جست‌وجوی استاد و پژوهشگر

Mark Libermanمشاهده پروفایل

استاد

• Corpus-based Phonetics
• Speech and Language Technology
• Clinical Applications of Linguistics
• +۶ مورد دیگر

Mark Liberman is a Trustee Professor at the University of Pennsylvania , holding appointments in the Department of Linguistics and Department of Computer and Information Science . He serves as Director of the Linguistic Data Consortium and Faculty Director of Ware College House . His career spans linguistics, speech technology, and computational methods. Education: Harvard University (1965-1969), MIT (M.S. 1972, Ph.D. 1975) Professional Experience: AT&T Bell Laboratories (1975-1990), University of Pennsylvania (1990-present) His research interests include: Corpus-based Phonetics : Analyzing speech patterns via large-scale datasets. Clinical Applications : Developing speech biomarkers for neurodegenerative diseases. Tonal Phonology : Studying lexical tone and intonation in languages like Yoruba and Mandarin. Formal Annotation Models : Creating frameworks for linguistic data standardization. Recent publications highlight automated speech analysis, cross-linguistic prosody, and digital biomarkers for conditions like ALS-FTD and Alzheimer’s. His collaborations span computational linguistics , neurology , and cognitive science . Scientific awards include the IEEE James L. Flanagan Award (2017), Antonio Zampolli Prize (2010), and fellowships from the AAAS and Linguistic Society of America . He advises PhD students May Chan and Jonathan Him Nok Lee and contributes to editorial boards for journals like Cognition and Annual Review of Linguistics . His work bridges speech science , language technology , and neurocognitive research .

Marlyse Baptistaمشاهده پروفایل

استاد

• Language Contact
• Cognitive Linguistics
• Pidgins and Creoles
• +۴ مورد دیگر

Marlyse Baptista is the President's Distinguished Professor of Linguistics at the University of Pennsylvania, Department of Linguistics. She is affiliated with the School of Arts & Sciences and MindCore initiative. Her research focuses on language contact, creolization processes, bilingualism, and experimental methods in creole studies. Baptista leads the Language Contact and Cognition Lab, previously known as the Cognition, Convergence and Language Emergence (CCLE) group at the University of Michigan. Education includes a PhD in Linguistics (Harvard, 1997), MA degrees from Harvard and the Université de Bordeaux III, and extensive training in multilingual education. Her work bridges generative syntax with experimental approaches, including artificial language learning to study language convergence. Key themes include the cognitive underpinnings of creole formation, bidirectional influences in Cape Verdean Creole, and the role of congruence in language acquisition. Research highlights include studies on Cape Verdean Creole's grammatical properties, genetic-linguistic admixture correlations, and pedagogical resources for creole language education. Recent projects explore experimental validation of creole genesis theories through multilingual acquisition studies. Scientific Awards: President's Distinguished Professorship (University of Pennsylvania) Labs/Teams: Language Contact and Cognition Lab, MindCore Grants/Projects: MULTI Project (creole language educational resources), NSF-funded studies on creole genesis mechanisms Baptista's work emphasizes interdisciplinary approaches, integrating syntax theory, psycholinguistics, and sociolinguistics to address foundational questions in contact linguistics and creolistics.

Yee Whye Tehمشاهده پروفایل

استاد

• Statistical Machine Learning
• Probabilistic Learning
• Deep Learning
• +۴ مورد دیگر

Yee Whye Teh is a Professor at the Department of Statistics, University of Oxford, and a research scientist at DeepMind. His work focuses on statistical machine learning, including probabilistic learning, Bayesian nonparametrics, deep learning, and Monte Carlo methods. He co-directs the ELLIS programme on Robust Machine Learning and has held roles such as Programme Co-chair for ICML 2017. Teh has delivered keynotes at UAI 2019, an IMS Medallion Lecture at JSM 2019, and the Breiman Lecture in 2017. His research emphasizes scalable inference algorithms, hierarchical models, and applications in genetics and natural language processing. Teh's educational background includes a PhD from the University of Toronto (2003) and a Master's from the same institution (2000). He has contributed to widely used software tools like the Sequence Memoizer and has been recognized for his work through prestigious lectureships. Research interests span Bayesian nonparametric models, MCMC methods, and their applications in genetics and data compression. His lab collaborates on projects like fragmentation-coagulation processes for genetic variation modeling and Mondrian forests for online learning. Teh advises students through Oxford's graduate programs, though he notes high demand for mentorship. His work often bridges theory and practice, addressing challenges in big data learning and small data problems.

• Epigenetics
• Retroelements
• Transposable elements
• +۵ مورد دیگر

Didier Trono is a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL), where he leads the Laboratory of Virology and Genetics (LVG) within the School of Life Sciences. Formerly, from 2004 to 2012, he served as the founding dean of EPFL's Faculty of Life Sciences, orchestrating its development and growth during this formative period. Trono received his medical education at the University of Geneva, followed by clinical training in pathology, internal medicine, and infectious diseases in Geneva and at Massachusetts General Hospital in Boston. His scientific career began at the Whitehead Institute of MIT, and in 1990 he was recruited by the Salk Institute of San Diego to launch an AIDS research center. After seven years in the United States, he returned to Europe and eventually joined EPFL. Dr. Trono's research has evolved significantly over his career. Initially focusing on virus-host interactions, he studied pathogens like HIV and Hepatitis B virus, creating HIV-derived genetic transfer tools that are now successfully used in gene therapy. For approximately the last fifteen years, his research has centered on epigenetics, particularly exploring the impact of retroelements and their control mechanisms on development and physiology of higher organisms, including humans. His laboratory investigates how transposable elements and KRAB zinc finger proteins regulate gene expression, with important implications for understanding cancer biology and developing new diagnostic and therapeutic approaches. Analysis of his recent publications (2022-2024) reveals a strong focus on transposable elements, KRAB zinc finger proteins, and their roles in gene regulation and cancer. His work combines molecular biology, genomics, and bioinformatics approaches to understand how these ancient viral remnants have been co-opted by the host genome to regulate development and cellular functions. The research spans basic molecular mechanisms to potential clinical applications in cancer diagnosis and therapy, with some recent work also addressing SARS-CoV-2 and immune responses. Throughout his career, Professor Trono has mentored numerous PhD students, including Bojkowska Karolina, Brandão Sanches Vong Martins Filipe Amândio, Bulliard Yannick, Coluccio Andrea, Corsinotti Andrea, Coudray Alexandre, De Tribolet-Hardy Jonas Caspar, and Dorschel Iris Arianna. His laboratory has received significant funding to support research at the intersection of virology, genetics, and epigenetics, contributing to EPFL's reputation as a leading institution in life sciences research. The Trono Laboratory continues to be at the forefront of research on retroelements and their regulatory mechanisms, maintaining a vibrant research environment that bridges fundamental biological questions with potential medical applications, particularly in cancer research and precision medicine.

Harris H. Wangمشاهده پروفایل

دانشیار

• Systems Biology
• Synthetic Biology
• Genome Engineering
• +۱۷ مورد دیگر

Harris H. Wang is an Associate Professor in the Department of Systems Biology and Department of Pathology and Cell Biology at Columbia University's Vagelos College of Physicians and Surgeons, where he also serves as Interim Chair of Systems Biology. He is affiliated with the Center for Computational Biology and Bioinformatics (C2B2) and the Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS). B.S., Physics and Mathematics, MIT Ph.D., Biophysics, Harvard University Dr. Wang's research lies at the intersection of systems and synthetic biology, focusing on developing foundational technologies for genome engineering, microbiome manipulation, and synthetic genomics. His lab pioneers methods such as MAGE, MAGIC, CAST, and CAMII to enable high-throughput genetic manipulation, in situ microbiome engineering, and AI-driven microbial culturomics. Key research themes include understanding microbial community dynamics, engineering cellular memory systems, designing biocontained genetic circuits, and applying synthetic biology to human health challenges in personalized medicine and infectious disease. His recent publications reveal a strong trend in spatial and functional metagenomics, CRISPR-based microbiome editing, and synthetic biology tools for data storage and genetic stability. The articles span high-impact journals like Nature , Science , and Nature Biotechnology , reflecting his leadership in developing scalable, programmable biological systems. Scientific Awards: NIH Director’s Early Independence Award Forbes 30 Under 30 in Science Sloan Research Fellowship NSF CAREER Award ONR Young Investigator Award Burroughs Wellcome Fund PATH Award Schaefer Scholar Blavatnik National Award Vilcek Prize PECASE Dr. Wang has advised numerous PhD and postdoctoral researchers, many of whom have gone on to independent scientific careers. His lab is supported by major grants from NIH, NSF, DARPA, DOE, and foundations including the Bill & Melinda Gates Foundation and CZ Biohub NY. He is actively involved in educational initiatives, including organizing Columbia’s iGEM team and the Cold Spring Harbor Laboratory Synthetic Biology course. The Wang Lab is based at the Columbia University Irving Medical Center and is part of national consortia such as the Engineering Biology Research Consortium (EBRC) and the Genome Project-Write (GP-Write) initiative. The lab develops and applies cutting-edge technologies in automation, machine learning, and synthetic biology to engineer microbiomes for applications in medicine, global health, and climate change.

Osbert Bastaniمشاهده پروفایل

دانشیار

• Machine Learning
• Neurosymbolic AI
• Program Synthesis
• +۱۰ مورد دیگر

Osbert Bastani is an Associate Professor at the Department of Computer and Information Science, University of Pennsylvania, leading the trustml@Penn research group. He is affiliated with the ASSET , PRECISE , and PRiML centers, and the PLClub research group. His research focuses on Trustworthy Neurosymbolic Systems , Synthesizing Neurosymbolic Programs , and Machine Learning for Programmer Productivity , with applications in verification, fairness, and human-AI collaboration. He received the NSF CAREER Award in 2023. His recent publications (2024-2025) emphasize AI Safety , LLM Robustness , and Algorithmic Fairness , including work on adversarial robustness, conformal prediction, and program synthesis. Students he has advised include Sagnik Anupam, Stephen Mell, Jason Ma, Shuo Li, and others. Awards: NSF CAREER Award (2023)

Maria Craigمشاهده پروفایل

استاد

• Childhood Diabetes
• Type 1 Diabetes
• Virology and Diabetes
• +۴ مورد دیگر

Professor Maria Craig is a distinguished academic and researcher at the University of New South Wales, Faculty of Medicine & Health, specializing in childhood diabetes research. She holds a prominent position as a Professor with extensive contributions to the field of pediatric endocrinology and diabetes, particularly focusing on type 1 diabetes in children. Professor Craig's educational background includes: MB BS from the University of Melbourne MMedSc(ClinEpid) from the University of Newcastle PhD from the University of Sydney FRACP (Fellow of the Royal Australasian College of Physicians) Professor Craig's research primarily focuses on childhood diabetes, with special emphasis on prediction and prevention of type 1 diabetes. She has a significant interest in the association between viruses and type 1 diabetes, collaborating with the Virology Research Group at Prince of Wales Hospital (POWH). Together with Professor Bill Rawlinson, she leads the viral theme for the multicentre ENDIA study (endia.org.au). As principal investigator for the CoRD trial, she is conducting a world-first phase 1 study using autologous cord blood for prevention of type 1 diabetes in children with islet autoimmunity. Additionally, she serves as principal investigator for the Australasian Diabetes Data Network (ADDN). Her research portfolio also encompasses the epidemiology of various forms of childhood diabetes (type 1, type 2, cystic fibrosis related diabetes and monogenic diabetes) and diabetes complications, in collaboration with Professor Kim Donaghue at the Children's Hospital at Westmead. Professor Craig's extensive publication record, including over 361 journal articles, demonstrates her leadership in advancing our understanding of childhood diabetes. Her recent work shows increasing focus on early detection methods, risk prediction models, technological interventions for diabetes management, and the complex interplay between viral infections and autoimmune diabetes development. She has been instrumental in developing clinical practice guidelines through her role as co-editor of the International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines. Professor Craig has received numerous prestigious awards recognizing her contributions to pediatric endocrinology and diabetes research: Australian Paediatric Endocrine Group Young Investigator's Award (1997) Asia Pacific Paediatric Endocrine Society Clinical Teaching Award (2008) Lifetime Honorary Member, Caring and Living as Neighbours (2013) Australian Diabetes Society Jeff Flack Diabetes Data Award (2019) Australian Paediatric Endocrine Group Norman Wettenhall Award for Research and Innovation (2019) Throughout her career, Professor Craig has demonstrated exceptional leadership in professional societies, having served as former president/treasurer of the Australasian Paediatric Endocrine Group (APEG) and currently as Scientific Convenor of the Asia Pacific Paediatric Endocrine Society Fellows school. Her work with the ENDIA study and Australasian Diabetes Data Network represents significant collaborative research efforts involving multiple institutions across Australia and internationally. Her principal investigator roles for major studies indicate substantial research funding support. Professor Craig leads several important research initiatives including the ENDIA study, the CoRD trial, and the Australasian Diabetes Data Network. These programs involve multidisciplinary teams of researchers, clinicians, and support staff working collaboratively to advance understanding and treatment of childhood diabetes. Her work at the intersection of virology and diabetes represents a unique and innovative approach to understanding the environmental triggers of type 1 diabetes.

Keith Alexander Sharkeyمشاهده پروفایل

استاد

• Enteric nervous system
• Gut-brain axis
• Endocannabinoid system
• +۳ مورد دیگر

Dr. Keith Alexander Sharkey is a Professor in the Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He is also a Full Member of both the Hotchkiss Brain Institute and The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases. Dr. Sharkey has been at the University of Calgary since his appointment as Assistant Professor in 1990, dedicating his career to understanding the neural control of the gastrointestinal tract. From 2005-2021, he held the Crohn's and Colitis Canada Chair in Inflammatory Bowel Disease Research, demonstrating his longstanding commitment to advancing knowledge in gastrointestinal sciences. Dr. Sharkey's educational journey began with a BSc (Hons) in Nutrition from the University of London in 1981, followed by a PhD in Physiology from the University of Liverpool in 1985. After completing postdoctoral training in Hungary, the UK, and Canada, he joined the University of Calgary faculty in 1990, where he has remained throughout his distinguished academic career. Dr. Sharkey's research program centers on understanding the physiology and pathophysiology of the neural control of the gastrointestinal tract and brain-gut interactions in health and disease. His laboratory investigates two main areas: the role of the endocannabinoid system in regulating GI motility and intestinal barrier function, and the physiology of the enteric nervous system in controlling motility and barrier function. His work employs state-of-the-art approaches including live cell imaging and molecular genetics. Recent publications show his expanding interest in connections between gut function and neurodegenerative conditions like ALS, with multiple 2024-2025 papers examining sexual dimorphism in disease processes and gut-brain axis mechanisms. Fellow, Royal Society of Canada (2024) Cumming School of Medicine's van de Sande Distinguished Achievement Award for Mentorship (2021) Distinguished Research Award, American Physiological Society (2021) Finkelstein Award for Excellence, Crohn's and Colitis Canada (2016) Fellow, Canadian Academy of Health Sciences (2015) Fellow, Canadian Association of Gastroenterology (2015) Killam Annual Professor Award, University of Calgary (2013) Dr. Sharkey has mentored numerous students throughout his career, as evidenced by his 2021 Mentorship Award. His research is supported by significant funding, including a CIHR Foundation grant exploring how enteric nerves and glia maintain intestinal homeostasis. He has also participated in university strategic initiatives focused on Brain and Mental Health (2015-2021) and Infections, Inflammations and Chronic Diseases (2015-2021), demonstrating his interdisciplinary approach. The Sharkey Lab provides a safe, inclusive, and diverse research environment that encourages open scientific exchange from diverse viewpoints. His laboratory is actively engaged in multiple collaborative projects, including investigations with UBC Okanagan on diet and probiotics targeting the gut-brain metabolic interactome, and with University of Calgary colleagues studying gut microbiota's role in ALS. Dr. Sharkey continues to advance our understanding of neural mechanisms controlling gastrointestinal function with upcoming courses scheduled for Fall 2024 and Winter 2025.

Richard M. Murrayمشاهده پروفایل

استاد

• Control Theory
• Autonomous Vehicles
• Biological Circuit Design
• +۳ مورد دیگر

Richard M. Murray is the Thomas E. and Doris Everhart Professor of Control and Dynamical Systems and Bioengineering at the California Institute of Technology (Caltech). He holds a B.S. from Caltech (1985), M.S. from UC Berkeley (1988), and Ph.D. from UC Berkeley (1990). He has served in academic roles from Assistant Professor (1991–1997) to his current endowed professorship. He chaired the Engineering and Applied Science division (2000–2005) and Biology and Biological Engineering (2020–2024). His research focuses on feedback control in biological and autonomous systems, synthetic cells, and networked control systems. Collaborators include experts in robotics, synthetic biology, and systems biology. Key awards include the IEEE Control Systems Award and election to the National Academy of Engineering. His educational contributions span courses on control systems, robotics, and bioengineering. Current research projects include the Developer Cell initiative (Sloan Foundation), layered testing for autonomous systems (AFOSR), and microbiome-based environmental solutions (CHARMME, ARO). He advises numerous graduate students and postdocs, with notable alumni in academia and industry. Labs include facilities in Keck and Steele laboratories at Caltech. His work bridges control theory, synthetic biology, and autonomous systems to address societal challenges like environmental monitoring and safe autonomy.

Thomas Walzمشاهده پروفایل

استاد

• Membrane Biology
• Structural Biology
• Cryo-electron Microscopy
• +۵ مورد دیگر

Thomas Walz, PhD, is a Professor at The Rockefeller University and Head of the Laboratory of Molecular Electron Microscopy. Previously, he held positions as Assistant, Associate, and Professor at Harvard Medical School (1999–2015) and was an Investigator at the Howard Hughes Medical Institute (2008–2015). He earned his PhD and BS in biophysics from the University of Basel, Switzerland, and completed postdoctoral research at the University of Sheffield. Walz completed his education at the Biozentrum, University of Basel, Switzerland, where he received his Diploma in Biophysics (1992) and PhD in Biophysics (1996). He furthered his training as a postdoctoral researcher at the University of Sheffield (1996–1999). His research focuses on understanding membrane-related processes and the structural biology of membrane proteins in lipid environments. Utilizing cryo-electron microscopy and nanodisc technology, he investigates how lipid bilayers influence membrane protein structure and function. Key areas include mechanosensitive channels, T-cell receptor dynamics, and telomere maintenance mechanisms. Collaborations with the de Lange lab explore the CST-Polα/primase complex's role in telomere regulation. Walz has been recognized with the Genzyme Award for Outstanding Achievement in Biomedical Sciences (2004) and continues to contribute to advancements in structural biology and membrane protein research. While specific student advisees are not listed, Walz actively mentors through his roles in the David Rockefeller Graduate Program and Tri-Institutional programs. His research is supported by grants and institutional funding, though specific grants are not detailed here. He directs the Laboratory of Molecular Electron Microscopy at Rockefeller, a hub for innovative structural biology and membrane protein studies. The lab collaborates widely, integrating cryo-EM with electrophysiology and molecular dynamics simulations.

• Plant Biotechnology
• Molecular Biology
• Synthetic Biology
• +۵ مورد دیگر

Jun Hyung Lee is a Visiting Assistant Professor in the Department of Environmental Biology at SUNY College of Environmental Science and Forestry (ESF). His research focuses on advancing forest tree improvement and conservation through molecular and synthetic biology approaches, with a particular emphasis on enhancing plant resilience to environmental stresses via beneficial microbial interactions. He teaches courses in plant biotechnology and tissue culture methods. Education includes a Ph.D. in Forest Genetics from Purdue University (USA), and M.S. and B.S. degrees in Plant Science from Seoul National University (South Korea). His work integrates cutting-edge genetic engineering techniques with ecological studies to address challenges in plant stress tolerance, symbiosis, and epigenetic regulation. Recent projects include identifying novel symbiosis pathways for thermotolerance and analyzing flooding tolerance in hybrid poplars. Publications highlight contributions to plant-microbe interaction research, synthetic biology applications, and genome editing epigenetic impacts. Collaborations span institutions like Oak Ridge National Laboratory and the University of Georgia, reflecting his transdisciplinary approach to plant science. Lee’s teaching emphasizes practical skills in biotechnology, bridging laboratory innovation with field applications.

Hang Luمشاهده پروفایل

استاد

• Microfluidics
• Systems Biology
• Neuroscience
• +۶ مورد دیگر

Hang Lu is a Professor and holds the Cecil J. "Pete" Silas Chair of Chemical & Biomolecular Engineering at the Georgia Institute of Technology. Dr. Lu also holds a Love Family Professorship and leads the Lµ Fluidics Group, which focuses on engineering microfluidic systems and machine learning tools to address complex questions in neuroscience, developmental biology, and cell biology that are difficult to address with conventional techniques. Dr. Lu's research lies at the intersection of engineering and biology, with primary interests including: Microfluidic systems for high-throughput screens and image-based genetics and genomics Systems biology: large-scale experimentation and data mining Microtechnologies for optical stimulation and optical recording Big data, machine vision, and automation Developmental neurobiology, behavioral neurobiology, and systems neuroscience Cancer biology, immunology, embryonic development, and stem cells Her laboratory engineers microfluidic devices and BioMEMS to study neuroscience, genetics, cancer biology, and biotechnology. These miniaturized Lab-on-a-chip tools operate at scales comparable to biological systems, leveraging unique micro and nano-scale phenomena to gather large-scale quantitative data about complex biological systems. Current projects include Microfluidics for Life Sciences, Optical Neuron Recordings and Manipulations, Machine Learning Tools for Neuroscience, Measuring and Modeling Behavior, and High-throughput, High-content Cell-based Assays. Analysis of Dr. Lu's recent publications (2024-2025) reveals a strong trend toward integrating microfluidics with advanced computational methods: Development of deep learning frameworks for biological image analysis Advanced neuron tracking and functional imaging techniques Non-invasive characterization of 3D organoid cultures Sophisticated neuromechanical modeling of locomotion Microfluidic temperature control systems for in vivo studies Label-free imaging pipelines for neural development Dr. Lu's significant professional honors include: Cecil J. "Pete" Silas Chair of Chemical & Biomolecular Engineering Love Family Professorship The Lµ Fluidics Group actively mentors students and postdocs, currently accepting new postdoctoral researchers. The lab receives substantial funding for interdisciplinary projects at the engineering-biology interface, with research implications spanning fundamental biological understanding to therapeutic development. The group operates within Georgia Tech's School of Chemical & Biomolecular Engineering, with specialized facilities for microfluidic device fabrication, biological experimentation, and advanced imaging, maintaining strong collaborative ties across engineering, neuroscience, and biological disciplines.

Adam Runionsمشاهده پروفایل

پژوهشگر

• Computational Modeling
• Developmental Biology
• Computer Science
• +۴ مورد دیگر

Adam Runions is a researcher in the Department of Computer Science at the University of Calgary, leading the MPG Partner Group in computational analysis of leaf development through collaborative work with Miltos Tsiantis. His group is embedded in the Graphics Cluster, focusing on interdisciplinary problems at the intersection of computer science and developmental biology. University of Calgary - Department of Computer Science MPG Partner Group (2022) Graphics Cluster affiliation His research explores computational modeling and analysis of plant form and development across multiple scales, integrating geometric modeling, physically-based simulation, and computer-aided design. Key themes include plant morphogenesis, self-organization of natural forms, and cross-disciplinary applications in computer graphics and animation. Recent publications emphasize plant development (leaf shape, bark patterning), mathematical modeling (auxin-driven patterning), and geometric techniques (subdivision surfaces, PUPs). Collaborations span institutions like the Max Planck Institute for Plant Breeding Research. Scientific Awards Marie Sklodowska-Curie Fellowship Best Paper Award (International Conference on Cyberworlds 2015) Best Student Paper Award (Computer Graphics International 2011) The group actively recruits BSc, MSc, and PhD students with backgrounds in computer science and mathematics for projects on plant form simulation and digital content creation. Research integrates evolutionary biology, biomechanical modeling, and computational techniques.

Joseph Kableمشاهده پروفایل

استاد

• Behavioral Neuroscience
• Cognitive Neuroscience
• Decision Processes
• +۳ مورد دیگر

Joseph Kable is the Jean-Marie Kneeley President's Distinguished Professor of Psychology at the University of Pennsylvania's Department of Psychology within the School of Arts and Sciences. His research integrates experimental economics, cognitive neuroscience, and personality psychology to investigate the neural and psychological mechanisms underlying decision-making. He explores how subjective value is represented in the brain, deviations from rational choice theory, and individual differences in decision processes. His lab employs fMRI and interdisciplinary methods to study topics like risk tolerance, impulsivity, and neural plasticity. Education: BS in Chemistry from Emory University (undergraduate), PhD in Neuroscience from the University of Pennsylvania (doctoral). Research focuses on behavioral and cognitive neuroscience mechanisms of choice, including studies on temporal predictions, value signals, and brain structure-function relationships. His recent work examines how neural markers correlate with decision-making variability across individuals. He currently advises graduate students in Psychology and has post-doctoral researchers in his lab. Associated with MindCORE, Penn's hub for integrative mind research. Lab activities include undergraduate research programs and active studies exploring decision neuroscience and neuroeconomics.

Daniel Finleyمشاهده پروفایل

استاد

• Ubiquitin-Proteasome Pathway
• Proteostasis
• Protein Degradation
• +۷ مورد دیگر

Daniel Finley is a Professor of Cell Biology at Harvard Medical School (HMS), leading the Finley Lab focused on the ubiquitin-proteasome pathway and related regulatory mechanisms. He holds academic appointments within the Department of Cell Biology and sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals. His research investigates proteasome function, ubiquitin-like proteins, and proteostasis roles in diseases like Alzheimer’s and ALS. Dr. Finley earned his undergraduate degree in biochemistry from Harvard University and a Ph.D. in molecular biology from MIT. After postdoctoral training at MIT, he joined HMS in 1988. His lab explores topics including erythroid proteome remodeling, mitochondrial dysfunction, and neurodegenerative disease mechanisms. Key research areas include: (1) Ubiquitin-proteasome pathway regulation, (2) Proteasome structure/function, (3) Nonproteolytic roles of ubiquitination, and (4) Pathophysiological roles of proteostasis defects in diseases. His work bridges basic cell biology with translational medicine, particularly in neurodegeneration and anemia. Finley has secured NIH funding for projects like 'Regulation of Proteasome Activity' (R35GM145246) and 'Erythrocyte maturation through global proteome remodeling' (R01HL153970). Collaborations with industry and academic partners extend his impact in drug discovery and proteasome-targeted therapies. His lab’s contributions include defining ubiquitin chain editing mechanisms, identifying USP14’s role in mitophagy, and elucidating proteostasis defects in Alzheimer's models. Research tools developed include advanced cryo-EM analyses of proteasomal structures and functional assays for ubiquitin system enzymes.