Katherine Rose Sadleir is a Research Associate Professor in the Department of Neurology at the Feinberg School of Medicine, Northwestern University, specializing in Behavioral Neurology with a focus on Alzheimer's disease mechanisms. Her educational background: PhD, University of Chicago (2006) Postdoctoral Fellow, Cell and Molecular Biology, University of Chicago (2006) Postdoctoral Fellow, Alzheimer's Disease, Northwestern University (2014) Dr. Sadleir's research centers on the interplay between amyloid and tau pathology in Alzheimer's disease, with specific expertise in membrane repair mechanisms and calcium dysregulation. Her work employs advanced molecular and cellular approaches to identify therapeutic targets for neurodegenerative processes, emphasizing the role of non-neuronal cells in disease progression. Recent publications (2024-2025) demonstrate her leadership in uncovering how oligodendrocytes contribute to amyloid plaque formation, how genetic mutations drive neurodegeneration through oxidative stress, and how membrane repair proteins mitigate tau pathology. These studies reveal multidisciplinary insights spanning neuroimmunology, glial biology, and molecular genetics, highlighting novel pathways for Alzheimer's intervention. Dr. Sadleir leads active research projects at Northwestern University, collaborating with interdisciplinary teams to investigate Alzheimer's disease mechanisms and translate findings into potential therapeutic strategies.
