جستجوی استاد راهنمای دانشگاهی

Thibault Mayorمشاهده پروفایل

استاد

• Protein Homeostasis
• Ubiquitin Proteasome System
• Neurodegenerative Diseases
• +۷ مورد دیگر

Thibault Mayor is a Professor in the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories at the University of British Columbia (Vancouver). His research focuses on understanding how cells manage misfolded proteins, with implications for neurodegenerative diseases like Parkinson's and Alzheimer's. He holds academic affiliations with the Centre for High-Throughput Biology (CHiBi) and has been recognized with awards including the UBC Killam Teaching Award (2020). Education: BSc, University of Geneva, Switzerland (1997) PhD, University of Geneva & Max Planck Institute of Biochemistry, Germany (2001) Postdoctoral Fellow, California Institute of Technology (2002) Research Interests: Mayor's lab investigates protein homeostasis, ubiquitin-proteasome system dynamics, and the molecular mechanisms underlying protein aggregation in aging and disease. Projects include proteomic approaches to identify aggregation-prone proteins and develop microbial cell factories for protein production. Grants & Awards: CIHR Project Grant ($730K, 2018) Michael Smith Foundation Career Award (2012) UBC Killam Teaching Award (2020) Labs & Collaborations: The Mayor Lab is part of the Michael Smith Laboratories and collaborates with computational biologists like Jörg Gsponer. They maintain active partnerships in proteomics and systems biology, contributing to initiatives like the BC Proteomics Network.

Steven G. Clarkeمشاهده پروفایل

استاد

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

Waldemar Kolanusمشاهده پروفایل

استاد

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +۴ مورد دیگر

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

• Cell Biology
• Developmental Biology
• Neuroscience
• +۳ مورد دیگر

Callista Yee will join the University of British Columbia as an Assistant Professor in the Department of Zoology (Faculty of Science) starting September 2025. Her research focuses on decoding molecular mechanisms governing nervous system development and synaptogenesis using Caenorhabditis elegans as a model organism. Research Focus Dr. Yee's work investigates: Transcriptional programs activated by neuronal activity Role of Groucho co-repressors in cellular switches Proteostasis and stress resilience in neurons Molecular regulation of synapse formation Publication Trends Her recent articles (2017–2025) span developmental biology, neuroscience, and molecular genetics, with a consistent emphasis on C. elegans as a model system. Key themes include transcriptional regulation of cell invasion, protein degradation tools, and aging-related pathways.

Donald Rioمشاهده پروفایل

استاد

• Nucleic Acid Transactions
• Transposable Elements
• RNA Binding Proteins
• +۳ مورد دیگر

Donald Rio holds the Richard and Rhoda Goldman Distinguished Chair in the Biological Sciences and is a Professor of Biochemistry, Biophysics, and Structural Biology. He is affiliated with the Division of Biochemistry and Molecular Biology and the Center for Integrative Genetics. His lab focuses on nucleic acid transactions, including transposable element mobilization (P elements) and RNA binding protein mechanisms controlling alternative splicing. Research highlights include studies on THAP9 proteins in humans/zebrafish, cryo-EM structural analysis of transposase-DNA complexes, and splicing regulation in neurodegenerative diseases like ALS and Parkinson’s. His work combines biochemical, genetic, and computational approaches, including the development of the Junction Usage Model (JUM) for splicing analysis. Research interests span transposition mechanisms linked to HIV integration, immune system recombination, and evolutionary genome dynamics. His team investigates how RNA binding proteins like hnRNPA1 influence splicing in disease contexts, with projects involving CRISPR-based models and patient RNA-seq data analysis. Collaborations include studies on splicing accuracy across tissues and age, and the impact of splicing defects in neurodegenerative disorders. Key awards include the Goldman Chair. His lab’s contributions bridge fundamental molecular mechanisms with translational applications in genetic disease modeling and drug discovery. Recent work focuses on isogenic stem cell models (iSCORE-PD) for Parkinson’s research and structural biology insights into transposase function. Grants and projects involve NIH funding for ALS splicing studies and collaborations with institutions like the Buck Institute. His lab actively publishes in top journals such as Genome Research , PNAS , and Nature , with a strong emphasis on cryo-EM and bioinformatic methods.

Nicholas M. Kanaanمشاهده پروفایل

استاد

• Neurodegenerative Diseases
• Alzheimer's Disease
• Parkinson's Disease
• +۶ مورد دیگر

Nicholas M. Kanaan is a Professor of Translational Neuroscience and holds the Maibach Smiley Professorship of Alzheimer's Research at Michigan State University's College of Human Medicine. He serves as Director of Advanced Microscopy and is faculty in both the MSU Neuroscience Program and the MSU BioMolecular Science Gateway. His research is centered at the Grand Rapids Research Center where he leads the Kanaan Laboratory. Dr. Kanaan received his B.S. in Neuroscience, Psychology, and Sociology from Central Michigan University in 2001, followed by a Ph.D. in Neurological Sciences from Rush University Medical Center in 2007. He completed postdoctoral training at Northwestern University from 2007-2010 under Dr. Lester Binder. His research focuses on neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD), with emphasis on tau protein pathology. The Kanaan Lab investigates mechanisms underlying degenerative diseases using a combination of in vitro and in vivo model systems. A major focus is understanding how disease-related alterations in tau cause neuronal dysfunction through disruption of axonal transport. His lab has identified a phosphatase-activating domain (PAD) in tau that inhibits anterograde fast axonal transport. Analysis of Dr. Kanaan's publication record reveals a consistent focus on tau protein biology, with recent work emphasizing iPSC models, CRISPR screening, tau proteostasis, and therapeutic interventions targeting tau phosphorylation and oligomerization. His research spans basic molecular mechanisms to translational applications, with increasing use of primate models and advanced screening technologies in recent years. Scientific Awards and Recognition: Maibach Smiley Alzheimer's Research Professor Maibach Smiley Professor of Alzheimer's Research Dr. Kanaan mentors numerous students and postdoctoral fellows in his laboratory, with research supported by multiple grants focused on understanding and treating neurodegenerative diseases. His lab employs a wide range of technical expertise including recombinant protein purification, cell culture, monoclonal antibody production, various microscopy techniques, and behavioral testing in rodent models. Outside the lab, Dr. Kanaan enjoys photography, woodworking, and fishing.

• Neurobiology
• Synaptic Plasticity
• Molecular Genetics
• +۷ مورد دیگر

Prof. Stephan J. Sigrist is a Full Professor of Genetics at the Institute of Biology, Free University of Berlin. His lab focuses on synaptic active zone architecture, neuroplasticity, and aging-related neurodegeneration. He leads the Collaborative Research Center 958 on Membrane Scaffolding and co-directs NeuroCure, a DFG Cluster of Excellence at Charité. Education: PhD in Molecular Genetics (1997) and Habilitation (2005) from the University of Göttingen. Positions: Einstein Professor (2014–present), Spokesperson CRC 958 (2012–present), and Co-Director NeuroCure (2009–present). Research explores presynaptic mechanisms using Drosophila and mouse models, combined with STED microscopy. Key contributions include discoveries of Bruchpilot's role in active zones and spermidine's protective effects against age-related synapse decline. Grants: Over €6 million in funding, including DFG CRCs, Einstein Foundation, and ERC Advanced Grant (2025). Awards: Einstein Professorship, Best Habilitation Award, EMBO/HFSP Fellowships. Collaborations span structural biology (e.g., Stefan Hell), neurophysiology (David DiGregorio), and aging research (Frank Madeo).

Peter Chienمشاهده پروفایل

استاد مدعو

• Regulated Proteolysis
• Protein Quality Control
• Bacterial Cell Cycle Regulation
• +۴ مورد دیگر

Peter Chien is an Adjunct Professor in the Department of Biochemistry and Molecular Biology at the University of Massachusetts Amherst. His research focuses on regulated protein degradation and quality control in bacteria, with a particular emphasis on mechanisms governing proteolysis during the bacterial cell cycle. PhD, University of California, San Francisco Postdoctoral Training, Massachusetts Institute of Technology The Chien Lab employs interdisciplinary approaches including biochemistry, structural biology, and cell biology to study proteolytic mechanisms in Caulobacter crescentus. Their work explores how AAA+ proteases like ClpXP and Lon recognize substrates with precision and how this impacts cellular regulatory networks. Recent research trends from the lab include investigations into Lon protease modulation , DNA damage responses , protein homeostasis under stress , and genetic regulators of proteostasis . Studies often integrate structural analysis with functional assays to uncover molecular principles of protease specificity. The lab is affiliated with multiple graduate programs, including the Molecular and Cellular Biology (MCB) program, Chemistry-Biology Interface Program, Biotechnology Training Program, and the Institute for Applied Life Sciences at UMass Amherst.

Sean J. Morrisonمشاهده پروفایل

استاد

• Stem Cell Biology
• Cancer Progression
• Metabolism
• +۳ مورد دیگر

Sean J. Morrison is the founding Director of the Children’s Medical Center Research Institute at UT Southwestern (CRI) and a Howard Hughes Medical Institute Investigator. He holds the Mary McDermott Cook Chair in Pediatric Genetics and the Kathryne and Gene Bishop Distinguished Chair in Pediatric Research. Dr. Morrison earned his B.Sc. in Biology and Chemistry from Dalhousie University (1991), a Ph.D. in Immunology from Stanford University (1996), and completed a postdoctoral fellowship in Neurobiology at Caltech (1999). Education: B.Sc. - Dalhousie University (Biology & Chemistry, 1991) Ph.D. - Stanford University (Immunology, 1996) Postdoctoral Fellowship - Caltech (Neurobiology, 1999) Research Interests: Dr. Morrison’s laboratory investigates the mechanisms that maintain adult tissues and how cancer cells exploit these processes to form tumors. His team compares stem cell and cancer cell replication mechanisms to develop novel regenerative medicine and anticancer therapies. Key areas include: Stem cell self-renewal and aging Metabolic regulation of hematopoietic stem cells Leptin Receptor+ stromal cell function Cancer progression and metastasis Proteostasis and niche biology Mechanotransduction in stem cell niches Publications reveal trends in stem cell metabolism, tumor heterogeneity, and niche dynamics across Science , Nature , and Cell . His work on retrotransposons in stem cell activation (2024) and β-adrenergic receptor inhibition in hematopoietic regeneration (2024) highlights emerging therapeutic targets. Awards & Recognitions: Dr. Morrison is an elected member of the U.S. National Academy of Medicine (2018), National Academy of Sciences (2020), and EMBO (2023). He received the Presidential Early Career Award (2003), MERIT Award from NIA (2009), and UT Southwestern’s Excellence in Postdoctoral Mentoring Award (2020). Mentorship & Leadership: Dozens of graduate students and postdoctoral fellows from his lab have secured academic leadership roles or industry positions. He served as President of the International Society for Stem Cell Research (2015–2016) and actively engages in public policy debates about stem cell research, including Michigan’s constitutional protections for regenerative medicine.

Ramanujan Hegdeمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Membrane Proteins
• +۳ مورد دیگر

Ramanujan Hegde serves as a Professor and Group Leader at the MRC Laboratory of Molecular Biology (LMB), University of Cambridge, where he directs research on membrane protein biosynthesis and cellular quality control mechanisms. His work examines how membrane proteins are accurately targeted to organelles, inserted into lipid bilayers, folded, and assembled into functional complexes, with emphasis on the cellular pathways that eliminate defective proteins to prevent disease. Professor Hegde's research program focuses on fundamental questions in cell biology: How do cells ensure precise membrane protein localization? What molecular machinery governs protein insertion and folding? How do quality control systems detect and degrade misfolded proteins? His investigations reveal that biosynthetic failures are common, triggering degradation pathways linked to diseases like neurodegeneration. Key research areas include: Intramembrane chaperone mechanisms for multipass membrane proteins Orphan subunit recognition during complex assembly Ribosome-associated mRNA degradation in autoregulation Proteasome assembly quality control ER membrane protein complex functions Molecular basis of protein aggregation diseases His 2017-2023 publications in Cell, Nature, and Science demonstrate consistent innovation in protein quality control, with landmark discoveries including UBE2O's role in orphan subunit degradation, the EMC as a transmembrane domain insertase, and TTC5-mediated tubulin autoregulation. These works bridge basic cell biology with disease mechanisms through rigorous biochemical and structural approaches. Professor Hegde mentors a research team of 11 scientists: Christine Desroches Altamirano Zhong Yan Gan Dino Janssen Ryan Judy Jennifer Miao Elizabeth Miller Tim Stevens Julia Toplak Huping Wang Haoxi Wu Eszter Zavodszky His laboratory operates within the MRC LMB's world-class infrastructure, utilizing advanced techniques in biochemistry, structural biology, and cell imaging. Supported by Medical Research Council funding, the group maintains strong collaborations across Cambridge and internationally to dissect protein biogenesis pathways with implications for therapeutic development in protein-misfolding disorders.

Xinxin Songمشاهده پروفایل

استادیار

• Cell Death Mechanisms
• Ferroptosis
• Apoptosis
• +۴ مورد دیگر

Xinxin Song, M.D., Ph.D., is an Assistant Professor in the Department of Surgery at the University of Texas Southwestern Medical Center. She holds a medical degree from Peking University Health Science Center and a Ph.D. from Peking Union Medical College. After post-doctoral training at the University of Pittsburgh, she became a Research Assistant Professor at Northwestern University's Feinberg School of Medicine before joining UT Southwestern in 2020. Her lab focuses on understanding mechanisms of cell death (apoptosis, ferroptosis, pH-dependent death, immunogenic cell death) and their interplay with drug resistance, tumor microenvironment, and cancer immunogenicity. Education: M.D., Health Science Center, Peking University Ph.D., Peking Union Medical College Post-doctoral Training, University of Pittsburgh School of Medicine Research Interests: Mechanisms of programmed cell death (apoptosis, ferroptosis) Drug resistance in cancer Tumor microenvironment dynamics Immunogenic cell death pathways Labs/Teams: Established her independent lab in the Department of Surgery at UT Southwestern in 2023

Joel Blanchardمشاهده پروفایل

دانشیار

• Neuroscience
• Stem Cell Biology
• Neurodegeneration
• +۱۲ مورد دیگر

Joel Blanchard, PhD, is an Associate Professor in the Departments of Neuroscience and Cell, Developmental & Regenerative Biology at the Icahn School of Medicine at Mount Sinai. He is also an Investigator at the Black Family Stem Cell Institute and the Ronald Loeb Center for Alzheimer’s Disease. His research focuses on developing human brain models using induced pluripotent stem cells to study and treat neurodegenerative diseases. Education: BS, St. Lawrence University MLA, Harvard University PhD, The Scripps Research Institute & MIT Research Interests: Dr. Blanchard’s lab is dedicated to understanding the genetic and environmental vulnerabilities that lead to neurodegeneration. His team develops cutting-edge 3D brain organoids and blood-brain barrier models to investigate diseases like Alzheimer’s, Parkinson’s, and ALS. A major focus is on the role of APOE4 in myelination, cholesterol metabolism, and vascular dysfunction. Scientific Awards: Friedman Brain Institute Scholar Award (2021) ISSCR Merit Award (2019) Glenn Foundation Postdoctoral Fellowship (2018) California Institute for Regenerative Medicine Pre-doctoral Fellowship (2011) Funding & Grants: Dr. Blanchard’s lab is currently funded by NASA, NIH, and the Cure Alzheimer’s Fund. Active projects include the development of miBrain (multicellular integrated brain tissue), blood-brain barrier modeling, and APOE4-mediated mechanisms of neurodegeneration. Lab & Team: The Blanchard Lab is a multidisciplinary team of postdocs, graduate students, and research associates. The lab is actively recruiting postdoctoral fellows and is known for its collaborative, innovative environment focused on translational neuroscience.

Stephan A. Sieberمشاهده پروفایل

استاد

• Bioorganic Chemistry
• Antibiotic Development
• Chemical Proteomics
• +۵ مورد دیگر

Professor Stephan A. Sieber is a leading researcher in bioorganic chemistry at the Technical University of Munich (TUM), where he holds the Chair of Organic Chemistry II within the TUM School of Natural Sciences. His research program focuses on developing new drugs against multidrug-resistant bacteria through a multi-disciplinary approach that integrates synthetic chemistry, functional proteomics, microbiology, and protein biochemistry. His laboratory has made significant contributions to identifying unprecedented antibacterial targets beyond the scope of current antibiotics and exploiting these for chemical manipulation. Recent work has increasingly incorporated machine learning approaches to accelerate antibiotic discovery, with notable publications on AI-guided pipelines, drug-target interaction prediction, and high-throughput screening optimization. Sieber's research has resulted in the discovery of new active substances, some of which are currently being optimized for medical applications. His group's publications reveal a strong focus on chemical proteome mining, natural product mode of action studies, and novel antibacterial target identification. The lab has published extensively in top journals including Nature Chemistry, Nature Communications, and ACS Central Science. Inhoffen Medal (2024) Max Bergmann Medal (2023) ERC Advanced Grant (2023) Merck Future Insight Prize (2020) Klaus Grohe Prize (2020) ERC Consolidator Grant (2016) Professor Sieber leads an active research group that maintains a strong presence in the scientific community through regular publications, conference presentations, and collaborations. His laboratory website and BlueSky presence (@sieberlab.bsky.social) demonstrate ongoing research activities and engagement with the broader scientific community. He has successfully secured significant research funding including multiple ERC grants that have supported his innovative work in antibiotic discovery.

Bjoern Bauerمشاهده پروفایل

استاد

• Neuroscience
• Alzheimer’s Disease
• Blood-Brain Barrier Physiology
• +۳ مورد دیگر

Bjoern Bauer, PhD is a Professor in the Department of Pharmaceutical Sciences at the University of Kentucky, affiliated with the Sanders-Brown Center on Aging. His research focuses on blood-brain barrier (BBB) biology, Alzheimer’s disease mechanisms, and drug delivery strategies for neurological disorders. Bauer’s work explores how BBB dysfunction contributes to neurodegenerative diseases and cancer, with particular attention to efflux transporters like P-glycoprotein (ABCB1) and their roles in drug resistance and amyloid beta pathology. Key research areas include: 1) BBB leakage and its role in Alzheimer’s disease progression, 2) development of therapeutic strategies to modulate BBB transporters, 3) preclinical models of glioblastoma and neurodegeneration, and 4) biomarker discovery for early disease detection. His lab utilizes advanced in vitro BBB models, transgenic mouse models (e.g., 5xFAD), and imaging techniques to study these processes. Bauer’s contributions span over 40 peer-reviewed publications since 2001, with recent work emphasizing oxidative stress mechanisms, tumor drug resistance, and translational approaches to BBB targeting. Current efforts include investigating S100β as a plasma biomarker and exploring proteasome inhibition as a therapeutic avenue for restoring BBB integrity. He leads the Bauer-Hartz Lab, collaborating extensively with neurologists, oncologists, and pharmacologists to advance CNS drug delivery technologies. He holds a PhD in Pharmacology and has been a faculty member at the University of Kentucky since joining Sanders-Brown in [year not explicitly stated]. His research is supported by grants focusing on BBB biology, Alzheimer’s disease, and cancer pharmacology.

• Redox Biology
• Cancer Research
• Drug Metabolism
• +۴ مورد دیگر

Zhiwei Ye is an Associate Professor in the Department of Pharmacology & Immunology at the College of Medicine, Medical University of South Carolina. His research focuses on redox biology, cancer mechanisms, and drug metabolism with a particular emphasis on mitochondrial function, oxidative stress, and therapeutic resistance. He holds a PhD in Pharmaceutical Science from Katholieke Universiteit Leuven (Belgium, 2009) and prior degrees from Zhejiang University (China). PhD in Pharmaceutical Science, 2009 – Katholieke Universiteit Leuven, Belgium Master in Pharmaceutical Science, 2005 – Katholieke Universiteit Leuven, Belgium Master in Medicine, 2003 – Zhejiang University, China B.S. in Pharmacy, 2000 – Zhejiang University, China Dr. Ye’s research explores how redox regulation impacts cancer progression, drug resistance, and metabolic disorders. His work integrates enzymology (e.g., GSTP, PDI), mitochondrial dynamics, and zebrafish models to study mechanisms like S-glutathionylation, VDAC targeting, and drug-transporter interactions. Recent studies highlight novel therapeutic strategies for hepatocellular carcinoma, melanoma, and myeloma through modulation of redox pathways. Publications emphasize translational research bridging basic biology and clinical applications, including drug development (e.g., Telintra) and understanding treatment resistance in malignancies. His work also addresses metabolic disease mechanisms, such as hepatic steatosis and drug-induced renal toxicity. No scientific awards explicitly mentioned in provided texts. Active in grant-funded research areas like cancer biology and redox signaling. Collaborates on projects involving drug-transporter profiling in hepatocytes and cellular stress responses.