جستجوی استاد راهنمای دانشگاهی

Steven G. Clarkeمشاهده پروفایل

استاد

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

Ahmet Acarمشاهده پروفایل

دانشیار

• Cancer Biology
• Precision Medicine
• Drug Resistance Mechanisms
• +۳ مورد دیگر

Dr. Ahmet Acar is an Associate Professor at the Department of Biological Sciences, Middle East Technical University (METU), Ankara, Turkey. He leads the Cancer Precision Medicine and Drug Resistance Laboratory, focusing on understanding mechanisms of drug resistance in cancer. His research integrates experimental models, next-generation sequencing, and deep learning to address clinical challenges in cancer therapy. Dr. Acar holds a B.Sc. from METU's Biological Sciences department and a Ph.D. from the Cancer Research UK Manchester Institute. He completed postdoctoral training at the Institute of Cancer Research, London, and the University of Manchester. Research Interests: Drug resistance mechanisms, precision oncology, tumor microenvironment modeling, patient-derived organoids, computational pathology, and evolutionary cancer biology. His lab develops 2D/3D co-culture systems, PDO biobanks, and AI-driven histopathology tools to improve treatment strategies. Recent Work Trends: Recent publications emphasize tumor evolution modeling, matrix mechanics in drug resistance, and AI applications in histopathology. Collaborations with hospitals in Turkey and Europe support PDO biobank initiatives. His team explores evolutionary steering strategies to exploit collateral drug sensitivities. Labs/Teams: Precision Medicine and Drug Resistance Lab at METU focuses on interdisciplinary approaches combining wet-lab experiments with computational methods. Current projects include ex vivo tumor modeling and AI-driven diagnostic tools for oncology.

Steve Chaseمشاهده پروفایل

استاد

• Computational Neuroscience
• Neural Engineering and Technology
• Systems Neuroscience
• +۴ مورد دیگر

Steve Chase is a Professor at Carnegie Mellon University , affiliated with the Biomedical Engineering , Electrical and Computer Engineering , Neuroscience Institute , and Robotics Institute departments. His research spans Computational Neuroscience , Neural Engineering , and Systems Neuroscience , with a focus on neural circuits, motor control, and brain-computer interfaces (BCI). Research Areas: Sensation & Perception, Methods Development, Diseases & Disorders, Physiological & Anatomical Methods. Lab Highlights: Development of the RotaWheel, memory trace studies in the motor cortex, and investigations into BCI stabilization and learning dynamics. Scientific Contributions: His lab has published extensively in journals like Neuron , Nature Computational Science , eLife , and PNAS , with notable works on neural activity patterns, dimensionality reduction in calcium imaging, and sensory constraints on motor cortex modulation. Students and postdocs in his lab have received awards, including the CNBC best paper award.

Dewey G. McCaffertyمشاهده پروفایل

استاد

• Chemical Biology
• Chromatin Modification
• Enzymology
• +۳ مورد دیگر

Dewey G. McCafferty is Professor of Chemistry at Duke University with appointments in Biochemistry and the Duke Cancer Institute. His research focuses on chemical biology of chromatin-modifying enzymes and ubiquitin signaling pathways relevant to neurodegeneration and infection. Notable work includes discovering the lasso peptide antibiotic Arcumycin, characterizing the Nedd4 ubiquitin ligase in Parkinson's disease models, and developing chemoproteomic approaches for target identification. Key contributions include elucidation of the futalosine pathway in Chlamydia infections, mechanisms of CPAF protease in bacterial pathogenesis, and engineering of histone demethylase enzymes. McCafferty received the Eli Lilly Award in Biological Chemistry (2005) and directs NIH-funded projects on ubiquitin ligases in neurodegeneration.

David Vocadloمشاهده پروفایل

استاد

• Bioorganic Chemistry
• Chemical Biology
• Glycobiology
• +۳ مورد دیگر

David Vocadlo is a Distinguished Professor of Chemistry and Molecular Biology & Biochemistry at Simon Fraser University (SFU), holding the Canada Research Chair in Chemical Biology. His research focuses on Chemical Glycobiology, investigating carbohydrate-processing enzymes and developing chemical tools to study glycan roles in health and disease. His lab explores O-GlcNAc signaling, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), and enzyme inhibitors for therapeutic applications. Education: PhD from University of British Columbia (UBC), followed by a CIHR postdoctoral fellowship at UC Berkeley. Key roles include E.W.R. Steacie Memorial Fellow and Royal Society Fellow. Research highlights include O-GlcNAcase inhibitors for neuroprotection, glycan structure-function relationships, and enzyme activity imaging tools. Collaborates globally with experts in glycobiology and employs cutting-edge techniques like chemical synthesis, mass spectrometry, and live-cell imaging. Awards: Distinguished Professor title, Canada Research Chair, Royal Society Fellowship. Active in training researchers through SFU’s graduate programs, emphasizing interdisciplinary approaches. Lab members work on topics ranging from enzyme mechanisms to disease modeling.

Matthias Mannمشاهده پروفایل

استاد

• Mass Spectrometry
• Proteomics
• Systems Biology
• +۶ مورد دیگر

Professor Matthias Mann is a world-leading scientist serving as Director of the Proteomics and Signal Transduction department at the Max Planck Institute of Biochemistry in Martinsried, Germany, and Director of the Proteomics department at the Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Denmark. With an h-index exceeding 277 and over 350,000 citations, he is recognized as the highest cited German researcher and one of the most influential scientists globally in proteomics. His educational background includes: Ph.D. in Chemical Engineering from Yale University (1988) Master's Degree in Physics from Georg August University Göttingen (1984) Bachelor's of Arts in Mathematics from Georg August University Göttingen (1982) Professor Mann's research focuses on advancing mass spectrometry-based proteomics to understand biological systems at the protein level. His work spans technological developments in mass spectrometry, bioinformatics and computational analysis, signal transduction and posttranslational modifications, and clinical proteomics applications for disease diagnosis and treatment. The Mann lab has pioneered groundbreaking methods like SILAC for quantitative proteomics and MaxQuant for proteome data analysis. Their vision is to translate proteomics knowledge into clinical practice for predictive, diagnostic, and preventive medicine, with recent work focusing on AI-guided platforms for analyzing proteomes from minimal tissue samples. Analysis of Professor Mann's recent publications reveals a strong trend toward clinical applications of proteomics, particularly in cancer research, metabolic diseases, and neurodegenerative disorders. His work increasingly integrates spatial proteomics, single-cell resolution techniques, and artificial intelligence approaches to uncover disease mechanisms and identify potential biomarkers, with a clear shift from basic technology development toward direct clinical applications and personalized medicine. Professor Mann has received numerous prestigious awards throughout his career: 2025: Elected member of the American National Academy of Sciences 2024: Dr. H.P. Heineken Award for Biochemistry and Biophysics 2023: Otto Warburg Medal 2019: Nominated member of the Bavarian Academy of Sciences 2013: Elected member of Leopoldina German National Academy of Sciences 2012: Körber European Science Award, Louis-Jeantet Foundation Prize for Medicine, Ernst Schering Prize, and Leibniz Prize Professor Mann leads a highly collaborative research team involved in multiple international networks including the Bill & Melinda Gates Foundation, Michael J. Fox Foundation for Parkinson's Research, CLINSPECT-M, and Munich Heart Alliance. His lab has mentored numerous successful researchers, with several former postdocs receiving prestigious ERC Starting Grants. The Mann group has developed innovative clinical proteomics pipelines for analyzing archived tissue specimens and body fluids, aiming to identify protein markers for early detection of diseases such as diabetes and cancer. The Mann lab operates across two major research centers with state-of-the-art mass spectrometry facilities. Their Clinical Knowledge Graph platform integrates multi-omics data with extensive metadata, creating an ecosystem for machine learning applications in proteomics. Current research focuses on developing highly sensitive methods that can profile thousands of proteins from minimal cell samples, enabling the identification of critical disease-related proteins and supporting the development of individualized therapies.

• Cellular Toxicology
• In Vitro Methodology
• Fish Cell Biology
• +۲ مورد دیگر

Dr. Vivian Dayeh is an Associate Professor in the Department of Biology at the University of Waterloo, where she joined in 2004 as a full-time lecturer. Her roles include Teaching Fellow, Undergrad Advisor for Biomedical Science and Medical Physiology, and coordinator of the Biotech Technician Diploma program. Ph.D. Biology, University of Waterloo (2004) M.Sc. Biology, University of Waterloo (2001) B.Sc. Biology, University of Waterloo (1999) Dr. Dayeh specializes in cellular toxicology and in vitro methodology development , focusing on alternatives to whole-organism testing in aquatic environments. Her work explores toxicant effects on fish cells, particularly gill and intestinal epithelial systems, and employs protozoa as toxicity indicators. Recent research examines temperature and nutritional stress impacts on cell viability. Her publications from 2004-2025 demonstrate expertise in fish cell culture , cytotoxicity assays , and environmental contaminant testing , with applications in regulatory toxicology and industrial effluent analysis. 2024 Service Award, Society for In Vitro Biology 2021 Fellow Award, Society for In Vitro Biology Multiple Outstanding Performance Awards (2006-2020) Jack Carlson Teaching Excellence Awards (2006, 2018) Joseph F. Morgan Awards (2002, 2003) As an educator, Dr. Dayeh teaches core courses including Introductory Cell Biology , Human Anatomy , Human Physiology , Environmental Toxicology , and Animal Cell Biotechnology . She serves on the SIVB Board and facilitates instructional skills workshops.

• Biosensors
• Functional Nucleic Acids
• Sol-Gel Materials
• +۳ مورد دیگر

John D Brennan is a Professor in the Department of Chemistry & Chemical Biology at McMaster University. He is affiliated with the Biointerfaces Institute and focuses on developing innovative biosensing technologies and functional nucleic acid-based assays. His research integrates materials science, biochemistry, and analytical chemistry to create practical diagnostic tools for healthcare applications. Key research areas include the design of DNA aptamers and DNAzymes for detecting biomarkers (e.g., eosinophil peroxidase, SARS-CoV-2 spike proteins), development of paper-based diagnostic platforms, and optimization of sol-gel materials for enzyme entrapment. His work emphasizes high-throughput screening, point-of-care testing, and CRISPR-based biosensing systems. Notable contributions include a rapid sputum-based assay for asthma biomarkers and a universal DNA aptamer for SARS-CoV-2 variants. His lab also explores functional nucleic acid circuits and their integration into scalable diagnostic devices. Brennan’s teaching includes advanced courses in analytical chemistry and biochemical assay development. His work has been featured in journals like *Angewandte Chemie*, *Analytical Chemistry*, and *ChemBioChem*, with a focus on translating fundamental research into practical clinical applications.

Sachdev Sidhuمشاهده پروفایل

استاد پژوهش

• Synthetic Antibodies
• Protein Engineering
• Biotechnology
• +۵ مورد دیگر

Sachdev Sidhu is a Research Professor and Entrepreneur in Residence at the University of Waterloo. His research focuses on synthetic antibodies, protein engineering, and biotechnological applications. He leads efforts in developing novel therapeutic antibodies, engineered protein systems, and molecular tools for biomedical research. His work spans cancer therapy, viral infection countermeasures, and regenerative medicine. Sidhu is also involved in translational research, bridging academic discoveries with commercial applications through entrepreneurial ventures. Key research interests include synthetic antibody libraries, CAR T-cell engineering, ubiquitin-based therapeutics, and phage display technologies. He has contributed to advancements in targeted therapies for glioblastoma, leukemia, and ocular diseases. His team develops innovative methods for protein design, such as engineered ubiquitin variants and modular antibody architectures. Publications highlight breakthroughs in antibody-based treatments, including synNotch CAR T cells for glioblastoma and neutralizing antibodies against SARS-CoV-2. His work integrates structural biology, molecular biology, and computational approaches to address complex biomedical challenges. Sidhu collaborates with industry partners to advance technologies into clinical and commercial settings.

• Proteasome Research
• Structural Biology
• Enzyme Mechanisms
• +۲ مورد دیگر

Michael Groll serves as Professor and Chair of Biochemistry at the Technical University of Munich (TUM), where he leads structural biology and enzymology research with a focus on proteasome mechanisms and inhibitor development. His laboratory, located at the Ernst-Otto-Fischer-Str. 8 campus in Garching, maintains active collaborations in drug discovery for cancer and infectious diseases. His primary research domains include proteasome inhibition, enzyme catalysis, and natural product biosynthesis, employing X-ray crystallography, biochemical assays, and bioengineering to dissect molecular mechanisms. Recent work emphasizes AI-guided enzyme optimization, bacterial stress response targeting, and structural characterization of halogenation enzymes, reflecting interdisciplinary approaches bridging chemistry and biology. Analysis of his 2023-2025 publications reveals consistent innovation in proteasome-targeted therapeutics, with 15 high-impact papers featuring structural insights into enzyme-inhibitor complexes and biosynthetic pathways. Key trends include engineering megasynthetases for immunoproteasome inhibitors, optical control of protein degradation, and elucidating metal-dependent mechanisms in antibiotic biosynthesis. No scientific awards were documented in the provided source material. While specific grant details and student mentorship records were not disclosed, his extensive publication record indicates leadership in collaborative research projects involving structural biology and chemical biology methodologies. The Chair of Biochemistry under Prof. Groll operates as a hub for structural enzymology, housing facilities for protein crystallography, enzyme kinetics, and natural product characterization. His team actively contributes to TUM's research ecosystem through partnerships with pharmaceutical groups and international structural biology consortia.

• Stem Cell Mechanobiology
• Bone Tissue Engineering
• Regenerative Medicine
• +۳ مورد دیگر

Chao Liu is an Associate Professor at the Department of Biomedical Engineering , Southern University of Science and Technology (2024.11–present). Previously, he served as an Assistant Professor at the same institution (2019–2024.11) and completed a Postdoctoral Fellowship at New York University (2016–2019) with joint appointments in the Department of Biomedical Engineering and Orthopedics at NYU Langone Health . He holds a PhD in Biomedical Engineering (2016) and MASc in Mechanical Engineering (2010) from University of Toronto , following a BASc in Engineering Science (2008). Education : PhD (IBBME, U of Toronto, 2016), MASc (Mechanical Engineering, U of Toronto, 2010), BASc (Engineering Science, U of Toronto, 2008) His research focuses on mechanobiology of stem cells , bone tissue engineering , and functional implants . He investigates how mechanical forces modulate osteogenic and angiogenic stem cells, designs implants with micro-geometry to enhance cellular activity, and develops 3D real-time imaging modalities for bone repair processes. His work spans biomechanics , regenerative medicine , and cellular mechanotransduction . The selected publications from 2022 to 2010 reveal trends in mechanical force applications for bone regeneration, pharmacological impairments in healing, nanostructured biomaterials for stem cell differentiation, and microfluidic platforms for osteocyte studies. These works are published in journals like Bone , FASEB Journal , and ACS Applied Materials & Interfaces . Scientific Awards : International Conference BME Young Investigator Award (2019), IFMRS Travel Grant (2017), ASBMR Young Investigator Grant (2016), CIHR Travel Awards (2010–2014), Ontario Graduate Scholarship (2011–2013), Barbara and Frank Milligan Fellowship (2008, 2010) Chao Liu mentors graduate students, including Zhang Jianing (2022 Master’s graduate). His lab ( https://abtrl.bme.sustech.edu.cn/ ) recruits postdocs and research assistants for projects in mechanical force applications , micro-geometric implants , and 3D imaging . He has contributed to 14 journal articles with 714 citations and presented at 6 international conferences in the past three years.

Karoline Faustمشاهده پروفایل

دانشیار

• Microbial community dynamics
• Microbial systems biology
• Bioinformatics
• +۶ مورد دیگر

Karoline Faust is an Associate Professor at KU Leuven, affiliated with the Laboratory of Molecular Bacteriology (Rega Institute) and the Faculty of Medicine . She contributes to the iSi Health and Leuven One Health institutes, and serves on senior academic councils. Her research spans microbial systems biology, focusing on community dynamics and network analysis. Education: PhD in bioinformatics (2010, KU Leuven) Affiliations: KU Leuven, ISME Journal editorial board, Belgian Society for Microbiology Her research investigates microbial community dynamics , systems biology approaches to microbiomes, and bioinformatics tool development . She specializes in modeling human gut microbiota , synthetic microbial communities , and environmental microbiomes (e.g., microplastic impacts on Daphnia microbiomes). Her work integrates metabolic modeling , network analysis , and experimental systems to understand microbial interactions. Recent publications highlight her contributions to microbial network inference , 16S rRNA sequencing protocols , microfluidics , and ecological modeling of microbiomes. She develops tools like manta , miaSim , and CoNet to analyze community structures. Teaching: Karoline co-teaches courses in microbiology, bioinformatics, and network analysis at KU Leuven, and has contributed to international workshops on microbial network inference. Scientific Engagement: She serves as Senior Editor at ISME Journal and Secretary of the Belgian Society for Microbiology .

John W. Edmundsمشاهده پروفایل

استاد

• Infectious Disease Modelling
• Epidemiology
• Public Health Policy
• +۶ مورد دیگر

Professor John W. Edmunds is a leading academic in Infectious Disease Modelling at the London School of Hygiene and Tropical Medicine (LSHTM). Holding a Professor position since 2013 and serving as Dean of the Faculty of Epidemiology and Population Health (2013-2019), he combines mathematical, statistical, and economic models to inform public health policy. His part-time role at the Health Protection Agency (HPA) since 2008 underscores his policy advisory contributions. PhD in Infectious Disease Modelling (Imperial College, 1994) MSc in Health Economics (University of York, 1995) BSc in Biology (Imperial College, 1989) His research focuses on understanding disease transmission and optimizing control strategies. He has pioneered methods integrating social contact surveys , participatory surveillance (e.g., Influenzanet), and economic analysis to evaluate vaccines and interventions. Recent work includes SARS-CoV-2 dynamics , Ebola spatial forecasting , and typhoid vaccine prioritization . His 15 most recent publications highlight social contact patterns (Reconnect, CoMix studies), vaccine impact (HPV, typhoid), and real-time outbreak analytics (Ebola, cholera). Key trends include digital epidemiology , behavioral surveillance , and cross-country modeling for global health. Knighthood (2024) for services to epidemiology Weldon Memorial Prize (2022) for biostatistics contributions FMedSci (2018) for medical science excellence OBE (2016) for public service As an educator, he teaches "Modelling and the Dynamics of Infectious Diseases" and co-organizes "Pandemics: Emergence, Spread and Response" . Current grants include National Institute for Health and Care Research projects on post-pandemic surveillance and Bill & Melinda Gates Foundation funding for polio eradication. He leads collaborations with the Centre for Mathematical Modelling of Infectious Diseases , Vaccine Centre , and Health in Humanitarian Crises Centre , while advising UK and WHO committees on zoonotic influenza , variants , and testing programs .

Kevin M. Franksمشاهده پروفایل

دانشیار

• Neurobiology
• Olfactory System
• Neural Circuits
• +۳ مورد دیگر

Kevin M. Franks is an Associate Professor of Neurobiology at Duke University, where he investigates how the olfactory system forms neural representations of sensory environments. His work focuses on functional neural circuits in the olfactory bulb and piriform cortex, using techniques like in vivo recordings, optogenetics, and behavioral assays. His research explores Neural circuit dynamics and plasticity Odor coding mechanisms Role of recurrent circuitry Integration of sensory modalities Recent publications highlight his contributions to understanding cortical odor representations, developmental neural connectivity, and cross-modal interactions. Awards include the 2024 Don Tucker Finalist recognition. He teaches advanced neuroscience courses at Duke, including Neurobiology research and concepts in neuronal systems.

Lee Yong Limمشاهده پروفایل

استاد

• Drug Delivery Systems
• Pediatric Medicinal Products
• Taste-Masked Medicines
• +۴ مورد دیگر

Lee Yong Lim is a Professor of Pharmaceutics at The University of Western Australia (UWA), leading the Laboratory for Drug Delivery. She specializes in innovative drug delivery systems, particularly for pediatric populations and marine aquaculture. Her work focuses on overcoming medication challenges for children through taste-masked formulations and stable drug-loaded scaffolds for ear diseases. She has secured over $4.5 million in research grants from diverse funding bodies. Education: BSc (Pharmacy) Hons, National University of Singapore PhD, University of Manchester Research: Her team developed a patented chocolate-based formulation for bitter drugs and conducts pediatric trials. Collaborations include WA hospitals for safe compounded medicines and international projects in nanotechnology. Key research areas include pediatric medicinal products, veterinary drug delivery, and sustainable drug formulations aligned with UN SDGs. Grants & Funding: Major supporters include NHMRC, ARC, Telethon, and industry partnerships. Current active grants focus on pre-procedural chewables for children and perioperative analytics. Labs/Teams: Heads the Laboratory for Drug Delivery and collaborates with the Centre for Optimisation of Medicines and Institute for Paediatric Perioperative Excellence.