معرفی
Dr. Yiliang Chen is an Assistant Professor in the Department of Medicine at the Medical College of Wisconsin (MCW), affiliated with the Cardiovascular Research Center. He specializes in metabolic diseases, inflammation, and atherosclerosis. Dr. Chen holds a PhD from the University of Toledo (2009) and a BS in Genetics from Fudan University (2001). His postdoctoral work at the Blood Center of Wisconsin focused on CD36 signaling in chronic inflammation and atherosclerosis.
His research investigates the molecular mechanisms underlying macrophage-driven atherosclerosis, mitochondrial dynamics, and lipid metabolism. Techniques include single-cell RNA sequencing, Seahorse metabolic assays, and confocal microscopy. Key interests include CD36-mediated lipid trafficking, mitochondrial ROS production, and macrophage-adipocyte cross-talk in atherogenesis.
- Education:
- PhD, University of Toledo, 2009
- MS, National University of Singapore, 2004
- BS, Fudan University, 2001
Research Highlights:
Dr. Chen’s work targets CD36 signaling pathways in immune cells, focusing on how lipid metabolism and mitochondrial function drive inflammation. Recent studies highlight CD36’s role in restricting macrophage accumulation in adipose tissues during atherogenesis and its interaction with Na/K-ATPase in adipogenesis. His lab explores novel therapies targeting mitochondrial dynamics and redox regulation in cardiovascular diseases.
Awards:
- 2012 ATVB Travel Award for Young Investigators
- 2008 Retiree’s Scholarship Award, University of Toledo
- 2004-2009 Predoctoral Fellowship, University of Toledo
- 2002-2004 Research Fellowship, National University of Singapore
Lab & Collaboration: The Chen Laboratory collaborates on projects involving CD36 signaling, mitochondrial ROS, and exosome-mediated communication. Current members include graduate student Lance Vick and postdoctoral researchers Yaxin Wang and Jue Zhang. The lab emphasizes translational research to bridge basic science and clinical applications in cardiovascular and metabolic diseases.
