Adaptive Enzyme Evolution Professors and Supervisors | ApplySharif

جست‌وجوی استاد و پژوهشگر

استاد راهنما، استاد دانشگاه یا پژوهشگر مناسب برای مسیر پژوهشی‌تان را پیدا کنید و با او ارتباط بگیرید.

نمایش ۱۶-۳۰ از ۱٬۵۰۴ استاد راهنما

اطلاعات این پروفایل‌ها از صفحات عمومی دانشگاه‌ها جمع‌آوری شده و ممکن است به‌روز نباشد.

Gustavo M. Silvaمشاهده پروفایل

دانشیار

Duke UniversityUnited States

Gustavo M. Silva is the Jack H. Neely Associate Professor of Biology at Duke University's Trinity College of Arts & Sciences, a position he has held since 2025. Previously, he served as Associate Professor of Biology (2024-present) and Assistant Professor of Cell Biology (2022-present) at Duke. His research is conducted through the Silva Lab (sites.duke.edu/silvalab), which focuses on molecular mechanisms of cellular stress response. Education: Ph.D. from University of Sao Paulo (Brazil), 2010 B.Sc. from University of Sao Paulo (Brazil), 2004 Dr. Silva's research centers on understanding how gene expression is regulated at transcriptional and translational levels during cellular stress. His lab specifically investigates how the ubiquitin system controls protein synthesis and degradation dynamics under stress conditions, which are critical for cellular physiology. His work has significant implications for understanding disease mechanisms where protein homeostasis is disrupted. The research combines biochemical, genetic, and proteomic approaches to dissect these complex regulatory networks. His publication record demonstrates a clear evolution from fundamental studies on redox regulation and proteasome function to more complex investigations of ubiquitin signaling in translation control and stress response. Recent work increasingly focuses on K63-linked ubiquitination's role in ribosome function and translation regulation, with growing emphasis on the clinical implications of these mechanisms in disease contexts including cancer. Scientific Awards & Recognition: Paul T. Englund Emerging Scholar Award (Johns Hopkins School of Medicine, 2024) Dean's Award for Excellence in Mentoring (Duke Graduate School, 2023) Science Diversity Leadership Award (Chan Zuckerberg Initiative, 2022) Best Professor Award (Vanderbilt Basic Sciences Juneteenth Committee, 2022) 100 inspiring Black scientists in America (CellPress, 2020) Dr. Silva actively mentors students at multiple levels, as evidenced by his Dean's Award for Excellence in Mentoring. His research is supported by substantial funding including NIH grants such as the Tri-Institutional Molecular Mycology and Pathogenesis Training Program (2024-2029) and 'Stalling cancer at the ribosome' from the V Foundation for Cancer Research (2025-2028). He also serves as Principal Investigator on multiple R01 grants focused on ubiquitin's role in translation control and stress response. The Silva Lab maintains strong collaborative relationships with institutions including the Chan Zuckerberg Initiative and ETH Zurich, and participates in several interdisciplinary training programs at Duke that support underrepresented students in biomedical sciences.

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Victoria J. Orphanمشاهده پروفایل

استاد

California Institute of Technology (Caltech)United States

Victoria J. Orphan is the James Irvine Professor of Environmental Science and Geobiology at Caltech, where she directs the Center for Environmental Microbial Interactions. Her research investigates microbial processes in anaerobic ecosystems including deep-sea methane seeps, hydrothermal vents, and coastal sediments using interdisciplinary approaches combining molecular biology, stable isotope techniques, and geochemistry. Her laboratory focuses on: Microbial partnerships in methane cycling Ecophysiology of uncultured archaea and bacteria Viral ecology in marine environments Biogeochemical impacts of microbial communities Blue carbon sequestration in seagrass ecosystems Professor Orphan has developed innovative methods including BONCAT-FISH and nanoSIMS for studying microbial activity in environmental samples. Her research group maintains active field programs in Monterey Canyon and hydrothermal vent systems, and develops high-pressure incubation systems for studying deep-sea microbes. She teaches courses on microbial ecology and evolution, and mentors graduate students through the Geobiology and Environmental Science programs.

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Ralph Bockمشاهده پروفایل

استاد

Max Planck Institute of Molecular Plant PhysiologyGermany

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

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Shahid Siddiqueمشاهده پروفایل

دانشیار

University of California, DavisUnited States

Shahid Siddique is an Associate Professor in the Department of Entomology and Nematology at the University of California, Davis. His research focuses on understanding molecular and applied aspects of plant-parasitic nematode interactions with host plants. He aims to develop sustainable strategies to mitigate nematode-induced crop losses through genetic, biochemical, and biotechnological approaches. His lab is particularly interested in host resistance mechanisms, nematode effector proteins, and biocontrol solutions. Education: MSc, Bahauddin Zakariya University, Multan, Pakistan PhD, University of Natural Resources and Life Sciences, Vienna, Austria Habilitation, University of Bonn, Germany Research Interests: Siddique’s work bridges basic and applied research, including cell surface signaling in plant-parasitic nematode interactions, functional characterization of secretory proteins, molecular diagnostics for nematodes, and biocontrol strategies. Current projects explore recombination hotspots in nematode genomes, CRISPR-based resistance engineering, and redox signaling mechanisms. Teaching: General Plant Nematology (NEM100) in Spring 2020 Labs/Teams: The Siddique Lab focuses on translating molecular discoveries into practical pest management solutions. Collaborations involve genomic analysis, proteomics, and field trials to address global agricultural challenges.

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John F. Stolzمشاهده پروفایل

استاد

Duquesne UniversityUnited States

John Stolz is Professor of Environmental Microbiology and Director of Environmental and Energy Engineering at Duquesne University's School of Science and Engineering. His NASA-trained research examines microbial metal reduction, modern stromatolite ecosystems, and shale gas extraction impacts. His lab investigates arsenic/selenium biotransformation pathways, microbial communities in Shark Bay stromatolites, and environmental impacts of unconventional energy development. Recognized with multiple excellence awards including the Nobel J. Dick Endowed Chair. Over 150 publications explore microbial respiration mechanisms, biogeochemical cycling, and environmental bioremediation. Current grants support water quality testing near shale gas operations.

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Kunihiko Kanekoمشاهده پروفایل

استاد

University of CopenhagenDenmark

Kunihiko Kaneko is a Professor at the Niels Bohr Institute, University of Copenhagen, with a distinguished career in theoretical biophysics and complex systems. He received his PhD and MSc in Physics from the University of Tokyo, and has held leadership roles at the Universal Biology Institute and Center for Complex Systems Biology. PhD Physics, 1984 - University of Tokyo MSc Physics, 1981 - University of Tokyo His research spans five primary areas: Universal Biology, Evolutionary Constraints, Ecosystem Dynamics, Neural Cognition, and Universal Anthropology. He has published extensively on multi-level consistency principles, dimensional reduction in biological systems, and reciprocity between robustness and plasticity across scales. Recent publications show strong focus on microbial ecosystems (2025), evolutionary game theory (2025), neural modular architectures (2024), and dimensional reduction in cellular systems (2024). His work bridges physics and biology through dynamical systems theory applied to diverse phenomena from protocells to human societies.

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Vernita Gordonمشاهده پروفایل

دانشیار

University of Texas at AustinUnited States

Vernita Gordon is an Associate Professor in the Department of Physics at the University of Texas at Austin (since 2018), previously serving as an Assistant Professor there from 2010 to 2018. She holds a Ph.D. in Physics from Harvard University (2003) and a B.Sc. in Physics and Mathematics from Vanderbilt University (1997). Her research focuses on understanding how physical characteristics like mechanics and spatial structure influence bacterial biofilms, particularly their interactions with the immune system and resistance to antibiotics. She has pioneered techniques such as laser trapping to manipulate biofilm structures and studies radiation effects on bacteria like Deinococcus radiodurans . Education: Ph.D. in Physics, Harvard University (2003) B.Sc. in Physics and Mathematics, Vanderbilt University (1997) Research Interests: Dr. Gordon’s work integrates biophysics, microbiology, and materials science to explore biofilm mechanics, bacterial mechanosensing, and radiation biology. Key areas include: How biofilm mechanics resist immune clearance and antibiotic treatment Role of surface stiffness and shear stress in biofilm initiation Radiation resistance mechanisms in Deinococcus radiodurans Development of tools like laser trapping to study biofilm structure Key Achievements: Recipient of the Elizabeth B. Gleeson Professorship (2023) and Texas Mindset Initiative Fellowship (2023) Provost’s Teaching Fellow (2020–2024) and multiple teaching awards Funded by NSF, NIH, and Cystic Fibrosis Foundation Published over 60 peer-reviewed articles, including in Nature , PNAS , and Biophysical Journal Advising & Outreach: She mentors graduate students in Physics, Microbiology, and Biomedical Engineering, emphasizing interdisciplinary training. Her group actively recruits undergraduates and collaborates with industry partners like Solvay and the College of Pharmacy. Outreach includes lesson plans for high school STEM education and community science initiatives. Labs & Collaborations: Her lab uses advanced microscopy, microrheology, and computational modeling. Key collaborations include work with the Contreras Lab (UT Austin Chemical Engineering) on radiation-resistant bacteria and the Raizen Lab (UT Austin Physics) on self-sterilizing surfaces.

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Ueli Grossniklausمشاهده پروفایل

استاد

University of ZurichSwitzerland

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

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Kyu Y. Rheeمشاهده پروفایل

استاد

Cornell UniversityUnited States

Kyu Y. Rhee is a Professor of Medicine and Professor of Microbiology and Immunology at Weill Cornell Medical College . His research focuses on Mycobacterium tuberculosis , with emphasis on metabolic pathways , antibiotic resistance mechanisms , and drug development . Research highlights include: Multi-omic approaches to TB drug discovery Mechanistic studies of antibiotic action Deciphering TB transmission genetics Metabolomics-driven target identification Current funding includes: Bill & Melinda Gates Foundation : AI/ML-assisted bacterial permeability platform National Institute of Allergy & Infectious Diseases : UM1 TB drug regimen design consortium National Heart, Lung, & Blood Institute : Studies on M. tuberculosis PE/PPE proteins and fructose-induced cancer He has authored over 50 publications on TB metabolomics, drug development, and pathogen persistence. His work bridges systems biology , chemical biology , and clinical research to address antimicrobial resistance.

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Chris Greeningمشاهده پروفایل

استاد پژوهشی

Monash UniversityAustralia

Professor Chris Greening is a Research Professor in the Department of Microbiology at Monash University, leading the One Health Microbiology group at the Biomedicine Discovery Institute. He holds a first-class degree in Molecular and Cellular Biochemistry from the University of Oxford (2010) and a PhD from the University of Otago (2013). His career includes postdoctoral roles at Otago, CSIRO, and the Australian National University, followed by appointments as a group leader in Monash’s School of Biological Sciences (2016) and a medically-focused NHMRC EL2 Fellow in the Department of Microbiology (2020). Research Focus: Bacterial persistence mechanisms, microbial metabolism, antimicrobial resistance (AMR), and One Health approaches linking environmental, clinical, and public health challenges. Awards: Fenner Medal (2022) and Jim Pittard Award (2019). Key Projects: RISE, Global Research Alliance on Agricultural GHGs, SAEF, and the ARC Carbon Utilisation Hub. Leads Monash’s AMR R&D Facility. Research spans metabolic pathways enabling bacterial survival in extreme conditions (e.g., hydrogen oxidation, F420 cofactor roles), climate impacts (greenhouse gas regulation), and translational programs addressing diarrheal diseases and AMR. Grants: ARC DECRA Fellowship, NHMRC EL2 Fellowship. Cross-disciplinary collaborations with engineers, ecologists, social scientists, and industry. Lab facilities include advanced microbiology, structural biology, and systems biology tools. Contributions align with UN SDGs: climate action (SDG13), good health (SDG3), and sustainable cities (SDG11).

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Albert M. Berghuisمشاهده پروفایل

استاد

McGill UniversityCanada

Albert M. Berghuis is a Professor in the Department of Biochemistry at McGill University's Faculty of Medicine. His research focuses on structural mechanisms of antibiotic resistance and fungal pathogenesis using advanced techniques including X-ray crystallography, electron microscopy, and computational chemistry. His primary research interests include: Structural basis of antibiotic resistance mechanisms, particularly against aminoglycosides Development of novel antimicrobials through structure-based drug design Structural studies of fungal-specific metabolic pathways for antifungal drug discovery Enzyme mechanisms involving protein-small molecule interactions Analysis of his recent publications reveals a consistent focus on structural elucidation of resistance mechanisms, with particular emphasis on aminoglycoside-modifying enzymes and fungal targets. His work bridges structural biology with therapeutic development, showing strong translational potential in combating antimicrobial resistance. Professor Berghuis maintains the Berghuis Lab with facilities in both the McIntyre Medical Sciences Building and the Francesco Bellini Life Sciences Building. His laboratory employs integrated structural biology approaches to tackle pressing problems in infectious disease treatment.

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Peter Chienمشاهده پروفایل

استاد مدعو

University of Massachusetts AmherstUnited States

Peter Chien is an Adjunct Professor in the Department of Biochemistry and Molecular Biology at the University of Massachusetts Amherst. His research focuses on regulated protein degradation and quality control in bacteria, with a particular emphasis on mechanisms governing proteolysis during the bacterial cell cycle. PhD, University of California, San Francisco Postdoctoral Training, Massachusetts Institute of Technology The Chien Lab employs interdisciplinary approaches including biochemistry, structural biology, and cell biology to study proteolytic mechanisms in Caulobacter crescentus. Their work explores how AAA+ proteases like ClpXP and Lon recognize substrates with precision and how this impacts cellular regulatory networks. Recent research trends from the lab include investigations into Lon protease modulation , DNA damage responses , protein homeostasis under stress , and genetic regulators of proteostasis . Studies often integrate structural analysis with functional assays to uncover molecular principles of protease specificity. The lab is affiliated with multiple graduate programs, including the Molecular and Cellular Biology (MCB) program, Chemistry-Biology Interface Program, Biotechnology Training Program, and the Institute for Applied Life Sciences at UMass Amherst.

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Alicia Fajardo Lubianمشاهده پروفایل

پژوهشگر ارشد

University of SydneyAustralia

Dr. Alicia Fajardo Lubian serves as a Research Fellow at the Westmead Clinical School within the University of Sydney's Faculty of Medicine and Health. Her work bridges bacteriophage therapy, antimicrobial resistance, and gut microbiome dynamics, with a focus on translating research into clinical solutions for infectious diseases. Her research explores the interplay between bacteriophages and human immunity, antibiotic effects on microbial communities, and molecular mechanisms of pathogen evolution. She employs genomic and experimental approaches to investigate Klebsiella pneumoniae, Escherichia coli, and phage-based therapeutics. Publications spanning 2014-2025 demonstrate concentrated expertise in antimicrobial resistance surveillance (e.g., AGAR reports), phage-immune interactions, and microbiome disruption models. Over 85% of articles involve international collaborations, reflecting strong engagement with global health challenges. Awards: EMCR Emerging Star Funding (2022) Grant involvement includes the 2022 EMCR Emerging Star Funding from the Faculty of Medicine and Health, supporting innovative research in phage therapeutics.

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Sven Pankeمشاهده پروفایل

استاد

ETH ZurichSwitzerland

Prof. Dr. Sven Panke is a Full Professor and Head of the Department of Biosystems Science and Engineering at ETH Zürich. His research focuses on bioprocess engineering, synthetic biology, and enzymatic process development. Key areas include miniaturized bioreactor systems, microbial engineering for novel metabolite production, and high-throughput screening methodologies. Education: Studied Biotechnology at TU Braunschweig, with postgraduate research at the German National Research Center for Biotechnology and ETH Zurich. Transitioned from industry (DSM) to academia in 2001 as an Assistant Professor, progressing to Associate Professor (2007-2009) before leading the BSS department. Research interests emphasize directed evolution of enzymes, metabolic pathway engineering, and systems biology approaches to optimize microbial production systems. Current projects include bio-indigo synthesis, antimicrobial peptide discovery, and synthetic biology tools for cellular engineering. Labs/Teams: Leads the Bioprocess Engineering Lab at ETH Zurich, collaborating on projects like the E. coli import system design and γ-glutamyltransferase engineering. Active in developing microfluidics platforms for parallel reaction analysis. Grants/Advising: Funded by initiatives in sustainable biomanufacturing and synthetic biology. Supervises graduate students in bioprocess design and microbial systems engineering.

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Lailiang Chengمشاهده پروفایل

استاد

Cornell UniversityUnited States

Lailiang Cheng is a Professor in the Horticulture Section of Cornell University's School of Integrative Plant Science, specializing in the physiological processes of deciduous fruit crops (particularly apple). His research focuses on sugar/malate metabolism, mineral nutrition, and environmental stress responses to improve orchard productivity and fruit quality. He integrates physiological, biochemical, and molecular approaches to study sorbitol signaling and nutrient management in high-density orchards. Education: Doctorate, Oregon State University (1999) Master of Science, Shandong Agricultural University (1989) Bachelor of Science, Shandong Agricultural University (1984) Research Focus: Cheng's work investigates carbon partitioning, malate accumulation, and nutrient transport dynamics in apple trees under abiotic stresses. His extension program delivers nutrient management strategies to the apple industry, while his teaching emphasizes analytical techniques (PLSCI 6170) and crop nutrition principles (PLSCI 4551/6551). Publication Analysis: Recent articles (2021-2025) reveal dominant themes in molecular regulation of fruit acidity, transporter biology, stress-responsive transcription factors, and omics-assisted breeding. Over 70% of publications involve collaborative work on apple genomics, with consistent emphasis on translating basic research into orchard management solutions. Awards & Recognition: No scientific awards mentioned in source materials. Academic Contributions: Advises graduate students in Horticulture; research supported by Cornell University Agricultural Experiment Station. Collaborates extensively with pomology breeders, extension specialists, and molecular biologists globally.

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