معرفی
Warren D. Kruger is a Professor in the Cancer Signaling and Microenvironment program at Fox Chase Cancer Center, part of Temple University Health System. His research focuses on amino acid genetics and human disease, particularly methionine metabolism and its role in cancer and metabolic disorders. He leads an active laboratory studying the methionine salvage pathway gene MTAP and cystathionine beta-synthase (CBS) deficiency using mouse models.
Educational Background:
- BA in Biology, Cornell University, Ithaca, NY (1985)
- PhD in Genetics, University of California at San Francisco, San Francisco, CA (1991)
Dr. Kruger's research centers on understanding how mutations affecting key enzymes in methionine metabolism cause disease. His lab investigates four major projects: the role of MTAP in tumorigenesis, targeting MTAP-loss for cancer therapy, mouse models for CBS deficiency, and alterations in serum amino acids in renal cell carcinoma. His work has significant implications for understanding metabolic pathways connecting folate/nucleotide biosynthesis, sulfur and redox metabolism, choline and lipid metabolism, and methylation reactions involving S-adenosylmethionine.
Analysis of Dr. Kruger's recent publications reveals a strong focus on CBS deficiency and MTAP deletion in cancer. His research employs mouse models, metabolic profiling, and therapeutic development approaches. Key trends include developing gene therapy for metabolic disorders, identifying biomarkers for renal cell carcinoma, and exploring novel cancer therapies targeting metabolic vulnerabilities.
Scientific Awards:
- American Heart Association Researcher Award (2006)
- Elected President of Fox Chase Cancer Center Faculty Senate (2010)
Dr. Kruger leads an active research laboratory with several senior staff members including Sapna Gupta, PhD (Senior Research Associate), Baiqing Tang, PhD (Senior Research Associate), Hyung-Ok Lee, PhD (Assistant Research Professor), and Liqun Wang, MD (Senior Technical Specialist). His lab has received significant funding for research on methionine metabolism, CBS deficiency, and MTAP deletion in cancer. Current projects include developing novel therapeutic approaches for homocystinuria and exploring metabolic vulnerabilities in cancer cells.
The Kruger lab maintains four major research areas focused on methionine metabolism: understanding the role of MTAP in tumorigenesis, developing the MTA protection strategy for cancer therapy, creating mouse models for CBS deficiency, and investigating serum amino acid alterations as biomarkers for renal cell carcinoma. The lab employs advanced techniques including metabolic profiling, gene therapy approaches, and sophisticated molecular analyses to address these research questions.
