Trevor P. Creamer

Trevor P. Creamer is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, where he also serves as Associate Dean for Faculty Affairs in Basic Sciences and Director of Graduate Studies. His research focuses on intrinsically disordered proteins and their roles in cellular signaling, particularly through the calcineurin-calmodulin pathway.

His educational background includes a Ph.D. in Physical Chemistry from the University of Western Australia, followed by postdoctoral training at Johns Hopkins School of Medicine, Washington University at St. Louis, University of North Carolina at Chapel Hill, and The Pennsylvania State University.

Dr. Creamer's research interests center on the structural and biophysical properties of intrinsically disordered regions (IDRs) in proteins. He investigates how these dynamic regions regulate essential cellular processes, particularly through calcineurin, a phosphatase involved in memory, cardiac development, and immune responses. His work bridges structural biology, biophysics, and disease mechanisms, providing insights into Alzheimer’s, Down syndrome, and autoimmune disorders.

His recent publications reveal a sustained focus on protein conformational dynamics, macromolecular interactions, and phase separation phenomena. The articles span topics from viral protein assembly to nuclear receptor ligand binding, indicating a broad yet cohesive research program in molecular recognition and disorder-to-order transitions.

• Research on calcineurin regulation and calmodulin interactions
• Studies on polyproline II helix formation and protein folding
• Investigations into viral membrane fusion and phase separation

Dr. Creamer has held major academic leadership roles, including Director of Graduate Studies and Associate Dean, indicating active involvement in training and institutional development. While specific grants are not listed, his sustained publication record suggests ongoing funded research. He advises graduate students through the Molecular and Cellular Biochemistry program.

He leads an active research laboratory at the University of Kentucky, focusing on protein dynamics and signaling mechanisms. The lab employs biophysical, biochemical, and computational approaches to dissect molecular interactions involving disordered protein regions.