معرفی
Dr. Tina Kroll is a researcher at the Institute of Neuroscience and Medicine (INM-2) at the Research Center Jülich GmbH. Her work focuses on neuroimaging, particularly positron emission tomography (PET), to study neurodegenerative diseases like Alzheimer’s, adenosine receptor dynamics, and the effects of sleep deprivation on brain function. She investigates synaptic density, molecular pathology quantification, and the interplay between sleep architecture and neurodegenerative processes.
Key projects include developing novel PET-derived biomarkers for Alzheimer’s (e.g., spatial extent analysis of pathology), optimizing awake PET methodologies in rodents, and exploring sex differences in synaptic density measurement. Her research integrates genetics, neurophysiology, and advanced imaging techniques to understand brain mechanisms in health and disease. Collaborations span neurology, psychiatry, and computational biology, with a focus on translating findings into clinical staging models (e.g., T-POT cohort for tau propagation).
Technical contributions include enhancing PET/MRI image quality with deep learning, improving motion correction in animal PET studies, and validating radiotracer applications for adenosine receptors. Her work bridges preclinical models and clinical applications, addressing challenges in neuroimaging accuracy and translational research.
