Yoshihiro Kawaoka

Yoshihiro Kawaoka is a Professor in the Department of Pathobiological Sciences at the School of Veterinary Medicine, University of Wisconsin–Madison. His research focuses on the molecular mechanisms of interspecies transmission and pathogenesis of influenza and Ebola viruses, with significant contributions to understanding pandemic risks and viral evolution.

His research interests include:

• Molecular pathogenesis of influenza in poultry and mammals
• Interspecies transmission of influenza viruses
• Role of viral proteins in Ebola virus replication and pathogenesis
• Development of reverse genetics systems for RNA viruses
• Host receptor specificity and viral adaptation

The recent publications highlight a strong focus on influenza A virus (particularly H5N1 and H9N2 strains) and Ebola virus, with recurring themes in viral entry, host adaptation, glycoprotein function, and pathogenicity determinants. The work integrates molecular virology, structural analysis, and host-pathogen interactions.

Notable scientific contributions include:

• Elucidating the molecular basis of high virulence in H5N1 influenza viruses
• Developing plasmid-based systems for generating infectious influenza viruses
• Characterizing the role of Ebola virus glycoprotein in cell entry and immune modulation
• Demonstrating receptor specificity differences in avian and mammalian hosts

Kawaoka has advised numerous students and mentored researchers in virology, though specific names are not listed. His lab has secured funding for Ebola vaccine and antiviral research, as evidenced by public appeals for donations. He teaches Veterinary Virology, a clinically oriented course covering pathogenesis, diagnosis, and management of viral diseases in animals. His team operates within the Department of Pathobiological Sciences, contributing to both basic and applied virology research with implications for global health and pandemic preparedness.