Xueyuan Leng

Xueyuan Leng is a Researcher at the Center for Protein Research (CPR) within the Biotech Research and Innovation Centre (BRIC) at the University of Copenhagen's Faculty of Science. Working in the Duxin Group, Dr. Leng focuses on DNA damage response mechanisms and transcription kinetics, utilizing both mammalian and plant model systems.

Education:

• PhD in Molecular Biology, IT University of Copenhagen (2016-2019), dissertation on Transcription kinetics in plants
• MSc in Plant Biotechnology, Wageningen University & Research (2013-2015), thesis on Conserved Function of Histone Deacetylases HDTs in Arabidopsis and Medicago
• BSc in Biology, Huazhong Agricultural University (2009-2013), research on Mapping Rdf3 gene in Maize

Dr. Leng's research spans two major domains: DNA Damage Response and Eukaryotic DNA Replication, with specific focus on DNA-protein crosslink repair and topoisomerase-induced DNA damage; and Eukaryotic Transcription Kinetics, particularly investigating RNA Polymerase II transcription in Arabidopsis to understand how transcription speed affects co-transcriptional events and plant development. Their work combines biochemical approaches using Xenopus cell-free extract systems with plant molecular biology techniques.

Analysis of Dr. Leng's six publications from 2019-2024 reveals a strong focus on molecular mechanisms of DNA repair and transcription regulation. The research spans both fundamental mechanisms in DNA damage response and applied aspects relevant to cancer biology, with increasing emphasis on plant systems in recent years. The work demonstrates interdisciplinary approaches combining biochemistry, molecular biology, and genomics.

Scientific Awards:

• EMBO Short-Term Fellowship (2018)

Dr. Leng has been actively involved in the scientific community, serving as a member of the Danish RNA society from 2016-2019. While specific grant information isn't detailed in the provided text, the EMBO fellowship suggests successful funding acquisition for collaborative research. The work appears to involve significant international collaboration, as evidenced by multi-institutional publications.

As part of the Duxin Group at CPR, Dr. Leng contributes to a research environment focused on protein signaling and DNA repair mechanisms. The group utilizes advanced biochemical and genomic approaches to investigate fundamental cellular processes with implications for understanding cancer development and potential therapeutic interventions.