معرفی
Vivian Saridakis is an Associate Professor in the Department of Biology at York University's Faculty of Science, serving concurrently as Associate Dean Research and Graduate Studies. Their research focuses on deubiquitinating enzymes, particularly ubiquitin-specific protease 7 (USP7), and its role in cellular processes such as proteasomal degradation, DNA replication, and cancer biology. Key interests include understanding USP7's interactions with viral proteins, its regulation of ubiquitin-conjugating enzymes, and therapeutic opportunities in oncology.
Research emphasizes structural and biochemical analyses of USP7's substrate recognition mechanisms and its role in epigenetic regulation via histone ubiquitination. Notable projects include studies on Kaposi's sarcoma-associated herpesvirus (KSHV) and the molecular basis of USP7's involvement in cancer pathways. The lab employs techniques like X-ray crystallography and functional genomics to explore these interactions.
Publications highlight advancements in understanding USP7's roles in viral pathogenesis, chromatin modification, and metabolic enzyme regulation. The work bridges fundamental biology and translational medicine, with implications for developing targeted cancer therapies.
