جست‌وجوی استاد و پژوهشگر

• Epigenetics
• Retroelements
• Transposable elements
• +۵ مورد دیگر

Didier Trono is a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL), where he leads the Laboratory of Virology and Genetics (LVG) within the School of Life Sciences. Formerly, from 2004 to 2012, he served as the founding dean of EPFL's Faculty of Life Sciences, orchestrating its development and growth during this formative period. Trono received his medical education at the University of Geneva, followed by clinical training in pathology, internal medicine, and infectious diseases in Geneva and at Massachusetts General Hospital in Boston. His scientific career began at the Whitehead Institute of MIT, and in 1990 he was recruited by the Salk Institute of San Diego to launch an AIDS research center. After seven years in the United States, he returned to Europe and eventually joined EPFL. Dr. Trono's research has evolved significantly over his career. Initially focusing on virus-host interactions, he studied pathogens like HIV and Hepatitis B virus, creating HIV-derived genetic transfer tools that are now successfully used in gene therapy. For approximately the last fifteen years, his research has centered on epigenetics, particularly exploring the impact of retroelements and their control mechanisms on development and physiology of higher organisms, including humans. His laboratory investigates how transposable elements and KRAB zinc finger proteins regulate gene expression, with important implications for understanding cancer biology and developing new diagnostic and therapeutic approaches. Analysis of his recent publications (2022-2024) reveals a strong focus on transposable elements, KRAB zinc finger proteins, and their roles in gene regulation and cancer. His work combines molecular biology, genomics, and bioinformatics approaches to understand how these ancient viral remnants have been co-opted by the host genome to regulate development and cellular functions. The research spans basic molecular mechanisms to potential clinical applications in cancer diagnosis and therapy, with some recent work also addressing SARS-CoV-2 and immune responses. Throughout his career, Professor Trono has mentored numerous PhD students, including Bojkowska Karolina, Brandão Sanches Vong Martins Filipe Amândio, Bulliard Yannick, Coluccio Andrea, Corsinotti Andrea, Coudray Alexandre, De Tribolet-Hardy Jonas Caspar, and Dorschel Iris Arianna. His laboratory has received significant funding to support research at the intersection of virology, genetics, and epigenetics, contributing to EPFL's reputation as a leading institution in life sciences research. The Trono Laboratory continues to be at the forefront of research on retroelements and their regulatory mechanisms, maintaining a vibrant research environment that bridges fundamental biological questions with potential medical applications, particularly in cancer research and precision medicine.

Thomas Walzمشاهده پروفایل

استاد

• Membrane Biology
• Structural Biology
• Cryo-electron Microscopy
• +۵ مورد دیگر

Thomas Walz, PhD, is a Professor at The Rockefeller University and Head of the Laboratory of Molecular Electron Microscopy. Previously, he held positions as Assistant, Associate, and Professor at Harvard Medical School (1999–2015) and was an Investigator at the Howard Hughes Medical Institute (2008–2015). He earned his PhD and BS in biophysics from the University of Basel, Switzerland, and completed postdoctoral research at the University of Sheffield. Walz completed his education at the Biozentrum, University of Basel, Switzerland, where he received his Diploma in Biophysics (1992) and PhD in Biophysics (1996). He furthered his training as a postdoctoral researcher at the University of Sheffield (1996–1999). His research focuses on understanding membrane-related processes and the structural biology of membrane proteins in lipid environments. Utilizing cryo-electron microscopy and nanodisc technology, he investigates how lipid bilayers influence membrane protein structure and function. Key areas include mechanosensitive channels, T-cell receptor dynamics, and telomere maintenance mechanisms. Collaborations with the de Lange lab explore the CST-Polα/primase complex's role in telomere regulation. Walz has been recognized with the Genzyme Award for Outstanding Achievement in Biomedical Sciences (2004) and continues to contribute to advancements in structural biology and membrane protein research. While specific student advisees are not listed, Walz actively mentors through his roles in the David Rockefeller Graduate Program and Tri-Institutional programs. His research is supported by grants and institutional funding, though specific grants are not detailed here. He directs the Laboratory of Molecular Electron Microscopy at Rockefeller, a hub for innovative structural biology and membrane protein studies. The lab collaborates widely, integrating cryo-EM with electrophysiology and molecular dynamics simulations.

• Virology
• Molecular Biology
• Genomics
• +۶ مورد دیگر

James Van Etten is the William Allington Distinguished Professor of Plant Pathology at the University of Nebraska-Lincoln, affiliated with the School of Biological Sciences and Nebraska Center for Virology. His research focuses on chloroviruses—large dsDNA viruses infecting Chlorella-like algae—with emphasis on DNA replication, restriction systems, and membrane transport proteins. Key research themes include: Viral DNA modification systems Host-virus interactions Structural virology Evolution of organellar genomes Recent work analyzed: SMRT sequencing of viral methylation patterns Chlorovirus cryopreservation methods Potassium channel biophysics Host chemical signaling mechanisms Lab webpage: vanettenlab.unl.edu

Jacques Archambaultمشاهده پروفایل

استاد

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +۴ مورد دیگر

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

Urs F. Greberمشاهده پروفایل

استاد

• Virology
• Molecular Cell Biology
• Virus-Host Interactions
• +۸ مورد دیگر

Prof. Dr. Urs F. Greber is an Ordinary Professor of Molecular Cell Biology at the Department of Molecular Life Sciences, Faculty of Mathematics and Natural Sciences, University of Zurich. His research focuses on understanding how viruses interact with host cells, particularly adenoviruses and rhinoviruses that cause human respiratory diseases. He leads the Greber Lab, which investigates viral entry mechanisms, replication processes, and the cellular responses to infection. Greber's research interests span virology, molecular cell biology, and infection mechanisms. His lab explores how viruses take control over membrane and lipid functions, cytoplasmic transport processes, and cellular metabolism to support their gene expression and progeny formation. They employ system-wide profiling, molecular cell biology approaches, light microscopy, and machine learning for image analysis to map the cell state underlying viral infections of cultured and primary human cells, including lung organoids and iPSC-derived macrophages. A key focus is understanding cell-to-cell variability in infection phenotypes and the mode-of-action of antiviral compounds. The Greber Lab has published extensively on adenovirus biology, including viral entry, uncoating, nuclear import, and assembly mechanisms. Their recent work has identified broad-spectrum antiviral compounds, elucidated alternative virus entry pathways, and developed innovative imaging and AI-based approaches for quantifying virus infectivity. Their research contributes to understanding how viruses break down host defense barriers and has implications for antiviral therapy development. Greber has supervised numerous PhD and Master's students including Cornelia Bircher, Alessandro Savi, Franziska Tomas, Alfonso Gomez-Gonzalez, Anthony Petkidis, and Dominik Olszewski. His lab has received funding from the Swiss National Science Foundation, including a grant for coronavirus research during the pandemic. The lab actively collaborates with other research groups at University of Zurich, ETH Zurich, and international institutions. Current projects include exploring how viral DNA interactions contribute to infection outcome variability, investigating adenovirus egress mechanisms, and developing high-throughput screening methods for antiviral compounds.

Ralph Bockمشاهده پروفایل

استاد

• Plant Molecular Biology
• Chloroplast Biology
• Organelle Biotechnology
• +۷ مورد دیگر

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

Joshua J. Coonمشاهده پروفایل

استاد

• Bioanalytical Chemistry
• Mass Spectrometry
• Proteomics
• +۴ مورد دیگر

Joshua J. Coon is a Professor at the University of Wisconsin-Madison with appointments in the Department of Biomolecular Chemistry and the Department of Chemistry. He leads the Coon Group, focusing on advancing mass spectrometry technologies for proteomics, metabolomics, and lipidomics. His research addresses fundamental questions in cell biology, including stem cell differentiation, epigenetic regulation, and cancer biomarker discovery. Affiliations : Director of the NIGMS National Center for Quantitative Biology of Complex Systems. Research Emphasis : Instrumentation development, data analysis software, ion chemistry, and biological applications of proteomics. Laboratory : Located in the Genome Center of Wisconsin with a dozen hybrid mass spectrometers, including Orbitrap systems. Collaborations : Long-term partnership with Thermo Fisher Scientific and the Wisconsin Alumni Research Foundation (WARF) for technology commercialization. Training : Mentored 27 Ph.D. students since 2009, emphasizing interdisciplinary research and professional development.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

• Virology
• Molecular Pathology
• Host-Pathogen Interactions
• +۵ مورد دیگر

Dr. Richard Y. Zhao is a tenured Professor in the Department of Pathology and Microbiology-Immunology at the University of Maryland School of Medicine. His research combines molecular biology, fission yeast genetics, mammalian biology, and virology to study virus-host interactions, particularly for HIV and Zika virus. He previously held academic positions at Northwestern University and Columbia University and has contributed to over 120 peer-reviewed articles. B.S., China Oceanography University (1981) M.S., Oregon State University (1995) Ph.D., Oregon State University (1991) Postdoctoral Training, Columbia University (1991-1992) Dr. Zhao's research focuses on: Virus-host interactions and pathogenicity High-throughput drug screening for antivirals Role of viral proteins in neuroinflammation and cancer Translational genomics in precision medicine His recent publications highlight SARS-CoV-2 ORF3a, Zika envelope proteins, and HIV protease inhibitors, emphasizing host-pathogen mechanisms across species. He has served on NIH panels and editorial boards for journals like Cell Research and Retrovirology . Scientific awards include: Fellow, American Academy of Microbiology (2019) Bernard L Mirkin Endowed Chair (2001-2004) Honorary Director, Shandong Gallo Institute (2009) Distinguished Service from SCBA (2015) Outstanding Service from CBA-USA (2016) Dr. Zhao also contributes to clinical diagnostics and personalized medicine through molecular testing and pharmacogenetics programs.

Julia Chamot-Rookeمشاهده پروفایل

پژوهشگر

• Proteomics
• Structural Biology
• Mass Spectrometry
• +۷ مورد دیگر

Julia Chamot-Rooke is a Principal Investigator and Researcher at the Institut Pasteur in Paris, France, affiliated with the Department of Structural Biology and Chemistry and the Mass Spectrometry for Biology unit (UTechS MSBio), a joint CNRS service and research unit (USR2000). She leads multiple projects in advanced proteomics and is the PI for the Institut Pasteur in the European Proteomics Infrastructure Consortium providing access (EPIC-XS). Her research focuses on developing innovative methods in top-down proteomics , cross-linking mass spectrometry , and structural proteomics to study intact proteins, post-translational modifications, and protein complexes. Her work has applications in microbiology, infectious diseases, and host-pathogen interactions. She has developed the ProteoCombiner software to integrate proteomics data for improved proteoform characterization. The recent publications reflect a strong emphasis on structural and functional proteomics , particularly in microbial systems and immune interactions. Trends include the use of advanced mass spectrometry techniques (HDX-MS, cross-linking MS, top-down MS) to investigate protein structure, dynamics, and interactions in pathogens and host systems. There is also a growing focus on software and tool development to enhance data analysis and reproducibility in proteomics. Principal Investigator, EPIC-XS at Institut Pasteur Coordinator, Joint Research Activity on Future and Emerging Proteomics Technologies Lead Developer, ProteoCombiner software She supervises PhD students and research engineers and collaborates widely on projects involving bacterial pathogenesis, immune evasion, and structural biology. Her lab is equipped with state-of-the-art Orbitrap mass spectrometers and participates in transnational access programs, providing cutting-edge proteomics services to the European research community.

• Genomic Instability
• DNA Replication and Repair
• Computational Biology
• +۵ مورد دیگر

Dr Michael Boemo is an Assistant Professor at the University of Cambridge, holding dual appointments in the Department of Pathology and Department of Genetics. He leads research at the intersection of computational biology, DNA replication, and cancer genomics, developing machine learning tools to analyze replication stress and genomic instability. Academic Background: BA in Mathematics (Rutgers University), PhD in Physics (University of Oxford) Research Focus: Genomic instability in cancer, DNA replication/repair defects, computational modeling using machine learning and high-performance simulations Teaching: Lectures in Natural Sciences Tripos (mathematical biology, genetics, systems biology), module organizer for cancer biology and biological modeling His research group leverages nanopore sequencing and AI to map replication fork dynamics, revealing how stalled forks generate mutations in cancer cells and pathogens. Recent work examines extrachromosomal DNA replication vulnerabilities and transcription-replication conflicts. Dr Boemo collaborates across computational biology and cancer research domains, with publications spanning journals like Nature Methods, Cell, and PLoS Computational Biology. His lab develops tools such as DNAscent for replication fork analysis and explores therapeutic targeting of replication stress.

• Structural Biology
• Biophysics
• Notch Signaling
• +۷ مورد دیگر

Wendy R Gordon serves as an Associate Professor in the Structural Biology and Biophysics department at the University of Minnesota Medical School. Her research program bridges structural biology, biophysics, and translational medicine with significant funding from NIH sources including the National Cancer Institute and National Institute of General Medical Sciences. Dr. Gordon leads multiple active research projects focused on mechanobiology, protein engineering, and cancer therapeutics. Dr. Gordon's research interests center on understanding molecular mechanisms of cell surface receptors, particularly the Notch signaling pathway, and developing innovative tools for studying cellular mechanics. Her work spans structural biology approaches to characterize protein-DNA interactions, mechanotransduction mechanisms, and receptor regulation. She has developed novel technologies including HUH-Tags for protein-DNA labeling and tension sensors for measuring cellular forces. Her research has significant implications for cancer immunotherapy, particularly in engineering protein modulators of Notch activation for CAR T-cell therapy. Analysis of Dr. Gordon's recent publications reveals a strong focus on three interconnected research themes: 1) molecular mechanisms of Notch signaling and receptor regulation, 2) development of innovative tools for protein-DNA conjugation and cellular mechanotype measurement, and 3) applications of these technologies to cancer biology and immunotherapy. Her work demonstrates increasing integration of structural biology with functional cellular assays and therapeutic applications, particularly in tumor microenvironment and immunotherapy contexts. Dr. Gordon currently leads or collaborates on seven major research projects totaling millions in NIH funding. Her active grants include: LUMICKS C-trap for Mechanistic Studies of Biological Systems (as PI), Engineering Protein Modulators of Notch Activation for CAR T-cell immunotherapy (as CoI), Viral vector technology for cell type specific gene delivery (as CoI), Decoding mechanotransduction mechanisms of cell-surface receptors (as PI), and the Center for Multiparametric Imaging of Tumor Immune Microenvironments (as CoI). These projects reflect her expertise spanning structural biology, mechanobiology, and translational applications. Dr. Gordon's laboratory operates at the intersection of structural biology and cellular mechanobiology, with strong collaborations across the University of Minnesota campus including with cancer researchers, bioengineers, and clinicians. Her team develops and applies cutting-edge technologies including single-molecule techniques, protein engineering approaches, and high-throughput cellular mechanotype measurement systems to address fundamental questions in receptor biology with therapeutic implications.

Christopher S. Sullivanمشاهده پروفایل

استاد

• Virology
• Non-coding RNA Biology
• RNA Interference
• +۵ مورد دیگر

Christopher S. Sullivan is a Professor in the Department of Molecular Biosciences within the College of Natural Sciences at the University of Texas at Austin. He directs an active research laboratory focused on viral non-coding RNA biology and host-pathogen interactions, with continuous funding evidenced by publications spanning 2005-2025. His work bridges molecular virology, immunology, and RNA biology through investigations of tumor viruses and host defense mechanisms. Research interests center on the role of non-coding RNAs in viral infection and host defense pathways, with particular emphasis on viral microRNAs , RNA interference mechanisms , and host-pathogen coevolution . His lab studies diverse virus families including Polyomaviridae, Herpesviridae, Retroviridae, and avipoxviruses, with key discoveries regarding viral miRNA functions in tumorigenesis and immune evasion. Research approaches integrate molecular virology, next-generation sequencing, and computational analysis to dissect RNA-based regulatory networks. Publications reveal consistent focus on viral non-coding RNA functions, particularly how viruses exploit host RNA machinery (notably DUSP11 phosphatase) to modulate immune responses. Recent work (2021-2025) expands into viral shedding dynamics, SARS-CoV-2 diagnostics, and circular RNA biology in polyomaviruses, demonstrating evolving yet cohesive research trajectory in RNA-virus interactions. Scientific contributions include: Pioneering identification of viral microRNAs across multiple virus families Discovery of DUSP11's critical role in RNA triphosphate regulation during infection Mechanistic insights into viral evasion of RNAi and innate immunity Development of novel RNA-based detection methods The Sullivan lab maintains active collaborations through the Center for Systems and Synthetic Biology, John Ring LaMontagne Center for Infectious Disease, and Interdisciplinary Life Sciences Graduate Programs. Lab culture emphasizes collective scientific inquiry with stated mission to 'increase understanding of pathogen-host interactions while enjoying the company of fellow lab members.' Current research directions include viral exploitation of RNA modification pathways and identification of novel host defense mechanisms using viruses as 'molecular divining rods.'

• Structural Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Nancy C. Horton is a Professor in the Department of Molecular and Cellular Biology at the University of Arizona, with joint faculty appointments in Biochemistry. Her research focuses on understanding the structures and mechanisms of proteins involved in DNA and RNA processing, particularly enzymes that modulate their activity through filament formation. She leads the Horton Lab, which employs structural techniques like X-ray crystallography, NMR, and cryo-electron microscopy alongside biochemical and high-throughput methods. Dr. Horton received her B.S. in Chemistry from Southern Illinois University (1986) and Ph.D. in Biological Chemistry from the University of Pennsylvania (1994). She completed postdoctoral training at The Upjohn Company and the University of California, Santa Barbara, before establishing her independent lab at the University of Arizona in 2001. Her work has contributed significantly to understanding enzyme filamentation in cellular defense mechanisms and host-virus interactions, particularly with Human Parvovirus B19. Research interests include structural biology, biophysics, and the functional implications of protein filaments. Her lab has elucidated the structural basis of enzyme activation via filamentation and its role in DNA cleavage specificity. She also engages in education initiatives, teaching courses on the molecular basis of life and professional development for graduate students. Key contributions include the discovery of enzyme filamentation as a regulatory mechanism and structural studies of SgrAI and NS1 proteins. The lab collaborates broadly, leveraging multi-scale modeling and experimental approaches to study macromolecular complexes. Dr. Horton’s work bridges basic science and translational research, with implications for antiviral drug development and understanding fundamental biological processes.

Masmudur Rahmanمشاهده پروفایل

استادیار

• Molecular Virology
• Cancer Biology
• Oncolytic Viruses
• +۳ مورد دیگر

Masmudur Rahman is an Assistant Professor at Arizona State University (ASU), affiliated with the School of Life Sciences and the Biodesign Center for Personalized Diagnostics. He leads research on molecular virology, focusing on oncolytic viruses like myxoma virus (MYXV) to treat cancers, particularly leveraging their ability to target cancer cells with compromised innate immunity. His work combines virology, genetic engineering, microscopy, and bioinformatics. Education highlights include a BSc and MSc from the University of Dhaka, a PhD in Molecular Virology from the Indian Institute of Science (IISc), and postdoctoral research at the University of Western Ontario and University of Florida, studying poxvirus immune modulation. He has received grants from NIH and the Arizona Biomedical Research Commission for projects on cancer virotherapy and virus-host interactions. Research interests span viral host range mechanisms, tumor tropism, and combination therapies (e.g., selinexor + MYXV). His lab develops strategies to enhance viral efficacy using stem cells and explores autosis induction in CAR-T cells. He teaches undergraduate research and honors courses in microbiology and cell biology, emphasizing hands-on training in virology techniques. Grants include NIH-funded studies on overcoming CAR-T resistance via autosis and targeting metastatic cancers with MYXV-selinexor combinations. His work has been published in Viruses , Cancer Research Communications , and International Journal of Molecular Sciences , among others.