جستجوی استاد راهنمای دانشگاهی

Kristian Helinمشاهده پروفایل

استاد

• Cancer biology
• Epigenetics
• Stem cells
• +۵ مورد دیگر

Kristian Helin is Chief Executive and President of The Institute of Cancer Research (ICR), London, and a Professor with affiliations at the University of Copenhagen and Memorial Sloan Kettering Cancer Center. He founded/directed the Biotech Research & Innovation Centre (BRIC), Centre for Epigenetics, and Danish Stem Cell Center. His research focuses on epigenetic regulation, cancer biology, and stem cell differentiation. Education: Ph.D. Molecular Biology, University of Copenhagen (1991) M.Sc. Chemical Engineering, Technical University of Denmark (1988) Research Interests: Helin's work deciphers molecular mechanisms in cancer, emphasizing epigenetic drivers (e.g., H3K4/H3K36 methylation), transcriptional control, and therapeutic targeting. His lab identified E2F transcription factors, linked epigenetic dysregulation to leukemia/lymphoma, and develops drugs targeting kinases/epigenetic enzymes. Research spans acute myeloid leukemia, B-cell lymphoma, and solid tumors using CRISPR screens and preclinical models. Publication Trends: Recent articles (2023-2025) focus on epigenetic therapy, chromatin remodeling, and kinase signaling in cancer. Key themes include targeting NSD1/KDM5C/RIOK2 enzymes, combination therapies (EZH2/DOT1L inhibitors), and metabolic regulation in leukemia. Studies bridge basic mechanisms (enhancer regulation, insulator accessibility) with translational applications. Awards: Anders Jahre Prize (2014), ERC Advanced Grant (2011), Novo Nordisk Prize (2008) Memberships: Academia Europaea, Royal Danish Academy, EMBO Leadership: Helin co-founded EpiTherapeutics (acquired by Gilead) and leads the Epigenetics and Cancer lab at ICR. His team investigates AML pathogenesis and chromatin complexes like HUSH/NURF. Grants include ERC funding and innovation prizes.

Peter Matthiasمشاهده پروفایل

استاد

• Biochemistry
• Cell Biology
• Cell division
• +۷ مورد دیگر

Matthias Peter is a Professor of Biochemistry at ETH Zurich, leading research into mechanisms governing cell growth and division. His laboratory focuses on ubiquitin-dependent regulation of DNA replication and mitosis, and autophagy's role in cellular quality control. He chairs the Department of Biology (2011-2015) and holds leadership roles in Switzerland's research infrastructure, including Vice Chair of ScopeM's microscopy platform. His academic career includes roles at ISREC (1996-2002) and postdoctoral training at UCSF (1991-1996). Education: PhD in Biochemistry from ISREC (1991), ETH Zurich diploma in Gene Technology (1987). Research interests span molecular mechanisms of cell division, ubiquitin systems, and autophagy. Awards include ERC Advanced Grant (2011) and UBS Excellence in Research (2002). Leadership: Member of Swiss National Research Council, SNF selection committee, and SWTR council. Over 20 years of committee service in national research programs. His lab's work is published in top journals like Science, Nature, and Molecular Cell.

Nikolaus Pfannerمشاهده پروفایل

استاد

• Protein Structure and Function
• Targeting, translocation and folding of mitochondrial proteins
• Biogenesis of Mitochondria: Protein Transport and Assembly

Professor Nikolaus Pfanner, a leading figure in mitochondrial biogenesis and protein transport, has held the Chair of Biochemistry and Molecular Biology at the Institute of Biochemistry and Molecular Biology, University of Freiburg, since 1992. His leadership roles include serving as President of the German Society for Biochemistry and Molecular Biology (2009–2011) and Council Member of the University of Freiburg (since 2008). His research focuses on the targeting, translocation, and folding of mitochondrial proteins , biogenesis of mitochondria , and protein structure and function . Key contributions include elucidating the TOM complex’s role in protein import and the SAM complex in β-barrel assembly. Recent publications explore mitochondrial import stress , complexome analysis , and MIMAS mega-assembly . His work integrates structural biology , proteomics , and kinase regulation . Awarded the Leibniz Prize (2004), Stein and Moore Award (2014), and Hector Research Award (2011), Pfanner is a member of EMBO , Leopoldina , and Academia Europaea . He has mentored numerous researchers, including Thomas Becker , Chris Meisinger , and Nils Wiedemann . His lab receives funding from the Deutsche Forschungsgemeinschaft (DFG) and EXZ BIOSS (since 2010).

John Diffleyمشاهده پروفایل

استاد

• DNA replication
• Cell cycle control
• Genome stability

John Diffley is a distinguished molecular biologist specializing in DNA replication and cell cycle control. He serves as Director of Clare Hall Laboratories and Deputy Director of the London Research Institute since 2006. Additionally, he holds the position of Honorary Full Professor in the Department of Biology at University College London since 1999. His research has significantly advanced our understanding of the mechanisms controlling DNA replication in eukaryotic cells. Professor Diffley's research focuses on three primary areas: DNA replication, cell cycle control, and genome stability. His work has elucidated key mechanisms in replication initiation, origin licensing, and the coordination between DNA replication and cell cycle progression. His laboratory has made seminal contributions to understanding how replication proteins assemble at origins of replication and how this process is regulated throughout the cell cycle. Analysis of Professor Diffley's recent publications reveals a strong focus on the molecular mechanisms of DNA replication initiation and control. His work spans from structural studies of replication complexes to systems-level analyses of replication timing and its relationship to gene expression. A recurring theme is the investigation of how DNA damage checkpoints regulate replication processes to maintain genome stability. His research employs diverse model systems including budding yeast and human cells, demonstrating the evolutionary conservation of core replication mechanisms. Elected member of European Molecular Biology Organisation (EMBO) (1998) Paul Marks Prize for Cancer Research (2003) Elected Fellow of the Royal Society (2005) Member of Academia Europaea (2009) Member of the European Academy of Cancer Sciences (2011) Fellow of the Academy of Medical Sciences (2011) Throughout his career, Professor Diffley has led the Chromosome Replication Laboratory, first at ICRF Clare Hall Laboratories (1990-1999) and subsequently at the London Research Institute. His laboratory has received substantial funding from Cancer Research UK and other major research organizations to investigate the fundamental mechanisms of DNA replication. Professor Diffley has mentored numerous graduate students and postdoctoral researchers who have gone on to establish independent research careers in molecular biology and related fields. Professor Diffley's research group, the Chromosome Replication Laboratory, operates at the forefront of DNA replication research. The laboratory combines biochemical, genetic, and cell biological approaches to dissect the complex machinery that ensures accurate DNA replication. Their work has important implications for understanding cancer development, as defects in DNA replication control are a hallmark of cancer cells.

• Premenstrual Dysphoric Disorder
• Neuroscience
• Stress Research
• +۲ مورد دیگر

Celine Bencker is an External Lecturer and Academic researcher in the Department of Clinical and Health Psychology at the University of Vienna. Her research focuses on psycho-biological interactions in premenstrual symptomatology and stress responses during daily life. Her primary research interests include Premenstrual Dysphoric Disorder, stress neuroscience, and psychobiological interactions across the menstrual cycle. She employs ecological momentary assessment to investigate real-time psychological and biological stress responses in clinical populations. She has received prestigious awards including the Early Career Award (2025) SBSM Scholar Award (2025) She leads the research project: Investigating psycho-biological interactions in premenstrual symptomatology and stress during daily life , funded through the ÖAW-DOC Fellowship.

Thomas Leonardمشاهده پروفایل

استاد

• Lipid signaling
• Protein kinases
• Signal transduction
• +۵ مورد دیگر

Thomas Leonard is a tenured Professor at the Max Perutz Labs (University of Vienna), where he leads a research group focused on lipid-mediated signal transduction and structural mechanisms of kinase regulation . His lab combines structural biology , biochemistry , and cell biology to dissect how cells integrate spatial and temporal signals. PhD in Structural Biology (MRC Laboratory of Molecular Biology, Cambridge) Postdoctoral work at NIH, Bethesda His research explores how lipid second messengers like PIP3 and PI3P control kinases such as Akt, PDK1, and Sgk3, with implications for cancer , neurodevelopmental disorders , and metabolic diseases . Recent work redefined PHLPP1/2 as pseudophosphatases and revealed novel activation mechanisms in Protein Kinase D (PKD) and DMPK kinases. The lab's publication trends highlight structural phylogenomics , membrane scaffolding , and allosteric regulation . Collaborations with institutions like LMU Munich and FWF-funded projects underscore their interdisciplinary approach. Lab Manager: Ronja Reinhardt PhD Students: Sumire Antonioli, Magdalena Otto, Lucas Piech, Eva Krotenheerdt, Felix Wolkenstein Master Students: Gabriela Ariza, Emese Galgóczi, Stefan Lenz The lab actively recruits at Master, PhD, and Postdoc levels for molecular signaling research.

Francesc Posas Garrigaمشاهده پروفایل

استاد

• Stress-activated MAP kinases
• Synthetic Biology
• Signal transduction
• +۳ مورد دیگر

Francesc Posas is a Full Professor at Universitat Pompeu Fabra (UPF) and Director of IRB Barcelona since 2018. He co-leads the Cell Signaling Research Group and has held leadership roles including Head of the Department of Experimental and Health Sciences (2007-2013) and Vice-rector for Science Policy (2013-2017). Doctorate in Biochemistry and Molecular Biology (UAB, 1995) Postdoctoral Fellow at Harvard University (1996-1998) His research focuses on cellular adaptive responses , particularly MAP kinase pathways and stress signaling in yeast and mammals. Recent work explores synthetic biology and biological computation. His publications span top journals including Nature , Science , and Molecular Cell . Scientific Awards : ICREA Acadèmia Award (2009-2023) Carmen y Severo Ochoa Award (2011) EURYI Young Investigators Award (2004) EMBO Membership (2006) Best PhD Thesis Award (UAB, 1995) He has received multiple teaching and research evaluations from Catalan and Spanish governments. His work has been cited over 7,000 times with an h-index of 43 (Web of Science) or 50 (Google Scholar).

• Neuroscience
• Neurophysiology
• Motor Control
• +۵ مورد دیگر

El Manira Abdeljabbar is a distinguished Professor of Neuroscience at Karolinska Institutet, Sweden, where he has held academic positions since 1992. He leads the Neurobiology of Motor Actions research group within the Department of Neuroscience, focusing on neural circuits governing motor behavior. His work integrates neurophysiology, neurochemistry, and developmental biology to understand how brainstem and spinal circuits translate intentions into movement. Education: BSc in Biology (University of Rabat, 1988), PhD in Neuroscience (University of Marseille, 1992), Postdoc (Karolinska Institutet, 1992–1994), and Docent (Karolinska Institutet, 1997). Research highlights include pioneering studies on synaptic transmission, motor neuron function, and spinal circuitry in zebrafish. He has received prestigious awards such as the Distinguished Professor Award (2010), Knight of the Order of the Throne (2016), and membership in the Royal Swedish and Moroccan Academies of Science. Professional roles include Director of the Graduate School in Neuroscience (2005–2012), Coordinator of the EU-funded Spinal Cord Repair consortium (2009–2012), and editorial roles at journals like Journal of Neuroscience . His research has advanced understanding of locomotor speed control, neural circuit plasticity, and neuromodulation mechanisms. Current projects explore molecular and circuit-level bases of motor actions, with implications for neurological disorders.

Crisanto Gutierrezمشاهده پروفایل

استاد

• Cell Cycle
• DNA Replication
• Chromatin
• +۵ مورد دیگر

Crisanto Gutierrez is a distinguished Professor at the Spanish National Research Council (CSIC) and Head of the Genome Dynamics and Function Program at the Center for Molecular Biology Severo Ochoa in Madrid, Spain. With over three decades of academic service since 1982, he has held progressive academic ranks from Assistant Professor to his current full Professor position since 2002, establishing himself as an internationally recognized leader in plant molecular biology. His pioneering research focuses on the interplay between chromatin dynamics, DNA replication, and cell proliferation in plants, utilizing multidisciplinary approaches across cellular, molecular, genetic, and genomic domains. Gutierrez achieved seminal breakthroughs including the discovery of the retinoblastoma (Rb) tumor suppressor protein in plants and deciphering geminivirus DNA replication mechanisms coupled to the cell cycle. His work primarily employs Arabidopsis thaliana as a model system to investigate fundamental biological processes, with particular expertise in endoreplication, epigenetics, chromatin organization, and root development. Analysis of his recent publications reveals a consistent trajectory exploring chromatin organization's role in genome function, with increasing emphasis on epigenetic regulation of DNA replication origins and their developmental implications. His research bridges fundamental cell cycle mechanisms with plant-specific adaptations, demonstrating how chromatin landscapes dictate replication timing and transcriptional activity across different tissue types. Honors and awards include: EMBO Council Member (2020) ERC Advanced Grant PLANTGROWTH (2019-2024) Research Prize from Fundacion Carmen y Severo Ochoa (2008) Membership in the Royal Academy of Medicine and Surgery of Cadiz (2009) EMBO Membership (1998) Gutierrez maintains an active research program with continuous competitive funding since 1993, including his current European Research Council Advanced Grant. He has trained over 60 PhD and postdoctoral researchers, nine of whom now lead independent laboratories worldwide. His editorial leadership includes positions at EMBO Journal , EMBO Reports , and Plant Journal , while his advisory roles extend to research institutes in France, Spain, and Argentina. He serves on prestigious evaluation panels including LABEX (France) and the ERC Consolidator Grant Life Sciences panel.

Echard Arnaudمشاهده پروفایل

استاد

• Cytokinesis
• Cell division
• Oxidoreduction
• +۳ مورد دیگر

Arnaud Echard is a Full Professor of Biology at Ecole Polytechnique (since 2018) and Head of the Membrane Traffic and Cell Division Lab at Institut Pasteur (since 2015). He holds dual roles as CNRS Research Director 1st class (since 2016) and has been a pivotal leader in cell biology, serving as President of the French Society for Cell Biology (2015–2018) and President of the Institut Pasteur's Scientific Council (2021–2023). His research focuses on cytokinesis, cell division mechanisms, and ESCRT machinery. Education: PhD in Biology, University of Paris XI (2000) with highest honours Fellow of Ecole Normale Supérieure de Lyon (1992–1996) M.Sc. Molecular and Cellular Biology Agrégation of Biochemistry (National highest teaching qualification) Research Interests: Echard explores fundamental mechanisms of cell division, including cytokinesis dynamics, membrane trafficking, and actin cytoskeleton regulation. His work bridges cell biology and biophysics, addressing how cellular components coordinate during division. Key areas include ESCRT machinery function, oxidoreduction processes, and abscission checkpoints. Awards: 2018 Gustave Roussy Prize (French Academy of Sciences) 2015 Dr. ST Huang-Chan Memorial Medal (University of Hong Kong) 2011 Schlumberger Foundation Prize Three Excellence Awards from CNRS (2012–2023) Leadership & Service: Echard chairs major scientific bodies, including the Institut Pasteur’s hiring committee and the French Society for Cell Biology. He also co-leads the Institute for Integrative Biology of the Cell (I2BC) and serves on editorial boards for Cells & Development and Biology of the Cell . Labs & Teams: He directs the Membrane Traffic and Cell Division Lab at Institut Pasteur, a hub for studying cell division mechanics. His work integrates molecular, cellular, and biophysical approaches to unravel cytokinesis processes.

Christian Lehnerمشاهده پروفایل

استاد

• Cell Biology
• Developmental Biology
• Cell cycle
• +۱ مورد دیگر

Christian Lehner is a Professor in Developmental Biology at the University of Zurich, with a career spanning over three decades in cell biology and genetics research. He has held academic positions at the Institute of Molecular Life Sciences (IMLS) and the Zoological Institute of the University of Zurich since 2007, preceded by a 11-year tenure as Professor (C4) for Genetics at the University of Bayreuth. Education: Habilitation in Zoology (Cell Biology), University of Zurich, 1994 Ph.D. in Cell Biology, ETH Zurich, 1983–1986 Undergraduate studies in Biochemistry, ETH Zurich, 1976–1981 His research focuses on fundamental mechanisms of cell cycle regulation and cell division , contributing to understanding developmental processes and genetic controls. These areas remain critical in modern molecular biology and genetics. Notable accolades include: Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft (DFG), 1997 Member of EMBO, 1998 Member of Academia Europaea, 2000 He has mentored numerous postdoctoral researchers and maintains an active role in academic leadership.

Sebastian Falkمشاهده پروفایل

دانشیار

• RNA Processing
• RNA Surveillance
• Small Non-coding RNA Biology
• +۳ مورد دیگر

Sebastian Falk is an Associate Professor at the Max Perutz Labs, part of the University of Vienna, within the Department of Structural and Computational Biology. His research focuses on the biogenesis and action of small RNAs, particularly piRNAs, employing structural biology and biochemical approaches to elucidate molecular mechanisms. He received the prestigious EMBO Young Investigator award in 2022. His lab investigates RNA surveillance pathways, mRNA splicing, and the interplay between RNA processing and degradation. Key projects include studying the MTR4-NRDE2-CCDC174 complex and piRNA processing factors in C. elegans. Falk has organized major symposia on RNA biology and contributed to high-impact publications in journals like Nature and Nucleic Acids Research . EMBO Young Investigator (2022) Grants: 'Characterization of piRNA processing factors in C. elegans' (2023-2026)

• Genetics
• Molecular Biology
• Biochemistry
• +۴ مورد دیگر

Christopher Campbell is an Associate Professor at Max Perutz Labs, specializing in Biochemistry and Cell Biology and Chromosome Biology . His research focuses on aneuploidy, chromosomal instability, and their implications in cancer and yeast genetics. Collaborations span diverse fields, including pharmacology, microbiology, and neuroscience. Key Research Areas: Aneuploidy, Budding Yeast, Spindle Checkpoint, Centromere, Chromosome Instability, MRSA, HSP90 Inhibition Recent Publications: Studies on aneuploidy patterns in cancer, yeast adaptation to chromosomal instability, and MRSA antibiotic resistance mechanisms Scientific Contributions: Investigated genetic interactions underlying aneuploidy Developed strategies for opioid therapy via spinal HSP90 inhibition Explored antibiotic adjuvants targeting bacterial metabolism Active Projects: Genome Instability, Meiosis, and chromosomal causes of aneuploidy (2024–2028)

Carlos Ibanezمشاهده پروفایل

استاد

• Neuroscience
• Neuronal Growth Factors
• Neurodevelopment
• +۳ مورد دیگر

Carlos Ibanez is a Professor in Neuroscience at the Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. His research focuses on neuronal growth factors, neurodevelopment, and neurotrophins. He has held his current position since 1996 and is affiliated with the Carlos Ibanez Lab @ KI, collaborating with institutions like Peking University and NUS. His work spans molecular biology, stem cell research, and genomics. Education and career: Ibanez earned his academic credentials and has been a member of prestigious organizations, including Academia Europaea (since 2007) and the European Molecular Biology Organization (EMBO, since 2006). He has received awards like the Goran Gustafssons prize in Molecular Biology (1998) and the Erik K. Fernstrom Young Researcher Prize. Research Interests: His lab investigates neurotrophin signaling, stem cell biology, and genomic approaches to neural development. Notable contributions include studies on neurotrophin-4, cholinergic neuron regulation, and spatial transcriptomics of the medial ganglionic eminence. Awards: Beyond his memberships, Ibanez has been recognized for contributions to molecular biology and neuroscience, including grants from the Swedish Cancer Society and the Swedish Research Council. His lab hosts international collaborations under networks like Molpark and Endocyte. Grants and Funding: Current grants include support from the Swedish Cancer Society (2019–2022) and the Swedish Research Council (2021–2024). His work integrates multidisciplinary approaches to understand neural development and disease mechanisms. Labs and Teams: The Ibanez Lab collaborates globally, with satellite groups at Peking University (CIBR) and NUS. Alumni include researchers like Sabrina Zechel and Pawel Zajac, contributing to genomics and stem cell projects.

Dirk Inzéمشاهده پروفایل

استاد

• Lab-to-field-to-lab concept
• Plant phenotyping
• Plants and climate emergency
• +۳ مورد دیگر

Dirk Inzé is a global leader in plant biology and Full Professor at Ghent University. He serves as Science Director and Head of the VIB-UGent Center for Plant Systems Biology, driving advanced research in plant systems biology since 2002. Research spans molecular networks regulating plant growth, crop productivity, and climate resilience Key initiatives include EU-SAGE (European Sustainable Agriculture through Genome Editing) Chair of the LS9 panel for Advanced ERC Grants and frequent advisor to international institutes Research Focus: Dirk Inzé's work addresses molecular mechanisms controlling plant organ growth and stress responses. His team develops genetic engineering strategies to enhance crop yield under climate stress, contributing to food security for a growing global population. Scientific Recognition: He has received numerous accolades including the Francqui Prize ("Belgian Nobel Prize") World Agriculture Prize (GCHERA) Double ERC Advanced Grant awardee AAAS Fellow Highly-cited researcher (H-index 131) Dirk Inzé has delivered over 150 invited lectures and leads policy advocacy for genome-edited crops in Europe through EU-SAGE. His lab at Ghent University comprises ~300 researchers, making it one of the world's premier plant science centers.