر

Patricia Boya is a Full Professor in the Department of Medicine at the University of Fribourg, within the Faculty of Mathematics, Natural Sciences and Medicine. She is a leading researcher in autophagy, mitophagy, and lysosomal biology, with a focus on retinal and neurodegenerative diseases. Her research interests center on the molecular mechanisms of autophagy and mitophagy, particularly their roles in retinal health, aging, neurodegeneration, and cell death. She investigates how mitochondrial dynamics, lysosomal function, and autophagic flux contribute to diseases such as retinitis pigmentosa, glaucoma, ALS, and Parkinson’s. Her work combines molecular biology, cell imaging, and preclinical models to uncover therapeutic targets. The analysis of her recent publications reveals a strong focus on mitophagy regulation, neuroinflammation (especially via the cGAS/STING pathway), and the development of neuroprotective compounds. She has contributed to high-impact reviews and guidelines in autophagy research, and her work spans fundamental mechanisms to translational applications. She is actively involved in scientific leadership, including the "Women in Autophagy" initiative to promote gender equity in science and the "DRIVE" international PhD training program in autophagy. Dr. Boya has published over 150 articles in top journals including Nature , Nature Communications , Autophagy , and Cell Death & Disease . Her work is highly collaborative, involving interdisciplinary teams across Europe. She leads a research group focused on cellular recycling mechanisms and their implications for vision and aging, contributing significantly to the understanding of autophagy in health and disease.

Andrew K. Godwinمشاهده پروفایل

استاد

• Translational Research
• Precision Medicine
• Ovarian Cancer
• +۷ مورد دیگر

Andrew K. Godwin, Ph.D., is a Chancellor’s Distinguished Chair in Biomedical Sciences Endowed Professor, Division Director of Genomic Diagnostics, and Director of Molecular Oncology at the University of Kansas Medical Center (KUMC). He is Deputy Director of the NCI-Designated KU Comprehensive Cancer Center and Founding Director of the Kansas Institute for Precision Medicine, the Biospecimen Shared Resource, and the Center for Genomic Services and Health Equity. With over 550 peer-reviewed publications and an h-index of 144, his work bridges basic and clinical sciences to advance precision oncology. Chancellor’s Distinguished Chair in Biomedical Sciences Division Director, Genomic Diagnostics Deputy Director, KU Cancer Center Founding Director, Kansas Institute for Precision Medicine Director, Biospecimen Shared Resource Director, Center for Genomic Services and Health Equity Dr. Godwin's research focuses on early cancer detection , liquid biopsies , and molecular therapeutics . His laboratory investigates extracellular vesicle biology , biosample ascertainment , and companion diagnostics to improve patient outcomes in ovarian cancer , breast cancer , and Ewing sarcoma . Recent work emphasizes multi-omics approaches for biomarker validation and therapeutic development . His laboratory has produced groundbreaking studies on AKT2 activation in ovarian cancer , KRAS mutations in EGFR-targeted therapy , and circulating tumor cell diagnostics . Current research trends integrate spatial transcriptomics , mitochondrial DNA mutations , and immune microenvironment profiling across cancer types. Scientific honors include: Dolph C. Simons, Sr. Higuchi Award (2020) KU Mentoring Awards (2021, 2024) NIH/NIGMS COBRE Grant ($24M total) CELLSEARCH® Clinical Validation Leadership Dr. Godwin mentors over 150 trainees across career stages and leads KUMC's Clinical Molecular Oncology Laboratory (CMOL) and Biomarker Discovery Lab (BDL) , advancing team science and translational research infrastructure.

• Mycology
• Fungal Systematics
• Seedless Plant Systematics

Merve Ulukapi is a Lecturer at the Faculty of Arts and Sciences , Kırşehir Ahi Evran University , affiliated with the Department of Molecular Biology and Genetics . Her academic career focuses on mycology and systematic biology. PhD (2024): Taxonomy of microfungi growing on trees and shrubs in Kaz Mountains National Park , Kirsehir Ahi Evran University MSc (2016): Plant microfungi of Mucur district (Kırşehir) , Ahi Evran University Research interests include: Mycology : Fungal taxonomy and ecology Fungal Systematics : Classification of microfungi Seedless Plant Systematics : Taxonomic relationships of non-vascular plants Recent publications focus on fungal diversity, taxonomy, and proteomic analysis. Collaborative works with researchers like Kevin Hyde and Faruk Selçuk dominate her bibliography. Professional Collaborations include: Kevin Hyde (2020-2024) Faruk Selçuk (2020-2024) Eric McKenzie (2023-2024) Metrics include a scientific impact of 64 citations and h-index of 2 .

Marlene Oeffingerمشاهده پروفایل

دانشیار

• RNA Processing
• Ribosome Biogenesis
• Neurodegenerative Diseases
• +۳ مورد دیگر

Marlene Oeffinger is an Associate Professor at the Faculty of Medicine, University of Montreal and holds a cross-appointment at the Division of Experimental Medicine, McGill University . She serves as Research Director of the Ribonucleoprotein Biochemistry Research Unit at the Montreal Clinical Research Institute (IRCM). Her research focuses on RNA maturation pathways, ribosome biogenesis, and their links to neurodegenerative diseases like Alzheimer's and ALS through RNA-protein complex dynamics. Education : Master's in Cell Biology (University of Vienna), PhD in Molecular Biology (University of Edinburgh). Training : Postdoctoral work in David Tollervey's lab (Edinburgh) and Mike Rout's lab (Rockefeller University). Her work combines proteomics , biochemical assays , and computational approaches to map RNA maturation networks and their connections to DNA damage repair. Recent articles highlight discoveries in archaeal ribosome evolution, mRNA export mechanisms, and RNA structure probing in yeast. She has received prestigious awards including the CIHR New Investigator Award , FRQ-S Junior Scholar Fellowships , and Revson Foundation Biomedical Fellowship . Marlene's lab trains students and researchers in RNA biology, with current members like Master's student Mauricio Hernandez Magana. Her affiliations span multiple platforms at the IRCM, including bioinformatics , proteomics , and molecular biology . She leads grants from CIHR , FRQNT , and Brain Canada , advancing understanding of RNA's role in disease etiology.

• Acute Lymphoblastic Leukemia
• Pediatric Brain Tumors
• Genetic Heterogeneity
• +۵ مورد دیگر

Stephen E. Sallan, MD , is a Professor of Pediatrics at Harvard Medical School and a Physician at Dana-Farber Cancer Institute and Children's Hospital . His career spans over five decades in pediatric hematology/oncology , with a focus on acute lymphoblastic leukemia (ALL) and pediatric brain tumors . Education : MD, Wayne State University School of Medicine (1967) Residencies : Boston Floating Hospital (1968), Children's Hospital of Philadelphia (1969), Hospital for Sick Children, London (1970) Fellowship : Pediatric Oncology, Children's Hospital/DFCI (1972) Leadership Roles : Chief of Staff (1995), Chairman of Medical Staff Executive Committee (1995), Chief of Staff Emeritus (2012) Dr. Sallan's research integrates genetic heterogeneity , disease recurrence , and drug resistance in ALL, with efforts to develop targeted therapies like tumor vaccines and antiangiogenesis agents. His work addresses long-term treatment toxicities (cardiac, skeletal, neurocognitive), particularly in survivors of childhood cancers. His 15 most recent publications (2024–2018) demonstrate ongoing engagement with pharmacogenomics, thrombosis risk models, dietary interventions, and molecular markers in brain tumors. Key subfields include TRK-C in medulloblastoma , asparaginase complications , and DFCI ALL Consortium Protocols . Scientific Awards : Distinguished Alumni Award, Wayne State University School of Medicine (1997) James Carreras Prize for International Pediatrician of the Year (1987) As a leader in pediatric leukemia research , Dr. Sallan has shaped treatment protocols that minimize late effects while improving survival. He collaborates with multidisciplinary teams in neuro-oncology and pharmacogenomics, maintaining active roles in clinical trials and laboratory investigations.