Toshi Kawate

Toshi Kawate is an Associate Professor at the Department of Molecular Medicine, Cornell University College of Veterinary Medicine. His research focuses on membrane proteins that regulate extracellular ATP-mediated signaling, a critical pathway in cell-cell communication related to immune responses and neurotransmission.

• Education:
  • PhD in Cellular, Molecular, Biophysical Studies (2005), Columbia University
  • MS in Medical Science (2000), Osaka University
  • BS in Biology (1998), Osaka University

Kawate's lab combines structural biology techniques (cryo-EM, X-ray crystallography) with electrophysiology and C. elegans behavioral studies to investigate the architecture and molecular mechanisms of ion channels. His work has revealed novel drug-binding pockets in P2X7 receptors, advancing understanding of chronic pain pathways.

Research trends from his publications indicate expertise in ion channel structure, ATP signaling dynamics, and membrane lipid interactions. His team explores subtype-specific inhibition mechanisms and develops functional reconstitution systems for drug screening.

• Scientific Awards:
  • Human Frontier Science Program Young Investigators Grant
  • NIH Pathway to Independence Awards (R00, K99)
  • NIH Fellows Award for Research Excellence

Kawate's lab investigates membrane protein physiology using C. elegans and CRISPR-Cas9 genome editing, aiming to bridge structural insights with in vivo behavior. Current projects include developing a "Painometer" biosensor for objective pain assessment in clinical and veterinary settings.