جست‌وجوی استاد و پژوهشگر

Keith Alexander Sharkeyمشاهده پروفایل

استاد

• Enteric nervous system
• Gut-brain axis
• Endocannabinoid system
• +۳ مورد دیگر

Dr. Keith Alexander Sharkey is a Professor in the Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He is also a Full Member of both the Hotchkiss Brain Institute and The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases. Dr. Sharkey has been at the University of Calgary since his appointment as Assistant Professor in 1990, dedicating his career to understanding the neural control of the gastrointestinal tract. From 2005-2021, he held the Crohn's and Colitis Canada Chair in Inflammatory Bowel Disease Research, demonstrating his longstanding commitment to advancing knowledge in gastrointestinal sciences. Dr. Sharkey's educational journey began with a BSc (Hons) in Nutrition from the University of London in 1981, followed by a PhD in Physiology from the University of Liverpool in 1985. After completing postdoctoral training in Hungary, the UK, and Canada, he joined the University of Calgary faculty in 1990, where he has remained throughout his distinguished academic career. Dr. Sharkey's research program centers on understanding the physiology and pathophysiology of the neural control of the gastrointestinal tract and brain-gut interactions in health and disease. His laboratory investigates two main areas: the role of the endocannabinoid system in regulating GI motility and intestinal barrier function, and the physiology of the enteric nervous system in controlling motility and barrier function. His work employs state-of-the-art approaches including live cell imaging and molecular genetics. Recent publications show his expanding interest in connections between gut function and neurodegenerative conditions like ALS, with multiple 2024-2025 papers examining sexual dimorphism in disease processes and gut-brain axis mechanisms. Fellow, Royal Society of Canada (2024) Cumming School of Medicine's van de Sande Distinguished Achievement Award for Mentorship (2021) Distinguished Research Award, American Physiological Society (2021) Finkelstein Award for Excellence, Crohn's and Colitis Canada (2016) Fellow, Canadian Academy of Health Sciences (2015) Fellow, Canadian Association of Gastroenterology (2015) Killam Annual Professor Award, University of Calgary (2013) Dr. Sharkey has mentored numerous students throughout his career, as evidenced by his 2021 Mentorship Award. His research is supported by significant funding, including a CIHR Foundation grant exploring how enteric nerves and glia maintain intestinal homeostasis. He has also participated in university strategic initiatives focused on Brain and Mental Health (2015-2021) and Infections, Inflammations and Chronic Diseases (2015-2021), demonstrating his interdisciplinary approach. The Sharkey Lab provides a safe, inclusive, and diverse research environment that encourages open scientific exchange from diverse viewpoints. His laboratory is actively engaged in multiple collaborative projects, including investigations with UBC Okanagan on diet and probiotics targeting the gut-brain metabolic interactome, and with University of Calgary colleagues studying gut microbiota's role in ALS. Dr. Sharkey continues to advance our understanding of neural mechanisms controlling gastrointestinal function with upcoming courses scheduled for Fall 2024 and Winter 2025.

Vikramaditya G. Yadavمشاهده پروفایل

دانشیار

• Biocatalysis
• Bioremediation
• Bioprocess engineering
• +۱۵ مورد دیگر

Vikramaditya G. Yadav is an Associate Professor at the University of British Columbia (UBC) in the Department of Chemical and Biological Engineering, Faculty of Applied Science. He directs the Master of Engineering Leadership (MEL) Program in Sustainable Process Engineering and leads the BioFoundry research group. Education: B.A.Sc., University of Waterloo (2007) Ph.D., Massachusetts Institute of Technology (2013) Postdoctoral Associate, Harvard University (2014) His research spans sustainable chemical manufacturing, metabolic engineering, and biotechnology. Key areas include: Designing biosynthetic enzymes for biomass valorization Developing bioremediation strategies for industrial water quality Creating innovative drug delivery systems and tissue engineering solutions Advancing synthetic biology for pharmaceutical and bioenergy applications His recent work focuses on ocular drug delivery, cannabinoid biosynthesis in E. coli, lignin-based nanoparticles for cancer therapy, and computational analysis of plant secondary metabolites. Collaborations with start-ups, industry, and medical labs drive innovation in Canada's bioeconomy. Professional Leadership: Chair, Biotechnology Division of the Chemical Institute of Canada Associate Editor, The Canadian Journal of Chemical Engineering He is affiliated with UBC's BioProducts Institute and contributes to project-based learning pedagogy.

Rotem Karniمشاهده پروفایل

دانشیار

• Alternative RNA Splicing
• RNA Biology
• Cancer Therapy
• +۴ مورد دیگر

Rotem Karni, PhD, is an Associate Professor of Genetics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He leads a research lab focused on understanding how alternative RNA splicing contributes to cancer and genetic diseases, with a strong emphasis on translating these findings into RNA-based therapies. Karni's lab develops decoy oligonucleotides, small molecules, and splice-switching technologies to modulate splicing factors and enhance immunotherapy. Education BSc in Biological Chemistry from The Hebrew University of Jerusalem (1997) PhD in Biological Chemistry from The Hebrew University of Jerusalem, Israel (2002) Postdoctoral Fellowship at Cold Spring Harbor Laboratory, NY (2002-2007) Karni's research explores the deregulation of alternative splicing in oncogenesis, particularly how splicing factors like RBFOX2 and S6K1 influence metastasis, DNA repair, and immune checkpoint modulation. His team investigates m6A RNA modifications for stabilizing mutant genes, with applications in Duchenne Muscular Dystrophy and pancreatic cancer. The lab's work is commercialized through biotech companies: SKIP Therapeutics, Andlit Therapeutics, and RNAble. Selected Research Trends RNA mis-splicing and neoantigen generation (2025) Splicing factor inhibition for tumor suppression (2023) Metastatic splicing signatures in pancreatic cancer (2023) Immune checkpoint splicing in cancer immunotherapy (2021) m6A modulation for mRNA stabilization (2023) Advising & Collaborations Karni has mentored numerous PhD and postdoctoral researchers, many of whom now hold leadership roles in academia, biotech, and medical institutions globally. His lab collaborates extensively on projects involving RNA innovation, including partnerships with the Institute for RNA Innovation. Contact Department of Genetics & Institute for RNA Innovation, One uCity Square, Room 4018, Philadelphia, PA 19104 Phone: 215-898-5072 Email: Rotem.Karni@Upenn.edu

Aditi Dasمشاهده پروفایل

استاد

• Biochemistry and Chemical biology of Lipids
• Mechanism of Membrane proteins in Nanodiscs
• Enzymology of metalloproteins
• +۵ مورد دیگر

Aditi Das is a Full Professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology, College of Sciences. She leads the Das Laboratory, which focuses on the biochemistry and chemical biology of lipids, particularly studying cytochrome P450 enzymes and their role in lipid metabolism, endocannabinoid systems, and inflammatory pathways. Her educational background includes: B.Sc. in Chemistry from St. Stephen's College M.Sc. in Chemistry from Indian Institute of Technology, Kanpur (I.I.T) Ph.D. in Chemistry from Princeton University Postdoctoral research at Northwestern University (NSF-NSEC fellow) and Beckman Institute for Advanced Science and Technology, University of Illinois UC Professor Das's research interests center around understanding the physiological role of lipids in sustaining homeostasis and their implications in disease states such as neurodegenerative disorders, cancer, and cardiovascular diseases. Her laboratory specializes in: Enzymology of cytochrome P450s, particularly CYP2J2 epoxygenase Metabolism of ω-3 and ω-6 fatty acids and their derivatives Minor cannabinoid metabolism by cytochrome P450 enzymes Discovery of novel anti-inflammatory lipid metabolites and endocannabinoids Mechanistic studies of membrane proteins using nanodisc technology Her work bridges biochemistry, chemical biology, and pharmacology to uncover novel therapeutic targets related to lipid signaling pathways. Analysis of Professor Das's recent publications (2023-2025) reveals a strong focus on cannabinoid metabolism by cytochrome P450 enzymes, with particular emphasis on how these metabolic processes generate bioactive compounds that interact with the endocannabinoid system. Her research increasingly explores the therapeutic potential of omega-3 derived endocannabinoid epoxides in inflammatory and neurodegenerative conditions. The use of nanodisc technology for studying membrane proteins in near-native environments remains a consistent methodological thread throughout her work, enabling detailed mechanistic insights into enzyme function. Professor Das has received numerous prestigious awards recognizing her research excellence and teaching: 2024 NIH Outstanding Researcher Award (MIRA R35) for established investigators 2024 Vasser Woolley Faculty Fellowship 2023 Plenary Lecture at the International Society of the Study of Xenobiotics (ISSX) 2021 E.L.R. Stokstad Award 2019-2021 List of Teachers Ranked as Excellent 2019 Eicosanoid Research Foundation Young Investigator Award 2019 Zoetis Research Excellence Award 2019 Mary Swartz Rose Young Investigator Award 2015 National Scientist Development Award from the American Heart Association 2022 El Sohly Award from the American Chemical Society Professor Das actively mentors a diverse group of students and postdoctoral researchers, with several former lab members now holding faculty positions or working at prestigious institutions. Her laboratory has secured significant funding from NIH, NSF, and other sources to support research on lipid metabolism, cannabinoid pharmacology, and membrane protein biochemistry. Notable grants include an NIH R35 Outstanding Investigator Award (MIRA), an NIH R21 grant from NIDA, and multiple collaborative grants with other research groups. The Das Laboratory operates within the Petit Institute of Bioengineering and Biosciences (IBB) at Georgia Tech, utilizing state-of-the-art facilities for biochemical and biophysical studies. The lab specializes in nanodisc technology to study membrane proteins in near-native environments, with particular expertise in cytochrome P450 enzymes and their interactions with lipid substrates. Recent work has expanded into collaborative projects involving lipidomics, structural biology, and translational applications of lipid signaling research.

Keith Edmistenمشاهده پروفایل

استاد

• Agronomy
• Crop Physiology
• Industrial Hemp Production
• +۳ مورد دیگر

Keith Edmisten is a Professor in the Department of Crop and Soil Sciences at NC State University, serving as Extension Cotton Specialist and Director of Undergraduate Programs. He holds a BS, MS from NC State University, and a PhD in Crop Physiology from Virginia Tech (1987). His career includes faculty roles at Mississippi State University and Auburn University before joining NCSU in 1992. His research focuses on cotton and industrial hemp agronomy, germplasm evaluation, and regulatory science in agriculture. Notable awards include Extension Cotton Specialist of the Year (1997) and Cotton Physiologist of the Year (2015). He teaches courses on biotechnology, seed science, and regulatory frameworks, and advises students in the Plant and Soil Science biotechnology concentration. Edmisten's program integrates applied research with extension efforts, emphasizing sustainable input management, variety trials, and on-farm experimentation. Collaborations span departments like Entomology, Plant Pathology, and Agricultural Economics. Publications highlight fertilizer management, weed science, and crop modeling in cotton and hemp systems.

• Environmental Toxicology
• Reproductive Health
• Metabolic Disorders
• +۳ مورد دیگر

Dr. Alison Holloway is a Professor at McMaster University's Faculty of Health Sciences, specializing in environmental toxicology and reproductive health. Her research focuses on the effects of environmental contaminants (e.g., oil sands pollutants, pesticides, endocrine disruptors) on maternal and child health, metabolic disorders, and developmental outcomes. She has conducted studies on naphthenic acids, synthetic food additives, and maternal exposure to pharmaceuticals like fluoxetine. Key research areas include: Environmental contaminants' impact on reproductive systems and placental function Metabolic disturbances caused by chemical exposures during critical developmental windows Neurobehavioral and gastrointestinal effects of prenatal drug exposure Assessment of urban air pollution on in vitro fertilization (IVF) success rates Her recent work highlights the role of the tryptophan-kynurenine pathway as a biomarker of environmental stress and the obesogenic effects of bisphenol analogs and food additives. Collaborations involve interdisciplinary teams addressing environmental health, with studies published in high-impact toxicology and public health journals. Dr. Holloway's research has informed policies on chemical safety and maternal health, emphasizing cross-species markers for organismal health and risk assessment of emerging contaminants like cannabis derivatives.

Mohsen Yoosefzadeh Najafabadiمشاهده پروفایل

استادیار

• Dry Bean Breeding
• Computational Biology
• Omics-Based Selection
• +۵ مورد دیگر

Dr. Mohsen Yoosefzadeh Najafabadi is an Assistant Professor in the Department of Plant Agriculture at the University of Guelph, Ontario Agricultural College. He holds a PhD in Plant Breeding from the University of Guelph (2022), following M.Sc. and B.Sc. degrees from the University of Tehran. His research focuses on dry bean breeding, computational biology, and integrating omics technologies to enhance crop resilience and productivity. Key areas include developing stress-tolerant dry bean varieties, leveraging remote sensing for trait prediction, and optimizing genomic selection methods. He leads the Dry Bean Breeding & Computational Biology Program and has contributed to over 30 peer-reviewed publications since 2017. Education : PhD, Plant Breeding, University of Guelph (2022) M.Sc., University of Tehran B.Sc., University of Tehran Research interests emphasize computational tools development (e.g., AllInOne preprocessing framework), omics-based selection strategies, and non-Mendelian heredity mechanisms. His lab combines machine learning with field phenotyping to address agricultural challenges such as disease resistance and climate adaptation. Collaborative projects include soybean cold stress analysis and cannabinoid profile prediction in cannabis. Publications span genomic approaches to crop improvement, remote sensing applications, and transcriptomic studies. He teaches courses in plant breeding methodologies and actively engages in technology transfer initiatives. Lab activities include developing high-yielding dry bean cultivars resistant to biotic/abiotic stresses and advancing data-driven pipelines for crop breeding. Future work aims to synergize AI with multi-omics data to enhance crop resilience in diverse environments.

Jashvant Unadkatمشاهده پروفایل

استاد

• Pharmacokinetics
• Pharmacodynamics
• Drug Transporters
• +۷ مورد دیگر

Jashvant Unadkat, Ph.D. is a Professor of Pharmaceutics at the University of Washington School of Pharmacy. He holds appointments in the Department of Pharmaceutics and is actively involved with the UWPKDAP (Program on Pharmacokinetics of Drugs of Abuse during Pregnancy). His research spans drug transport, metabolism, and pharmacokinetics with special emphasis on pregnancy and fetal pharmacology. Dr. Unadkat received his B.Pharm. from the University of London (1977), his Ph.D. from the University of Manchester (1982), and completed postdoctoral training at the University of California at San Francisco (1982-85). His educational background laid the foundation for his extensive career in pharmaceutical sciences. His research interests focus on mechanisms of drug transport and metabolism, particularly during pregnancy. Dr. Unadkat has made significant contributions to understanding placental drug transporters, blood-brain barrier function, and quantitative approaches to pharmacokinetics-pharmacodynamics. His work bridges computational modeling with experimental approaches to address complex questions in drug disposition. Analysis of his recent publications reveals a strong trend toward understanding drug interactions during pregnancy, cannabinoid pharmacology, and the application of physiologically based pharmacokinetic (PBPK) modeling to predict drug behavior in special populations. His research spans pharmacology, computational biology, obstetrics, and toxicology with particular emphasis on drug transporters and their regulation. Fellow of AAAS Fellow of AAPS Fellow of JSSX AAPS Research Achievement Award (2012) ISSX Research Achievement Award (2023) Founding co-chair (1999-2001) of AAPS focus group on Drug Transport and Uptake Dr. Unadkat has led significant research initiatives including the UW Research Affiliates Program on Transporters (UWRAPT) for 10 years, the NIDA-funded UWPKDAP program on drug disposition during pregnancy, and co-leads the NICHD-funded UW Transporter Elucidation Center. His work has generated over 250 peer-reviewed publications and has significantly influenced regulatory science and drug development practices. He is actively involved in research teams focusing on placental transport, hepatic drug metabolism, and quantitative pharmacology. His current work with the UW Transporter Elucidation Center aims to identify and characterize novel transporters in the placenta and developing intestine, with implications for drug safety during pregnancy and pediatric pharmacotherapy.

• Cerebral Microcirculation
• Vascular Biology
• Endothelial Cell Function
• +۶ مورد دیگر

William Mayhan is a Professor in Biomedical Sciences at the University of South Dakota . His research focuses on cerebral microcirculation and vascular biology , particularly examining endothelial cell function in disease states like diabetes and alcohol consumption. Education: PhD in Biomedical Sciences, University of Nebraska Medical Center (1983) Post-Doctoral Fellowship, University of Iowa (1985) BS in Biology, Creighton University (1977) His work investigates blood-brain barrier permeability and cerebral vasculature responses to hypertension, diabetes, and alcohol. Key findings include mechanisms of nitric oxide synthase (NOS) dysfunction and oxidative stress in diabetic and alcoholic models. Recent publications analyze prenatal alcohol exposure effects on cerebral arterioles and CB2 receptor agonists for vascular protection in diabetes. His studies span in vivo models, potassium channel dynamics , and inflammatory mediators in stroke pathogenesis.

Fadia Kamalمشاهده پروفایل

دانشیار

• Osteoarthritis Research
• Chondrocyte Biology
• Cartilage Homeostasis
• +۵ مورد دیگر

Fadia Kamal, PharmD, PhD is an Associate Professor holding dual appointments in the Department of Orthopaedics and Rehabilitation and the Department of Cell and Biological Systems. She leads research at the Center for Cannabis and Natural Product Pharmaceuticals (CCNPP) with a strong publication record including 33 research outputs and an h-index of 18 based on Scopus data. Dr. Kamal's research focuses on cellular pathways that control chondrocyte homeostasis in healthy tissue and the pathological processes leading to cartilage damage in osteoarthritis. Her work investigates how chondrocytes transform into pathological cells that cause cartilage degradation, with particular interest in discovering new pathways and drugs to control chondrocyte behavior and potentially reverse osteoarthritis progression. Her laboratory also explores the therapeutic potential of non-euphorigenic cannabis compounds for bone fracture pain management and healing. Her recent publications demonstrate a strong trend toward interdisciplinary research combining orthopedics, molecular biology, immunology, and pharmacology. The work spans from fundamental cellular mechanisms in osteoarthritis to applied therapeutic development, with particular emphasis on cannabis-based treatments, immune responses in fracture healing, and novel imaging techniques. Her research shows increasing collaboration across multiple institutions and disciplines. Scientific Awards: Samuel Hinkle Junior Faculty Research Scholar Award (2022) - widely recognized with coverage by 5 news outlets, blogged by 1 source, posted by 38 X users, and shared on 1 Facebook page with 33 Mendeley readers Dr. Kamal serves as Principal Investigator on significant research projects, most notably the NIH-funded 'Therapeutic targeting of GPCR Gbetagamma-GRK2 in osteoarthritis' project (2019-2023) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Her mentorship is evident through numerous co-authored publications with junior researchers who appear to be her students and postdoctoral fellows. She maintains active collaborations across immunology, bone healing, and natural product pharmacology research areas. Her work contributes to UN Sustainable Development Goals related to health and well-being, with research spanning osteoarthritis, heart failure progression, chondrocyte biology, and G protein-coupled receptor research. The Kamal lab maintains strong connections with the Center for Cannabis and Natural Product Pharmaceuticals, indicating a specialized research focus on natural compounds for musculoskeletal conditions.

Sara Liinمشاهده پروفایل

دانشیار

• Cardiac Rhythm
• Ion Channel Dysfunction
• Cardiac Arrhythmias
• +۳ مورد دیگر

Sara Liin is a Senior Associate Professor at Linköping University, affiliated with the Department of Biomedical and Clinical Sciences within the Faculty of Medicine and Health Sciences. Her research focuses on ion channel dysfunction in cardiac arrhythmias, particularly exploring polyunsaturated fatty acids and endocannabinoids as therapeutic avenues. She holds a PhD in Neurobiology (2011) and a Master in Medical Biology (2005). Her work emphasizes understanding how genetic mutations in cardiac ion channels lead to arrhythmias and developing targeted treatments. Recent studies highlight the role of estrogen in exacerbating arrhythmia risk and the potential of endocannabinoids like ARA-S to rescue mutant channels. Liin has secured grants totaling SEK 64 million and leads a research group investigating lipid-channel interactions and drug development strategies. Key achievements include the Eric K Fernström award (2021) and collaborative projects with institutions like the University of Miami and SciLifeLab. Her lab, part of the Division of Cell and Neurobiology, explores translational applications of ion channel research to combat heart rhythm disorders.

Raj Rajakumarمشاهده پروفایل

دانشیار

• Molecular Neuroscience
• Schizophrenia Mechanisms
• Autism Neurobiology
• +۳ مورد دیگر

Dr. Raj Rajakumar is an Associate Professor at Western University's Department of Anatomy and Cell Biology, cross-appointed with the Department of Psychiatry. His work focuses on molecular mechanisms underlying schizophrenia symptoms and autism neurobiology, employing animal models to study drug effects and neural signaling. He holds a PhD from the University of Western Ontario, with prior degrees in M.B.B.S. (University of Peradeniya) and M.Sc. (University of Western Ontario). Educations: Ph.D., Anatomy and Cell Biology, University of Western Ontario M.Sc., Anatomy and Cell Biology, University of Western Ontario M.B.B.S., Medicine, University of Peradeniya Research Interests: Molecular pathways in schizophrenia symptom manifestation Neurobiological basis of autism spectrum disorders Pharmacological interventions using antipsychotics and psychotropic drugs Neuroimaging techniques (fMRI, MRS) to study brain connectivity His research combines molecular biology, neuroanatomy, and behavioral assays in animal models to explore schizophrenia pathophysiology. Recent work includes maternal immune activation effects on fetal brain development, cannabinoid impact on executive function, and white matter inflammation in Alzheimer's models. Collaborations with Dr. W.J. Rushlow and others highlight translational research in neuropsychiatric disorders. Key contributions include automated MRI algorithms for medial temporal lobe analysis and longitudinal studies of glutamatergic deficits in schizophrenia. His work bridges basic science with clinical applications in mental health. Dr. Rajakumar's lab focuses on understanding brain circuitry disruptions in psychiatric disorders, with implications for novel therapeutic targets. No formal advisees are listed, but his research team actively engages in interdisciplinary collaborations.

Graham Laddsمشاهده پروفایل

استاد

• Pharmacology
• G protein-coupled receptors
• Signal Bias
• +۵ مورد دیگر

Professor Graham Ladds is a Professor of Receptor Pharmacology at the University of Cambridge's Department of Pharmacology and Fellow of St John's College. He serves as Co-Director of the Cambridge Academy of Therapeutic Science and Director of Studies for Pharmacology. His academic journey includes a BSc in Biochemistry from the University of Birmingham and PhD in yeast pheromone signalling from the University of Warwick, where he progressed to Associate Professor before joining Cambridge in 2015. His research focuses on G protein-coupled receptor (GPCR) pharmacology, specializing in: Agonist bias mechanisms and signaling dynamics Mathematical modeling of receptor-ligand interactions RAMPs (Receptor Activity-Modifying Proteins) in Class B1 GPCRs Intracellular calcium signaling pathways Development of biosensors for receptor activity screening He employs multidisciplinary approaches combining pharmacological assays, computational modeling, and machine learning. His recent publications demonstrate strong focus on adenosine receptor pharmacology, GPCR signaling bias, and therapeutic applications for metabolic/cardiovascular disorders. Research frequently appears in high-impact journals with significant industry collaboration themes. Honors include: Fellow of the British Pharmacological Society (2020) Royal Society Industry Fellowship for collaboration with AstraZeneca He leads a 17-member research group investigating GPCR signaling dynamics and maintains active industry partnerships with GSK, Takeda, and AstraZeneca. His teaching includes lectures on drug-receptor interactions and diabetes therapeutics for medical/natural sciences students. Laboratory activities focus on: BRET-based molecular probing of GPCR interactions Development of computational models for receptor activation Calcium signaling studies continuing legacy of Professor Colin Taylor Industry-linked drug discovery projects

Xi-Long Zhengمشاهده پروفایل

استاد

• Vascular Smooth Muscle Biology
• Atherosclerosis
• Vascular Disease Mechanisms
• +۴ مورد دیگر

Xi-Long Zheng is a tenured Professor in the Department of Biochemistry and Molecular Biology and Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He holds additional appointments as a Member of the Libin Cardiovascular Institute and Associate Member of both the Snyder Institute for Chronic Diseases and Arnie Charbonneau Cancer Institute. His research focuses on vascular smooth muscle biology and its role in cardiovascular diseases. Doctor of Medicine, Hunan Medical University (1986) M.S. in Pharmacology, Hunan Medical University (1989) Doctor of Philosophy in Pharmacology, University of Calgary (1997) Dr. Zheng's research centers on vascular smooth muscle cell differentiation, proliferation, and phenotypic switching in vascular diseases. His laboratory investigates mechanisms of vascular smooth muscle dedifferentiation in atherosclerosis, abdominal aortic aneurysms, and vascular stiffness. Current work explores ferroptosis, epigenetic regulation (particularly BRD4), and PCSK9 functions in vascular pathologies. His studies integrate molecular, cellular, and in vivo approaches to identify novel therapeutic targets for cardiovascular diseases. Analysis of his recent publications reveals strong emphasis on cell death mechanisms (ferroptosis, cuproptosis), epigenetic regulation, lipid metabolism, and immune-vascular interactions in atherosclerosis. His work demonstrates increasing focus on translational applications targeting vascular smooth muscle phenotypic switching and plaque stability. Alberta Innovates ‒ Health Solutions Senior Scholar Award (2008-2015) Heart & Stroke Foundation New Investigator Award (2001-2006) CIHR/Hypertension Society Scholarship Award (2001-2004) Heart & Stroke Foundation Fellowship Award (1999-2001) AHFMR Independent Investigator Award (2008) Dr. Zheng serves on grant panels for Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada. He is an editorial board member for Biochemical Journal and other scholarly publications. His laboratory receives funding from CIHR and NSERC for projects including smooth muscle PCSK9 in abdominal aortic aneurysm pathogenesis, smooth muscle autophagy in vascular aging, and epigenetic regulation of smooth muscle plasticity. The Zheng Lab investigates vascular smooth muscle functions across multiple organ systems including blood vessels, gastrointestinal tract, bladder, and uterus. His research has established critical mechanisms in vascular smooth muscle differentiation and cell cycle regulation, contributing over 100 peer-reviewed publications in high-impact journals including PNAS, ATVB, Diabetologia, JBC, and Hypertension.

Michael D. Burtonمشاهده پروفایل

دانشیار

• Neuroimmunology
• Pain Management
• Metabolic Disorders
• +۵ مورد دیگر

Dr. Michael D. Burton is an **Associate Professor** and **Eugene McDermott Distinguished Professor** in the Department of Neuroscience at the University of Texas at Dallas (UT Dallas), affiliated with the **School of Behavioral and Brain Sciences**. He is a founding member of the **Center for Advanced Pain Studies (CAPS)** and holds roles in the **Center for Vital Longevity (CVL)**. His research focuses on neuroimmunology, pain mechanisms, and metabolic disorders, emphasizing how immune-nervous system interactions influence chronic pain, depression, anxiety, and aging-related conditions. Dr. Burton’s work bridges preclinical and translational research, using rodent models and human clinical samples. Education: PhD in Animal Science (Immunophysiology and Behavior), University of Illinois at Urbana-Champaign (2012) B.S. in Animal Science and Biotechnology, University of Illinois at Urbana-Champaign (2006) Postdoc in Pain Neurobiology, UT Dallas (2017) Postdoc in Diabetes/Metabolism Research, UT Southwestern Medical Center (2015) Research Interests: Dr. Burton investigates how peripheral stimuli (diet, alcohol, immune activation) affect pain and behavior through neuroimmune pathways. Key areas include: Sex differences in pain sensitivity and neuroinflammation Risk factors for chronic pain (e.g., high-fat diets, aging) Neuroimmune biomarkers for pain and delirium Development of non-opioid analgesics (e.g., cannabinoids) Awards: 2024 ROAR Research Award, UT Dallas 2023 Eugene McDermott Distinguished Professorship 2022 SFNova/Rising Star (Society for Neuroscience) 2019 Mitchell Max Award for Pain Research Grants & Leadership:** Co-Director, **Enhancing Neuroscience Undergraduate Research Experiences (ENSURE)** program ($900K grant) NIH R35, R21 grants (pain and metabolism) Editorial roles: *Neurobiology of Pain*, *Journal of Neuroinflammation*, and others Labs & Teams:** Neuroimmunology and Behavior Lab (UT Dallas) Member, NIH Pain Consortium and Endocrine Society’s Basic Science Group