جستجوی استاد راهنمای دانشگاهی

Harris H. Wangمشاهده پروفایل

دانشیار

• Systems Biology
• Synthetic Biology
• Genome Engineering
• +۱۷ مورد دیگر

Harris H. Wang is an Associate Professor in the Department of Systems Biology and Department of Pathology and Cell Biology at Columbia University's Vagelos College of Physicians and Surgeons, where he also serves as Interim Chair of Systems Biology. He is affiliated with the Center for Computational Biology and Bioinformatics (C2B2) and the Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS). B.S., Physics and Mathematics, MIT Ph.D., Biophysics, Harvard University Dr. Wang's research lies at the intersection of systems and synthetic biology, focusing on developing foundational technologies for genome engineering, microbiome manipulation, and synthetic genomics. His lab pioneers methods such as MAGE, MAGIC, CAST, and CAMII to enable high-throughput genetic manipulation, in situ microbiome engineering, and AI-driven microbial culturomics. Key research themes include understanding microbial community dynamics, engineering cellular memory systems, designing biocontained genetic circuits, and applying synthetic biology to human health challenges in personalized medicine and infectious disease. His recent publications reveal a strong trend in spatial and functional metagenomics, CRISPR-based microbiome editing, and synthetic biology tools for data storage and genetic stability. The articles span high-impact journals like Nature , Science , and Nature Biotechnology , reflecting his leadership in developing scalable, programmable biological systems. Scientific Awards: NIH Director’s Early Independence Award Forbes 30 Under 30 in Science Sloan Research Fellowship NSF CAREER Award ONR Young Investigator Award Burroughs Wellcome Fund PATH Award Schaefer Scholar Blavatnik National Award Vilcek Prize PECASE Dr. Wang has advised numerous PhD and postdoctoral researchers, many of whom have gone on to independent scientific careers. His lab is supported by major grants from NIH, NSF, DARPA, DOE, and foundations including the Bill & Melinda Gates Foundation and CZ Biohub NY. He is actively involved in educational initiatives, including organizing Columbia’s iGEM team and the Cold Spring Harbor Laboratory Synthetic Biology course. The Wang Lab is based at the Columbia University Irving Medical Center and is part of national consortia such as the Engineering Biology Research Consortium (EBRC) and the Genome Project-Write (GP-Write) initiative. The lab develops and applies cutting-edge technologies in automation, machine learning, and synthetic biology to engineer microbiomes for applications in medicine, global health, and climate change.

• Bioelectronics
• Nanotechnology
• CMOS Technology
• +۱۲ مورد دیگر

Sandro Carrara is a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL), where he leads the Bio/CMOS Interfaces (BCI) laboratory. He is affiliated with the School of Engineering (STI), the Institute of Electrical Engineering (SCI-STI-SC), and the Integrated Systems Laboratory (LSI). His academic leadership spans teaching, doctoral supervision, and editorial roles in major journals including IEEE Sensors Journal and BioNanoScience. Education: Diploma in Electronics, National Technical Institute of Albenga, Italy Master in Physics, University of Genoa, Italy PhD in Biochemistry and Biophysics, University of Padua, Italy His research focuses on the integration of biological systems with CMOS technology, particularly in the development of nanoscale biosensors for health monitoring. Key areas include memristive biosensors, wearable and implantable sensors, electrochemical detection, and therapeutic drug monitoring. His work bridges electronics, nanotechnology, and biomedicine to enable point-of-care diagnostics and personalized medicine. His recent publications (2023–2025) show a strong trend toward sustainable printed electronics, machine learning for biosensing, in-memory computing for cancer diagnostics, and remote health monitoring. These works appear in high-impact journals such as IEEE Sensors Journal , Nanoscale , and Biosensors and Bioelectronics: X . Scientific Awards: IEEE Fellow (2015) IEEE Sensors Council Technical Achievement Award (2016) Distinguished Lecturer, IEEE Sensors Council (2017) Best Paper Award, IEEE MeMeA Symposium (2020) Multiple Gold and Bronze Leaf Prizes at PRIME and IEEE conferences Best Poster Awards at EMBEC and Nano-Tera meetings He actively advises PhD students and leads research projects involving CMOS-based biosensors, wireless implants, and smart sensor systems. His lab collaborates widely across disciplines and institutions, focusing on real-world applications in oncology, neurology, and environmental health. He has also contributed to the development of battery-free wearable devices, optical power transfer systems, and IoT-enabled telemedicine platforms. Laboratories and Teams: Bio/CMOS Interfaces (BCI) Laboratory, EPFL Integrated Systems Laboratory (LSI), EPFL Collaborations with IEEE Sensors Council and Circuits and Systems Society Editorial leadership in IEEE Sensors Journal and BioNanoScience

• Machine Learning
• Deep Learning
• Gaussian Processes
• +۵ مورد دیگر

Geoffrey Pleiss is an Assistant Professor in the Department of Statistics at the University of British Columbia's Faculty of Science. He is also a CIFAR AI Chair at the Vector Institute and an inaugural member of CAIDA's AIM-SI (AI Methods for Scientific Impact) cluster. His work bridges statistical theory, machine learning, and computational methods with applications across various scientific domains. Pleiss received his PhD from the Computer Science department at Cornell University in 2020, where he was advised by Kilian Weinberger and worked closely with Andrew Gordon Wilson. Prior to his faculty position at UBC, he was a postdoctoral researcher at Columbia University with John P. Cunningham. His research focuses on the intersection of deep learning and probabilistic modeling, particularly on developing heuristic and approximate notions of uncertainty from machine learning models. His work has significant implications for reliable and optimal decision-making in experimental design and scientific discovery. Major research thrusts include neural network uncertainty quantification, Bayesian optimization, Gaussian processes, and ensemble methods. Pleiss develops theoretical frameworks while maintaining strong connections to practical applications across scientific domains. An analysis of his recent publications reveals a strong focus on uncertainty quantification in deep learning models, with particular attention to the limitations and capabilities of ensemble methods in the era of overparameterized models. His work increasingly addresses practical challenges in Bayesian optimization for scientific discovery, especially in materials science. There's also a growing emphasis on computational efficiency in Gaussian process methods, reflecting his commitment to making advanced statistical techniques accessible for real-world applications. CIFAR AI Chair Pleiss currently advises several graduate students including Donney Fan (PhD, Computer Science), Tim G. Zhou (MSc, Computer Science), Zachary Lau (MSc, Statistics), Nathan Cantafio (BSc, Statistics), and Tristan Cinquin (Research Intern at Vector Institute). His research is supported by multiple funding sources including his CIFAR AI Chair position, which provides significant research resources for advancing machine learning methodologies with scientific impact. Pleiss co-created and maintains GPyTorch, a highly efficient and modular implementation of Gaussian processes in PyTorch designed for speed, modularity, and prototyping. He is also involved with CoLA (Compositional Linear Algebra), a library for structured linear algebra operations in JAX and PyTorch that enables fast linear algebra computations by automatically exploiting matrix structure.

Christopher Weidlichمشاهده پروفایل

استادیار بالینی

• Psychiatric Nursing
• Mental Health Disorders
• Healthcare Provider Well-being
• +۳ مورد دیگر

Christopher Weidlich is an Assistant Professor of Clinical in the School of Nursing and Health Studies at the University of Miami. His academic focus includes psychiatric nursing, mental health education, and healthcare provider well-being. He is involved in research addressing simulation-based education, mental health disorders in occupational groups such as fire investigators, and interventions to improve resilience among healthcare providers. His research interests span simulation modalities in psychiatric nursing education, organizational stigma's impact on mental health service utilization, and substance abuse trends like xylazine adulteration. He has also contributed to studies on military healthcare, including resilience programs for providers and PEMF therapy for chronic pain. Dr. Weidlich’s work is supported by his affiliation with the University of Miami’s School of Nursing and Health Studies, leveraging resources such as the Simulation Hospital Advancing Research and Education (S.H.A.R.E.®) facility. His research emphasizes practical applications in clinical settings and improving patient outcomes through innovative educational and therapeutic approaches.

• Machine Learning
• Deep Learning
• Theoretical Foundations of AI
• +۱۱ مورد دیگر

Mikhail (Misha) Belkin is a Professor at the Halicioglu Data Science Institute (HDSI) at the University of California San Diego , with an affiliated appointment in the Department of Computer Science and Engineering . He is also an Amazon Scholar , reflecting his impactful industry collaboration. Since January 2024, he has served as the Editor-in-Chief of the SIAM Journal on Mathematics of Data Science (SIMODS) . Research Interests: Belkin's research centers on the theoretical foundations of machine learning, particularly the mathematical understanding of modern deep learning. His work investigates interpolation , over-parameterization , and feature learning in neural networks. He is renowned for introducing the double descent risk curve, which reconciles classical bias-variance trade-offs with the success of overfitted models. His recent work identifies the Average Gradient Outer Product (AGOP) as a fundamental mechanism of feature learning, applicable across architectures like CNNs and transformers. Scientific Contributions and Trends: His recent publications, appearing in Science , PNAS , and NeurIPS , demonstrate a strong trend toward unifying theories of generalization and optimization in over-parameterized systems. He explores how interpolating models can be statistically optimal, how gradient descent converges in non-convex landscapes via the PL* condition, and how kernel methods can be enhanced to perform feature learning. ACM Fellow (2023) Editor-in-Chief, SIAM Journal on Mathematics of Data Science (2024–present) Advising and Grants: Belkin actively mentors students and collaborators such as Adityanarayanan Radhakrishnan , Daniel Beaglehole , and Chaoyue Liu , who are frequent co-authors. He is a Principal Investigator (PI) in the Collaboration on the Theoretical Foundations of Deep Learning , funded by the NSF and Simons Foundation. He is also an external collaborator with the Eric and Wendy Schmidt Center at the Broad Institute and part of the NSF-funded TILOS AI Institute . Laboratories and Teams: While not explicitly named, his research group at UCSD is deeply involved in theoretical machine learning, focusing on the intersection of statistics, optimization, and deep learning. His work often involves large-scale collaborations and is closely tied to initiatives like SIMODS and TILOS.

Ambuj K. Singhمشاهده پروفایل

استاد

• Machine Learning
• Social Networks
• Network Science
• +۷ مورد دیگر

Ambuj K. Singh is a Distinguished Professor of Computer Science at the University of California, Santa Barbara (UCSB), with a part-time appointment in the Biomolecular Science and Engineering Program. He holds a PhD from the University of Texas at Austin (1989), an MS from Iowa State University (1984), and a BTech from the Indian Institute of Technology, Kharagpur (1982). His campus affiliations include the Center for Bio-Image Informatics, Information Network Academic Research Center, and IGERT on Network Science. PhD, University of Texas at Austin, 1989 M.S., Iowa State University, 1984 B.Tech., Indian Institute of Technology, Kharagpur, 1982 Research interests span network science, machine learning, and bioinformatics, with a focus on graph-based methodologies. His work addresses: Data-centric modeling of dynamic networks Representation learning and explainability in graph neural networks Network analysis in social systems and biological networks Applications in drug discovery and brain sciences Geometry-preserving distance metrics for data integrity Recent publications highlight advancements in counterfactual explanations, GNN benchmarking, molecular graph pretraining, and self-attention for event detection. Scientific contributions include: Founding Acelot, Inc., an in silico drug discovery company Editorial roles at IEEE Transactions on Knowledge & Data Engineering and BMC Journal of Clinical Bioinformatics NSF-IGERT (2013-2018), ARL-funded Information Networks Academic Research Center (2009-2014), and US Army MURI grants Advising has involved mentoring over 50 graduate/postdoctoral students, including 30+ PhD candidates. He leads a multidisciplinary research group at UCSB and collaborates with off-campus entities like Acelot, Inc.

David R. Koesمشاهده پروفایل

دانشیار

• Computational Drug Discovery
• Machine Learning in Biology
• Open Source Software
• +۳ مورد دیگر

David R. Koes is an Associate Professor in the Department of Computational and Systems Biology at the University of Pittsburgh, affiliated with the School of Medicine. He holds roles such as Associate Director of the Joint CMU-Pitt Computational Biology PhD Program (CPCB) and is involved in multiple graduate programs including Intelligent Systems and Computational Biomedicine. His research focuses on developing computational algorithms and systems for drug discovery, emphasizing open-source software and machine learning applications in biomedical data. Koes teaches courses like MSCBIO2025 (Bioinformatics Programming in Python) and MSCBIO2065 (Scalable Machine Learning for Big Data Biology). He has secured NIH funding (R35GM140753) and collaborated on projects with institutions like NVIDIA and Google Cloud. His lab develops tools such as GNINA, Pharmit, and 3Dmol.js, and actively contributes to open drug discovery initiatives. Education: PhD in Computer Science from Carnegie Mellon University (CMU). Research Interests: Leveraging computation and AI for drug design, molecular docking, pharmacophore modeling, and open science. Specific areas include developing scalable machine learning pipelines, virtual screening systems, and tools for 3D molecular analysis. Grants and Funding: Current NIH R35 grant and prior support from NSF, Relay Therapeutics, and others. His work emphasizes translating computational methods into practical drug discovery solutions. Lab and Teams: Directs a lab focused on computational drug discovery, collaborating with multiple academic and industry partners. Supervises graduate students and postdocs in projects spanning AI-driven drug design, molecular modeling, and software development.

• Microbiology
• Biochemistry
• Synthetic and systems biology
• +۸ مورد دیگر

Tanja Narancic is an Assistant Professor at the School of Biomolecular and Biomedical Science at University College Dublin (UCD). She is also an academic collaborator at the Bioeconomy Research Centre BiOrbic, where she coordinates multiple research projects among PIs, PostDocs, PhD students, and designs projects proposed by industrial partners. Dr. Narancic earned her PhD in Applied Microbiology from the University of Belgrade, Serbia in 2012, followed by postdoctoral research at the Institute of Molecular Genetics and Genetic Engineering in Belgrade. In 2013, she joined University College Dublin as a Postdoctoral Research Fellow under Prof. Kevin O'Connor, where she investigated microbial metabolic pathways using proteomics, metabolomics, and synthetic biology tools as part of FP7 and H2020 projects. She became a Research Fellow at BiOrbic in 2019 before advancing to her current position as Assistant Professor. Her research focuses on elucidating bacterial metabolism and leveraging synthetic biology tools to exploit bacteria for producing high-value products. Key research areas include: Proteomics, Metabolomics, and Transcriptomics for microbial pathway analysis Metabolic engineering for bioproduction Biocatalysis and enzyme optimization Protein engineering and purification Polyhydroxyalkanoate (PHA) production from waste streams Plastic upcycling and biodegradation technologies Dr. Narancic's publication record demonstrates a strong focus on converting plastic waste into valuable biodegradable materials through innovative biotechnological approaches. Her recent work has centered on developing microbial systems for upcycling polyethylene terephthalate (PET), polyolefins, and other recalcitrant plastics into polyhydroxyalkanoates (PHAs) and other high-value products. She has made significant contributions to understanding the metabolic pathways involved in plastic monomer conversion and has developed engineered strains with enhanced capabilities for plastic upcycling. As a principal investigator, Dr. Narancic leads multiple significant research projects including the Ad Astra Studentship (2023-2028), the UPLIFT project on sustainable plastics for food packaging (2021-2025), and the PROMOFER project (2024-2028) on optimizing PHB production. She also serves as a reviewer for numerous prestigious journals including Enzyme and Microbial Technology, Journal of Applied Microbiology, and Microbial Biotechnology. Her teaching portfolio includes coordination of multiple modules such as Bioprocessing, Metabolism and Disease, and SynBio for Bioeconomy, demonstrating her commitment to educating the next generation of scientists in both fundamental and applied aspects of biomolecular science.

Kora DeBeckمشاهده پروفایل

استاد

• Substance Use
• Drug Policy
• Health Policy
• +۳ مورد دیگر

Kora DeBeck is a Distinguished Professor of Substance Use and Drug Policy in the School of Public Policy at Simon Fraser University, a CIHR Applied Public Health Chair, and Dorothy Killam Fellow. She is also a Research Scientist with the BC Centre on Substance Use and Principal Investigator of the At-Risk Youth Study (ARYS), a longitudinal cohort tracking over 1,200 street-involved youth. Her research focuses on substance use policy, health services for marginalized populations, and the structural drivers of drug-related harms. She has published over 200 peer-reviewed articles challenging ineffective drug enforcement models and advocating for policy reforms. Recent publications analyze trends in opioid use, harm reduction during the COVID-19 pandemic, drug decriminalization, and youth-focused interventions. Her work consistently addresses social inequities through data-driven approaches to the toxic drug crisis. CIHR Applied Public Health Chair Dorothy Killam Fellow Michael Smith Health Research BC Scholar Award Distinguished SFU Professorship She has secured over $50 million in research funding, including $21M as principal investigator for ARYS. Her lab collaborates with healthcare providers, community organizations, and policymakers to translate research into practice.

David S. Eisenbergمشاهده پروفایل

استاد

• Protein Aggregation
• Amyloid Structures
• Prion Diseases
• +۵ مورد دیگر

David S. Eisenberg is a Professor of Chemistry and Biochemistry and Biological Chemistry at the University of California, Los Angeles, where he also serves as Director of the UCLA-DOE Institute for Genomics and Proteomics and as an HHMI Investigator. His research focuses on protein interactions, particularly the structural basis for conversion of normal proteins to the amyloid state and conversion of prions to the infectious state. Dr. Eisenberg earned his undergraduate degree in biochemical sciences from Harvard College and his D.Phil. degree in theoretical chemistry from Oxford University on a Rhodes Scholarship. His postdoctoral research was on ice and water with Walter Kauzmann at Princeton and in protein crystallography with Richard Dickerson. He joined the UCLA faculty after his postdoctoral studies. Dr. Eisenberg and his research group focus on protein interactions in amyloid and prion diseases. These diseases involve protein aggregation where normal functional proteins convert to abnormal aggregated forms. Systemic amyloid diseases like dialysis-related amyloidosis result from fiber accumulation until organ failure, while neurodegenerative diseases like Alzheimer's, Parkinson's, ALS, and prion conditions appear to be caused by smaller oligomers. In 2005, his team determined the atomic-level structure for the amyloid fiber spine, revealing a 'steric zipper' of two parallel beta sheets packed across a dry interface. Since then, they've determined approximately 90 amyloid spines from 15 disease-related proteins. In 2010, they identified the structure of a toxic amyloid-related oligomer consisting of six anti-parallel beta strands forming a cylindrical barrel. His recent publications demonstrate continued innovation in amyloid research, with focus areas including structural prediction of amyloid formation, mechanisms of tau fibril disassembly in Alzheimer's disease, cryo-EM analysis of amyloid polymorphism, and structure-based design of inhibitors for amyloid toxicity. His work integrates computational, structural, and biochemical approaches to understand protein aggregation across multiple disease contexts. Dr. Eisenberg has received numerous prestigious awards and honors: National Academy of Sciences Member American Philosophical Society Member Institute of Medicine Member Howard Hughes Medical Institute Investigator Biophysical Society Emily M. Gray Award Harvard Westheimer Medal UCLA Seaborg Medal Technion - Israel Institute of Technology Harvey Prize in Human Health As Director of the UCLA-DOE Institute for Genomics and Proteomics and an HHMI Investigator, Dr. Eisenberg leads significant research initiatives in protein structure and aggregation. His laboratory combines X-ray crystallography, bioinformatics, and biochemical techniques to investigate protein interactions, with particular emphasis on amyloid-forming proteins and their role in disease. The Eisenberg Lab, located in Boyer Hall at UCLA, maintains an active research program investigating the structural basis of protein aggregation. The lab continues to build on its landmark discoveries of amyloid structures while exploring new frontiers in understanding protein misfolding diseases and developing potential therapeutic interventions.

John P.A. Ioannidisمشاهده پروفایل

استاد

• Meta-research
• Evidence-based Medicine
• Research Reproducibility
• +۱۲ مورد دیگر

John P.A. Ioannidis is the C.F. Rehnborg Professor in Disease Prevention and Professor of Medicine, Health Research and Policy, Biomedical Data Science, and Statistics at Stanford University. He is Co-Director of the Meta-Research Innovation Center at Stanford (METRICS) and an Einstein BIH Visiting Fellow at Charité - Universitätsmedizin Berlin. His academic appointments span multiple departments and institutes at Stanford, including the Stanford Prevention Research Center, Biomedical Data Science, and Statistics. He is internationally recognized for his work in meta-research, evidence-based medicine, and research reproducibility. Ioannidis holds an MD and DSc in Biopathology from the National University of Athens, with training in internal medicine and infectious diseases from Harvard and Tufts. He previously chaired the Department of Hygiene and Epidemiology at the University of Ioannina Medical School and held adjunct positions at Harvard, Tufts, and Imperial College. He joined Stanford in 2010, where he launched the PhD program in Epidemiology & Clinical Research, the MS in Community Health & Prevention Research, and METRICS in 2014. His research focuses on improving research methods, appraising biases, enhancing reproducibility, and integrating evidence across scientific disciplines. He is a pioneer in meta-research, with seminal contributions on the reliability of published findings, statistical practices, and research synthesis. His influential 2005 paper, "Why Most Published Research Findings Are False," is the most-accessed article in PLoS history. His recent work examines peer review, data sharing, AI in medicine, and pandemic research impact, consistently advocating for transparency and methodological rigor. His publications span epidemiology, statistics, genomics, clinical trials, and meta-analysis, with a strong emphasis on bias detection, replication, and open science. Trends in his recent articles highlight concerns about research integrity, citation practices, peer review reform, and the scientific response to global health crises. Founders' Medal for Lifetime Contributions to Meta-science (2024) Honorary doctorates from McMaster, Thessaloniki, Edinburgh, Tilburg, Athens, and Rotterdam Elected member, US National Academy of Medicine (2018) Elected member, European Academy of Sciences and Arts (2015) President, Association of American Physicians (2023–2024) President, Society for Research Synthesis Methodology Gordon Award, NIH (2019) Chanchlani Global Health Award (2017) Highly Cited Researcher (Clarivate) in Clinical Medicine, Social Sciences, and Psychiatry Ioannidis has advised numerous students and mentored early-career researchers. He has served as Senior Advisor for Knowledge Integration at the National Cancer Institute (2012–2016) and Editor-in-Chief of the European Journal of Clinical Investigation (2010–2019). He has received over 700 invited lectures and is deeply involved in shaping research policy and scientific infrastructure. He leads METRICS, a hub for meta-research innovation, and is affiliated with multiple Stanford institutes, including Bio-X, the Cardiovascular Institute, and the Stanford Cancer Institute.

Vasilis Ntziachristosمشاهده پروفایل

استاد

• Biomedical Imaging
• Optoacoustic Imaging
• Medical Diagnostics
• +۳ مورد دیگر

Prof. Vasilis Ntziachristos is a Professor and Chair of Biological Imaging at the Technical University of Munich (TUM), leading the Institute of Biological and Medical Imaging at the Helmholtz Centre Munich. His research focuses on developing novel optical and optoacoustic imaging techniques for early disease detection, diagnostics, and theranostics. He holds a PhD in Bioengineering from the University of Pennsylvania and previously served as an Assistant Professor at Harvard University and Massachusetts General Hospital. Affiliations: TUM School of Medicine and Health, Helmholtz Munich, Institute of Biological and Medical Imaging. Key Research Themes: Non-invasive imaging methods, molecular imaging, optoacoustic technology, and clinical translation. His work bridges theoretical developments with clinical applications, including advancements in glucose monitoring, cancer imaging, and drug delivery systems. Notable awards include the Leibniz Prize (2013) and the World Molecular Imaging Society Gold Medal (2015). Labs/Teams: Imaging to Sensing I2S, Optoacoustic Mesoscopy, Fluorescence Imaging, and AI in Optoacoustics. Grants/Projects: Involvement in Horizon Europe initiatives and collaborations with TranslaTUM and Helmholtz Munich. Prof. Ntziachristos actively contributes to education via courses like 'Biological Imaging' and 'Introduction to Bioengineering', fostering the next generation of imaging scientists.

Rotem Karniمشاهده پروفایل

دانشیار

• Alternative RNA Splicing
• RNA Biology
• Cancer Therapy
• +۴ مورد دیگر

Rotem Karni, PhD, is an Associate Professor of Genetics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He leads a research lab focused on understanding how alternative RNA splicing contributes to cancer and genetic diseases, with a strong emphasis on translating these findings into RNA-based therapies. Karni's lab develops decoy oligonucleotides, small molecules, and splice-switching technologies to modulate splicing factors and enhance immunotherapy. Education BSc in Biological Chemistry from The Hebrew University of Jerusalem (1997) PhD in Biological Chemistry from The Hebrew University of Jerusalem, Israel (2002) Postdoctoral Fellowship at Cold Spring Harbor Laboratory, NY (2002-2007) Karni's research explores the deregulation of alternative splicing in oncogenesis, particularly how splicing factors like RBFOX2 and S6K1 influence metastasis, DNA repair, and immune checkpoint modulation. His team investigates m6A RNA modifications for stabilizing mutant genes, with applications in Duchenne Muscular Dystrophy and pancreatic cancer. The lab's work is commercialized through biotech companies: SKIP Therapeutics, Andlit Therapeutics, and RNAble. Selected Research Trends RNA mis-splicing and neoantigen generation (2025) Splicing factor inhibition for tumor suppression (2023) Metastatic splicing signatures in pancreatic cancer (2023) Immune checkpoint splicing in cancer immunotherapy (2021) m6A modulation for mRNA stabilization (2023) Advising & Collaborations Karni has mentored numerous PhD and postdoctoral researchers, many of whom now hold leadership roles in academia, biotech, and medical institutions globally. His lab collaborates extensively on projects involving RNA innovation, including partnerships with the Institute for RNA Innovation. Contact Department of Genetics & Institute for RNA Innovation, One uCity Square, Room 4018, Philadelphia, PA 19104 Phone: 215-898-5072 Email: Rotem.Karni@Upenn.edu

• Longitudinal Data Analysis
• Time-to-Event Analysis
• Survival Analysis
• +۵ مورد دیگر

Alessandra Meddis serves as an Assistant Professor in the Section of Biostatistics within the Department of Public Health at the University of Copenhagen's Faculty of Health and Medical Sciences. Her academic work centers on developing and applying advanced statistical methodologies for longitudinal and time-to-event data analysis, with significant contributions to public health research in Denmark and internationally. Her institutional affiliation is clearly established through university contact details and departmental listings. Her primary research interests include correlated survival data analysis, competing risk modeling, informative cluster size methodology, causal inference techniques for observational studies, and environmental epidemiology applications. Dr. Meddis has developed specialized expertise in handling complex survival data structures while maintaining focus on real-world public health problems, particularly in HIV comorbidity patterns, environmental exposure effects, and pandemic-related mortality analyses. Her methodological innovations directly address challenges in clustered and censored data common across medical research domains. Analysis of Dr. Meddis's recent publication record reveals a consistent trajectory of high-impact interdisciplinary research spanning clinical medicine, epidemiology, and statistical methodology. Her work appears in leading journals across biostatistics, infectious diseases, and public health, demonstrating strong collaborative networks with clinical researchers and epidemiologists. Key thematic areas include HIV treatment outcomes, environmental health exposures, and critical care applications during the pandemic, with recent methodological papers advancing survival analysis techniques for complex data structures. Scientific Awards: No scientific awards were specified in the available institutional profile. Advising and Grants: The institutional profile does not provide details regarding graduate student supervision or specific research grant funding. Her collaborative publications suggest involvement in multi-investigator projects including the COCOMO HIV cohort study and pandemic-related research initiatives. Labs and Teams: Dr. Meddis is affiliated with the Section of Biostatistics within the Department of Public Health, though specific laboratory facilities or dedicated research teams are not described in the source material. Her extensive co-authorship patterns indicate active participation in multiple research consortia across medical specialties.

Virgil Percecمشاهده پروفایل

استاد

• Organic Chemistry
• Supramolecular Chemistry
• Nanotechnology
• +۴ مورد دیگر

Virgil Percec is the P. Roy Vagelos Professor of Chemistry at the University of Pennsylvania, affiliated with the School of Arts & Sciences and the Department of Chemistry. His research focuses on organic, supramolecular, and macromolecular chemistry, with an emphasis on self-assembly, drug delivery systems, and biomimetic nanosystems. He holds a B.S. and Ph.D. from institutions in Jassy, Romania, and conducted postdoctoral research at the University of Freiburg and the University of Akron. Research Interests: Percec’s work integrates synthetic methods, catalysis, and structural biology to design functional nanosystems. Key areas include hierarchical folding, supramolecular chirality, and synthetic mimics of biological membranes. His lab explores mRNA delivery systems using Janus dendrimers and studies self-organized structures like helical columns and quasicrystals. Recent Articles: His recent publications highlight advancements in mRNA delivery mechanisms, supramolecular architectures, and polymer synthesis innovations. The group’s work often involves interdisciplinary collaborations, bridging chemistry, materials science, and bioengineering. Awards: Percec was elected a Foreign Member of the Academia Europaea (2020) and delivered the inaugural ACS Kavli Lecture (2011). His lab has trained numerous students and postdocs, including Juncheng Lu (Master’s Capstone Award recipient) and Devendra Maurya (SET-LRP research). Labs & Teams: The Percec Research Laboratory at Penn develops cutting-edge biomaterials and supramolecular systems. The group collaborates globally, with projects funded by grants exploring nanotechnology and drug delivery.