Zhuoli Zhang

Zhuoli Zhang is a Professor in Radiological Sciences at the University of California, Irvine (UCI) School of Medicine. Their research focuses on MRI radiomics, irreversible electroporation (IRE), and oncological imaging, particularly in hepatocellular carcinoma. Zhang has pioneered the use of advanced statistical learning frameworks to differentiate IRE zones from reversible electroporation regions using standard MRI data. Their work integrates clinical outcomes with histological tumor biomarkers, emphasizing translational applications in cancer treatment assessment.

Zhang's studies leverage NIH grants (e.g., R01 CA196967, R01 CA241532) to explore IRE ablation efficacy, therapeutic combinations (e.g., sorafenib + NK cells), and MRI-based monitoring techniques. Collaborations with experts like Dr. Yaghmai and Dr. Abi-Jaoudeh highlight multidisciplinary approaches to tumor treatment evaluation.

Key contributions include preclinical and clinical studies demonstrating MRI radiomics' ability to predict treatment response, quantify tumor viability, and correlate with apoptosis rates. Zhang's work bridges radiology and oncology, offering novel tools for personalized therapy and outcome prediction in liver cancer.

Recent efforts extend to combining IRE with immunotherapies (e.g., dendritic cell vaccines, NK cell therapies) and refining transcatheter drug delivery systems. Their research underscores the importance of imaging biomarkers in advancing precision medicine for malignant and autoimmune diseases.

Grants and collaborations: NIH R01 grants (CA196967, CA209886, CA241532), multi-institutional partnerships in oncology and rheumatology.