Daniela M Witten is a Professor of Statistics and Biostatistics at the University of Washington, holding the Dorothy Gilford Endowed Chair in Mathematical Statistics. Her research focuses on developing statistical machine learning methods for high-dimensional data, with a particular emphasis on unsupervised learning and theoretical foundations. Witten earned her BS in Math and Biology with Honors and Distinction from Stanford University in 2005 and her PhD in Statistics from Stanford University in 2010 under Robert Tibshirani. Her academic journey established her expertise in bridging mathematical theory with biological applications. Her research program centers on high-dimensional statistical learning , where she develops methods for unsupervised learning and graphical modeling when features outnumber observations. She pioneers statistical models for neural activity through collaborations with the Allen Institute for Brain Science and Princeton University, addressing functional connectivity and neuron sub-population identification. Her groundbreaking work on selective inference solves the "double-dipping" problem in hypothesis generation and testing, enabling valid inference after hierarchical clustering and regression trees. Additionally, she advances multi-view data analysis to integrate complementary data sources like clinical and genomic measurements. Applications span genomics, neuroscience, microbial ecology, and pathology, demonstrating her commitment to solving real-world biomedical challenges. Her 2025 publications reveal a cohesive trend toward developing theoretically rigorous inference frameworks for high-dimensional settings, with emphasis on linear regression validity, semi-supervised efficiency, Gaussian decomposition, and PCA variance quantification—showcasing her signature blend of methodological innovation and practical applicability. Witten's exceptional contributions are recognized through extensive honors: Presidents’ Award, Committee of Presidents of Statistical Societies (COPSS) (2022) Mortimer Spiegelman Award, American Public Health Association (2019) Simons Investigator Award (2018-2023) Sloan Research Fellowship (2013-2015) NSF CAREER Award (2013-2018) NIH Director’s Early Independence Award (2011-2016) 23 major awards including named lectureships, fellowships, and editorial leadership As a dedicated mentor, she has guided students like Olivia McGough (NSF GRFP winner), Dwight (Zichun) Xu (ASA Nonparametrics Student Paper Award winner), Yiqun Chen (Hopkins Biostat faculty), and Anna Neufeld (Williams College faculty). Her research is sustained by major grants from NIH, NSF, and Simons Foundation. Witten co-authored the seminal textbook "Introduction to Statistical Learning" and currently serves as Joint Editor of the Journal of the Royal Statistical Society, Series B (2023-2025), shaping the field through both scholarship and community leadership.
