Andrew Holle is an Assistant Professor at the Mechanobiology Institute , National University of Singapore , where he leads the Confinement Mechanobiology Lab within the Department of Biomedical Engineering . His work spans mechanobiology, stem cell differentiation, cancer mechanobiology, and microfluidics, with a focus on understanding how physical confinement influences cellular behavior. Education: B.S.E. in Bioengineering (Minor in Statistics), Arizona State University (2008) Ph.D. in Bioengineering, University of California San Diego (2013) Research in the Confinement Mechanobiology Lab centers on the hypothesis that stem cell differentiation is driven by mechanical cues during migration through confined extracellular matrix (ECM) environments. The lab develops microfluidic systems to mimic ECM confinement and studies its impact on osteogenic differentiation , cancer cell migration , and cellular condensates . Recent publications highlight interdisciplinary approaches combining mechanobiology , nanotechnology , and microfluidics to explore nuclear morphological changes, volume regulation, and ligand signaling in confined cellular environments. Laboratory Members: Privita Edwina (Research Fellow) Vaishnavi Rangaraj (Research Assistant) Sriram Muthukumar (Research Fellow) Chang Ye Ji (PhD Student) Gao Xu (PhD Student) Lim Yuan Bin (PhD Student) Shinny Sunny (PhD Student) Lee Jia Wen Nicole (PhD Student) Li Yixuan (PhD Student)
Vivek Shenoy is the Eduardo D. Glandt President's Distinguished Professor at the University of Pennsylvania, with primary appointments in the Department of Materials Science and Engineering and secondary appointments in Bioengineering and Mechanical Engineering and Applied Mechanics. He leads the Multiscale Mechanobiology and Biomaterials Laboratory, which focuses on developing theoretical frameworks and numerical methods to understand complex biological and engineering systems across multiple length scales. Shenoy's research spans mechanobiology, chromatin organization, cell mechanics, and biomaterials. His work addresses the fundamental challenge of modeling how small-scale cellular phenomena couple with long-range tissue-level interactions across micrometers to centimeters. By integrating insights from soft matter physics, solid mechanics, chemistry, and applied mathematics, his group develops multiphysics continuum and mesoscale theories to elucidate mechanisms controlling both biological and engineering systems. His recent publications demonstrate an increasing focus on nuclear mechanics, chromatin organization, and the interplay between mechanical forces and gene regulation. Analysis of Shenoy's publication record reveals a strong interdisciplinary approach, with high-impact papers spanning biophysics, materials science, and cell biology. His work shows consistent evolution from fundamental mechanics of materials to complex biological systems, with recent emphasis on the mechanical regulation of chromatin architecture, cell migration dynamics in 3D environments, and mechanotransduction in development and disease. His publications appear regularly in top journals including Nature, Science, and their affiliated publications, demonstrating significant influence across multiple fields. Eduardo D. Glandt President's Distinguished Professor Multiple publications in Nature, Science, and PNAS Active research program with publications through 2025 Shenoy actively mentors students and postdocs through his laboratory, with numerous co-authored publications indicating strong mentorship. His research program appears to be well-funded through multiple grants supporting his work in mechanobiology and biomaterials. The Multiscale Mechanobiology and Biomaterials Laboratory maintains active collaborations across disciplines and institutions, reflecting the interdisciplinary nature of his research. The Multiscale Mechanobiology and Biomaterials Laboratory, housed within the Department of Materials Science and Engineering at the University of Pennsylvania, serves as the primary research hub for Shenoy's work. The lab maintains an active presence on social media (Twitter: @ShenoyLab) for updates on activities and publications. Their research approach combines theoretical modeling with experimental validation to address fundamental questions at the interface of mechanics, materials science, and biology.
Andre Levchenko is the John C. Malone Professor of Biomedical Engineering at Yale University, with secondary appointments in the Department of Neurosurgery and affiliations with the Cancer Signaling Networks, Immunology, and the Yale Program in Neurodevelopment and Regeneration. His research focuses on systems biology, signal transduction, and cell-cell communication, utilizing microfluidics and computational modeling to study cancer progression, stem cell behavior, and neurological disorders. PhD, Columbia University MEng, Moscow Institute of Physics and Technology Levchenko's work explores how cells process dynamic signals to make critical decisions, particularly in glioblastoma migration, organoid development, and cardiovascular tissue engineering. His lab develops innovative microfluidic platforms and mathematical models to dissect multicellular communication and signaling networks. Recent publications highlight his contributions to understanding YAP-driven cancer invasion , NOTCH signaling in angiogenesis , and metabolic regulation of hypoxia responses . He has pioneered methods for organoid modeling and single-cell analysis , advancing precision in biological signaling studies. Scientific Awards : Computational Molecular Biology Post-Doctoral Fellowship (Burroughs Wellcome Fund) National Academies Keck Futures Conference Invitee Distinguished Guest Lecturer, University of Virginia American Asthma Foundation Early Excellence Award Fellow, American Institute for Medical and Biological Engineering Levchenko leads the Levchenko Lab at the Yale Systems Biology Institute, collaborating with institutions like Mayo Clinic and Yale Cancer Center. His research has received recognition in Faculty of 1000 and multiple journal highlights.
Michael McAlpine is a Professor in the Mechanical Engineering department at the University of Minnesota . He also holds affiliations with the Biomedical Engineering and Electrical and Computer Engineering departments. His research focuses on 3D printing functional materials & devices , Nanoscale inks , Biomedical devices , Bioelectronics , and Flexible Microsystems . Research Interests : 3D Printing, Biomedical Engineering, Nanotechnology, Flexible Electronics, Microfluidics Labs : ME 361/363 Contact : mcalpine@umn.edu , (612) 626-3303, ME 117 Recent Research Trends include 3D Printed Biomedical Devices , Flexible Electronics , and Bioprinting Applications . His work spans from Spinal Organoid Formation to Programmable Drug Release Capsules . Scientific Award : Circulation Research 2020 Best Manuscript Award
Michele Klingbeil is a Professor in the Department of Microbiology at the University of Massachusetts Amherst, where she leads the Klingbeil DNA Replication Laboratory. She received her PhD in Cell and Molecular Biology from the University of Toledo in 1996 and previously worked at Johns Hopkins School of Medicine before moving to UMass in July 2007. Her educational background includes: PhD in Cell and Molecular Biology, University of Toledo, 1996 Dr. Klingbeil's research focuses on the unique biology of trypanosomatid parasites, particularly Trypanosoma brucei , the causative agent of African sleeping sickness. Her laboratory investigates two main areas: (1) replication of the unusual mitochondrial DNA network called kinetoplast DNA (kDNA), and (2) nuclear DNA replication initiation. Her work on kDNA is particularly significant as this structure is essential for parasite survival but has no counterpart in mammalian hosts, making it an attractive drug target. She employs a combination of reverse genetics (RNAi), cell biology, and biochemistry to understand the replication and repair mechanisms of kDNA, with a special focus on a family of four DNA polymerases related to bacterial Pol I. Dr. Klingbeil's recent publications reveal her laboratory's deep investigation into mitochondrial DNA polymerases in trypanosomatids, with discoveries showing multiple polymerases having specialized functions in kDNA replication and repair. Her research has established that several of these polymerases are essential for parasite viability, opening new avenues for drug development. She has also made significant contributions to understanding the simplified Origin Recognition Complex in trypanosomatids compared to other eukaryotes. Dr. Klingbeil has received the Thomas G. Lessie Distinguished Lectureship Award for her impact on teaching at the graduate level. Her research is funded by the National Institutes of Health, U.S. Department of Agriculture, the Joeph P. Healey Endowment, and the University of Massachusetts Amherst. She has mentored numerous graduate and undergraduate students, including current PhD candidates Dave Bruhn, Jeniffer Concepción, and Juemin Luo, as well as visiting scholar Eva Vidal Rico. Her former students have gone on to positions at institutions including Dana Farber/Broad Institute, Regis College, and Flagship Ventures. The laboratory regularly participates in scientific conferences including the Molecular Parasitology Meeting at Woods Hole and the Kinetoplastid Molecular Cell Biology conference. Dr. Klingbeil teaches several courses including Parasitology (MICRO 590S), Parasitology Lab (MICRO 590L), Molecular Mechanisms of Pathogenesis (MICRO 797P), Advanced Cell Biology (MCB 641), and Writing in Microbiology (MICRO 360). Her laboratory organizes regular social events including pumpkin carving parties and outings to Six Flags New England and Mt. Sugarloaf.
Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788
Santiago F. González is a Group Leader at the Institute for Research in Biomedicine (IRB) in Bellinzona, Switzerland, and an extraordinary professor at the University of Italian Switzerland (USI). He earned dual PhDs in microbiology (University of Santiago de Compostela, Spain) and immunology (University of Copenhagen, Denmark), followed by postdoctoral work (2007–2011) at Harvard Medical School's Immune Disease Institute under Michael Carroll. PhD in Microbiology, University of Santiago de Compostela PhD in Immunology, University of Copenhagen His research focuses on immune system dynamics during respiratory viral infections, vaccination, and cancer metastasis. Key areas include influenza recognition , lymph node inflammation , and immune cell behavior in vivo. He pioneered studies on C-type lectin receptors (e.g., SIGN-R1) in viral immunity and epigenetic modulators for inflammation. Recent publications highlight his work in epigenetic drug development , nanovaccines , and computational tools for immune cell tracking. His group uses two-photon intravital microscopy and spatial-temporal modeling to dissect immune responses. Scientific awards include three EU Marie Curie Fellowships (2004–2013), enabling his transition to independent research. His collaborations span Harvard, USI, and European institutions, with grants from the EU and Swiss research bodies. His lab at IRB, established via the 2013 Marie Curie Career Integration Grant , develops novel imaging approaches and therapeutic strategies for infectious and immune-mediated diseases.
Prof. Dr. Markus Meissner is a Professor at the Faculty of Veterinary Medicine, Ludwig Maximilian University of Munich, leading the Chair of Experimental Parasitology. His research focuses on the molecular mechanisms of host cell invasion and modulation by Apicomplexan parasites, particularly Toxoplasma gondii and Plasmodium species. Research Group: Meissner Laboratory Location: Lena-Christ-Str. 48, 82152 Planegg-Martinsried Contact: markus.meissner@lmu.de His work investigates the secretory pathway of parasites, vesicular trafficking systems, and essential genes involved in host cell invasion and intracellular development. Toxoplasma gondii serves as a model organism for studying Apicomplexan biology, including nuclear division and CRMP complex functionality. Recent publications highlight the role of Rab GTPases in protein trafficking, chromatin remodeling in Plasmodium, and actin dynamics in parasite motility. Articles span topics such as egress factors, Golgi pathways, and lineage-specific organelle emergence, reflecting a multidisciplinary approach combining molecular biology, cell biology, and evolutionary analysis. The Meissner Lab includes PhD students (Peipei Qin, Yuan Song, Ella Schadt, Vitoria Catschor dos Santos) and postdocs (Dr. Wei Li, Dr. Miriam Rafajlovic). Research is conducted in Lena-Christ-Str. 48, Planegg-Martinsried, with a focus on experimental systems for studying parasite mechanisms.
Isabella Guido is a Senior Lecturer in Experimental Soft Matter Physics at the University of Surrey's School of Mathematics and Physics. She holds a PhD from TU Berlin (2010) and has conducted postdoctoral research at Peking University and the Max Planck Institute for Dynamics and Self-Organization. Her research focuses on synthetic biology, active bioinspired systems, and microtubule-motor protein dynamics. Guido's work bridges active matter physics and synthetic biology, aiming to develop minimal systems mimicking natural cellular structures. Key projects include synthetic beating structures resembling cilia, 3D active nematics, and investigations into cellular symmetry breaking via biomimetic systems. Her education includes a PhD on dielectrophoretic effects in mammalian cells, followed by postdoctoral studies on cell mechanics, microfluidics, and electroporation. Guido's interdisciplinary approach combines experimental biophysics with synthetic biology to uncover principles governing living matter. She leads the Synthetic Active Systems group and collaborates internationally on projects such as light-powered artificial cells and motor-driven microtubule networks. Her work addresses sustainable development goals through bio-inspired material design and active matter applications. Publications highlight contributions to electrotaxis mechanisms, live-cell imaging techniques (e.g., MIET), and microtubule network dynamics under depletion forces. Guido's research has advanced understanding of ciliary beating patterns, synthetic axoneme models, and biopolymer self-organization under mechanical stress.
Lin He is the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research and Professor of Cell Biology and Physiology at the University of California, Berkeley. His laboratory focuses on understanding the biological functions of non-coding RNAs in development and disease, with particular emphasis on microRNAs (miRNAs) in cancer, stem cell biology, and developmental processes. He developed the CRISPR-EZ method for highly efficient mouse genome editing, significantly advancing genetic research. Research interests include miRNAs' roles in tumor progression, metastasis, and pluripotency regulation in stem cells. His work bridges mouse genetics, genomics, and molecular biology to uncover mechanisms governing non-coding RNA functions. Current projects address miRNAs in oncogenesis, stem cell fate determination, and the interplay between non-coding RNAs and retrotransposons in development. Key contributions include identifying miRNA networks in cancer pathways, demonstrating miRNA requirements for ciliogenesis and lung development, and advancing CRISPR-based genome editing techniques. His interdisciplinary approach integrates genetic, genomic, and cellular tools to explore fundamental questions in biology and medicine. Lab website: helabucb.org CRISPR-EZ technology enables 100% genome editing efficiency in mouse zygotes Pioneering studies on miRNA regulation of PTEN, p53, and oncogene pathways
Zvonimir Dogic is a Research Associate Professor of Physics at the Martin A. Fisher School of Physics, Brandeis University. He leads the Dogic Lab, focusing on self-assembly of active and soft materials, with interdisciplinary work spanning statistical mechanics, biochemistry, and biophysics. His research explores how particle shape, chirality, and entropic forces drive emergent structures in colloidal systems and active matter. He holds a PhD from Brandeis University (2001) and has supervised numerous PhD students now in academic and industrial roles. Notable honors include the 2010 Cozzarelli Prize and the 2013 Andor Insight Award for his work on oscillating microtubule bundles. Research interests include active matter dynamics, liquid crystalline phases, and biomimetic systems. Recent work includes studies on microtubule-based active gels, chiral colloids, and self-organized cilia-like structures. His lab collaborates with institutions like Harvard, the Mayo Clinic, and the Francis Crick Institute. Key funding sources include the NSF MRSEC, W.M. Keck Foundation, and NIH. The lab’s YouTube channel and Science Blog posts highlight breakthroughs like self-propelled emulsions and entropy-driven membrane formation.
Jennifer Curtis is a Full Professor in the School of Physics at Georgia Institute of Technology and serves as an ADVANCE Professor for the College of Sciences. Her research focuses on the physics of cell-cell and cell-extracellular matrix interactions, particularly within glycobiology and immunobiology contexts. Dr. Curtis earned her Ph.D. in Physics from the University of Chicago (2002) and her B.A. in Physics from Columbia University (1997). Her research interests span biophysics at interfaces, quantitative modeling of collective cellular interactions, cell mechanics, motility, adhesion, and the role of bulky sugars in tissue organization. Her laboratory investigates collective and single cell migration, immunophage therapy (combining immune cells with phages to combat bacterial infections), and molecular biophysics of hyaluronan synthase. Recent work demonstrates applications in soft materials, biomaterials, tissue engineering, and advanced characterization techniques. Analysis of her publication record reveals consistent focus on glyco-biophysics and cellular mechanics, with increasing emphasis on microbial communities and therapeutic applications. Her work bridges physics, biology, and engineering through interdisciplinary approaches. Honors include the NSF CAREER Award (2010), Georgia Tech College of Sciences Faculty Mentor Award (2015), and Cullen Peck Award (2020). She serves on the Biophysical Journal editorial board. Dr. Curtis actively mentors students through the Georgia Tech Physics REU program (which she directs) and collaborates with biologists, chemists, and materials scientists. Her laboratory maintains strong partnerships with institutions including Emory University and international collaborators. The Curtis Lab operates the Cell Physics Laboratory in the Molecular Science & Engineering Building, utilizing advanced techniques including holographic optical tweezers, thermochemical nanolithography, and single-molecule imaging to study cellular mechanics and polymer physics at biological interfaces.
Prof. dr. Tessa Quax is an Associate Professor at the Faculty of Science and Engineering, University of Groningen, leading research in Molecular Microbiology . Her work focuses on archaeal virology and virus-host interactions, supported by prestigious grants including an ERC Starting Grant (2022) and NWO Vidi Grant (2023). Key Research Areas: Archaeal virus entry/egress mechanisms Cell surface dynamics and motility Extreme environment microbiology Genetic tool development for archaea Recent publications in Nature Reviews Microbiology (2025) and Current Opinion in Microbiology (2024) highlight her work on viral host recognition and structural diversity. Her lab's 44 research outputs span archaeal cell biology, viral evolution, and ecological impacts of virus-induced lysis. Scientific Recognition: KNAW Beijerinck Premium (2022) KNAW Early Career Award (2021) Hector Research Career Development Award (2021) ERC Starting Grant (2022) As Chair of the International Society for Viruses of Microbes SAB and Speaker of the German Microbiology Society's Microbial Viruses group, she coordinates global research networks including a HFSP grant (2023) with Japan/Australia/USA collaborators. Her lab currently includes PhD candidate Zaloa Aguirre Sourrouille and multiple postdoctoral researchers.
Prof. Andreas Bausch holds the Heinz Nixdorf Endowed Chair of Cell Biophysics at the Technical University of Munich (TUM) within the TUM School of Natural Sciences . His research focuses on cellular biophysics , particularly the mechanical properties of cytoskeletal networks and self-organization mechanisms in biological systems, with applications in biomimetic materials and organoid modeling. Research Areas : Cytoskeletal mechanics, active matter systems, organoid morphogenesis, integrin signaling, synthetic cell models Techniques : Microrheology, in vitro reconstitution, microfluidics, advanced imaging His work has produced over 100 publications in Nature, Science, PNAS , and Physical Review Letters , with recent emphasis on pancreatic cancer organoids and artificial cell membranes . Key findings include: Discovery of topological excitations governing endothelial cell ordering Elucidation of PIP2/PIP3 regulation in integrin phase separation Development of 3D patterned organoid systems for drug screening Major awards include: ERC Synergy Grant (2018) ERC Advanced Grant (2012) ERC Starting Grant (2011) Berlin-Brandenburg Academy of Sciences Prize (2014) He serves as founding director of the Center for Functional Protein Assemblies (CPA) since 2015 and teaches biomechanics , biophysics , and protein assemblies at TUM. His lab investigates both fundamental biophysical principles and their medical applications in cancer and cardiovascular systems.
Professor Maryse Bailly is a Professor of Cell Biology at the UCL Institute of Ophthalmology, University College London, where she has been employed since December 2000, progressing from Lecturer to Reader/Associate Professor and finally to Professor in October 2020. Her research focuses on understanding fibroblast behavior in the context of ocular diseases, scarring, and fibrosis, with particular emphasis on cytoskeletal dynamics and mechanotransduction pathways. Education: Doctor of Philosophy, Universite Claude Bernard (Lyon 1), 1992 Diplome Universitaire de Technologie, Universite Claude Bernard (Lyon 1), 1983 Professor Bailly's research program investigates how fibroblasts sense and respond to mechanical and chemical stimuli in their environment, with applications to multiple ocular pathologies including trachoma, thyroid eye disease, glaucoma scarring, and myopia. Her laboratory has developed innovative in vitro and ex vivo models that allow the study of tissue contraction mechanisms within pseudo-physiological 3D environments, leading to the identification of novel therapeutic targets such as the Rac1 small GTPase and the MRTF/SRF pathway. She has established significant collaborations with clinicians at Moorfields Eye Hospital, particularly with Dr. Annegret Dahlmann-Noor on pediatric eye growth and myopia research. Analysis of Professor Bailly's publication record reveals a consistent focus on fibroblast mechanobiology with increasing emphasis on pediatric ocular development in recent years. Her work bridges fundamental cell biology with translational applications, particularly in understanding the biomechanical properties of fibroblasts in myopia development and post-surgical scarring. The research demonstrates strong interdisciplinary connections between ophthalmology, cell biology, and tissue engineering. Teaching: CELL0016 - Actin cytoskeleton and Intermediate Filaments CELL0017 - Fibrosis and mechanotransduction CELL0009 - Models organisms and techniques MECH0031 MSc Biomaterials & Tissue Engineering - Modeling tissue contraction and fibrosis
