Uwe Wolfrum

Professor Uwe Wolfrum is a faculty member at Johannes Gutenberg University Mainz, where he holds a position in the Department of Biology and Institute of Molecular Physiology. His research program focuses on molecular mechanisms underlying sensory cell function and retinal diseases.

Research interests span several interconnected domains:

• Retinal biology and AAV-based gene therapy for Usher syndrome
• Ciliary cytoskeleton dynamics and molecular motors
• Scaffold protein functions in cellular organelles
• Non-canonical G protein signaling pathways

He currently leads two major DFG-funded projects:

• USH1C/harmoninin retinal function and gene therapy in porcine models (Priority Program)
• Molecular characterization of USH1G/SANS in cilia and nuclei (Research Grant)

Previously completed projects include studies on ciliary cytoskeletal components, molecular motors, centrin-G protein interactions, and VLGR1 signaling pathways.

Professor Wolfrum has collaborated as a participating scientist in Research Training Group GRK 1044 (neural system modifications) and as a partner in retinal gene therapy optimization initiatives. His laboratory is embedded within the Institute of Molecular Physiology, though no specific lab name or website is provided.