Ulrich Broeckel

Dr. Ulrich Broeckel is a Professor and Chief of the Division of Genomic Pediatrics at the Medical College of Wisconsin. He serves as Research Unit Leader for Genetics and Genomics at the Children's Research Institute and maintains membership in three major research centers: the Cancer Center, the Cardiovascular Research Center, and the Mellowes Center for Genomic Sciences and Precision Medicine. His extensive academic contributions span multiple disciplines within genomic medicine.

Dr. Broeckel's research focuses on cardiovascular genomics, pharmacogenetics, and structural variant analysis. His work encompasses genome-wide association studies of cardiovascular traits, genetic factors in drug response, and the development of genomic reference materials. He investigates how genetic variation influences blood pressure regulation, coagulation factors, and drug-induced cardiotoxicity, with recent work utilizing hiPSC-derived cardiomyocytes for personalized medicine applications. His methodological expertise includes whole genome sequencing, GWAS, exome analysis, DNA copy number variation analysis, and high-throughput nucleotide sequencing.

Analysis of Dr. Broeckel's recent publications (2023-2024) reveals three major thematic areas: 1) Development of pharmacogenomic reference materials (DPYD, CYP2D6, CYP3A4/5), 2) Cardiovascular genomics including polygenic risk scores for blood pressure response, and 3) Application of hiPSC-derived models for studying drug responses. His work consistently emphasizes practical applications of genomic discoveries with strong representation in high-impact collaborative studies through the TOPMed Consortium.

Dr. Broeckel's research has significant translational impact, particularly in pharmacogenomics where his work directly informs clinical testing guidelines. His development of reference materials for genetic testing has practical applications in clinical laboratories. The work on polygenic risk scores for blood pressure response and cardiotoxicity prediction has direct implications for personalized medicine approaches in cardiology and oncology.

Dr. Broeckel is deeply embedded in major national collaborative research networks, particularly the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. He has contributed to numerous multi-institutional projects including the GeT-RM Collaborative Project focused on pharmacogenetic reference materials. His authorship on papers with dozens of co-authors across multiple institutions demonstrates extensive national and international collaboration in large-scale genomic studies.