Professor Hedeel Guy-Evans is a distinguished faculty member in the Department of Chemistry at Eastern Michigan University, with joint appointments in Neuroscience. Her research bridges the fields of biochemistry, cancer biology, and neurodegenerative diseases, with a particular focus on the intersection between Alzheimer's disease and cancer mechanisms. Education: A-levels, Worthing College, England, 1980 BS, Eastern Michigan University, 1984 MS, Wayne State University Medical School, 1986 Ph.D., Wayne State University Medical School, 1992 Postdoctoral Fellow, Biochemistry, 1992-1994, Université Pierre et Marie CURIE (University of Paris VI), Paris, France Fulbright Research Scholar, 2008-2009, Département de Biologie Cellulaire, Institut Curie, Paris, France Dr. Guy-Evans's research program centers on two major areas: 1) The regulation of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) and β-Amyloid by Humanin (HN) in both Alzheimer's disease and cancer, and 2) Pyrimidine biosynthesis. Her work explores how IGFBP-3, β-Amyloid, and Humanin interact in neuronal cell death seen in Alzheimer's disease and in cancer cell proliferation. She investigates the mechanisms by which Humanin protects against neuronal cell death induced by IGFBP-3 and β-Amyloid, with potential applications for new therapeutics. In her pyrimidine biosynthesis research, she studies the structure/function of intrinsically disordered regions on dihydroorotase (DHO) and their order upon association with aspartate transcarbamoylase (ATC). Dr. Guy-Evans has received continuous NIH funding for her research, including her current R15GM131222 grant 'Probing the Role of Insulin-Like Growth Factor-Binding Protein 3 and Humanin in Regulating Hyaluronan Function.' Her publication record shows a clear trend toward increasingly sophisticated investigations of the molecular connections between neurodegenerative processes and cancer biology, with particular emphasis on lung cancer models and the role of neurotransmitter-related pathways. Scientific Awards: 2019 Ronald W. Collins Distinguished Faculty Research Award Dr. Guy-Evans actively mentors numerous undergraduate and graduate students through her research program, with students frequently appearing as co-authors on her publications. Her NIH grants have provided substantial funding for research equipment, student stipends, and collaborative opportunities. She has successfully integrated research into teaching through innovative approaches like team-based learning in biochemistry laboratory courses, as documented in her 2016 Journal of Chemical Education publication.
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Krister Wennerberg is a Professor at the University of Copenhagen, affiliated with the Biotech Research & Innovation Centre (BRIC) within the Faculty of Health and Medical Sciences. His research group, the Wennerberg Group, focuses on advancing cancer therapeutics through computational and experimental approaches. Wennerberg's research interests span cancer biology, particularly leukemia, with expertise in drug discovery, computational biology, and precision medicine. His work investigates synthetic lethality, cancer signaling pathways (particularly KRAS and ERK), and the development of novel therapeutic strategies for hematological malignancies. His approach combines high-throughput screening, machine learning, and molecular biology to identify effective drug combinations and repurposing opportunities. His publications demonstrate significant contributions to understanding drug resistance mechanisms in acute myeloid leukemia, development of microenvironment models for leukemia studies, and identification of novel therapeutic targets in cancer. His research has been published in high-impact journals including Science, Nature Reviews Drug Discovery, and Blood, reflecting the translational significance of his work. Wennerberg maintains extensive collaborative networks across Scandinavia and internationally, as evidenced by his co-authorships on numerous publications with researchers from multiple institutions. His work receives attention across academic and clinical communities, with mentions in peer review sites, news outlets, and social media platforms.
- Cancer Biology
- Leukemia Research
- Drug Discovery
- +۵ مورد دیگر