جست‌وجوی استاد و پژوهشگر

Xu Dong Zhangمشاهده پروفایل

پژوهشگر ارشد

• Skin Cancer Research
• Melanoma Pathways
• Cancer Biology
• +۳ مورد دیگر

Professor Xu Dong Zhang is an NHMRC Research Fellow and Head of the Melanoma Research Laboratory at the University of Newcastle's School of Biomedical Sciences and Pharmacy, within the College of Health, Medicine and Wellbeing. A globally recognized leader in skin cancer research, his work focuses on melanoma pathways, particularly the molecular mechanisms governing tumor resistance and metastasis. Key discoveries include identifying the role of PIB5PA in melanoma progression and its potential as a therapeutic target. His research integrates molecular biology, biochemistry, and clinical translation. Professor Zhang's education background includes a decade as a cancer surgeon in China before pursuing research at the University of Newcastle since 1995. His work bridges basic science and clinical applications, with collaborations at institutions like the Hunter Medical Research Institute (HMRI) and the Melanoma Institute Australia. He leads comparative studies on skin cancer biology between Australian and Asian populations, highlighting population-specific treatment differences. Research interests span apoptosis resistance, endoplasmic reticulum stress responses, and long non-coding RNAs (e.g., MILIP, PLANE) in cancer progression. His lab explores metabolic pathways, such as oxidative phosphorylation dependencies and the Warburg effect, to develop targeted therapies. Notable achievements include an H-index of 31 and editorial roles in top journals. Current projects address biomarker discovery (e.g., PIB5PA), obesity-melanoma links, and therapeutic strategies against BRAF/MEK inhibitor resistance. Collaborations with Chinese institutions (e.g., University of Science and Technology of China) have yielded over 30 co-authored studies. Grants and awards include NHMRC funding and equipment grants for cancer research infrastructure.

Ihab Younisمشاهده پروفایل

استاد آموزشی

• Intron Splicing
• Gene Expression Regulation
• Cancer Biology
• +۳ مورد دیگر

Ihab Younis is a Teaching Professor in the Department of Biological Sciences at Carnegie Mellon University , leading the Biological Sciences Program at CMU Qatar. He holds a Ph.D. in Molecular, Cellular, and Developmental Biology from The Ohio State University, with M.S. and B.S. degrees in Biology from the American University of Beirut. His research focuses on post-transcriptional regulation of gene expression , particularly intron splicing mechanisms and their role in cancer. His lab employs cutting-edge techniques like RNA-seq and high-throughput screening to study splicing defects in cancer cells and has identified novel splicing regulators. A key focus is the role of minor introns as stress-induced molecular switches, mediated by the unstable U6atac snRNA component of the minor spliceosome. Younis teaches courses including Genetics, Molecular Biology, Virology, and Cancer Biology. His lab integrates computational and experimental approaches, including projects exploring splicing aberrations in cancer and mechanisms controlling mRNA length. He has published extensively on splicing regulation, HTLV viral replication, and the SMN complex's role in RNP assembly. His work bridges basic science and translational research, aiming to uncover therapeutic targets for cancer and viral diseases. Despite no explicitly listed awards, his contributions to splicing mechanisms and stem cell applications highlight impactful academic leadership.

• Neurobiology
• Sensory Neuroscience
• Molecular Biology
• +۳ مورد دیگر

Yang Xiang is an Associate Professor in the Department of Neurobiology at the University of Massachusetts Chan Medical School (UMMS), affiliated with the T.H. Chan School of Medicine and the Morningside Graduate School of Biomedical Sciences. He holds additional roles in the NeuroNexus Institute, MD/PhD Program, Neuroscience, and Translational Science departments. His research focuses on understanding how the nervous system processes sensory stimuli to generate behavior, using Drosophila as a model. Key projects include studying photoreception mechanisms in larvae, particularly class IV dendritic arborization neurons' role in detecting harmful light, heat, and chemicals. Techniques employed include genetics, functional imaging, and behavioral assays. Yang Xiang earned his B.S. in Biochemistry from Nanjing University (1999) and a Ph.D. in Neurobiology from the Chinese Academy of Sciences (2003), followed by postdoctoral training at UCSF under Dr. Yuh-Nung Jan. He leads a lab with postdoctoral fellows (e.g., Pengyu Gu) and graduate students (e.g., Kendra Takle). His research interests span molecular mechanisms of sensory transduction, neural circuitry underlying escape behaviors, and the role of gustatory receptors (e.g., Gr28b) in phototransduction. Recent work explores TRP channels' roles in mechanosensation and nociception. Collaborations include studies on axon regeneration and stem cell regulation. Awards and grants are not explicitly listed here, but his lab's contributions are highlighted through publications in high-impact journals like Neuron , Science , and Nature .

Selma Masriمشاهده پروفایل

دانشیار

• Circadian Rhythms
• Sirtuins
• Metabolism
• +۲ مورد دیگر

Selma Masri is Associate Professor of Biological Chemistry at UC Irvine School of Medicine, investigating circadian regulation of metabolism and chromatin dynamics. Research explores sirtuin-mediated epigenetic control of metabolic pathways and circadian disruption in cancer. Key findings reveal partitioning of circadian transcription by SIRT6 and metabolic control mechanisms. Current studies examine DNA damage responses, tumor immunosuppression rhythms, and therapeutic modulation of circadian-metabolic interactions in disease.

• Hematopoietic Stem Cell Research
• T Cell Development
• Immunotherapy
• +۷ مورد دیگر

Christopher Sy Seet is an Assistant Professor-in-Residence in the Department of Medicine at the University of California Los Angeles (UCLA), where he conducts cutting-edge research at the intersection of immunology, stem cell biology, and cancer therapy. His work primarily focuses on developing novel cellular immunotherapies through innovative engineering of T cells and natural killer T cells using stem cell technologies. Dr. Seet's research interests center on hematopoietic stem cell differentiation, T cell development, and the engineering of cellular immunotherapies for cancer and infectious diseases. His laboratory investigates how to generate antigen-specific T cells from pluripotent stem cells using artificial thymic organoids, with particular emphasis on optimizing CAR (chimeric antigen receptor) signaling for therapeutic applications. His work has significant implications for creating off-the-shelf cellular therapies that can be used to treat various malignancies and potentially HIV infection. Analysis of Dr. Seet's recent publications reveals a strong focus on advancing cellular immunotherapy through stem cell engineering. His research demonstrates expertise in generating CAR-T and CAR-NKT cells from stem cells, understanding T cell differentiation pathways, and developing novel approaches to overcome limitations in current immunotherapies. His work spans basic science investigations of T cell development mechanisms to translational studies with direct clinical applications, particularly in cancer immunotherapy and HIV treatment. Dr. Seet collaborates extensively with leading researchers at UCLA, particularly with Dr. Gay Crooks and Dr. Donald Kohn, who are pioneers in stem cell and gene therapy research. His work is supported by multiple NIH-funded projects and is published consistently in high-impact journals including Nature, Cell, and Science family journals, reflecting the significance and innovation of his contributions to the field of cellular immunotherapy.

• leukemogenesis
• molecular immunology
• stem cell biology
• +۴ مورد دیگر

Stephen T. Smale is a Professor at the University of California, Los Angeles, holding appointments in the David Geffen School of Medicine and the College of Letters and Science. He leads the Department of Microbiology, Immunology, and Molecular Genetics, with a research focus on molecular immunology, gene regulation, and stem cell biology. Ph.D. in Biochemistry, University of California, Berkeley (1986) B.A. in Chemistry, Cornell University (1981) His research investigates the molecular logic of pro-inflammatory gene regulation, emphasizing the roles of transcription factors like NF-κB and Ikaros, chromatin dynamics, and signaling pathways in immune responses. Recent work explores evolutionary divergence of NF-κB family members, lipid metabolism reprogramming during inflammation, and transcriptional mechanisms in stem cells. Key publication trends include transcriptional regulation in inflammation, chromatin remodeling during immune activation, metabolic-immune interactions , and single-cell transcriptional analysis . His lab's output spans high-impact journals like Nature Immunology , Cell , and Genes & Development . Fellow, American Association for the Advancement of Science (2020) Sherie L. and Donald G. Morrison Chair in Molecular Immunology (2014–present) Howard Hughes Medical Institute Investigator (1990–2007) Graduate Research Fellowship, National Science Foundation (1982–1986) Smale has held leadership roles including Vice Dean for Research in the David Geffen School of Medicine and Director of the UCLA Jonsson Comprehensive Cancer Center's Basic and Translational Research. His mentorship extends to collaborative networks in immunity, inflammation, and stem cell research.

Marlin Toumaمشاهده پروفایل

دانشیار

• Congenital Heart Defects
• Cardiac Development
• Genetics and Genomics
• +۵ مورد دیگر

Dr. Marlin Touma is an Associate Professor-in-Residence in the Department of Pediatrics at the David Geffen School of Medicine, University of California Los Angeles (UCLA). His research focuses on understanding the genetic and molecular mechanisms underlying congenital heart defects and cardiac development, with particular emphasis on gene-environment interactions during perinatal heart maturation. Dr. Touma's research interests span multiple areas including congenital heart defects, cardiac development genetics, long noncoding RNA biology, and precision cardiovascular medicine. His work bridges basic science with clinical applications, investigating how genetic variants and environmental factors interact to influence cardiac chamber development and function. His laboratory employs cutting-edge genomic technologies including whole-exome sequencing, ChIRP-seq, and murine models to uncover molecular pathways critical for normal heart development and to identify pathogenic mechanisms in congenital heart disease. Analysis of Dr. Touma's recent publications reveals a strong focus on genetic causes of congenital heart defects, with particular attention to chamber-specific development and maturation. His work combines genomic approaches with functional validation to identify novel variants in genes like GATA5/6, FBN1/2, and LMOD2 that cause specific cardiac phenotypes. A significant portion of his research investigates the role of long noncoding RNAs, particularly Ppp1r1b-lncRNA, in regulating cardiac development through epigenetic mechanisms. His publications also demonstrate a growing interest in environmental influences on cardiac development, including air pollution exposure and hypoxemia during perinatal transition. Dr. Touma serves as Principal Investigator on NIH-funded research projects including 'Novel Gene-Environment Regulatory Circuit in Chamber-Specific Growth of Perinatal Heart' (R01HL153853, 2020-2024) and previously led the R56HL146738 project. His collaborative work involves multiple co-investigators across UCLA, particularly with the Congenital Heart Defects-BioCore Faculty, and extends to clinical applications in precision child health cardiovascular medicine.

Stephen Lawrence Zipurskyمشاهده پروفایل

استاد

• Neuroscience
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Stephen Lawrence Zipursky, Ph.D. is a Professor of Biological Chemistry at the UCLA School of Medicine, where he holds the prestigious Jerome J. Belzer Chair for Medical Research. His research program focuses on the molecular mechanisms underlying neural circuit assembly, with particular emphasis on how cell surface molecules guide wiring of the nervous system. Dr. Zipursky's research interests center on neural development and circuit formation, investigating how neurons recognize appropriate partners during brain development. His laboratory has made seminal contributions to understanding DSCAM (Down Syndrome Cell Adhesion Molecule) proteins and protocadherins, which provide molecular diversity enabling neurons to distinguish self from non-self during circuit assembly. His work bridges molecular biology, neurobiology, and genetics using Drosophila as a primary model system. Analysis of his publication record reveals a consistent focus on molecular mechanisms of neural connectivity, with early work on cell cycle regulation in Drosophila eye development evolving into groundbreaking research on molecular diversity in neural recognition systems. His most influential papers have established foundational principles in how molecular recognition codes govern neural circuit assembly. Scientific Recognition: Jerome J. Belzer Chair for Medical Research Dr. Zipursky has mentored numerous graduate students and postdoctoral fellows who have gone on to establish independent research careers. His laboratory has been consistently supported by NIH funding, including participation in UCLA's NIH T32 Training Grants in bioscience research. His conceptual frameworks on molecular diversity in neural recognition have shaped the field of neurodevelopment. His laboratory is part of UCLA's vibrant neuroscience community, collaborating with researchers across the campus including those in the Departments of Neurobiology, Molecular, Cell and Developmental Biology, and the Brain Research Institute. Current research continues to explore the relationship between molecular diversity and neural circuit complexity in both invertebrate and vertebrate systems.

Nikolas Nikolaidisمشاهده پروفایل

استاد

• Comparative genomics
• Bioinformatics
• Phylogenetics
• +۴ مورد دیگر

Nikolas Nikolaidis is a Professor in the Department of Biological Science at California State University, Fullerton (CSUF). His work focuses on molecular evolution, protein function, and stress response mechanisms. He holds a PhD and BSc from Aristotle University of Thessaloniki, Greece. Education: PhD and BSc in Biological Sciences, Aristotle University of Thessaloniki Affiliations: Center for Applied Biotechnology Studies (CSUF) Teaching: Genetics and Molecular Biology, Bioinformatics Research interests include comparative genomics of immune-related proteins, lipid interactions with Hsp70 proteins, and functional divergence of stress response systems. Recent work emphasizes the role of lipids in Hsp70 membrane localization during heat shock, with implications for cancer and cellular stress adaptation. Publications highlight Hsp70-lipid interactions, evolutionary studies of immunoglobulin loci, and structural analysis of bacterial expansins. His lab collaborates on projects involving transcriptomics and lipidome reorganization under stress. Advises students on molecular mechanisms of stress response, including co-authors C McCallister, R Tako, and U Mohamedy. Active in developing bioinformatics tools for gene expression analysis (e.g., PRRGO).

Murli Nairمشاهده پروفایل

استاد

• Cancer Genomics
• RNA Sequence and Structural Patterns
• Nucleosome Positioning
• +۳ مورد دیگر

Murli Nair is a Professor of Bioinformatics at Indiana University. His research focuses on cancer genomics, RNA sequence analysis, nucleosome positioning, and machine learning applications in biological systems. He leads 'Murli's Lab,' which develops computational tools like MAASE and DNAV for genomic visualization and splicing array analysis. He teaches courses including Introduction to Bioinformatics, Biostatistics, and Genomics. Research interests include understanding chromosomal rearrangements via paired-end sequencing, identifying biomarkers through splicing arrays, and applying neural networks to model biological complexity. Key projects involve preeclampsia heterogeneity analysis and epigenetic programming in liver development. His work bridges computational methods with experimental validation, emphasizing translational applications in oncology and systems biology. Notable contributions include the MAASE database for alternative splicing studies and the DNAV tool for 3D genome visualization. His publications span cancer biology, bioinformatics algorithms, and genomic technologies. Current grants include NSF funding for genomics and RNA sequence studies. Collaborations focus on integrating machine learning with experimental data to address biological questions at scale.

Heidi S Feilerمشاهده پروفایل

استاد پژوهشی

• Genomics
• Cancer Biology
• Molecular Oncology
• +۳ مورد دیگر

Heidi S Feiler is a Research Professor and Scientific Program Manager at the Knight Cancer Institute, Oregon Health & Science University (OHSU). Her work focuses on understanding genomic, transcriptomic, and proteomic mechanisms underlying breast and pancreatic cancers' progression and therapeutic responses. She investigates how molecular abnormalities drive cancer pathophysiology and resistance to treatments, aiming to develop strategies for early detection of aggressive cancers and more effective therapies. Her research integrates multi-omic approaches, including spatial and longitudinal analyses, to study tumor evolution and therapeutic adaptation. Notable contributions include identifying resistance mechanisms to CDK4/6 inhibitors in breast cancer and defining subtypes of pancreatic and ovarian carcinomas with distinct therapeutic responses. She has led collaborative projects like the NIH-funded Library of Integrated Network-Based Cellular Signatures (LINCS) program, cataloging cellular responses to perturbations. Feiler's work spans drug sensitivity profiling, systems biology modeling, and genomic characterization of glioblastoma. Her studies often involve large-scale datasets and interdisciplinary teams, emphasizing translational applications for precision oncology.

Cathy Savage-Dunnمشاهده پروفایل

استاد

• Cell Signaling
• Developmental Biology
• Molecular Biology
• +۳ مورد دیگر

Dr. Cathy Savage-Dunn is a Professor at Queens College, City University of New York (CUNY), specializing in cell signaling mechanisms using the model organism Caenorhabditis elegans . Her laboratory focuses on TGFβ-related pathways, particularly the DBL-1 signaling pathway, investigating its roles in body size regulation, fat storage, and developmental processes. She leads the CSwormlab, active on Twitter and Instagram (@CSwormlab). Education: Ph.D., Columbia University. Her research integrates genetic, molecular, and imaging techniques to study how TGFβ signaling influences developmental outcomes and disease-relevant processes. She has mentored numerous doctoral and undergraduate students, many of whom have pursued academic and industry careers. Key research interests include: Cell-cell signaling in development and disease. Body size control via epidermal signaling and cuticle collagen regulation. Feedback mechanisms between TGFβ pathways and extracellular matrix components. Genetic screens identifying novel TGFβ signaling components, including sma-9 and adt-2 . Advising: Current students include PhD candidates Emma Ciccarelli and Kat Yamamoto, and undergraduates Moshe Bendelstein and Hannah Reich. Alumni have transitioned into academic, medical, and industry roles. Lab alumni include researchers at institutions like Columbia University and Thomas Jefferson University. Labs/Teams: The lab is located in NSB D-349, Queens College, with active collaborations in developmental biology and C. elegans genetics.

Mauricio Rocha-Martinsمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Cellular Plasticity
• Neuroscience
• +۳ مورد دیگر

Dr. Mauricio Rocha-Martins is a Researcher at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, leading the Rocha Lab focused on Embryo Self-Correction . His work investigates how embryos overcome genetic and environmental stressors to develop functional organs, emphasizing developmental robustness, cellular plasticity, and nervous system development. Affiliations: Max Planck Institute for Molecular Biomedicine Role: Lab Head (Rocha Lab) and Supervisor in the CiM-IMPRS Graduate Programme Methodologies: Live imaging of in vivo systems, organoids, CRISPR genetics, light-sheet microscopy, and deep-learning image restoration Research Interests: His lab explores mechanisms enabling embryos to recover from developmental defects using advanced imaging and molecular profiling. Key areas include: Cellular cooperation under stress Regeneration of tissue organization Biophysical and molecular dynamics in repair processes Scientific Contributions: Publications span retinal development, neuronal migration, and imaging innovations. Recent work (2023-2025) highlights novel insights into progenitor cell behavior, neurogenic signaling, and stress adaptation in embryonic systems. Lab & Team: The Rocha Lab combines experimental and computational approaches, collaborating with the Cells in Motion initiative. Their work bridges basic research with potential applications in regenerative medicine and developmental disorder modeling.

• DNA damage signalling in cancers
• Cancer metabolism
• 3D tumour models
• +۶ مورد دیگر

Dr. Shafiq U Ahmed serves as a Senior Lecturer in Molecular Biology at the University of Sunderland's School of Medicine, a position he assumed in 2021 after previously serving as a Senior Lecturer in Biochemistry in the School of Pharmacy, Pharmaceutical and Cosmetic Sciences since 2016. His research laboratory focuses on glioblastomas, an incurable form of brain tumor that affects adults, with the goal of identifying novel therapeutic targets through molecular and cellular approaches. Dr. Ahmed received his BSc (Hons) in Biochemistry from Queen Mary (University of London) in 2001 and completed his PhD in 2005 from the Northern Institute for Cancer Research at the University of Newcastle, where he developed small molecule inhibitors targeting protein-protein interactions for cancer treatment. His postdoctoral training included research at the University of York investigating basal signaling pathways in cancers and later at the CRUK Beaton Institute and Institute of Cancer Sciences at the University of Glasgow. His primary research interest centers on glioblastoma stem-like cells (GSCs), which drive tumor recurrence following standard treatments of surgery, chemotherapy, and radiotherapy. His laboratory employs metabolomics, DNA damage signaling analysis, and high-throughput screening approaches to identify vulnerabilities in GSCs that could be targeted therapeutically. His work has revealed distinct metabolic alterations in GSC circuitry and optimal strategies to target this resistant cell population. Dr. Ahmed's publication record demonstrates consistent focus on brain tumor biology, DNA damage response mechanisms, and cancer therapeutics development. His most recent work explores vitamin B6 pathways in glioblastoma cell survival, while earlier publications examine replication stress, glutamine metabolism, and protein-protein interactions as therapeutic targets. His research bridges fundamental molecular biology with translational applications for improving patient outcomes. As an educator, Dr. Ahmed teaches across multiple programs including MBChB Medicine, MPharm Pharmacy, MSc Drug Discovery and Development, and MSc Pharmaceutical and Biopharmaceutical Formulation. He currently supervises two PhD students investigating metabolic signatures and small molecule inhibitors for glioblastoma treatment, and has previously mentored a PhD student whose work on 2D and 3D glioblastoma stem-like cell culture models led to a research scientist position at Histocyte Laboratories in Newcastle. Dr. Ahmed's laboratory utilizes advanced techniques including metabolomics studies, DNA damage response analysis, high-throughput siRNA screening, and drug library screening in glioblastoma stem cells. His research program represents a comprehensive approach to understanding the fundamental biology of glioblastoma recurrence mechanisms while actively developing novel therapeutic strategies to target this devastating disease.

Marco Mariottiمشاهده پروفایل

استاد پژوهشی

• Comparative Genomics
• Selenocysteine Biology
• Translational Recoding
• +۳ مورد دیگر

Marco Mariotti is a Research Professor at the University of Barcelona's Faculty of Biology, affiliated with the Department of Genetics, Microbiology, and Statistics. He leads the Molecular Evolutionary Genetics research group, focusing on comparative genomics of selenocysteine, stop codon readthrough mechanisms, and computational methods for evolutionary analysis. His lab, established in 2021, combines bioinformatics and molecular biology to study translational recoding processes and their evolutionary implications. Mariotti holds a Ramon y Cajal Investigator Fellowship (2019) and has secured grants from agencies like the Ministerio de Ciencia e Innovación and AGAUR. His work includes developing tools like SECISearch3 and Seblastian for selenoprotein annotation. Key research themes include selenoproteome evolution, genetic code variations, and aging-related molecular mechanisms. He collaborates internationally, particularly on projects involving selenium metabolism and translational recoding in diverse organisms. Education: Bachelor's in Biotechnologies (University of Bologna, 2006), PhD in Biomedicine (Centre de Regulació Genòmica, 2013), and Master in Bioinformatics (University of Bologna, 2008). Research grants span studies on stop codon readthrough therapies, selenoprotein annotation, and aging biology. His team explores applications in biotechnology and genetic medicine, including strategies to treat nonsense mutations in diseases like Duchenne muscular dystrophy.