Xiche Hu

Xiche Hu, Ph.D., is an Associate Professor in the Department of Chemistry & Biochemistry at the University of Toledo, affiliated with the College of Natural Sciences and Mathematics. His research spans computational and theoretical chemistry, focusing on

• Modeling membrane protein structures
• X-ray crystallography methods
• Chemical reaction dynamics
• Molecular recognition mechanisms

Education:

• B.S. (1982) and M.S. (1985) from Wuhan University
• Ph.D. (1991) from Wayne State University
• Postdoctoral work at UC Irvine (1992-1994) and UIUC (1994-1998)

Research Interests: Dr. Hu's work combines quantum chemical methods with computational biology to study energy transfer in photosynthetic systems, molecular recognition in protein-drug interactions, and reaction dynamics in enzyme mechanisms. He has developed ab initio molecular replacement techniques for membrane protein structure determination.

Scientific Contributions: His publications from 1988-2021 reflect expertise in

• X-ray crystallography
• Quantum mechanical modeling
• Classical trajectory simulations
• Structure-function relationships
• Photobiology
• Computational enzymology

Laboratory: Based in Bowman-Oddy Laboratories (Room BO 2022), his team investigates light-harvesting complexes and protein-ligand interactions through computational approaches.