Tim Yeh

Tim Yeh is a Professor in the Department of Biomedical Engineering at The University of Texas at Austin, holding the David & Doris Lybarger Endowed Faculty Fellowship in Engineering. His research focuses on nanobiosensor development, single-molecule spectroscopy, and advanced imaging techniques to elucidate biological processes at the molecular and cellular levels.

His work integrates nanotechnology and quantitative biology to address challenges in disease diagnosis and treatment. Key areas include the creation of novel nanomaterial-based probes (e.g., fluorescent gold/silver nanoclusters) and high-resolution imaging systems like 3D molecular tracking microscopes and super-resolution STED microscopy. These tools are applied to study cancer biomarkers, cellular signaling networks, and metabolic pathways in live cells and tissues.

Notable projects include developing nanopore sensing platforms for protein detection, optimizing fluorogenic aptamers using high-throughput sequencing, and enhancing fluorescence lifetime imaging (FLIM) for real-time metabolic monitoring in cancer cells. His lab, the NanoBiosensors and Molecular Tracking Laboratory, emphasizes interdisciplinary approaches to bridge gaps between nanotechnology and biomedical applications.

Recent publications highlight innovations in multiphoton imaging, deep learning-driven resolution enhancement, and systems biology modeling of neural dynamics. These advancements aim to improve diagnostic precision and enable deeper insights into cellular heterogeneity and stochastic molecular processes.