جستجوی استاد راهنمای دانشگاهی

Harris H. Wang is an Associate Professor in the Department of Systems Biology and Department of Pathology and Cell Biology at Columbia University's Vagelos College of Physicians and Surgeons, where he also serves as Interim Chair of Systems Biology. He is affiliated with the Center for Computational Biology and Bioinformatics (C2B2) and the Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS). B.S., Physics and Mathematics, MIT Ph.D., Biophysics, Harvard University Dr. Wang's research lies at the intersection of systems and synthetic biology, focusing on developing foundational technologies for genome engineering, microbiome manipulation, and synthetic genomics. His lab pioneers methods such as MAGE, MAGIC, CAST, and CAMII to enable high-throughput genetic manipulation, in situ microbiome engineering, and AI-driven microbial culturomics. Key research themes include understanding microbial community dynamics, engineering cellular memory systems, designing biocontained genetic circuits, and applying synthetic biology to human health challenges in personalized medicine and infectious disease. His recent publications reveal a strong trend in spatial and functional metagenomics, CRISPR-based microbiome editing, and synthetic biology tools for data storage and genetic stability. The articles span high-impact journals like Nature , Science , and Nature Biotechnology , reflecting his leadership in developing scalable, programmable biological systems. Scientific Awards: NIH Director’s Early Independence Award Forbes 30 Under 30 in Science Sloan Research Fellowship NSF CAREER Award ONR Young Investigator Award Burroughs Wellcome Fund PATH Award Schaefer Scholar Blavatnik National Award Vilcek Prize PECASE Dr. Wang has advised numerous PhD and postdoctoral researchers, many of whom have gone on to independent scientific careers. His lab is supported by major grants from NIH, NSF, DARPA, DOE, and foundations including the Bill & Melinda Gates Foundation and CZ Biohub NY. He is actively involved in educational initiatives, including organizing Columbia’s iGEM team and the Cold Spring Harbor Laboratory Synthetic Biology course. The Wang Lab is based at the Columbia University Irving Medical Center and is part of national consortia such as the Engineering Biology Research Consortium (EBRC) and the Genome Project-Write (GP-Write) initiative. The lab develops and applies cutting-edge technologies in automation, machine learning, and synthetic biology to engineer microbiomes for applications in medicine, global health, and climate change.

• Systems Biology
• Synthetic Biology
• Genome Engineering
• +۱۷ مورد دیگر

Dawn Y. Sumner is a Professor in the Department of Earth and Planetary Sciences at the University of California, Davis. Her research focuses on geobiology, paleobiology, and planetary science, particularly reconstructing ancient environments on Earth and Mars. She is a key member of NASA’s Mars Science Laboratory team, contributing to the Curiosity rover’s exploration of Gale Crater on Mars. Sumner’s work integrates field studies, lab analyses, and interdisciplinary approaches to understand microbial life’s role in shaping Earth’s history and potential habitability on other planets. Education: Ph.D., Massachusetts Institute of Technology (1995). Research interests include microbialite formation, Antarctic lake ecosystems, and the evolution of oxygenic photosynthesis. She investigates modern microbial communities in ice-covered lakes (e.g., Lake Vanda) to understand ancient environments and their biosignatures. Her scientific awards include the California Academy of Sciences Academy Fellow (2020) and Geological Society of America Fellow (2014). Sumner emphasizes inclusive education and supports student success in STEM through feminist research practices. Labs/Teams: W.M. Keck Center for Active Visualization in the Earth Sciences (KeckCAVES), Antarctic Lake Research Group.

• Geobiology
• Paleobiology
• Geochemistry
• +۳ مورد دیگر

James B. Kaper is a Professor and Chair of the Department of Microbiology & Immunology at the University of Maryland School of Medicine. He serves as Vice Dean for Academic Affairs and previously held leadership roles as Senior Associate Dean (2014–2019) and Chair (2007–present). His research focuses on the molecular pathogenesis of diarrheagenic Escherichia coli and Vibrio cholerae , including vaccine development and bacterial-host interactions. Education: BS (1973) and PhD (1979) in Microbiology from University of Maryland; Postdoc in Molecular Pathogenesis at University of Washington (1979–1981) Dr. Kaper’s work has led to the creation of live attenuated cholera vaccines, including CVD 103-HgR, the first licensed recombinant bacterial vaccine. His lab investigates bacterial genetics, intestinal colonization, and immune system activation, particularly TLR5 response to V. cholerae flagellin. He has authored 303 peer-reviewed articles and 68 book chapters. His research has been funded continuously by NIAID since 1982. Key publications include foundational work on V. cholerae vaccines (1984), genomic structure (1998), and quorum sensing in EHEC/EPEC (1999). His lab’s recent studies focus on phosphotyrosine proteomics (2013) and pathogenicity island regulation (2007). Scientific awards: Fellow, American Academy of Microbiology (1994); NIH Merit Award (2004); ASM DC White Award (2019) Editorial roles: Editor-in-Chief, EcoSal (2006–present); Associate Editor, International Journal of Medical Microbiology (2000–present) As an academic leader, Dr. Kaper has mentored over 60 graduate students and postdoctoral fellows. He holds multiple patents for cholera vaccines and E. coli diagnostics, including U.S. Patents 4,935,364; 5,399,494; and 6,204,004. His lab at UMSOM combines basic science with translational applications for enteric disease prevention.

• Microbiology
• Immunology
• Bacterial Vaccines
• +۵ مورد دیگر

Dr. Mihai Pop is a Professor of Computer Science and Director of the University of Maryland Institute for Advanced Computer Studies (UMIACS). He holds appointments in the Department of Computer Science, UMIACS, and the Center for Bioinformatics and Computational Biology (CBCB). His research focuses on computational biology, metagenomics, and algorithm development for genomic data analysis. He received a Ph.D. in Computer Science from Johns Hopkins University (2000), followed by work at The Institute for Genomic Research (TIGR) developing genome assembly algorithms. Education: Ph.D., Computer Science, Johns Hopkins University, 2000. Research Interests: Bioinformatics, genomics, metagenomics, computational geometry, software testing. His lab develops tools for analyzing microbial communities and has pioneered methods for metagenomic assembly and analysis. Notable tools include the AMOS genome assembly toolkit. Recent Article Trends: Recent work emphasizes long-read sequencing, metagenomic profiling (e.g., TIPP3), and strain-level analysis (e.g., Strainy). He addresses challenges in scaling sequence-based searches and improving taxonomic resolution in large datasets. Awards: ACM Fellow (2019), ISCB Fellow (2022), UMD Excellence in Teaching Award (2015). Grants & Leadership: Co-leader of the Human Microbiome Project data analysis group. Active in diversity initiatives to promote inclusivity in computational fields. Labs/Teams: Pop Lab (pop-lab.org) focuses on computational methods for microbial genomics and metagenomics.

• Bioinformatics
• Genomics
• Computational Biology
• +۳ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Angela D. Kent is a Professor in the Department of Natural Resources and Environmental Sciences at the University of Illinois Urbana-Champaign, where she also serves as Director of the Program in Ecology, Evolution, and Conservation Biology within the School of Integrative Biology. She is affiliated with the Carl R. Woese Institute for Genomic Biology. Her research focuses on microbial communities in agroecosystems and natural environments, particularly their roles in nitrogen cycling, soil health, and sustainable bioenergy production. Key research interests include microbial interactions in plant-microbe systems, the impact of genetic variation in crops on microbial processes, and the ecological and biogeochemical implications of soil microbiomes. She has authored over 99 publications and supervised datasets on topics such as denitrification dynamics, rhizosphere microbiome assembly, and microbial contributions to nitrogen retention. Dr. Kent has received the NACTA Educator Award (2012) and has contributed to high-impact studies on topics like microbial community responses to environmental stressors and the application of stable isotopes in bioenergy research. Her work bridges microbial ecology, agronomy, and environmental science, emphasizing practical solutions for sustainable agriculture and ecosystem management.

• Microbial Ecology
• Nitrogen Cycling
• Agroecosystems
• +۳ مورد دیگر

Steven Cresawn is an Associate Professor in the Department of Biology at James Madison University and a long-standing instructor in the HHMI SEA-PHAGES program since 2014. He teaches undergraduate courses in phage discovery (BIO 203) and genomics (BIO 204), engaging students in authentic research from isolation to bioinformatics. His research interests center on bacteriophage biology and genomics, using diverse bacterial hosts including Mycobacterium smegmatis and Streptomyces griseus . Students in his courses isolate novel phages, sequence genomes, and contribute to the PhagesDB database, advancing knowledge of phage diversity and evolution. Although specific awards are not detailed, his role in the nationally recognized SEA-PHAGES program, funded by HHMI, underscores his impact on science education. Dr. Cresawn has mentored over 300 undergraduate students across 15+ course sections since 2014. The program's HHMI funding supports phage isolation, sequencing, and analysis, providing students with cutting-edge research experiences. As part of the SEA-PHAGES network, he collaborates with institutions nationwide, contributing to a growing database of phage genomes and fostering the next generation of scientists.

• Phage Discovery
• Microbiology
• Genomics
• +۱ مورد دیگر

Kelly Arnold is an Associate Professor in the Department of Biomedical Engineering at the University of Michigan. Her research integrates systems engineering principles with immunology to investigate variability in immune responses across infection, vaccination, and injury, with a focus on computational modeling and clinical translation. Research Focus Systems-level immune response modeling Vaccination and antibody functionality Vaginal microbiome-host interactions Chronic lung disease progression Computational serology and proteomics Recent Work Her 2025 studies examine SARS-CoV-2 vaccination responses in cancer patients and computational frameworks for vaginal probiotics. Earlier works (2024-2007) span COPD progression, lupus fibrosis, HIV susceptibility, and tissue engineering for fertility preservation. Methodologies include proteomic profiling, network modeling, and microfluidic systems.

• Biomedical Computation and Modeling
• Drug Delivery and Therapeutics
• Systems Immunology
• +۵ مورد دیگر

Michele Klingbeil is a Professor in the Department of Microbiology at the University of Massachusetts Amherst, where she leads the Klingbeil DNA Replication Laboratory. She received her PhD in Cell and Molecular Biology from the University of Toledo in 1996 and previously worked at Johns Hopkins School of Medicine before moving to UMass in July 2007. Her educational background includes: PhD in Cell and Molecular Biology, University of Toledo, 1996 Dr. Klingbeil's research focuses on the unique biology of trypanosomatid parasites, particularly Trypanosoma brucei , the causative agent of African sleeping sickness. Her laboratory investigates two main areas: (1) replication of the unusual mitochondrial DNA network called kinetoplast DNA (kDNA), and (2) nuclear DNA replication initiation. Her work on kDNA is particularly significant as this structure is essential for parasite survival but has no counterpart in mammalian hosts, making it an attractive drug target. She employs a combination of reverse genetics (RNAi), cell biology, and biochemistry to understand the replication and repair mechanisms of kDNA, with a special focus on a family of four DNA polymerases related to bacterial Pol I. Dr. Klingbeil's recent publications reveal her laboratory's deep investigation into mitochondrial DNA polymerases in trypanosomatids, with discoveries showing multiple polymerases having specialized functions in kDNA replication and repair. Her research has established that several of these polymerases are essential for parasite viability, opening new avenues for drug development. She has also made significant contributions to understanding the simplified Origin Recognition Complex in trypanosomatids compared to other eukaryotes. Dr. Klingbeil has received the Thomas G. Lessie Distinguished Lectureship Award for her impact on teaching at the graduate level. Her research is funded by the National Institutes of Health, U.S. Department of Agriculture, the Joeph P. Healey Endowment, and the University of Massachusetts Amherst. She has mentored numerous graduate and undergraduate students, including current PhD candidates Dave Bruhn, Jeniffer Concepción, and Juemin Luo, as well as visiting scholar Eva Vidal Rico. Her former students have gone on to positions at institutions including Dana Farber/Broad Institute, Regis College, and Flagship Ventures. The laboratory regularly participates in scientific conferences including the Molecular Parasitology Meeting at Woods Hole and the Kinetoplastid Molecular Cell Biology conference. Dr. Klingbeil teaches several courses including Parasitology (MICRO 590S), Parasitology Lab (MICRO 590L), Molecular Mechanisms of Pathogenesis (MICRO 797P), Advanced Cell Biology (MCB 641), and Writing in Microbiology (MICRO 360). Her laboratory organizes regular social events including pumpkin carving parties and outings to Six Flags New England and Mt. Sugarloaf.

• Parasitology
• Molecular Biology
• Microbiology
• +۴ مورد دیگر

Benjamin Machta is an Assistant Professor of Physics at Yale University, affiliated with the Department of Physics and the QBio Institute. He holds a BS from Brown University and a PhD from Cornell University, followed by a postdoctoral fellowship at Princeton University. His research focuses on applying theoretical physics to understand biological systems, particularly leveraging statistical physics and information theory to study biological membranes near critical points and the energetic constraints of biological signaling. Education: BS in Physics (Brown University), PhD in Physics (Cornell University), Postdoc at Princeton University (Lewis-Sigler Theory Fellow). Research Interests include: membrane criticality, phase transitions in biological systems, information-theoretic limits in organism function, and energy dissipation in biological processes. His work often bridges theoretical models with experimental data, such as collaborations with Sarah Veatch’s lab on membrane phase behavior. Publications highlight themes like membrane criticality, protein phase separation, and energy constraints in signaling. His group’s current projects explore cochlear mechanics, thermodynamic control in biological systems, and the role of criticality in sensory systems. Awards: 2019 Simons Investigator Award. Lab Affiliations: QBio Institute and Department of Physics at Yale, located in YSB-C164. Group members include postdocs Isabella Graf and Michael Abbott, and graduate students Asheesh Momi, Mason Rouches, and others.

• Biophysics
• Condensed Matter Physics
• Statistical Physics
• +۳ مورد دیگر

Mary K. Firestone is Professor of the Graduate School in the Department of Environmental Science, Policy and Management at UC Berkeley. Her research revolutionized understanding of soil microbial processes, particularly oak regeneration techniques and microbial mediation of carbon/nitrogen cycling in terrestrial ecosystems. Firestone's work examines microbial responses to environmental change, including drought, rewetting, and warming scenarios. Her lab develops innovative methods like quantitative stable isotope probing (qSIP) to trace microbial activity in complex soil environments. Research spans grassland, rangeland, and agricultural ecosystems. Honors include election to the National Academy of Sciences (2017), Soil Ecology Society Career Achievement Award (2017), and American Geophysical Union Fellowship (2016). She holds the Betty and Isaac Barshad Chair in Soil Sciences. Current PhD candidates and postdoctoral researchers in the Firestone Lab investigate viral-bacterial interactions in soil, mycorrhizal carbon transfer, and drought impacts on soil carbon persistence. Field studies at California's Hopland Research Center examine grassland responses to climate variability.

• Soil Microbial Ecology
• Carbon Cycling
• Nitrogen Cycling
• +۲ مورد دیگر

Karl Griswold is a Professor of Engineering at Dartmouth College's Thayer School of Engineering, where he leads the Griswold Research Group focused on protein engineering and biotherapeutics development. His interdisciplinary work spans chemical, biological, and engineering disciplines to address critical challenges in drug-resistant infections and protein therapeutics. Education: BS in Chemistry from Southwest Texas State University (1995) PhD in Chemistry from the University of Texas at Austin (2005) Research Focus: Professor Griswold's laboratory specializes in protein engineering, directed evolution, and biotherapeutics development , creating novel biomolecules with superior functionality compared to natural proteins. The group develops high-throughput screening methods, protein deimmunization strategies, enhanced expression systems, and antibacterial agents targeting drug-resistant infections. Their work has significant translational potential for treating conditions like MRSA and Pseudomonas aeruginosa infections. Scientific Recognition: Wallace H. Coulter Foundation Early Career Translational Research Award in Biomedical Engineering (2008) NIH Biotechnology Training Grant (2000-2003) Royston M. Roberts - Regents Fellowship, University of Texas (1999) DOW Chemical Foundation Scholar, Texas State University (1991-1995) Senior Fellow, National Academy of Inventors Research Leadership: As co-founder and CEO of Stealth Biologics, Professor Griswold translates academic research into commercial applications. His work has secured NIH funding and Dartmouth Innovations Accelerator support, with research featured in Chemical & Engineering News, Vermont Public Radio, and the New Hampshire Union Leader for developing alternatives to traditional antibiotics. Research Environment: The Griswold Research Group maintains extensive collaborations across disciplines including clinical medicine, immunology, structural biology, and chemical engineering. This interdisciplinary approach prepares trainees for careers at the intersection of multiple scientific fields, with research focusing on Biomolecular Antimicrobial Therapies, Deimmunizing Protein Therapeutics, and Gene Library Construction Technologies.

• Protein engineering
• Directed evolution
• Biotherapeutics
• +۲ مورد دیگر

Jennifer L. Clarke is a Professor in the Department of Statistics at the University of Nebraska–Lincoln and Director of the Quantitative Life Science Initiative. She holds leadership roles in enabling big data integration across the University of Nebraska system through collaborative research programs. Her affiliations include the Institute of Agriculture and Natural Resources (IANR) and the College of Agriculture and Natural Resources. Dr. Clarke's research focuses on statistical methodology for high-dimensional data, computational biology, bioinformatics, and bacterial genomics. Her work bridges statistical innovation with applications in oncology, microbiome analysis, and agricultural phenomics. Key areas include predictive modeling, machine learning, and genomic/metagenomic data integration. Her recent publications span cancer biomarker discovery, plant phenotyping methodologies, and microbial community analysis, reflecting her interdisciplinary approach. Articles emphasize translational applications like therapeutic target identification and precision agriculture. Dr. Clarke leads initiatives fostering collaboration between statisticians and domain scientists, including the Quantitative Life Science Initiative and contributions to the Agricultural Genome-to-Phenome Initiative (AG2PI). Her work advances data-driven solutions for healthcare and food security challenges. Notable projects include developing statistical tools for microbiome studies, analyzing root architecture via 3D imaging, and investigating cranberry-derived compounds' cancer-inhibitory mechanisms. Her methodological contributions include hybrid clustering techniques and predictive model validation frameworks.

• Statistical Methodology
• Bioinformatics/Computational Biology
• Data Mining/Machine Learning
• +۳ مورد دیگر

Katy D. Heath is a Professor of Plant Biology and Affiliate Professor in Microbiology at the University of Illinois Urbana-Champaign (UIUC). She leads the Plant Biology department and is affiliated with the Carl R. Woese Institute for Genomic Biology. Her research focuses on the evolution of mutualisms, particularly plant-microbe interactions such as legume-rhizobium symbiosis, emphasizing genetic and ecological factors influencing symbiotic stability and adaptation. She investigates how environmental pressures (e.g., global change) shape mutualistic relationships and microbial community dynamics. Education: B.S. (2000) and Ph.D. (2007) from the University of Illinois and University of Minnesota, respectively, followed by postdoctoral work at the University of Toronto (2007–2009). Research Interests: Symbiosis evolution, microbial genetics, plasmid transmission dynamics, and the impacts of agricultural practices on rhizobia populations. She studies diverse systems, including Medicago-Sinorhizobium, soybean-Bradyrhizobium, and invasive legume-rhizobium interactions. Recent publications (2020–2025) highlight studies on endophyte impacts on soybean yield, rhizobia diversity under conventional farming, and genomic analyses of symbiotic coevolution. Her work integrates molecular biology, quantitative genetics, and ecology. Grants & Collaborations: Lead PI on a $12.5M NSF Biology Integration Institute (Genomics and Eco-evolution of Multi-scale Symbiosis). Her team includes collaborations with institutions like Indiana University and the University of Chicago. Labs & Teams: Heath Lab focuses on symbiosis research, with active projects on microbiome dynamics, plasmid-host coevolution, and community outreach (e.g., Boys and Girls Club collaborations). Recent lab highlights include student graduations (e.g., Ivan Sosa Marquez, Chase) and awards like the John R. Laughnan Award in Plant Biology.

• Microbiome and Microbial Communities
• Evolutionary Genetics
• Symbiosis and Mutualism Evolution
• +۳ مورد دیگر

Jonathan Conway is an Assistant Professor in the Department of Chemical and Biological Engineering at Princeton University and an associated faculty member of the High Meadows Environmental Institute (HMEI). He leads the Conway Lab, which focuses on engineering plant-microbe interactions for applications in bioagriculture, bioenergy, and biochemical industries. Education: B.S. Chemical Engineering, University of Notre Dame (2011) M.S. Chemical Engineering, North Carolina State University (2013) Ph.D. Chemical Engineering, North Carolina State University (2017) Postdoctoral Fellow, University of North Carolina Chapel Hill & Howard Hughes Medical Institute (2017-2021) Research Interests: The Conway Lab develops genetic engineering approaches for non-model bacteria at plant-microbe interfaces. Key research areas include: chemical signaling between plants and microbes, microbiome impacts on plant immunity, environmental stress responses in agricultural systems, and enzymatic degradation of lignocellulosic biomass using thermophilic bacteria. The lab employs bacterial genetics, systems biology, and biomolecular engineering to create technologies for sustainable bioindustries. Publication Trends: Recent work demonstrates strong emphasis on molecular mechanisms of plant-microbe communication (2020-2024), enzyme characterization in biomass degradation (2024-2025), and development of synthetic microbial communities for climate resilience (2024). Earlier research focused on extremophile enzymology and metabolic engineering (2012-2019). Student Advising: Currently mentors 4 graduate students and 8 undergraduates. Alumni include 9 former advisees who graduated between 2022-2024. The lab actively recruits students through Princeton's Chemical Engineering graduate program and undergraduate research initiatives. Laboratory: The Conway Lab develops microfluidic systems for root microbiome studies and genetic tools for engineering plant-associated bacteria. Current projects include designing thermophilic microbial consortia for consolidated bioprocessing and characterizing bacterial immune evasion strategies.

• Plant-microbe interactions
• Biomolecular engineering
• Systems biology
• +۴ مورد دیگر