معرفی
Yusuf A. Hannun, MD is the Joel Strum Kenny Professor in Cancer Research at the School of Medicine, Stony Brook University. He is based at the MART Building on Lauterbur Drive in Stony Brook, NY.
Dr. Hannun received his MD with distinction from the American University of Beirut Medical Center in Beirut, Lebanon, in Internal Medicine. He completed his fellowship in Hematology-Oncology and postgraduate training in Biochemistry at Duke University Medical Center.
His research focuses on bioactive lipids, particularly sphingolipids, and their critical roles in eukaryotic stress responses. His laboratory investigates the regulation of sphingolipid metabolism and the functions of bioactive sphingolipids such as sphingosine and ceramide. Using both human cancer cells and yeast as a model organism, his team conducts six major projects:
- Project I: Sphingolipid Network in Yeast - studying how sphingolipids enable adaptation to heat and other stresses in yeast.
- Project II: Regulation and Function of Neutral Sphingomyelinases - exploring how these enzymes regulate ceramide and act as nodes in cell regulation.
- Project III: Regulation and Function of Acid Sphingomyelinase - defining two forms of the enzyme and their roles in cancer and inflammation.
- Project IV: Ceramide activated protein phosphatases - studying how ceramide induces apoptosis and cell cycle arrest.
- Project V: Protein Kinase C - investigating the role of PKC in regulating receptor function and membrane trafficking.
- Project VI: Neutral Ceramidase - examining the enzyme's regulation and role in infectious disease susceptibility.
Dr. Hannun's laboratory is supported by a lab manager, Janet Allopenna. While specific scientific awards and student advisees are not mentioned in the provided text, his work contributes significantly to the understanding of lipid signaling in cancer and stress responses.
