Xudong Fan

Xudong Fan is a Professor at the University of Michigan specializing in advanced analytical and diagnostic technologies. His work bridges engineering, chemistry, and clinical medicine through innovative device development.

His research focuses on:

• Miniaturized gas chromatography systems for portable chemical analysis and planetary science missions
• Optofluidic immunoassays using biolasers for ultrasensitive, label-free biomarker detection
• Machine learning integration for chromatographic data analysis and biosensor accuracy enhancement
• Breath-based diagnostics for cancer, infectious diseases, and respiratory conditions
• Microfluidic platforms requiring minimal sample volumes (e.g., 1μL fingertip blood)

Professor Fan's 2025 publications reveal a strong emphasis on device miniaturization, automation, and multimodal sensing. Key trends include the convergence of micro-GC with photoionization detectors for field-deployable chemical analysis, deep learning solutions for chromatographic co-elution challenges, and biolaser-based platforms enabling antigen-independent cancer cell detection. These efforts target affordable point-of-care diagnostics with applications in tuberculosis monitoring, COVID-19 immunity assessment, and early lung cancer screening through breath analysis.

His work demonstrates significant translational impact, particularly in resource-limited settings where cost, portability, and minimal sample requirements are critical. Current projects show strong alignment with NASA planetary science objectives through micro-GC development for extraterrestrial organic analysis.