Volodymyr Pidoplichko

Volodymyr Pidoplichko serves as Research Associate Professor in the Department of Anatomy, Physiology and Genetics at Uniformed Services University of the Health Sciences (USUHS) School of Medicine, Bethesda. His research investigates CNS ligand-gated ion channels with emphasis on amygdala modulation through Acid-Sensitive Ion Channels (ASIC1aRs) and their role in anxiety pathways.

Education:

• B.S. in Molecular Physics, Faculty of Physics, Shevchenko State University, Kyiv (1965-1970)
• Ph.D. (Candidate of Biol. Sciences), Bogomoletz Institute of Physiology, Kyiv (1969-1972, 1974-1975)
• Doctor of Biol. Sciences (1975-1987)

Pidoplichko's research trajectory spans five decades, beginning with fundamental biophysical studies of ion channels in snail neurons and cardiomyocytes. His work progressively shifted toward mammalian neural systems, particularly hippocampal and amygdala circuits. Key contributions include identifying proton receptors in nerve membranes, characterizing ASIC channel functions in anxiety regulation, and demonstrating ammonium's neurotoxic effects on dopamine neurons through acid-sensitive channels. His methodology innovations in solution exchange and localized compound application remain influential in electrophysiology.

Publication analysis reveals consistent focus on ion channel mechanisms across model systems, with recent work (2005-2014) emphasizing translational implications for anxiety disorders and hyperammonemia. His 2014 Journal of Neuroscience paper established ASIC1a's role in amygdala inhibition as an anxiety-reducing mechanism.

Scientific Awards:

• State prize USSR Council of Ministers (1983)

Throughout his career, Pidoplichko has collaborated with leading neuroscientists including Dr. P.G. Kostyuk (Bogomoletz Institute), Dr. K.G. Reymann (Magdeburg), Dr. John A. Dani (Baylor), and currently Prof. Maria F. Braga at USUHS. While specific grant details aren't documented, his sustained publication record indicates continuous research funding. He currently operates within Prof. Braga's laboratory at Walter Reed National Military Medical Center, advancing research on amygdala ion channels and anxiety neurobiology.