معرفی
Dr Wu Min is a Principal Investigator and NRF Fellow at the Mechanobiology Institute (MBI) and the Department of Biological Sciences, National University of Singapore. She leads the Wu Lab, whose goal is to deconstruct the endocytic machinery and to understand cell-matrix and cell-cell mechanotransduction.
Education
- PhD, Cornell University
- Bachelor of Science in Chemistry, Peking University
Research Interests
Dr Wu’s research focuses on the organization and dynamics of subcellular membrane compartments. Her lab investigates how biological membranes are shaped via collective protein-lipid interactions and how membrane geometry couples to cellular functions. Using an integrated approach that combines cell biology, biophysics and biochemistry, the Wu Lab explores endocytosis, membrane trafficking, membrane curvature, actin cytoskeleton and mechanotransduction.
Recent Publications Overview
Between 2018 and 2024, Dr Wu’s group has published extensively on cytoskeletal dynamics and membrane trafficking. Key themes include the competition and synergy between Arp2/3 complex and formins in actin nucleation, collective actin-microtubule dynamics mediated by FHDC1, curvature sensing by F-BAR domains, dynamic instability of clathrin assembly, and membrane shape-mediated wave propagation of cortical proteins. These studies advance our understanding of how membrane geometry and cytoskeletal networks orchestrate fundamental cellular processes.
Scientific Awards
- NRF Fellowship (2011)
Laboratory & Team
Dr Wu heads the Wu Lab – Deconstructing the Endocytic Machinery located at MBI, NUS. The lab forms an integral part of the Cell-Matrix and Cell-Cell Mechanotransduction Group at MBI, fostering interdisciplinary collaborations across cell biology, biophysics and biochemistry.
