جستجوی استاد راهنمای دانشگاهی

• Apoptosis
• Cell Death
• BCL-2 Proteins
• +۹ مورد دیگر

Samuel G. Katz, MD, PhD is an Associate Professor of Pathology at Yale University School of Medicine with primary appointments in Pathology and multiple secondary affiliations including Genomics, Genetics and Epigenetics, Hematopathology, Molecular Medicine, Pharmacology and Physiology, and the Yale Cancer Center. His research bridges fundamental cell death mechanisms with translational immunotherapy approaches. Dr. Katz earned his combined B.S./M.S. from Yale University in 1995, followed by dual M.D./Ph.D. training through the Health Sciences & Technology program at MIT and Harvard. His PhD thesis with Stuart H. Orkin focused on transcriptional regulation of hematopoiesis. He completed pathology residency and hematopathology fellowship at Brigham and Women's Hospital, followed by postdoctoral studies on apoptosis with Loren D. Walensky at Dana Farber Cancer Institute. His research focuses on BCL-2 family proteins, particularly the poorly understood BOK protein, which resides in one of the 20 most frequently deleted genomic regions in human cancers. The lab investigates how BCL-2 proteins regulate cell viability and integrate multiple cellular functions beyond apoptosis. Using conditional mouse knockouts, biochemistry, and genetic screening, the lab aims to unravel complex cellular signaling pathways to develop therapeutic strategies against cancer. The Katz Lab has published consistently in high-impact journals with recent work spanning from fundamental BCL-2 protein mechanisms to CAR-T cell engineering. The lab's research shows a clear trajectory from basic molecular mechanisms to translational immunotherapy applications, particularly in lymphoma and leukemia. Mantle Cell Lymphoma Consortium Member (2011) Career Development Award, Mentored (K08) from NIH (2010) Post-Doctoral Fellow Career Development Award from Leukemia and Lymphoma Society (2008) Yamaguchi Award in Hematology Research (1999) Pre-Doctoral Fellow Award from Howard Hughes Medical Institute (1998) Dr. Katz leads a vibrant research group that includes graduate students, postdoctoral associates, and research scientists. His lab collaborates extensively with the Yale New Haven Hospital's Advanced Cell Therapy core and clinical oncologists. The lab was recently awarded an NIH grant to study the role of BOK protein in the cell death pathway, demonstrating continued research excellence and funding success. Dr. Katz also maintains active clinical work as a hematopathologist, diagnosing blood cancers and collaborating with clinicians on patient care. The Katz Lab maintains strong connections with the Yale Cancer Center and Yale Center for Immuno-Oncology, positioning it at the forefront of cancer research and immunotherapy development. The lab's work on reprogramming immune cells using multifactor mRNA approaches represents a cutting-edge direction in cancer treatment.

• Hair follicle development
• Regeneration
• Dermal niche
• +۷ مورد دیگر

Peggy Myung, MD, PhD is Vice Chair of Research and Associate Professor of Dermatology and Pathology at Yale School of Medicine. She maintains strong affiliations across multiple Yale entities including the Yale Cancer Center, Yale Stem Cell Center, Cancer Signaling Networks Program, and Pathology Research Program in Translational Biomedicine. Dr. Myung leads the Myung Lab which focuses on hair follicle development and regeneration research, with applications to understanding skin cancer mechanisms. Dr. Myung received her MD and PhD from the University of Pennsylvania in 2003, completed residencies at Hospital of the University of Pennsylvania and University Hospitals Case Medical Center, and a fellowship at Yale University School of Medicine in 2014. She is board certified in both Dermatology (2012) and Dermatopathology (2014, with recertification in 2025). Her research program investigates how heterotypic signals between the skin epidermis and dermis regulate robust and organized hair follicle growth during embryonic development and adult regeneration. The Myung Lab specifically examines: (1) how cellular behaviors such as cell divisions and movement are regulated by key morphogenetic signals during regeneration, (2) how these signals are spatially disseminated to ensure robust but patterned growth, and (3) how these mechanisms contribute to disorganized growth during tumorigenesis. The hair follicle serves as an ideal model for these studies due to its accessibility and well-characterized cyclical regeneration dependent on resident stem cells. Dr. Myung's recent publication record demonstrates consistent productivity in high-impact journals, with a growing emphasis on single-cell genomic techniques and computational approaches to understand cellular interactions at unprecedented resolution. Her work bridges developmental biology, dermatology, and cancer research, with particular focus on Wnt/β-catenin signaling and epithelial-mmesenchymal interactions. Dr. Myung has received notable recognition including: $30K Biotech Accelerator Award (June 2023) Yale Medicine 'Top Doctor' listing (2024) As Vice Chair of Research, Dr. Myung oversees research initiatives within the Department of Dermatology while maintaining an active laboratory program that combines multi-photon imaging, quantitative RNA fluorescent in situ hybridization, single-cell RNA/ATAC sequencing, and in vivo mouse genetic models. Her long-term goal is to develop novel treatments for hair loss and to prevent and treat non-melanoma skin cancer by applying knowledge of hair morphogenetic signals to suppress aberrant growth in carcinogenesis.

James Noonanمشاهده پروفایل

استاد

• Embryonic and Fetal Development
• Epigenomics
• Molecular Evolution
• +۷ مورد دیگر

James Noonan is the Albert E. Kent Professor of Genetics and Professor of Neuroscience at Yale University School of Medicine, where he also serves as co-Director of Graduate Studies in Genetics. His primary appointment is in the Department of Genetics, with secondary appointments in the Department of Ecology & Evolutionary Biology and Neuroscience. He maintains extensive affiliations across Yale, including the Yale Cancer Center, Yale Center for Genomic Health, Yale Stem Cell Center, Wu Tsai Institute, and Kavli Institute for Neuroscience. Dr. Noonan's research focuses on understanding human-specific gene regulation and its role in evolution and development. His lab pioneered the discovery that Human Accelerated Regions (HARs) encode transcriptional enhancers with human-specific activity in the developing embryo. The lab has developed innovative approaches including humanized mouse models to study how HARs alter developmental gene expression and drive the evolution of novel phenotypes. They also pioneered massively parallel screening approaches to characterize gene regulatory functions in human brain development and evolution. The lab's recent publications reveal significant insights into how uniquely human sequence changes affect enhancer activity, how HARs contribute to cortical development, and how autism risk genes like CHD8 regulate neurodevelopmental pathways. Their work demonstrates that HARs have clear biological functions in neurodevelopment and has identified specific regulatory innovations contributing to the emergence of the mammalian neocortex. Mallinckrodt Foundation Fellowship (2008) Professor Noonan has mentored at least 11 PhD students to completion, with his most recent student (Atreyo Pal) defending in 2025. His lab maintains multiple active grants from NIH, SFARI, NOMIS Foundation, and other major funding agencies. Students in the lab gain training in cutting-edge genomic techniques including CRISPR genome editing, single-cell genomics, and comparative epigenomics. The lab's interdisciplinary approach provides students with opportunities to work across multiple departments and research centers at Yale, with recent students winning prestigious awards like the Carolyn Slayman Prize in Genetics. The Noonan Lab (noonanlab.org) maintains an active presence in the scientific community, regularly sharing research updates and engaging with broader issues affecting biomedical research. Their work continues to advance our understanding of what makes us uniquely human at the molecular level.

• Epigenetics
• Genome Biology
• Embryonic Development
• +۷ مورد دیگر

Zachary Smith is an Assistant Professor (Adjunct) in the Department of Genetics at Yale School of Medicine, with additional affiliations at the Yale Stem Cell Center, Center for RNA Science and Medicine, and the Genomics, Genetics, and Epigenetics program. His research focuses on epigenetic regulation during mammalian development. Dr. Smith received his B.S. in Biology from M.I.T. in 2008 and his Ph.D. in Biology from Harvard University in 2019. His doctoral work focused on applying cutting-edge genomic technologies to understand chromatin dynamics during mammalian development. He joined the Yale Stem Cell Center and Department of Genetics as an Assistant Professor in September 2020. Dr. Smith's research program investigates three critical developmental processes: fertilization, implantation, and gastrulation. His lab seeks to understand how the genome is reconstructed after fertilization, how distinct epigenetic states are established in embryonic versus extraembryonic lineages, and how chromatin regulators orchestrate the complex process of gastrulation. They employ advanced genomic techniques including single-cell sequencing, Cas9-mediated genome editing, and novel molecular recording technologies. His recent publications highlight significant contributions to understanding DNA methylation dynamics in development and disease, X-chromosome biology, and the development of innovative genomic technologies. Dr. Smith's work bridges fundamental developmental biology with potential applications to understanding developmental disorders and cancer. Epigenetic regulation of mammalian development Chromatin dynamics during embryogenesis DNA methylation reprogramming Single-cell genomic analysis Novel molecular recording technologies Dr. Smith's lab collaborates extensively with researchers at Yale and other institutions, including Michael Caplan, Berna Sozen, and Biff Forbush. His interdisciplinary approach combines expertise in genetics, developmental biology, and technology development to address fundamental questions about how epigenetic mechanisms shape development. Students and postdocs in Dr. Smith's lab have opportunities to work at the forefront of developmental epigenetics, gaining expertise in both experimental and computational approaches to studying genome regulation during development.

Marc Boelhauveمشاهده پروفایل

استاد

• Animal Hygiene
• Parasitology
• Multi-resistant Bacteria
• +۳ مورد دیگر

Prof. Dr. Marc Boelhauve is Professor and Dean of the Department of Agricultural Economics at the Faculty of Agriculture in Soest. His research integrates animal hygiene, parasitology, and biotechnology to address challenges in livestock health and antimicrobial resistance. He directs the Laboratory for Genetic Engineering, Microbiology and Molecular Biology, focusing on practical solutions for modern agriculture. Research Focus: Prof. Boelhauve's work spans: Prevention of multi-resistant bacteria in livestock environments Reproductive biotechnology for cattle and swine Optimization of animal hygiene protocols Zoonotic disease transmission dynamics Development of digital tools for herd management His recent publications (2020-2022) demonstrate strong emphasis on: LA-MRSA mitigation strategies in pig farming Calf health optimization to reduce antibiotic usage Rodent control for disease prevention Farmer behavioral factors influencing hygiene compliance Molecular characterization of livestock pathogens Active Research Projects: #1HealthPREVENT: Reducing antimicrobial-resistant pathogens in pig farms Aqua-MRE: Zoonotic pathogen surveillance in aquatic ecosystems Digital Cow 3.0: Health management systems for dairy cattle Biosecurity enhancement in cattle operations Thermal stress management during equine transport

• Virology
• Avian Influenza
• Vaccine Development
• +۳ مورد دیگر

Dr. El-Sayed M. Abd El-Whab is a Researcher at the Institute of Molecular Biology, Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health) in Greifswald, Germany, where he co-leads the Research Group Avian Influenza. His work centers on combatting avian influenza viruses through interdisciplinary approaches. Research Focus: The group investigates: Molecular mechanisms of AIV host adaptation and pathogenicity Reverse genetics for viral mutant generation Recombinant vaccine development (e.g., NDV/HVT-vectored vaccines) Immune evasion strategies in vaccinated poultry Experiments utilize BSL-3+ containment for high-pathogenicity strains. Laboratory: He co-directs the Research Group Avian Influenza, employing in vitro (cell cultures, embryonated eggs) and in vivo (poultry) models to evaluate viral dynamics and vaccine efficacy.

• Developmental Biology
• Vertebrate Biology
• Cell Biology
• +۲ مورد دیگر

Prof. Dr. Virginie Lecaudey serves as Professor and Head of Department at the Institute of Cell Biology and Neuroscience, Department 15 - Life Sciences, Goethe University Frankfurt. She also holds the position of Managing Director of the Institute. Her research focuses on the Developmental Biology of Vertebrates , with particular emphasis on cellular and molecular mechanisms governing embryonic development in vertebrate organisms. Her work bridges cell biology and neuroscience within the context of developmental processes. As Managing Director of the Institute, she oversees research operations and academic activities within the Department of Life Sciences at Goethe University. Her laboratory is specifically affiliated with the Developmental Biology of Vertebrates research group, indicating specialized expertise in this field. Contact information: Email: lecaudey@bio.uni-frankfurt.de Phone: 069/798-42102 Office: 2,218, Biologicum Building Address: Max-von-Laue-Str. 13, 60438 Frankfurt am Main

• Evolutionary Developmental Biology
• Invertebrate Zoology
• Morphology
• +۴ مورد دیگر

Dr. Sandra Treffkorn is a Postdoctoral Researcher in the Department of Zoology at the University of Kassel, Germany. Her research focuses on evolutionary developmental biology of invertebrates, particularly tardigrades (water bears) and onychophorans (velvet worms). Education: 2019: Doctorate (Dr. rer. nat.), University of Kassel, Germany 2012: Master of Science Biology (M.Sc.), University of Leipzig, Germany 2010: Bachelor of Science Biology (B.Sc.), University of Leipzig, Germany Research Interests: Dr. Treffkorn's work lies at the intersection of evolutionary biology, developmental biology, and morphology. She investigates the embryonic development, gene expression patterns, and morphological evolution of tardigrades and onychophorans. Her research employs molecular techniques to understand the genetic basis of development in these ancient invertebrate lineages, providing insights into the evolution of arthropods and other ecdysozoans. Publication Trends: Her recent publications (2013-2022) reveal a strong focus on the embryology and molecular development of tardigrades and onychophorans. Key themes include the expression of developmental genes (such as Hox and NK genes), extra-embryonic tissue formation, miniaturization, and reproductive biology. Her work often compares these two phyla to understand the evolution of developmental mechanisms in Ecdysozoa. Collaboration: Dr. Treffkorn is a key member of the research group led by Prof. Georg Mayer at the University of Kassel, contributing to multiple collaborative projects and publications.

• Placental vascular development
• Cardiac vascular development
• Pregnancy pathologies
• +۵ مورد دیگر

Dr. Jacinta Kalisch-Smith is a BHF Intermediate Fellow and Group Leader at the Institute of Developmental & Regenerative Medicine (IDRM), University of Oxford, where she leads the Kalisch-Smith Lab. Her research focuses on placental and cardiac vascular development in pregnancy pathologies including miscarriage, congenital heart defects, and fetal growth restriction. Dr. Kalisch-Smith's research spans placental vascular development, cardiac vascular formation, and the relationship between placental blood vessels and fetal growth. Her work integrates developmental biology and vascular science to investigate how vascular defects contribute to pregnancy complications. She employs approaches including molecular biology, genetic models, and imaging to study trophoblast-endothelial signaling and placental vascular progenitors. Her recent publication in Development journal synthesizes current knowledge about placental vascular development across species, highlighting how defects in this process correlate with embryonic heart abnormalities and other pregnancy pathologies. This work identifies key research gaps in understanding the molecular mechanisms that regulate feto-placental vascular development. BHF Intermediate Fellowship recipient supporting her five-year research program As a Group Leader at the IDRM, Dr. Kalisch-Smith directs research investigating how placental blood vessels develop to support fetal growth and prevent complications during pregnancy. Her lab collaborates with researchers across Oxford's Department of Physiology, Anatomy and Genetics and the wider university community to advance understanding of developmental processes critical to healthy pregnancy outcomes.

Jens Allmerمشاهده پروفایل

استاد

• Medical Informatics
• Bioinformatics
• Omics Disciplines
• +۵ مورد دیگر

Prof. Dr. Jens Allmer is a full Professor of Medical Informatics and Bioinformatics at Ruhr West University of Applied Sciences (HRW) in Mülheim an der Ruhr, Germany. He previously held academic positions as Cluster Leader at Wageningen University and Research in the Netherlands (2017-2018) and as Assistant and Associate Professor at Izmir Institute of Technology in Turkey (2008-2016). His academic journey began with a PhD in Biology with distinction from the University of Münster in 2006. Prof. Allmer's research spans multiple omics disciplines with a primary focus on microRNA regulation and pathogen-host interactions. He employs machine learning techniques to explore these complex biological systems. His work has evolved from foundational bioinformatics methods to sophisticated integrative analyses, particularly in proteogenomics and computational miRNomics. He has made significant contributions to understanding microRNA detection algorithms, proteogenomic peptide mapping, and the development of comprehensive frameworks for omics data analysis. His recent publications demonstrate a strong trend toward integrative approaches that combine multiple data types, with increasing emphasis on machine learning applications in bioinformatics. The research spans from fundamental database development for noncoding RNAs to clinical applications in disease mechanisms, particularly in HIV infection and cancer pathways. His work shows consistent progression from method development to application in biological and medical contexts. Outstanding Young Scientist in Bioinformatics by the Turkish Academy of Sciences (2010) EMBO Short Term Fellowship Award (2013) DAAD Research Stays for University Academics and Scientists (2013, declined) Outstanding Young Researcher, Turkish Academy of Science (2010) Prof. Allmer has advised numerous doctoral and master's students throughout his career, primarily during his tenure at Izmir Institute of Technology. He has secured substantial research funding, with over 650,000 euros received for his projects. His teaching portfolio includes courses in medical informatics, bioinformatics, data mining, machine learning, and database systems across multiple institutions in Germany, Turkey, and through ERASMUS programs. He maintains active collaborations with researchers across Europe and continues to contribute significantly to both theoretical and applied aspects of bioinformatics.