معرفی
William M Shih is a Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and a researcher at Dana-Farber Cancer Institute and the Wyss Institute. He earned his PhD from Stanford University in 2000, followed by postdoctoral training at The Scripps Research Institute, where he pioneered DNA nanostructure design. His research focuses on programmable self-assembly of biomolecular systems, particularly DNA-based architectures for molecular robotics, single-molecule analysis tools, and therapeutic applications. Key projects include crisscross polymerization for scalable DNA nanoconstruction, nanoscale calipers for protein structure analysis, and DNA-corralled nanodiscs for membrane protein studies. Shih’s work spans interdisciplinary collaborations across academia and industry, aiming to advance nanomedicine and molecular engineering.
Education
- PhD in Chemistry, Stanford University, 2000
- Postdoctoral Research, The Scripps Research Institute
Research Focus
- Development of DNA-based nanotechnologies for molecular robotics
- Design of self-assembling DNA nanostructures for diagnostics and therapeutics
- Single-molecule tools for structural and functional analysis of biomolecules
Labs
- Shih Laboratories at Dana-Farber Cancer Institute and the Wyss Institute
- Collaborations with institutions including LMU Munich, Oxford University, and Brigham and Women’s Hospital
