معرفی
Tom Wandless is a Professor at the Department of Chemical and Systems Biology, Stanford University School of Medicine, with memberships in Bio-X and the Stanford Cancer Institute. His career spans synthetic chemistry, chemical biology, and systems biology.
- Education:
- Ph.D. in Chemistry, Harvard University (1993)
- B.S. in Biochemistry, Trinity University (1988)
Research focuses on inventing molecules and techniques for biological studies, particularly destabilizing domains (DDs) that enable ligand-dependent protein regulation. His lab pioneered systems using Shield-1, light, and ubiquitin-derived linkers for reversible protein control. Key areas include:
- Protein quality control mechanisms
- Unfolded protein stress responses
- Ubiquitin-proteasome system
- Chemogenetic and optogenetic tools
- Applications in cancer immunotherapy
Publications highlight innovations in protein degradation, transcriptional stress responses, and cAMP sensor development. Awards include NSF CAREER, Ellison Medical Foundation, and Alfred P. Sloan Fellowship. Teaching accolades include multiple Stanford teaching awards and the Phi Beta Kappa Prize. Lab members include Joseph Park (PhD student) and Ling-Chun Chen (Research Scientist).
