جست‌وجوی استاد و پژوهشگر

• Computational Biology
• Single-Cell Genomics
• Machine Learning
• +۶ مورد دیگر

Dana Pe'er is Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute (SKI) and an Investigator at the Howard Hughes Medical Institute (HHMI). She holds the Alan and Sandra Gerry Endowed Chair and leads an interdisciplinary lab combining single-cell genomics, machine learning, and computational modeling to study cancer biology, immunity, and development. Pe'er earned her PhD at the Hebrew University in Jerusalem and focuses on cellular plasticity, epigenetic regulation, and tumor-immune interactions. Her lab develops tools like CellRank , Wishbone , and SEACells to analyze single-cell data and uncover mechanisms in cancer progression and immunotherapy. Key research areas: Computational Biology, Single-Cell Genomics, Cancer Systems Biology, Epigenetics, Immunotherapy Recent trends: Articles from 2025-2024 emphasize spatial transcriptomics, tumor microenvironment mapping, and regulatory network inference using machine learning. Scientific honors include the NIH Director’s Pioneer Award , AACR Academy Induction , and Packard Fellowship . Her work has direct clinical implications for precision medicine and cancer immunotherapy. Labs & Teams: Leads the Dana Pe'er Lab at SKI, directs the Single Cell Research Initiative (SCRI), and collaborates with the SAIL program.

Jun Wuمشاهده پروفایل

استادیار

• Stem Cell Biology
• Genome Editing
• Interspecies Chimeras
• +۶ مورد دیگر

Dr. Jun Wu is an Assistant Professor in the Department of Molecular Biology at UT Southwestern Medical Center. He holds a PhD in Life Science from the University of Tennessee and completed postdoctoral training at the University of Southern California and the Salk Institute. His research focuses on stem cell biology, genome editing, and interspecies chimeras to advance regenerative medicine and developmental biology. Education: Bachelor of Medicine, Shandong University School of Medicine (China) PhD in Life Science, University of Tennessee (2013) Postdoctoral Fellowships: USC (2013-2015) and Salk Institute (2015-2017) Research Interests: Generation of pluripotent stem cells with distinct molecular/phenotypic features Development of interspecies blastocyst complementation systems Modeling peri-implantation human development using stem cell embryo models Study of species-specific developmental barriers and evolutionary biology Application of chimeras to study cancer resistance and organ size determination Lab Activities: The Wu Lab develops stem cell models to study mammalian development and create regenerative therapies. Key projects include: Creation of interspecies chimeras (human-monkey, rat-mouse) Development of blastoids and peri-gastruloids Analysis of species-specific cell competition mechanisms Engineering cross-species organogenesis systems Grant Activities: Focuses on NIH-funded projects related to stem cell biology, interspecies chimerism, and regenerative medicine applications. Collaborates with institutions like Salk Institute and University of California campuses. Lab Team: Includes postdoctoral researchers like Dr. Yi Ding and a multidisciplinary team of molecular biologists, bioengineers, and computational biologists.

Kathryn E. Dickersonمشاهده پروفایل

استادیار

• Pediatric Hematology
• Myeloid Malignancies
• Epigenetic Regulation
• +۴ مورد دیگر

Kathryn E. Dickerson, M.D., M.S.C.S., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center, specializing in the Division of Hematology and Oncology. She holds dual appointments as a 2015 Translational Research Scholar in the UTSW Center for Translational Medicine and as an NIH KL2 scholar. Her clinical focus is pediatric hematology, emphasizing bone marrow failure disorders, cancer predisposition syndromes, and thalassemia/dyserythropoietic anemias. Her research investigates epigenetic regulation of myeloid malignancies, clonal hematopoiesis in childhood cancer survivors, and molecular mechanisms underlying acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and myeloproliferative disorders (MPD). Education: Bachelor's in Biochemistry (Indiana University), minor in Spanish Medical degree (Indiana University School of Medicine) Masters of Science in Clinical Sciences (UT Southwestern Center for Translational Medicine) Training: Pediatric residency with research pathway (Ohio State University/Nationwide Children’s Hospital) Pediatric hematology-oncology fellowship (UT Southwestern) Dr. Dickerson’s research bridges basic science and clinical practice, leveraging CRISPR-based epigenetic editing, genomic analysis, and translational studies to understand disease mechanisms. Key projects include interrogating enhancer dysregulation in leukemia, studying metabolic reprogramming in cancers, and evaluating clonal hematopoiesis in survivors of childhood cancers. Her work has advanced understanding of EZH2’s role in AML and identified therapeutic vulnerabilities in myeloid malignancies. Awards: 2015 Translational Research Scholar (UTSW Center for Translational Medicine) NIH KL2 Career Development Award Grants/Initiatives: NIH-funded investigator-initiated study on clonal hematopoiesis Industry/consortia-sponsored trials for bone marrow failure and rare blood disorders She collaborates with the Children’s Research Institute and North American Pediatric Aplastic Anemia Consortium, contributing to clinical trials and translational initiatives. Her lab focuses on developing biomarkers for disease severity (e.g., immature platelet fraction in pediatric COVID-19) and therapeutic strategies targeting epigenetic dependencies in leukemia.

• Epigenetic Pharmacology
• Cancer Therapy
• Drug Discovery
• +۶ مورد دیگر

Noël J-M Raynal is a Professor in the Department of Pharmacology and Physiology at the Université de Montréal and a researcher at the CHU Sainte-Justine Research Center. His expertise lies in epigenetic pharmacology of cancer and drug discovery, particularly using 3D cell culture models to study pediatric and adult cancers. He has held senior research awards from the FRQS and has led multiple projects funded by CIHR, CRSNG, and others. His work focuses on developing novel therapies targeting epigenetic modifications in cancers like neuroblastoma, sarcomas, lung cancer, and triple-negative breast cancer. Education: Ph.D. in Biology (INRS-IAF, 2008), Postdoctoral training at MD Anderson Cancer Center and Temple University. Teaching roles include courses in pharmacology and physiology. Research affiliations: GRUM (University Research Group on Medicine), Azrieli Research Center at CHU Sainte-Justine Awards: Senior FRQS Scholar (2024–2028), Junior FRQS Awards (2016–2024) Supervised 15+ students in M.Sc. and Ph.D. programs, focusing on epigenetic drug discovery and 3D tumor modeling Active in grants: Over 20 projects funded by CIHR, FRQS, and industry partnerships Research highlights include repurposing drugs like disulfiram for neuroblastoma and developing CDK9 inhibitors. His lab innovates in 3D co-culture models to better mimic tumor environments and improve drug screening accuracy.

Simbarashe Mazambaniمشاهده پروفایل

استادیار

• Cancer Metabolism
• Biochemistry
• Functional Genomics
• +۳ مورد دیگر

Simbarashe Mazambani is an Assistant Professor of Instruction in the Department of Biological Sciences at the University of Texas at Dallas (UTD), affiliated with the School of Natural Sciences and Mathematics. His academic preparation includes a Ph.D. in Molecular and Cell Biology from UTD (2023), an M.S. in Biological Sciences from Texas A&M University-Commerce (2017), and a B.S. in Biological Sciences from the same institution (2014). Dr. Mazambani's research focuses on cancer metabolism, biochemistry, and functional genomics, with a particular emphasis on metabolic vulnerabilities in squamous cell carcinomas and the role of glucose-insulin signaling pathways in tumor growth. His work integrates oxidative stress mechanisms, epigenetic regulation, and xenobiotic detoxification pathways to elucidate cancer progression and therapeutic strategies. Notable publications include groundbreaking studies on targeting the glucose-insulin axis in head and neck squamous cell carcinoma, the role of Hedgehog signaling in lung adenocarcinoma suppression, and epigenetic control of breast cancer via xenobiotic pathways in agouti mouse models. His research spans disciplines such as oncology, cell signaling, and metabolic reprogramming, with implications for precision medicine and cancer therapy. Dr. Mazambani currently does not accept undergraduate or graduate students, focusing instead on instructional and research activities. His work is supported by experimental models and collaborative studies, though specific grants or lab affiliations are not detailed in the provided materials.

Zhishan Wangمشاهده پروفایل

استاد پژوهشی

• Environmental Carcinogenesis
• Cancer Biology
• Cancer Therapy
• +۴ مورد دیگر

Zhishan Wang, MD, PhD is a Research Professor in the Department of Pathology at Stony Brook University's Renaissance School of Medicine . His work focuses on environmental carcinogenesis , particularly mechanisms of cancer biology and cancer therapy , with a specialization in metal-induced carcinogenicity. Research Interests: Environmental Carcinogenesis Epigenetic and Epitranscriptomic Mechanisms Tumor Microenvironment Remodeling Metal Toxicity Pathobiology Non-Coding RNA Regulatory Networks Scientific Contributions: Analysis of 15 recent publications reveals expertise in: Metal-Induced Oncogenic Pathways (e.g., NF-κB activation, Hedgehog signaling) RNA Modification Dynamics (m6A, lncRNA-splicing interactions) Stem Cell Plasticity in Carcinogenesis Multi-Carcinogen Synergy Mechanisms Epigenetic-Genotoxic Interplay Transcriptomic Reprogramming by Toxicants

Marco Contiمشاهده پروفایل

استاد

• Reproductive Biology
• Oocyte Development
• Signal Transduction
• +۳ مورد دیگر

Dr. Marco Conti is the Fred Gellert Endowed Professor at the University of California San Francisco (UCSF) School of Medicine, where he serves in the Department of Obstetrics, Gynecology and Reproductive Sciences. He previously directed the Center for Reproductive Sciences at UCSF, a leading institution in reproductive biology research. Dr. Conti received his M.D. from the University of Rome School of Medicine in 1974, followed by postdoctoral training in Reproductive Biology at the same institution (1974-75) and Endocrinology at the National Institutes of Health in Bethesda, MD (1975-77). His research career spans over four decades with significant contributions to understanding oocyte development and reproductive biology. Dr. Conti's research program focuses on signal transduction pathways required for germ cell development, particularly those controlling oocyte meiotic maturation and developmental competence. His lab has identified critical signals arising in somatic cells during ovulation that establish oocyte developmental competence. The research examines how disruption of these pathways affects maternal mRNA translation patterns into proteins critical for nuclear reprogramming and early embryo development. This work has significant implications for stem cell research, understanding mechanisms controlling cell replication during preimplantation development, and developing embryonic stem cells into artificial gametes. Additional research interests include fertility preservation for cancer patients. Analysis of Dr. Conti's publication record reveals a consistent focus on reproductive biology with particular emphasis on cAMP signaling pathways, phosphodiesterases, mRNA translation regulation, and oocyte maturation. His work shows progression from foundational studies on cAMP-specific phosphodiesterases in the 1990s to more recent sophisticated analyses of maternal mRNA translation programs using single-cell approaches and multi-omics techniques. The research demonstrates increasing complexity in methodology while maintaining focus on fundamental questions of oocyte developmental competence. International Fogarty Fellow (1975-77) Phi Beta Kappa Teaching Excellence Award (2000) Sandler Foundation Senior Investigator Award (2001) Society for the Study of Reproduction Research Award (2003) Board of Directors Society for the Study of Reproduction (2006) Dr. Conti has mentored numerous researchers in reproductive biology and has been instrumental in establishing genetic models to study oocyte developmental competence. His laboratory work has significant translational potential for improving assisted reproductive technologies and understanding age-related declines in fertility. The Center for Reproductive Sciences at UCSF, which he previously directed, serves as a hub for interdisciplinary research connecting basic science discoveries with clinical applications in reproductive medicine.

Hokyung Kay Chungمشاهده پروفایل

استادیار

• Synthetic Biology
• Cancer Immunology
• T Cell Engineering
• +۶ مورد دیگر

Hokyung Kay Chung, PhD is an Assistant Professor in the Department of Cell Biology and Physiology at the University of North Carolina at Chapel Hill School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. Her research program integrates synthetic biology, immunology, and cancer biology to engineer T cells for enhanced anti-tumor efficacy. Dr. Chung's research focuses on harnessing synthetic biology to reprogram T cell differentiation states for cancer immunotherapy. Her laboratory employs protein engineering, next-generation sequencing, CRISPR screening, and bioinformatics to develop three core platforms: (1) Transcription factor recipes for T cell programming using multiomics atlas-based analysis and in vivo CRISPR screening; (2) Synthetic toolkits for designer immunity including drug-inducible transcription factor circuits and signal rewiring platforms; (3) Hijacking tumors via engineered oncolytic viruses to encode immune modulators. Her work aims to create context-specific cell state programming that enhances T cell therapy efficacy across diverse cancer types. Her publication portfolio demonstrates significant contributions to synthetic immunology, with high-impact papers in Science, Nature Chemical Biology, Cell, and Immunity covering protease-based control systems, T cell differentiation engineering, and tumor microenvironment remodeling. Recent work includes developing sonogenetic CAR-T cells controllable by ultrasound and elucidating metabolic mechanisms of T cell exhaustion. K01 Research Scientist Development Award, NIH, 2023 Keystone Symposia Future of Science Fund Scholarship, 2020 Damon Runyon Fellowship Award, 2019 Salk Women & Science Special Award, 2019 Hans Neurath Outstanding Promise Travel Award, 2017 Dr. Chung leads the Chung Lab at the UNC Lineberger Comprehensive Cancer Center, where she directs research on synthetic T cell engineering. Her lab utilizes advanced techniques including single-cell CRISPR screening, protein engineering, and oncolytic virology to develop next-generation immunotherapies. Current projects focus on creating artificial T cell differentiation pathways and engineering the tumor microenvironment to support persistent anti-tumor immunity.

Shengyu Muمشاهده پروفایل

دانشیار

• Hypertension
• Heart Failure Mechanisms
• Immune-Mediated Pathways in Cardiovascular Disease
• +۴ مورد دیگر

Shengyu Mu is an Associate Professor in the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. His research focuses on the pathogenesis of hypertension and its progression to heart failure, with a particular emphasis on immune mechanisms in renal salt retention. Mu holds an M.D. from TianJin Medical University (2004) and a Ph.D. from the University of Tokyo (2011). His research portfolio includes NIH-funded projects investigating T cell homing to the kidney and immune memory in hypertension. Current grants span NIH-NHLBI (2R01 HL146713), American Heart Association (AHA23TPA1076467), and USDA-NIFA collaborations. Completed projects include studies on renal lymph-angiogenesis and macrophage metabolism in diabetes/tuberculosis comorbidity. Research areas integrate physiology, molecular genetics, and epigenetics to bridge basic science and clinical applications. The Mu Lab includes Assistant Professor Yunmeng Liu, Ph.D. candidates Christoph Mora and Kathrine Deck, and research team members recognized for awards like the AHA Predoctoral Fellowship and APS Research Recognition Awards. Key themes include CD8+ T cell activation, IFNγ signaling, and macrophage transition in hypertension pathogenesis.

Luke Lairsonمشاهده پروفایل

استاد

• Chemical Biology
• Drug Discovery
• Cancer Biology
• +۴ مورد دیگر

Professor Luke Lairson leads the Lairson Laboratory at The Scripps Research Institute (TSRI), focusing on chemical biology to study cell fate mechanisms in disease. His work spans small molecule discovery targeting cancer stem cells, tumor microenvironment modulation, and myelination enhancement using primary human and rodent cell models. Education: PhD in Chemistry (2007, University of British Columbia), BS in Biochemistry (2002, University of Guelph). Professional roles include Assistant Professor at TSRI (2010–present), Principal Investigator at the Genomics Institute of the Novartis Research Foundation (2010–2011), and Director of High Throughput Discovery at California Institute for Biomedical Research (2016–2017). Research Interests: Chemical approaches to cancer immunotherapy, drug discovery for neurodegenerative diseases, and modulation of immune checkpoint proteins. Key projects include STING agonist development, HSP90 inhibitors, and metabolite-driven oligodendrocyte maturation. Publications: Over 50 peer-reviewed articles, including high-impact work in PNAS , Nature Chemical Biology , and Cancer Research . Recent focus areas include microbiota-derived STING activators and JAK-inhibitor immunotherapy combinations. Awards: Canadian Society for Chemistry Boehringer Ingelheim Thesis Award (2010), Royal Society Short Visit Award (2007), and multiple scholarships for organic chemistry innovation. Lab Activities: Integrates high-content screening, medicinal chemistry, and proteomics to identify mechanism-based therapies. Current initiatives include repurposing drugs for remyelination and developing non-nucleotide STING agonists for systemic cancer immunotherapy.

• Cancer Metabolism
• Metabolic Reprogramming
• Tumor Metastasis
• +۳ مورد دیگر

Sophia Lunt is a Professor in the Department of Biochemistry & Molecular Biology and Chemical Engineering & Materials Science at Michigan State University , where she has been since 2015 (Assistant Professor 2015-2021, Associate Professor 2021-2025, Professor 2025-present). She leads the Lunt Lab , focusing on cancer metabolism , particularly metabolic reprogramming in tumor proliferation, heterogeneity, and metastasis . Her work combines mass spectrometry , genetic cancer models , cell biology , and fluorescent agents to develop targeted cancer therapies . Ph.D. (2010) & B.S. (2005) in Chemistry Postdoctoral Fellow at MIT (2010-2015) NSF CAREER awardee (2019) 20+ peer-reviewed publications since 2007 Research Focus : Cancer metabolism (Warburg effect, PHGDH heterogeneity, TIGAR regulation) Photodynamic therapy (counterion-tuned agents, metal halide nanoclusters) Metabolomics (tumor-immune interactions, microbiome effects) Selected Scientific Awards : 2022 MSU College of Natural Science Teacher-Scholar Award 2022 MSU BMB Teaching Award 2020 MANA Young Investigator Award 2019 NSF CAREER & METAvivor Early Career Investigator Awards Her teaching includes BMB 101: Frontiers in Biochemistry (curriculum overhaul for freshman success) and BMB 461: Advanced Biochemistry I , covering metabolic regulation and pathways.

Zhengqing Huمشاهده پروفایل

استاد

• Hearing Loss Treatment
• Stem Cell Biology
• Auditory Neuroscience
• +۳ مورد دیگر

Dr. Zhengqing Hu is a tenured, full-time Professor in the Department of Otolaryngology – Head and Neck Surgery at Wayne State University School of Medicine. He holds joint appointments in the Department of Physiology/Cell Biology and has active research programs in stem cell-based hearing restoration. Dr. Hu's academic journey includes dual MD and PhD training in China, a second PhD at Karolinska Institute, Sweden, and postdoctoral work at the University of Virginia. Education : MD from Shanghai Medical University, PhD in neurotology from China, second PhD in cell replacement therapy at Karolinska Institute Grants : NIH R01, DoD grants, VA SPiRE, and Wayne State OVPR funding His research focuses on auditory synapse regeneration , epigenetic reprogramming for hair cell repair, and development of biological hearing restoration models . The Hu lab employs stem cell biology, in vitro and in vivo transplantation, advanced microscopy, and electrophysiology to investigate inner ear progenitor cell differentiation and neural integration. Recent publications highlight DNA demethylation strategies for hair cell regeneration and auditory neuron synaptogenesis. Dr. Hu serves on multiple NIH, VA, and international grant review panels. He teaches graduate courses in Stem Cell Biology , Molecular Physiology , and Cell Biology at Wayne State University, including directing the Embryonic Stem Cell Biology course. His lab's work aims to establish a Biological-EAR model for future hearing loss treatments.

Gary K. Owensمشاهده پروفایل

استاد

• Cardiovascular Biology
• Atherosclerosis
• Smooth Muscle Cell Biology
• +۴ مورد دیگر

Dr. Gary K. Owens is a Professor in the Department of Molecular Physiology and Biological Physics at the University of Virginia , with a secondary appointment in the Department of Medicine, Division of Cardiology. He serves as Director of the Robert M. Berne Cardiovascular Research Center and leads groundbreaking research on vascular smooth muscle cell (SMC) dynamics in atherosclerosis. His work challenges conventional paradigms about SMC roles in plaque stability and thromboembolic events. Primary Affiliation: University of Virginia Key Titles: Robert M. Beirne Professor of Cardiovascular Research, Professor, Director of CVRC Research Themes include: Cardiovascular Biology Atherosclerosis Pathogenesis Smooth Muscle Cell Plasticity Epigenetic Regulation Inflammatory Signaling Tumor Metastasis Mechanisms Publication Trends (2015–2024) reveal expertise in Nature Medicine and Circulation studies, focusing on SMC gene regulation (Klf4/Oct4), plaque stability, and cross-talk between vascular cells and tumors. His work demonstrates that SMCs account for >80% of advanced lesion cells and that Klf4 inhibition reduces metastasis by >70%. Lab Leadership includes mentoring PhD students Anita Salamon and Victoria Milosek , alongside senior scientists and postdocs. Collaborations span with Dr. Gwen Randolph (Washington University) and Dr. Rosey Kaplan (NIH) on IL1β signaling and metastasis.

Elizabeth T Bartomمشاهده پروفایل

دانشیار

• Computational Biology
• Genomics
• Transcriptional Regulation
• +۳ مورد دیگر

Elizabeth T Bartom, PhD is an Associate Professor in the Department of Biochemistry and Molecular Genetics at the Feinberg School of Medicine, Northwestern University. She is affiliated with the Simpson Querrey Institute for Epigenetics, Center for Genetic Medicine, and Robert H. Lurie Comprehensive Cancer Center. PhD: Cold Spring Harbor Laboratory (2004) Postdoctoral Fellow: Harvard University and Broad Institute (2006–2010) Her research focuses on chromatin organization , transcriptional regulation , and genomic integrity in cancer and immunobiology. Recent work explores 3D genome effects in bladder cancer and pediatric brain tumors, lipid metabolism in breast cancer, and novel genomic labeling techniques. R50 Research Specialist Award, National Cancer Institute (2023) Outstanding Teacher Award, Feinberg School of Medicine (2021) Dean’s Teaching Award, Driskill Graduate Program (2019) She is a member of the Robert H Lurie Comprehensive Cancer Center (2020–present) and Simpson Querrey Center for Epigenetics (2018–present), with expertise in computational biology and genomics.

Maureen Sartorمشاهده پروفایل

استاد

• Epigenetics
• Bioinformatics
• Cancer Research
• +۷ مورد دیگر

Maureen Sartor is a Professor in the Department of Computational Medicine and Bioinformatics at the University of Michigan Medical School. Her work bridges computational biology, epigenetics, and cancer research, with recent contributions to understanding environmental toxicant impacts on DNA methylation, HPV-associated head and neck cancers, and neurodegenerative disease mechanisms. Key research themes: Epigenetic regulation, bioinformatics modeling, environmental health Active clinical trial collaborations in immunotherapy rechallenge and neoadjuvant treatment strategies Leadership in cross-species toxicoepigenetic studies and microbiome-immune crosstalk in oral cancer Recent publications highlight her expertise in: Epigenetic age acceleration in ALS and its environmental correlates HPV integration mechanisms in oropharyngeal cancer Chemical oxidation techniques for piRNA discovery Sex-specific epigenetic responses to lead and phthalate exposure Her interdisciplinary approach connects computational methods with experimental validation across multiple disease models.