Upender Manne

Dr. Upender Manne is a Professor in the Department of Anatomic Pathology at the University of Alabama at Birmingham (UAB), holding joint appointments in Surgery (General Surgery Gastrointestinal Section) and Epidemiology. He leads the Comprehensive Cancer Research Partnership programs funded by the National Cancer Institute, focusing on reducing cancer health disparities. His research emphasizes molecular mechanisms underlying racial disparities in colorectal and breast cancers, with a focus on biomarker discovery and precision medicine.

**Education**: Dr. Manne earned his M.S. in Biochemistry, Histochemistry, Parasitology, and Zoonosis, and his Ph.D. in energy metabolic pathways of endoparasites from Osmania University, India. He completed postdoctoral training in molecular immunology, helicobacter infections, histopathology, and tumor biology at institutions including the University of New South Wales and UAB.

**Research Interests**: His lab investigates molecular markers predictive of chemotherapy response, tumor progression, and clinical outcomes in gastrointestinal and breast cancers. Key projects include developing the MammOnc-DB platform for breast cancer data analysis, studying racial disparities in mutation profiles, and discovering novel therapeutic targets like pan-RAS inhibitors (e.g., ADT-1004).

**Grants/Leadership**: He directs the UAB Tissue Biorepository and leads NCI-funded programs partnering UAB with Tuskegee University, Morehouse School of Medicine, and Alabama State University. His grants total over $20 million, focusing on disparities research, drug development, and cancer control.

**Awards**: While no explicit awards are listed, his leadership roles and sustained federal funding reflect significant recognition in the field.