Ruben Vazquez Uribe is a Co-Principal Investigator at the Bacterial Synthetic Biology Section, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark (DTU). His research is centered on developing programmable microbial therapeutics for metabolic and inflammatory diseases, leveraging synthetic biology and microbiome engineering. Research Interests: His work spans bacterial synthetic biology, microbiome modulation, engineered probiotics, oral delivery of peptides, and AI applications in drug discovery. He focuses on conditions like metabolic diseases, cancer cachexia, and NAFLD, aiming to develop living microbial medicines with precise therapeutic functions. The recent articles highlight a strong trend toward advanced microbiome therapeutics , combining synthetic biology with gut microbiome manipulation. Key themes include engineering Saccharomyces boulardii and Escherichia coli for enhanced delivery and immunomodulation, using AI to accelerate screening, and applying metagenomics to isolate novel gut microbes. These efforts reflect a multidisciplinary approach integrating biotechnology, computational methods, and translational medicine. Scientific Contributions: Co-PI in multiple long-term research projects since 2015. Supervisor for four active PhD projects on microbiome therapeutics and cancer. Host and guest lecturer in national and international academic events. Advising and Grants: He actively supervises PhD students across projects related to microbiome synthetic biology and personalized medicine. He is involved in research funded by the Novo Nordisk Foundation, contributing to high-impact publications and innovative therapeutic platforms. His team collaborates widely across Europe, focusing on translational microbiome applications. Labs and Teams: He leads research within the Bacterial Synthetic Biology Section at DTU Biosustain, a center dedicated to sustainable biotechnology. The team specializes in engineering microbial consortia, developing synthetic genetic circuits, and translating findings into clinical applications.






