Vincent Rotello

Vincent Rotello is a University Distinguished Professor of Chemistry at the University of Massachusetts Amherst. He holds multiple affiliations including Faculty in the Graduate Program in Molecular & Cellular Biology, the Center for Bioactive Delivery, the Models to Medicine program, the Center for Personalized Health Monitoring, and the Materials Science and Engineering Interdisciplinary Graduate Program at the Institute for Applied Life Sciences.

Dr. Rotello received his B.S. in Chemistry (Honors) from Illinois Institute of Technology in 1985, followed by an M. Phil and Ph.D. in Chemistry from Yale University in 1987 and 1990, respectively. He completed an NSF Postdoctoral Fellowship at the Massachusetts Institute of Technology from 1990-1993 before joining the faculty at UMass Amherst.

Professor Rotello's research focuses on supramolecular chemistry, particularly the study and application of non-covalent interactions including hydrogen bonding and aromatic stacking. His work spans nanotechnology, bionanotechnology, bioorthogonal chemistry, drug delivery, and antimicrobial development. His laboratory explores how these molecular recognition concepts can address essential questions in biology, biomedicine, and material chemistry, with particular emphasis on using synthetic organic chemistry to engineer interfaces between synthetic and biological worlds. The group has published over 650 peer-reviewed papers to date.

His recent publications reveal a strong trend toward bioorthogonal catalysis, particularly 'nanozymes' and 'polyzymes' - nanomaterial scaffolds incorporating transition metal catalysts for localized drug and imaging agent generation. His research increasingly addresses biomedical applications including cancer treatment, bacterial infection control, and diagnostic development, with significant focus on antimicrobial applications and biofilm eradication.

• Arthur C. Cope Scholar Award (2023)
• Highly Cited Researcher by Clarivate (2014, 2015, 2018-2023)
• Fellow of the American Association for the Advancement of Science
• Fellow of the Royal Society of Chemistry (UK)
• NSF CAREER award
• Cottrell Scholar award
• Camille Dreyfus Teacher-Scholar
• Sloan Fellowship

Professor Rotello has mentored numerous graduate students and postdoctoral fellows, with recent PhD graduates including Dr. Aarohi Gupta and Dr. Aritra Nath Chattopadhyay. His research group maintains active collaborations across multiple disciplines and has secured significant funding for their work in nanotechnology and bionanotechnology. The group has published over 650 peer-reviewed papers, demonstrating consistent productivity and impact in their field.

The Rotello Lab operates within the Lederle Graduate Research Tower at UMass Amherst, with office in room 379 and laboratory space in room 320. The group consists of graduate students, postdoctoral fellows, and visiting scholars from around the world, working collaboratively on projects spanning antimicrobials, bioorthogonal chemistry, drug delivery, and sensing technologies. The lab has documented numerous visiting scholars from institutions across Europe, Asia, and North America, indicating strong international collaborations.